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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for KLF7

Z-value: 0.28

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Transcription factors associated with KLF7

Gene Symbol Gene ID Gene Info
KLF7
ENSG00000118263.15 KLF7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
KLF7hg38_v1_chr2_-_207166818_2071668710.487.9e-03Click!

Activity profile of KLF7 motif

Sorted Z-values of KLF7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF7

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_+_155758990 0.59 ENST00000505154.5
ENST00000652626.1
ENST00000502959.5
ENST00000264424.13
ENST00000505764.5
ENST00000507146.5
ENST00000503520.5
GUCY1B1
guanylate cyclase 1 soluble subunit beta 1
chr4_+_155759365 0.53 ENST00000513437.1
GUCY1B1
guanylate cyclase 1 soluble subunit beta 1
chr1_+_201283452 0.37 ENST00000263946.7
ENST00000367324.8
PKP1
plakophilin 1
chr17_-_82098187 0.36 ENST00000634990.1
FASN
fatty acid synthase
chr17_-_82098223 0.35 ENST00000306749.4
ENST00000635197.1
FASN
fatty acid synthase
chr16_+_11345429 0.35 ENST00000576027.1
ENST00000312499.6
ENST00000648619.1
RMI2
RecQ mediated genome instability 2
chr17_+_43398984 0.27 ENST00000320033.5
ARL4D
ADP ribosylation factor like GTPase 4D
chr1_-_18902520 0.24 ENST00000538839.5
ENST00000290597.9
ENST00000375341.8
ALDH4A1
aldehyde dehydrogenase 4 family member A1
chr8_+_11284789 0.22 ENST00000221086.8
MTMR9
myotubularin related protein 9
chr19_+_38899680 0.20 ENST00000576510.5
ENST00000392079.7
NFKBIB
NFKB inhibitor beta
chr19_+_38899946 0.18 ENST00000572515.5
ENST00000313582.6
ENST00000575359.5
NFKBIB
NFKB inhibitor beta
chr6_-_104859828 0.17 ENST00000519645.5
ENST00000262903.9
ENST00000369125.6
HACE1
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
chr8_+_17247030 0.15 ENST00000521829.5
ENST00000521005.1
VPS37A
VPS37A subunit of ESCRT-I
chr19_-_7629531 0.14 ENST00000358368.5
XAB2
XPA binding protein 2
chr17_+_40219276 0.14 ENST00000583268.1
ENST00000323571.9
WIPF2
WAS/WASL interacting protein family member 2
chr19_-_38899800 0.13 ENST00000414941.5
ENST00000358931.9
ENST00000392081.6
SIRT2
sirtuin 2
chr21_+_31873010 0.12 ENST00000270112.7
HUNK
hormonally up-regulated Neu-associated kinase
chr17_-_44385332 0.12 ENST00000648408.1
ITGA2B
integrin subunit alpha 2b
chr5_+_177133005 0.10 ENST00000510954.5
ENST00000354179.8
NSD1
nuclear receptor binding SET domain protein 1
chr19_-_38899529 0.10 ENST00000249396.12
ENST00000437828.5
SIRT2
sirtuin 2
chr15_+_74130243 0.10 ENST00000561740.5
ENST00000435464.5
ISLR2
immunoglobulin superfamily containing leucine rich repeat 2
chr1_-_161132577 0.10 ENST00000464113.1
DEDD
death effector domain containing
chr2_+_69741974 0.10 ENST00000409920.5
ANXA4
annexin A4
chr3_-_105868964 0.09 ENST00000394030.8
CBLB
Cbl proto-oncogene B
chr3_+_179148341 0.09 ENST00000263967.4
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
chr2_-_74482914 0.09 ENST00000290418.4
ENST00000393965.8
CCDC142
coiled-coil domain containing 142
chr17_+_19378476 0.09 ENST00000395604.8
ENST00000482850.1
MAPK7
mitogen-activated protein kinase 7
chr2_+_112721486 0.08 ENST00000327581.4
NT5DC4
5'-nucleotidase domain containing 4
chr6_-_30617232 0.08 ENST00000376511.7
PPP1R10
protein phosphatase 1 regulatory subunit 10
chr19_-_45792755 0.08 ENST00000377735.7
ENST00000270223.7
DMWD
DM1 locus, WD repeat containing
chr8_+_17246921 0.08 ENST00000518038.1
ENST00000324849.9
VPS37A
VPS37A subunit of ESCRT-I
chr3_-_33097132 0.07 ENST00000307363.10
ENST00000307377.12
ENST00000440656.1
ENST00000436768.1
ENST00000342462.5
GLB1
TMPPE
galactosidase beta 1
transmembrane protein with metallophosphoesterase domain
chrX_-_93673558 0.07 ENST00000475430.2
ENST00000373079.4
NAP1L3
nucleosome assembly protein 1 like 3
chr17_-_4948519 0.07 ENST00000225655.6
PFN1
profilin 1
chr8_+_89757789 0.06 ENST00000220751.5
RIPK2
receptor interacting serine/threonine kinase 2
chr12_+_49961864 0.06 ENST00000293599.7
AQP5
aquaporin 5
chr2_+_97113600 0.06 ENST00000620383.1
ANKRD36
ankyrin repeat domain 36
chr13_-_32538819 0.05 ENST00000674452.1
ENST00000674422.1
ENST00000674349.1
ENST00000674465.1
ENST00000674327.1
ENST00000505213.5
ENST00000357505.10
ENST00000399396.7
N4BP2L2
NEDD4 binding protein 2 like 2
chr1_-_161132659 0.05 ENST00000368006.8
ENST00000490843.6
ENST00000545495.5
DEDD
death effector domain containing
chr12_+_53380141 0.05 ENST00000551969.5
ENST00000327443.9
SP1
Sp1 transcription factor
chr1_+_26826682 0.05 ENST00000374142.9
ZDHHC18
zinc finger DHHC-type palmitoyltransferase 18
chr7_+_49773632 0.04 ENST00000340652.5
VWC2
von Willebrand factor C domain containing 2
chr6_+_37257762 0.03 ENST00000373491.3
TBC1D22B
TBC1 domain family member 22B
chr15_+_97960692 0.03 ENST00000268042.7
ARRDC4
arrestin domain containing 4
chrX_+_103376389 0.03 ENST00000372645.3
ENST00000372635.1
BEX3
brain expressed X-linked 3
chr12_-_46372763 0.03 ENST00000256689.10
SLC38A2
solute carrier family 38 member 2
chr6_+_43635832 0.03 ENST00000372171.5
MAD2L1BP
MAD2L1 binding protein
chr15_+_92393841 0.03 ENST00000268164.8
ENST00000539113.5
ENST00000555434.1
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr17_+_81239310 0.03 ENST00000431388.3
NDUFAF8
NADH:ubiquinone oxidoreductase complex assembly factor 8
chrX_+_103376488 0.03 ENST00000361298.9
BEX3
brain expressed X-linked 3
chr17_-_18314956 0.03 ENST00000321105.10
ENST00000542570.5
TOP3A
DNA topoisomerase III alpha
chr12_-_6753134 0.03 ENST00000203630.10
MLF2
myeloid leukemia factor 2
chr14_-_100568070 0.02 ENST00000557378.6
ENST00000443071.6
ENST00000637646.1
BEGAIN
brain enriched guanylate kinase associated
chr17_+_40219325 0.02 ENST00000585043.5
ENST00000394103.7
WIPF2
WAS/WASL interacting protein family member 2
chr10_-_16817362 0.02 ENST00000377921.7
ENST00000345264.10
RSU1
Ras suppressor protein 1
chr17_+_18315273 0.02 ENST00000406438.5
SMCR8
SMCR8-C9orf72 complex subunit
chr2_+_74483067 0.02 ENST00000233623.11
ENST00000442235.6
ENST00000410003.5
TTC31
tetratricopeptide repeat domain 31
chr1_-_157138388 0.01 ENST00000368192.9
ETV3
ETS variant transcription factor 3
chrX_+_103376887 0.01 ENST00000372634.1
BEX3
brain expressed X-linked 3
chr9_+_127802858 0.01 ENST00000393706.6
ENST00000630236.2
ENST00000373247.7
ENST00000373228.5
FPGS
folylpolyglutamate synthase
chr7_+_128791390 0.01 ENST00000459946.5
ENST00000378685.8
ENST00000464832.5
ENST00000472049.1
ENST00000488925.1
CCDC136
coiled-coil domain containing 136
chr15_+_57706725 0.01 ENST00000380557.4
ENST00000649091.1
POLR2M
RNA polymerase II subunit M
chr6_-_109382431 0.00 ENST00000324953.9
ENST00000275080.11
ENST00000413644.6
CD164
CD164 molecule

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.2 GO:1900195 positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.1 0.7 GO:0015939 pantothenate metabolic process(GO:0015939)
0.1 0.4 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 0.1 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.0 0.1 GO:0030821 negative regulation of cyclic nucleotide catabolic process(GO:0030806) negative regulation of cAMP catabolic process(GO:0030821)
0.0 0.1 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.0 0.1 GO:0033091 positive regulation of immature T cell proliferation(GO:0033091)
0.0 0.1 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.1 GO:1904016 response to Thyroglobulin triiodothyronine(GO:1904016)
0.0 0.0 GO:1900239 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0042587 glycogen granule(GO:0042587)
0.0 0.1 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.0 0.2 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0016420 [acyl-carrier-protein] S-malonyltransferase activity(GO:0004314) 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) S-malonyltransferase activity(GO:0016419) malonyltransferase activity(GO:0016420)
0.1 0.2 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.0 0.4 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0070051 fibrinogen binding(GO:0070051)
0.0 0.1 GO:0005163 nerve growth factor receptor binding(GO:0005163)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.4 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex