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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for MECP2
Z-value: 1.67
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Transcription factors associated with MECP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MECP2 | hg38_v1_chrX_-_154097731_154097746 | 0.27 | 1.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MECP2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_50968125 Show fit | 5.95 |
ENST00000594641.1
|
kallikrein related peptidase 6 |
|
| chr2_-_224039278 Show fit | 5.62 |
ENST00000409304.6
ENST00000258405.9 ENST00000454956.1 |
serpin family E member 2 |
|
| chr17_+_72121012 Show fit | 4.69 |
ENST00000245479.3
|
SRY-box transcription factor 9 |
|
| chr19_-_50968966 Show fit | 4.55 |
ENST00000376851.7
|
kallikrein related peptidase 6 |
|
| chr1_-_231040218 Show fit | 4.43 |
ENST00000366654.5
|
family with sequence similarity 89 member A |
|
| chr13_-_20232303 Show fit | 4.18 |
ENST00000400065.7
ENST00000643121.1 ENST00000647029.1 ENST00000643211.1 ENST00000400066.8 ENST00000644283.1 |
gap junction protein beta 6 |
|
| chr1_-_16980607 Show fit | 4.09 |
ENST00000375535.4
|
microfibril associated protein 2 |
|
| chr2_+_23385170 Show fit | 4.01 |
ENST00000486442.6
|
kelch like family member 29 |
|
| chr21_-_6468040 Show fit | 3.89 |
ENST00000618024.4
ENST00000617706.4 |
cystathionine beta-synthase like |
|
| chr10_+_28677487 Show fit | 3.88 |
ENST00000375533.6
|
BMP and activin membrane bound inhibitor |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 19.2 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 1.7 | 10.2 | GO:0006535 | cysteine biosynthetic process from serine(GO:0006535) |
| 0.1 | 9.1 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 0.1 | 8.5 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.5 | 8.2 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 1.1 | 8.0 | GO:0030421 | defecation(GO:0030421) |
| 0.5 | 7.5 | GO:0035878 | nail development(GO:0035878) |
| 0.2 | 7.4 | GO:2000811 | negative regulation of anoikis(GO:2000811) |
| 1.0 | 7.3 | GO:0010757 | negative regulation of plasminogen activation(GO:0010757) |
| 0.3 | 7.1 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 42.7 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 38.3 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 19.8 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.2 | 18.5 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.3 | 9.8 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 9.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.4 | 9.6 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.4 | 9.6 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 9.6 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.6 | 9.5 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 43.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 33.9 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 21.8 | GO:0002020 | protease binding(GO:0002020) |
| 0.1 | 14.0 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 12.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 12.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 10.6 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.1 | 10.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.7 | 10.2 | GO:0004122 | cystathionine beta-synthase activity(GO:0004122) |
| 0.4 | 9.1 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 45.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 20.5 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.3 | 19.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 13.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.6 | 11.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 10.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 9.2 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.1 | 8.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 8.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.3 | 7.1 | PID S1P S1P1 PATHWAY | S1P1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 14.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 12.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.4 | 9.6 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.4 | 9.3 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.2 | 9.3 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 9.2 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.2 | 8.9 | REACTOME LIPOPROTEIN METABOLISM | Genes involved in Lipoprotein metabolism |
| 0.1 | 8.9 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 8.6 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |