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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for MSX1

Z-value: 0.55

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Transcription factors associated with MSX1

Gene Symbol Gene ID Gene Info
ENSG00000163132.8 MSX1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MSX1hg38_v1_chr4_+_4859658_4859672-0.337.2e-02Click!

Activity profile of MSX1 motif

Sorted Z-values of MSX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr3_-_167407837 2.35 ENST00000455345.7
zinc finger B-box domain containing
chr5_+_122129533 2.11 ENST00000296600.5
ENST00000504912.1
ENST00000505843.1
zinc finger protein 474
chr11_+_94512452 1.64 ENST00000542198.3
chromosome 11 open reading frame 97
chr11_+_101914997 1.46 ENST00000263468.13
centrosomal protein 126
chr7_+_139133744 1.36 ENST00000430935.5
ENST00000495038.5
ENST00000474035.6
ENST00000478836.6
ENST00000464848.5
ENST00000343187.8
tetratricopeptide repeat domain 26
chr6_+_26240385 1.35 ENST00000244537.6
H4 clustered histone 6
chr3_-_180679468 1.34 ENST00000651046.1
ENST00000476379.6
coiled-coil domain containing 39
chr3_+_108589667 1.28 ENST00000361582.8
ENST00000486815.5
DAZ interacting zinc finger protein 3
chr2_-_208163588 0.88 ENST00000304502.5
crystallin gamma A
chr5_+_122129597 0.84 ENST00000514925.1
novel zinc finger protein
chr6_-_149890900 0.78 ENST00000529948.1
ENST00000357183.8
ENST00000367363.3
retinoic acid early transcript 1E
chr3_+_171843337 0.76 ENST00000334567.9
ENST00000619900.4
ENST00000450693.1
transmembrane protein 212
chr6_-_75363003 0.75 ENST00000370020.1
filamin A interacting protein 1
chr7_-_56034133 0.69 ENST00000421626.5
phosphoserine phosphatase
chr1_-_150765785 0.64 ENST00000680311.1
ENST00000681728.1
ENST00000680288.1
cathepsin S
chr7_-_105691637 0.57 ENST00000472195.1
ataxin 7 like 1
chr12_+_9827517 0.56 ENST00000537723.5
killer cell lectin like receptor F1
chr3_-_123620496 0.54 ENST00000578202.1
myosin light chain kinase
chr3_-_123620571 0.54 ENST00000583087.5
myosin light chain kinase
chr9_-_128656649 0.54 ENST00000372715.7
dynein 2 intermediate chain 2
chr6_+_6588082 0.53 ENST00000379953.6
lymphocyte antigen 86
chr14_+_30577752 0.52 ENST00000547532.5
ENST00000555429.1
G2/M-phase specific E3 ubiquitin protein ligase
chr4_-_99219230 0.48 ENST00000394897.5
ENST00000508558.1
ENST00000394899.6
alcohol dehydrogenase 6 (class V)
chr14_+_77116562 0.42 ENST00000557408.5
transmembrane protein 63C
chr8_-_71361860 0.37 ENST00000303824.11
ENST00000645451.1
EYA transcriptional coactivator and phosphatase 1
chr9_-_123184233 0.37 ENST00000447404.6
spermatid perinuclear RNA binding protein
chr3_-_94062906 0.36 ENST00000314636.3
ENST00000394221.3
dihydrofolate reductase 2
chr18_-_50195138 0.35 ENST00000285039.12
myosin VB
chr12_-_12684490 0.35 ENST00000540510.1
G protein-coupled receptor 19
chr1_-_53940100 0.33 ENST00000371376.1
heat shock protein family B (small) member 11
chr9_-_15510289 0.32 ENST00000397519.6
PC4 and SFRS1 interacting protein 1
chr3_-_94062881 0.32 ENST00000619045.1
dihydrofolate reductase 2
chrX_-_104254921 0.31 ENST00000372588.4
ESX homeobox 1
chr16_-_71484543 0.30 ENST00000565100.6
zinc finger protein 19
chr3_+_190388120 0.30 ENST00000456423.2
ENST00000264734.3
claudin 16
chr6_-_52840843 0.29 ENST00000370989.6
glutathione S-transferase alpha 5
chr10_-_43397220 0.29 ENST00000477108.5
ENST00000544000.5
heterogeneous nuclear ribonucleoprotein F
chr5_+_140841183 0.28 ENST00000378123.4
ENST00000531613.2
protocadherin alpha 8
chr12_+_9827472 0.26 ENST00000617793.4
ENST00000617889.5
ENST00000354855.7
ENST00000279545.7
killer cell lectin like receptor F1
chr1_+_210328244 0.25 ENST00000541565.5
ENST00000413764.6
hedgehog acyltransferase
chr10_+_112283399 0.23 ENST00000643850.1
ENST00000646139.2
ENST00000645243.1
tectorin beta
chr11_-_102625332 0.23 ENST00000260228.3
matrix metallopeptidase 20
chr2_-_168890368 0.23 ENST00000282074.7
SPC25 component of NDC80 kinetochore complex
chr14_+_93185304 0.23 ENST00000415050.3
transmembrane protein 251
chr4_+_112647059 0.23 ENST00000511529.1
La ribonucleoprotein 7, transcriptional regulator
chr15_+_76336755 0.23 ENST00000290759.9
ISL LIM homeobox 2
chr18_+_63970029 0.23 ENST00000353706.6
ENST00000542677.5
ENST00000397985.7
ENST00000636430.1
ENST00000397988.7
ENST00000448851.5
serpin family B member 8
chr15_-_77420135 0.22 ENST00000560626.6
pseudopodium enriched atypical kinase 1
chr15_-_77420087 0.22 ENST00000564328.5
ENST00000682557.1
ENST00000558305.5
pseudopodium enriched atypical kinase 1
chr10_+_17228215 0.21 ENST00000544301.7
vimentin
chr13_+_48976597 0.21 ENST00000541916.5
fibronectin type III domain containing 3A
chr8_+_2045058 0.21 ENST00000523438.1
myomesin 2
chr8_+_2045037 0.19 ENST00000262113.9
myomesin 2
chr4_+_70242583 0.19 ENST00000304954.3
casein kappa
chr1_-_160523204 0.19 ENST00000368055.1
ENST00000368057.8
ENST00000368059.7
SLAM family member 6
chr6_+_131573219 0.18 ENST00000356962.2
ENST00000368087.8
ENST00000673427.1
ENST00000640973.1
arginase 1
chrX_+_135520616 0.18 ENST00000370752.4
ENST00000639893.2
integrator complex subunit 6 like
chr10_-_32378720 0.18 ENST00000375110.6
enhancer of polycomb homolog 1
chr21_+_32298945 0.18 ENST00000339944.4
melanocortin 2 receptor accessory protein
chr1_+_244835616 0.17 ENST00000366528.3
ENST00000411948.7
cytochrome c oxidase assembly factor COX20
chr8_-_17697654 0.17 ENST00000297488.10
microtubule associated scaffold protein 1
chr7_+_2596897 0.17 ENST00000423196.1
IQ motif containing E
chr7_+_2559422 0.17 ENST00000325979.11
ENST00000423395.5
IQ motif containing E
chr21_+_42199686 0.16 ENST00000398457.6
ATP binding cassette subfamily G member 1
chr12_-_42144823 0.15 ENST00000398675.8
glucoside xylosyltransferase 1
chr17_+_57085092 0.14 ENST00000575322.1
ENST00000337714.8
A-kinase anchoring protein 1
chr2_+_188292814 0.14 ENST00000409580.5
ENST00000409637.7
GULP PTB domain containing engulfment adaptor 1
chr15_-_76012390 0.14 ENST00000394907.8
neuregulin 4
chr1_-_158426237 0.14 ENST00000641042.1
olfactory receptor family 10 subfamily K member 2
chr20_+_58389197 0.13 ENST00000475243.6
ENST00000395802.7
VAMP associated protein B and C
chr14_-_74923234 0.13 ENST00000556776.1
ENST00000557413.6
ENST00000555647.5
ribosomal protein S6 kinase like 1
chr6_+_156776020 0.13 ENST00000346085.10
AT-rich interaction domain 1B
chr16_-_11527245 0.13 ENST00000598234.6
novel lipoprotein amino terminal region containing protein
chr1_+_224183197 0.13 ENST00000323699.9
delta 4-desaturase, sphingolipid 1
chr5_+_173889337 0.12 ENST00000520867.5
ENST00000334035.9
cytoplasmic polyadenylation element binding protein 4
chr6_-_32816910 0.12 ENST00000447394.1
ENST00000438763.7
major histocompatibility complex, class II, DO beta
chr19_-_49036885 0.12 ENST00000604577.1
ENST00000591656.1
ENST00000301407.8
ENST00000601167.1
novel protein
chorionic gonadotropin subunit beta 1
chr5_-_76623391 0.12 ENST00000296641.5
ENST00000504899.1
coagulation factor II thrombin receptor like 2
chr5_+_83471764 0.12 ENST00000512590.6
ENST00000513960.5
ENST00000513984.5
versican
chr14_+_51860632 0.12 ENST00000555472.5
ENST00000556766.5
G protein subunit gamma 2
chr13_-_51974775 0.11 ENST00000674147.1
ATPase copper transporting beta
chr8_+_24384455 0.11 ENST00000522298.1
ADAM like decysin 1
chr9_-_21240002 0.11 ENST00000380222.4
interferon alpha 14
chr1_+_76074698 0.11 ENST00000328299.4
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr6_+_135851681 0.10 ENST00000308191.11
phosphodiesterase 7B
chr17_+_76732978 0.10 ENST00000587459.1
novel protein
chr20_+_35542038 0.10 ENST00000357394.8
ENST00000348547.7
ENST00000416206.5
ENST00000640748.1
ENST00000411577.5
ENST00000413587.5
ERGIC and golgi 3
chr19_-_53159004 0.10 ENST00000599096.1
ENST00000597183.5
ENST00000601804.5
ENST00000334197.12
ENST00000601469.2
ENST00000452676.6
zinc finger protein 347
chr11_+_61430100 0.09 ENST00000542074.1
ENST00000534878.5
ENST00000301761.7
ENST00000537782.5
ENST00000543265.1
succinate dehydrogenase complex assembly factor 2
chrX_-_123623155 0.09 ENST00000618150.4
THO complex 2
chr6_+_96563117 0.09 ENST00000450218.6
four and a half LIM domains 5
chr1_-_12831410 0.09 ENST00000619922.1
PRAME family member 11
chr14_+_55027576 0.09 ENST00000339298.2
suppressor of cytokine signaling 4
chr16_+_56935371 0.08 ENST00000568358.1
homocysteine inducible ER protein with ubiquitin like domain 1
chr5_+_83471736 0.08 ENST00000265077.8
versican
chr5_+_83471668 0.08 ENST00000342785.8
ENST00000343200.9
versican
chr8_+_24384275 0.08 ENST00000256412.8
ADAM like decysin 1
chr4_+_158521714 0.07 ENST00000613319.4
ENST00000423548.5
ENST00000448688.6
relaxin family peptide receptor 1
chr14_+_55027200 0.07 ENST00000395472.2
ENST00000555846.2
suppressor of cytokine signaling 4
chr2_-_77522347 0.07 ENST00000409093.1
ENST00000409884.6
ENST00000409088.3
leucine rich repeat transmembrane neuronal 4
chr4_+_118888829 0.07 ENST00000448416.6
ENST00000307142.9
ENST00000429713.7
synaptopodin 2
chr2_+_147845020 0.07 ENST00000241416.12
activin A receptor type 2A
chr11_-_129024157 0.07 ENST00000392657.7
Rho GTPase activating protein 32
chr12_+_7711418 0.07 ENST00000345088.3
developmental pluripotency associated 3
chr4_+_158521872 0.07 ENST00000307765.10
relaxin family peptide receptor 1
chr2_-_135530561 0.06 ENST00000536680.5
ENST00000401392.5
zinc finger RANBP2-type containing 3
chr14_+_55129242 0.06 ENST00000254301.14
ENST00000554715.1
galectin 3
chr3_-_15440560 0.06 ENST00000595627.5
ENST00000597949.1
ENST00000494875.3
ENST00000595975.1
ENST00000598878.1
EAF1 antisense RNA 1
methyltransferase like 6
chr6_-_109483208 0.06 ENST00000230122.4
zinc finger and BTB domain containing 24
chr2_+_95165784 0.06 ENST00000622059.4
ENST00000614034.5
ENST00000611147.1
zinc finger protein 2
chr4_-_185775271 0.04 ENST00000430503.5
ENST00000319454.10
ENST00000450341.5
sorbin and SH3 domain containing 2
chrX_+_1591590 0.04 ENST00000313871.9
ENST00000381261.8
A-kinase anchoring protein 17A
chr19_-_9107475 0.04 ENST00000641081.1
olfactory receptor family 7 subfamily G member 2
chr11_-_93197932 0.04 ENST00000326402.9
solute carrier family 36 member 4
chr8_+_28891304 0.04 ENST00000355231.9
homeobox containing 1
chr1_+_7961894 0.04 ENST00000377491.5
ENST00000377488.5
Parkinsonism associated deglycase
chr19_-_20039205 0.03 ENST00000358523.9
ENST00000397162.5
ENST00000601100.5
zinc finger protein 682
chr17_-_8210203 0.03 ENST00000578549.5
ENST00000582368.5
aurora kinase B
chr9_-_83978429 0.03 ENST00000351839.7
heterogeneous nuclear ribonucleoprotein K
chr4_+_118888918 0.03 ENST00000434046.6
synaptopodin 2
chrX_-_123622809 0.03 ENST00000441692.5
THO complex 2
chr11_-_55936400 0.02 ENST00000301532.3
olfactory receptor family 5 subfamily I member 1
chr15_+_77420668 0.02 ENST00000381714.7
ENST00000558651.5
high mobility group 20A
chr16_-_29923237 0.02 ENST00000568995.1
ENST00000566413.1
potassium channel tetramerization domain containing 13
chr8_+_116950951 0.02 ENST00000427715.2
solute carrier family 30 member 8
chr7_+_148590760 0.02 ENST00000307003.3
chromosome 7 open reading frame 33
chr13_-_52159559 0.01 ENST00000620675.4
ENST00000610828.5
NIMA related kinase 3
chr15_+_77420880 0.01 ENST00000336216.9
ENST00000558176.1
high mobility group 20A
chr6_+_118548289 0.01 ENST00000357525.6
phospholamban
chr11_+_6863057 0.01 ENST00000641461.1
olfactory receptor family 10 subfamily A member 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0034769 basement membrane disassembly(GO:0034769)
0.2 1.3 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.2 1.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.7 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.2 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.1 0.5 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.1 0.7 GO:0046654 glycine biosynthetic process(GO:0006545) tetrahydrofolate biosynthetic process(GO:0046654)
0.1 0.2 GO:0009720 detection of hormone stimulus(GO:0009720)
0.1 0.4 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.3 GO:0032439 endosome localization(GO:0032439)
0.0 0.2 GO:0043091 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.0 0.4 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.1 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.0 0.1 GO:0060003 copper ion export(GO:0060003)
0.0 0.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.5 GO:0006069 ethanol oxidation(GO:0006069)
0.0 1.7 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.1 GO:0034553 mitochondrial electron transport, succinate to ubiquinone(GO:0006121) respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.1 GO:0044725 chromatin reprogramming in the zygote(GO:0044725)
0.0 0.1 GO:0036292 DNA rewinding(GO:0036292)
0.0 1.5 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.1 GO:0097026 dendritic cell dendrite assembly(GO:0097026)
0.0 0.2 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.8 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.0 0.3 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 0.2 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.1 GO:2001189 regulation of immunological synapse formation(GO:2000520) negative regulation of immunological synapse formation(GO:2000521) negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001189)
0.0 0.0 GO:1902958 detoxification of copper ion(GO:0010273) enzyme active site formation(GO:0018307) neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) detoxification of mercury ion(GO:0050787) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384) stress response to copper ion(GO:1990169) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.0 0.1 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.2 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 1.4 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 0.2 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.1 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 0.3 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0000835 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 0.6 GO:0036021 endolysosome lumen(GO:0036021)
0.1 1.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.2 GO:0031262 Ndc80 complex(GO:0031262)
0.0 1.5 GO:0097546 ciliary base(GO:0097546)
0.0 0.3 GO:0045179 apical cortex(GO:0045179)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.4 GO:0032982 myosin filament(GO:0032982)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 1.3 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.3 GO:0035327 transcriptionally active chromatin(GO:0035327)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004146 dihydrofolate reductase activity(GO:0004146)
0.1 0.7 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 1.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 1.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.8 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 0.5 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 0.8 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.1 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.0 0.2 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.0 0.1 GO:0031780 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.0 0.1 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.0 0.2 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.2 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.6 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.0 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID AURORA B PATHWAY Aurora B signaling
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.3 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.7 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation