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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for MXI1_MYC_MYCN
Z-value: 2.00
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Transcription factors associated with MXI1_MYC_MYCN
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MXI1 | hg38_v1_chr10_+_110225955_110226016, hg38_v1_chr10_+_110207587_110207684 | -0.85 | 3.5e-09 | Click! |
| MYCN | hg38_v1_chr2_+_15940537_15940566 | 0.19 | 3.1e-01 | Click! |
| MYC | hg38_v1_chr8_+_127736046_127736084, hg38_v1_chr8_+_127735597_127735659, hg38_v1_chr8_+_127737610_127737626, hg38_v1_chr8_+_127736220_127736241 | 0.19 | 3.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MXI1_MYC_MYCN
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_11060000 Show fit | 8.51 |
ENST00000376957.7
|
spermidine synthase |
|
| chr2_-_10448318 Show fit | 7.87 |
ENST00000234111.9
|
ornithine decarboxylase 1 |
|
| chr12_-_57752265 Show fit | 4.33 |
ENST00000547281.5
ENST00000257904.11 ENST00000546489.5 ENST00000552388.1 |
cyclin dependent kinase 4 |
|
| chr20_+_59628609 Show fit | 4.27 |
ENST00000541461.5
|
phosphatase and actin regulator 3 |
|
| chrX_+_16786421 Show fit | 4.24 |
ENST00000398155.4
ENST00000380122.10 |
taxilin gamma |
|
| chr12_-_57752345 Show fit | 4.08 |
ENST00000551800.5
ENST00000549606.5 ENST00000312990.10 |
cyclin dependent kinase 4 |
|
| chr2_-_231464156 Show fit | 3.87 |
ENST00000453992.6
ENST00000454824.6 ENST00000417652.6 |
nucleolin |
|
| chr15_-_82647503 Show fit | 3.76 |
ENST00000567678.1
ENST00000620182.4 |
cytoplasmic polyadenylation element binding protein 1 |
|
| chr10_+_68956436 Show fit | 3.28 |
ENST00000620315.1
|
DExD-box helicase 21 |
|
| chr17_+_7308339 Show fit | 3.19 |
ENST00000416016.2
|
eukaryotic translation initiation factor 5A |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.5 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.1 | 12.3 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.2 | 11.8 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 1.3 | 10.5 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 2.0 | 10.0 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 0.6 | 9.7 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.6 | 9.6 | GO:1901838 | regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901836) positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838) |
| 1.3 | 8.9 | GO:0008295 | spermidine biosynthetic process(GO:0008295) |
| 1.7 | 8.4 | GO:1904637 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 0.1 | 8.4 | GO:0045815 | positive regulation of gene expression, epigenetic(GO:0045815) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 44.2 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 30.5 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 23.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.5 | 16.6 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 15.2 | GO:0016363 | nuclear matrix(GO:0016363) |
| 1.9 | 11.1 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.6 | 9.9 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.3 | 9.6 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 1.3 | 9.4 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.3 | 7.7 | GO:0030686 | 90S preribosome(GO:0030686) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 73.6 | GO:0003723 | RNA binding(GO:0003723) |
| 0.4 | 15.3 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.3 | 10.0 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.4 | 9.2 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 2.8 | 8.5 | GO:0004766 | spermidine synthase activity(GO:0004766) |
| 0.4 | 8.5 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 1.1 | 8.4 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.2 | 7.9 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.2 | 7.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.6 | 7.2 | GO:0004526 | ribonuclease P activity(GO:0004526) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 50.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.9 | 17.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 7.0 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 6.7 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 6.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 5.9 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 5.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 3.9 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 3.4 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 3.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 19.2 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.3 | 18.6 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 14.6 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.3 | 13.8 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.2 | 9.3 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.1 | 9.1 | REACTOME LATE PHASE OF HIV LIFE CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 0.6 | 8.9 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.3 | 7.0 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 6.7 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 6.2 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |