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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for MYBL2
Z-value: 1.88
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Transcription factors associated with MYBL2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYBL2 | hg38_v1_chr20_+_43667105_43667125, hg38_v1_chr20_+_43667019_43667098 | 0.01 | 9.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYBL2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 18.6 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 0.8 | 13.4 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
| 0.6 | 12.5 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 0.8 | 8.9 | GO:0043985 | histone H4-R3 methylation(GO:0043985) |
| 0.4 | 8.1 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 0.0 | 6.5 | GO:0007286 | spermatid development(GO:0007286) |
| 0.4 | 6.3 | GO:0061525 | hindgut development(GO:0061525) |
| 0.0 | 6.1 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 1.9 | 5.8 | GO:0006756 | dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571) |
| 0.7 | 5.8 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 16.4 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 13.8 | GO:0005813 | centrosome(GO:0005813) |
| 0.1 | 12.4 | GO:0031514 | motile cilium(GO:0031514) |
| 0.1 | 10.2 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.7 | 8.6 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.7 | 7.3 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.3 | 7.3 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 7.3 | GO:0045171 | intercellular bridge(GO:0045171) |
| 2.1 | 6.3 | GO:0097598 | sperm cytoplasmic droplet(GO:0097598) |
| 0.0 | 4.7 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.8 | GO:0042393 | histone binding(GO:0042393) |
| 0.5 | 6.0 | GO:0050145 | nucleoside phosphate kinase activity(GO:0050145) |
| 0.2 | 5.9 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.2 | 4.3 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.6 | 4.0 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.1 | 4.0 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.1 | 3.9 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 3.9 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 3.8 | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814) |
| 1.2 | 3.7 | GO:0035248 | alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 3.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.0 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 3.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 2.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 2.1 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 2.1 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 2.0 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.2 | PID E2F PATHWAY | E2F transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 7.8 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.0 | 4.0 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 3.7 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 3.6 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 2.7 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 2.5 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 2.3 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.7 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |