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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX1-1

Z-value: 0.43

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Transcription factors associated with NKX1-1

Gene Symbol Gene ID Gene Info
NKX1-1
ENSG00000235608.2 NKX1-1

Activity profile of NKX1-1 motif

Sorted Z-values of NKX1-1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_+_6904733 2.20 ENST00000007969.12
ENST00000622489.4
ENST00000443597.7
ENST00000323702.9
LRRC23
leucine rich repeat containing 23
chr2_+_8682046 2.02 ENST00000331129.3
ENST00000396290.2
ID2
inhibitor of DNA binding 2
chr12_+_6904962 1.75 ENST00000415834.5
ENST00000436789.5
LRRC23
leucine rich repeat containing 23
chr13_+_35476740 1.43 ENST00000537702.5
NBEA
neurobeachin
chr19_+_32405758 1.23 ENST00000392250.7
DPY19L3
dpy-19 like C-mannosyltransferase 3
chr19_+_32406076 1.23 ENST00000342179.9
ENST00000586427.1
DPY19L3
dpy-19 like C-mannosyltransferase 3
chr19_+_32405789 1.16 ENST00000586987.5
DPY19L3
dpy-19 like C-mannosyltransferase 3
chr3_-_105869035 0.82 ENST00000447441.6
ENST00000403724.5
ENST00000405772.5
CBLB
Cbl proto-oncogene B
chr6_-_79537423 0.76 ENST00000369846.9
ENST00000392959.5
ENST00000467898.3
LCA5
lebercilin LCA5
chr10_+_119029711 0.69 ENST00000425699.3
NANOS1
nanos C2HC-type zinc finger 1
chr16_-_57536543 0.66 ENST00000258214.3
CCDC102A
coiled-coil domain containing 102A
chr6_-_166627244 0.61 ENST00000265678.9
RPS6KA2
ribosomal protein S6 kinase A2
chrX_-_152830721 0.60 ENST00000370277.5
CETN2
centrin 2
chr20_-_41618362 0.51 ENST00000373222.3
ENST00000373233.8
CHD6
chromodomain helicase DNA binding protein 6
chr16_+_590056 0.49 ENST00000248139.8
ENST00000568586.5
ENST00000538492.5
RAB40C
RAB40C, member RAS oncogene family
chr11_-_106022209 0.47 ENST00000301919.9
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4
Myb/SANT DNA binding domain containing 4 with coiled-coils
chr1_-_51330527 0.46 ENST00000439482.6
TTC39A
tetratricopeptide repeat domain 39A
chr7_+_129144691 0.45 ENST00000486685.3
TSPAN33
tetraspanin 33
chr1_+_100352451 0.40 ENST00000361544.11
ENST00000370124.8
ENST00000336454.5
CDC14A
cell division cycle 14A
chr1_+_15236509 0.39 ENST00000683790.1
FHAD1
forkhead associated phosphopeptide binding domain 1
chr3_+_186842687 0.39 ENST00000444204.2
ENST00000320741.7
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr2_+_216659600 0.37 ENST00000456764.1
IGFBP2
insulin like growth factor binding protein 2
chr11_-_4608226 0.34 ENST00000300747.10
ENST00000526337.5
TRIM68
tripartite motif containing 68
chr2_-_238288600 0.33 ENST00000254657.8
PER2
period circadian regulator 2
chr19_+_42306937 0.33 ENST00000595750.2
PRR19
proline rich 19
chr1_-_107965009 0.31 ENST00000527011.5
ENST00000370056.9
VAV3
vav guanine nucleotide exchange factor 3
chr7_-_73842508 0.31 ENST00000297873.9
METTL27
methyltransferase like 27
chr19_+_45001430 0.31 ENST00000625761.2
ENST00000505236.1
ENST00000221452.13
RELB
RELB proto-oncogene, NF-kB subunit
chr7_-_87220567 0.31 ENST00000433078.5
TMEM243
transmembrane protein 243
chr19_-_46634685 0.31 ENST00000300873.4
GNG8
G protein subunit gamma 8
chr7_+_100049765 0.27 ENST00000456748.6
ENST00000292450.9
ENST00000438937.1
ENST00000543588.2
ZSCAN21
zinc finger and SCAN domain containing 21
chr1_+_174874434 0.27 ENST00000478442.5
ENST00000465412.5
RABGAP1L
RAB GTPase activating protein 1 like
chr7_+_100119607 0.27 ENST00000262932.5
CNPY4
canopy FGF signaling regulator 4
chr13_-_109786567 0.24 ENST00000375856.5
IRS2
insulin receptor substrate 2
chr1_-_23344259 0.23 ENST00000476451.2
ENST00000302271.11
ENST00000606561.5
ENST00000374616.7
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr1_-_23344314 0.22 ENST00000374612.5
ENST00000675048.1
ENST00000478691.5
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr1_+_160400543 0.21 ENST00000368061.3
VANGL2
VANGL planar cell polarity protein 2
chr13_+_77741160 0.21 ENST00000314070.9
ENST00000351546.7
SLAIN1
SLAIN motif family member 1
chr7_+_71132123 0.21 ENST00000333538.10
GALNT17
polypeptide N-acetylgalactosaminyltransferase 17
chr11_-_62754141 0.21 ENST00000527994.1
ENST00000394807.5
ENST00000673933.1
ZBTB3
zinc finger and BTB domain containing 3
chr5_-_160119389 0.20 ENST00000523662.1
ENST00000456329.7
ENST00000307063.9
PWWP2A
PWWP domain containing 2A
chr12_+_16347665 0.20 ENST00000535309.5
ENST00000540056.5
ENST00000396209.5
ENST00000540126.5
MGST1
microsomal glutathione S-transferase 1
chr4_-_65670478 0.19 ENST00000613740.5
ENST00000622150.4
ENST00000511294.1
EPHA5
EPH receptor A5
chr4_-_145180496 0.19 ENST00000447906.8
OTUD4
OTU deubiquitinase 4
chr6_-_31862809 0.19 ENST00000375631.5
NEU1
neuraminidase 1
chr12_+_16347637 0.17 ENST00000543076.5
ENST00000396210.8
MGST1
microsomal glutathione S-transferase 1
chrX_-_154097668 0.16 ENST00000407218.5
ENST00000303391.11
ENST00000453960.7
MECP2
methyl-CpG binding protein 2
chr12_+_48105466 0.16 ENST00000549003.5
ENST00000550924.6
PFKM
phosphofructokinase, muscle
chr7_-_6009072 0.15 ENST00000642456.1
ENST00000642292.1
ENST00000441476.6
PMS2
PMS1 homolog 2, mismatch repair system component
chr21_+_33025927 0.15 ENST00000430860.1
ENST00000382357.4
ENST00000333337.3
OLIG2
oligodendrocyte transcription factor 2
chr4_-_65670339 0.14 ENST00000273854.7
EPHA5
EPH receptor A5
chr1_-_51330553 0.14 ENST00000680483.1
ENST00000371747.7
TTC39A
tetratricopeptide repeat domain 39A
chr2_-_96740034 0.14 ENST00000264963.9
ENST00000377079.8
LMAN2L
lectin, mannose binding 2 like
chr11_-_61161414 0.14 ENST00000301765.10
VPS37C
VPS37C subunit of ESCRT-I
chr6_-_73395133 0.13 ENST00000441145.1
OOEP
oocyte expressed protein
chr5_+_64505981 0.13 ENST00000334025.3
RGS7BP
regulator of G protein signaling 7 binding protein
chr7_-_100119840 0.12 ENST00000437822.6
TAF6
TATA-box binding protein associated factor 6
chr15_-_64093746 0.12 ENST00000557835.5
ENST00000380290.7
ENST00000300030.8
ENST00000559950.1
CIAO2A
cytosolic iron-sulfur assembly component 2A
chr3_-_105868964 0.12 ENST00000394030.8
CBLB
Cbl proto-oncogene B
chr1_-_51331315 0.12 ENST00000262676.9
TTC39A
tetratricopeptide repeat domain 39A
chr2_+_86720282 0.11 ENST00000283632.5
RMND5A
required for meiotic nuclear division 5 homolog A
chr16_-_2268373 0.11 ENST00000566458.5
RNPS1
RNA binding protein with serine rich domain 1
chrX_+_19343893 0.10 ENST00000540249.5
ENST00000545074.5
ENST00000379806.9
ENST00000423505.5
ENST00000422285.7
ENST00000417819.5
ENST00000355808.9
ENST00000379805.3
PDHA1
pyruvate dehydrogenase E1 subunit alpha 1
chr12_+_28257195 0.10 ENST00000381259.5
CCDC91
coiled-coil domain containing 91
chr9_+_113463697 0.10 ENST00000317613.10
RGS3
regulator of G protein signaling 3
chr7_-_6009019 0.10 ENST00000382321.5
ENST00000265849.12
PMS2
PMS1 homolog 2, mismatch repair system component
chr10_-_54801262 0.10 ENST00000373965.6
ENST00000616114.4
ENST00000621708.4
ENST00000495484.5
ENST00000395440.5
ENST00000395442.5
ENST00000617271.4
ENST00000395446.5
ENST00000409834.5
ENST00000361849.7
ENST00000373957.7
ENST00000395430.5
ENST00000395433.5
ENST00000437009.5
PCDH15
protocadherin related 15
chr11_-_125111708 0.10 ENST00000531909.5
ENST00000529530.1
TMEM218
transmembrane protein 218
chr10_-_54801221 0.09 ENST00000644397.2
ENST00000395445.6
ENST00000613657.5
ENST00000320301.11
PCDH15
protocadherin related 15
chr19_-_45782388 0.09 ENST00000458663.6
DMPK
DM1 protein kinase
chr3_+_158801926 0.08 ENST00000622669.4
ENST00000392813.8
ENST00000415822.8
ENST00000651862.1
ENST00000264266.12
MFSD1
major facilitator superfamily domain containing 1
chr12_-_23584600 0.08 ENST00000396007.6
SOX5
SRY-box transcription factor 5
chr10_-_124418912 0.08 ENST00000368845.6
ENST00000539214.5
OAT
ornithine aminotransferase
chr10_+_1049476 0.07 ENST00000358220.5
WDR37
WD repeat domain 37
chr3_+_23810436 0.07 ENST00000467766.5
ENST00000424381.5
UBE2E1
ubiquitin conjugating enzyme E2 E1
chr12_+_16347102 0.07 ENST00000536371.5
ENST00000010404.6
MGST1
microsomal glutathione S-transferase 1
chr16_-_2268054 0.07 ENST00000561518.5
ENST00000561718.5
ENST00000567147.5
ENST00000562690.5
ENST00000569598.6
RNPS1
RNA binding protein with serine rich domain 1
chr19_+_56141317 0.06 ENST00000592949.5
ZNF444
zinc finger protein 444
chr11_-_47176851 0.06 ENST00000629231.2
ENST00000526342.5
ENST00000528444.5
ENST00000530596.5
ENST00000525398.5
ENST00000524782.6
ENST00000527927.5
ENST00000525314.5
ARFGAP2
ADP ribosylation factor GTPase activating protein 2
chr1_-_151790475 0.06 ENST00000368825.7
ENST00000368823.5
ENST00000368824.8
ENST00000458431.6
ENST00000368827.10
ENST00000440583.6
TDRKH
tudor and KH domain containing
chrX_+_73563190 0.05 ENST00000373504.10
ENST00000373502.9
CHIC1
cysteine rich hydrophobic domain 1
chr17_-_46579651 0.05 ENST00000573185.5
ENST00000570550.5
ENST00000445552.6
ENST00000329240.10
ENST00000622488.6
ENST00000336125.6
ARL17A
ADP ribosylation factor like GTPase 17A
chr16_-_2268111 0.05 ENST00000301730.12
ENST00000564822.1
ENST00000320225.10
RNPS1
RNA binding protein with serine rich domain 1
chr17_-_10469558 0.05 ENST00000255381.2
MYH4
myosin heavy chain 4
chr7_-_100119323 0.05 ENST00000523306.5
ENST00000344095.8
ENST00000417349.5
ENST00000493322.5
ENST00000520135.5
ENST00000460673.2
ENST00000453269.7
ENST00000452041.5
ENST00000452438.6
ENST00000451699.5
TAF6
TATA-box binding protein associated factor 6
chr11_-_59615673 0.04 ENST00000263847.6
OSBP
oxysterol binding protein
chr17_-_46361718 0.04 ENST00000575960.5
ENST00000575698.5
ENST00000571246.5
ENST00000434041.6
ENST00000656849.1
ENST00000570618.5
ENST00000450673.4
ENST00000622877.4
ARL17B
ADP ribosylation factor like GTPase 17B
chr19_+_54137740 0.04 ENST00000644245.1
ENST00000646002.1
ENST00000221232.11
ENST00000440571.6
ENST00000617930.2
CNOT3
CCR4-NOT transcription complex subunit 3
chr12_-_55296569 0.04 ENST00000358433.3
OR6C6
olfactory receptor family 6 subfamily C member 6
chr1_+_240091866 0.03 ENST00000319653.14
FMN2
formin 2
chr15_-_78234513 0.02 ENST00000558130.1
ENST00000258873.9
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr14_+_22202561 0.02 ENST00000390460.1
TRAV26-2
T cell receptor alpha variable 26-2
chr9_+_34646589 0.01 ENST00000450095.6
GALT
galactose-1-phosphate uridylyltransferase
chr8_+_97644164 0.01 ENST00000336273.8
MTDH
metadherin
chr11_+_134331874 0.01 ENST00000339772.9
ENST00000535456.7
GLB1L2
galactosidase beta 1 like 2
chr22_+_41205292 0.01 ENST00000216237.10
L3MBTL2
L3MBTL histone methyl-lysine binding protein 2
chrY_-_24813393 0.01 ENST00000382365.7
ENST00000315357.9
ENST00000446723.4
DAZ3
deleted in azoospermia 3
chr9_+_34646654 0.01 ENST00000378842.8
GALT
galactose-1-phosphate uridylyltransferase
chr10_-_1049110 0.01 ENST00000381344.8
IDI1
isopentenyl-diphosphate delta isomerase 1
chr19_-_8005590 0.01 ENST00000407627.7
ENST00000593807.1
ELAVL1
ELAV like RNA binding protein 1
chr17_-_4967790 0.00 ENST00000575142.5
ENST00000206020.8
SPAG7
sperm associated antigen 7

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.5 3.6 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 0.4 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.1 0.4 GO:0072249 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) metanephric glomerular epithelium development(GO:0072244) metanephric glomerular visceral epithelial cell differentiation(GO:0072248) metanephric glomerular visceral epithelial cell development(GO:0072249) metanephric glomerular epithelial cell differentiation(GO:0072312) metanephric glomerular epithelial cell development(GO:0072313) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.1 0.3 GO:0051946 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.1 0.2 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 0.5 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 0.2 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.9 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.3 GO:0019236 response to pheromone(GO:0019236)
0.0 0.2 GO:0010746 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.2 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.0 0.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.7 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0 0.2 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.2 GO:0050957 equilibrioception(GO:0050957)
0.0 0.3 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.3 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.0 0.6 GO:0000717 nucleotide-excision repair, DNA duplex unwinding(GO:0000717)
0.0 0.3 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.3 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.4 GO:0010226 response to lithium ion(GO:0010226)
0.0 0.0 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.1 GO:0055059 asymmetric neuroblast division(GO:0055059)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0071942 XPC complex(GO:0071942)
0.1 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.1 GO:0034657 GID complex(GO:0034657)
0.0 3.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.4 GO:0060091 kinocilium(GO:0060091)
0.0 0.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.3 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.2 GO:0061574 ASAP complex(GO:0061574)
0.0 0.5 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 2.7 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.2 GO:0052796 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.4 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.3 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.0 0.4 GO:0043295 glutathione binding(GO:0043295)
0.0 0.2 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 0.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.7 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 2.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.6 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.9 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.6 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets