Project

Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

Navigation
Downloads

Results for NKX1-2_RAX

Z-value: 0.33

Motif logo

Transcription factors associated with NKX1-2_RAX

Gene Symbol Gene ID Gene Info
ENSG00000229544.9 NKX1-2
ENSG00000134438.10 RAX

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX1-2hg38_v1_chr10_-_124450027_124450043-0.393.2e-02Click!
RAXhg38_v1_chr18_-_59273447_59273459,
hg38_v1_chr18_-_59273379_59273429
0.242.0e-01Click!

Activity profile of NKX1-2_RAX motif

Sorted Z-values of NKX1-2_RAX motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-2_RAX

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image
Promoter Score Transcript Gene Gene Info
chr5_-_35938572 1.78 ENST00000651391.1
ENST00000397366.5
ENST00000513623.5
ENST00000514524.2
ENST00000397367.6
calcyphosine like
chr12_+_6904733 1.12 ENST00000007969.12
ENST00000622489.4
ENST00000443597.7
ENST00000323702.9
leucine rich repeat containing 23
chr12_+_6904962 0.98 ENST00000415834.5
ENST00000436789.5
leucine rich repeat containing 23
chr12_-_25195074 0.68 ENST00000354189.9
ENST00000676236.1
ENST00000545133.5
ENST00000554347.1
ENST00000674567.1
ENST00000395987.8
ENST00000320267.13
ENST00000395990.6
cilia and flagella associated protein 94
chr3_-_105869035 0.57 ENST00000447441.6
ENST00000403724.5
ENST00000405772.5
Cbl proto-oncogene B
chr13_+_35476740 0.43 ENST00000537702.5
neurobeachin
chr8_-_42768602 0.29 ENST00000534622.5
cholinergic receptor nicotinic alpha 6 subunit
chr4_+_76435216 0.29 ENST00000296043.7
shroom family member 3
chr20_-_31390483 0.28 ENST00000376315.2
defensin beta 119
chr1_+_160400543 0.25 ENST00000368061.3
VANGL planar cell polarity protein 2
chr12_-_9869345 0.25 ENST00000228438.3
C-type lectin domain family 2 member B
chr4_+_94974984 0.24 ENST00000672698.1
bone morphogenetic protein receptor type 1B
chr7_+_71132123 0.23 ENST00000333538.10
polypeptide N-acetylgalactosaminyltransferase 17
chr16_-_28597042 0.22 ENST00000533150.5
ENST00000335715.9
sulfotransferase family 1A member 2
chr11_+_124183219 0.22 ENST00000641351.2
olfactory receptor family 10 subfamily D member 3
chr11_+_72189659 0.21 ENST00000393681.6
folate receptor alpha
chr11_+_72189528 0.20 ENST00000312293.9
folate receptor alpha
chr9_+_122371014 0.19 ENST00000362012.7
prostaglandin-endoperoxide synthase 1
chr5_-_160119389 0.19 ENST00000523662.1
ENST00000456329.7
ENST00000307063.9
PWWP domain containing 2A
chrX_-_152830721 0.18 ENST00000370277.5
centrin 2
chr2_+_216659600 0.17 ENST00000456764.1
insulin like growth factor binding protein 2
chr9_+_122371036 0.17 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
prostaglandin-endoperoxide synthase 1
chr5_-_20575850 0.17 ENST00000507958.5
cadherin 18
chr19_+_49513353 0.16 ENST00000596975.5
Fc fragment of IgG receptor and transporter
chr1_-_92486916 0.16 ENST00000294702.6
growth factor independent 1 transcriptional repressor
chr17_-_41184895 0.15 ENST00000620667.1
ENST00000398472.2
keratin associated protein 4-1
chr3_-_180679468 0.15 ENST00000651046.1
ENST00000476379.6
coiled-coil domain containing 39
chr5_-_83673544 0.12 ENST00000503117.1
ENST00000510978.5
hyaluronan and proteoglycan link protein 1
chr3_+_140678041 0.12 ENST00000286349.4
tripartite motif containing 42
chrX_+_44844015 0.12 ENST00000339042.6
dual specificity phosphatase 21
chr4_-_25863537 0.12 ENST00000502949.5
ENST00000264868.9
ENST00000513691.1
ENST00000514872.1
SEL1L family member 3
chr8_-_100559702 0.11 ENST00000520311.5
ENST00000520552.5
ENST00000521345.1
ENST00000523000.5
ENST00000335659.7
ENST00000358990.3
ENST00000519597.5
ankyrin repeat domain 46
chr11_-_59615673 0.11 ENST00000263847.6
oxysterol binding protein
chr3_+_186842687 0.11 ENST00000444204.2
ENST00000320741.7
adiponectin, C1Q and collagen domain containing
chr8_+_104223344 0.11 ENST00000523362.5
regulating synaptic membrane exocytosis 2
chr5_+_64505981 0.11 ENST00000334025.3
regulator of G protein signaling 7 binding protein
chr14_+_22202561 0.10 ENST00000390460.1
T cell receptor alpha variable 26-2
chr13_+_77741160 0.10 ENST00000314070.9
ENST00000351546.7
SLAIN motif family member 1
chr3_-_115071333 0.09 ENST00000462705.5
zinc finger and BTB domain containing 20
chr5_-_103562775 0.09 ENST00000230792.7
ENST00000507423.1
nudix hydrolase 12
chr11_+_92969651 0.08 ENST00000257068.3
ENST00000528076.1
melatonin receptor 1B
chr15_+_92900338 0.08 ENST00000625990.3
chromodomain helicase DNA binding protein 2
chr16_-_81220370 0.08 ENST00000337114.8
polycystin 1 like 2 (gene/pseudogene)
chr16_-_55833186 0.08 ENST00000361503.8
ENST00000422046.6
carboxylesterase 1
chr16_-_55833085 0.08 ENST00000360526.8
carboxylesterase 1
chr6_+_26440472 0.08 ENST00000494393.5
ENST00000482451.5
ENST00000471353.5
ENST00000361232.7
ENST00000487627.5
ENST00000496719.1
ENST00000244519.7
ENST00000490254.5
ENST00000487272.1
butyrophilin subfamily 3 member A3
chr4_-_65670478 0.07 ENST00000613740.5
ENST00000622150.4
ENST00000511294.1
EPH receptor A5
chr14_-_99480784 0.07 ENST00000329331.7
ENST00000436070.6
SET domain containing 3, actin histidine methyltransferase
chr9_-_5304713 0.07 ENST00000381627.4
relaxin 2
chr11_-_7941708 0.07 ENST00000642047.1
olfactory receptor family 10 subfamily A member 3
chr4_-_65670339 0.07 ENST00000273854.7
EPH receptor A5
chr7_-_88226965 0.07 ENST00000490437.5
ENST00000431660.5
sorcin
chr7_-_88226987 0.07 ENST00000394641.7
sorcin
chr7_-_100119840 0.07 ENST00000437822.6
TATA-box binding protein associated factor 6
chr20_+_45416551 0.07 ENST00000639292.1
phosphatidylinositol glycan anchor biosynthesis class T
chr9_+_122370523 0.07 ENST00000643810.1
ENST00000540753.6
prostaglandin-endoperoxide synthase 1
chr6_+_26402289 0.06 ENST00000414912.2
butyrophilin subfamily 3 member A1
chr6_-_31862809 0.06 ENST00000375631.5
neuraminidase 1
chr1_-_158426237 0.06 ENST00000641042.1
olfactory receptor family 10 subfamily K member 2
chr12_-_91180365 0.06 ENST00000547937.5
decorin
chr11_+_19712823 0.06 ENST00000396085.6
ENST00000349880.9
neuron navigator 2
chr11_-_62754141 0.06 ENST00000527994.1
ENST00000394807.5
ENST00000673933.1
zinc finger and BTB domain containing 3
chr15_+_49170200 0.06 ENST00000396509.6
galactokinase 2
chr8_-_101790934 0.06 ENST00000523645.5
ENST00000520346.1
ENST00000220931.11
ENST00000522448.5
ENST00000522951.5
ENST00000522252.5
ENST00000519098.5
neurocalcin delta
chr3_-_11643871 0.06 ENST00000430365.7
vestigial like family member 4
chr15_+_49170237 0.06 ENST00000560031.6
ENST00000558145.5
ENST00000544523.5
ENST00000560138.5
galactokinase 2
chr12_+_26195313 0.06 ENST00000422622.3
sarcospan
chr19_-_45782388 0.06 ENST00000458663.6
DM1 protein kinase
chr16_+_53099100 0.05 ENST00000565832.5
chromodomain helicase DNA binding protein 9
chr8_+_106726012 0.05 ENST00000449762.6
ENST00000297447.10
oxidation resistance 1
chr12_-_21910853 0.05 ENST00000544039.5
ATP binding cassette subfamily C member 9
chr6_-_166627244 0.05 ENST00000265678.9
ribosomal protein S6 kinase A2
chr4_-_145180496 0.05 ENST00000447906.8
OTU deubiquitinase 4
chr19_-_9107475 0.05 ENST00000641081.1
olfactory receptor family 7 subfamily G member 2
chr9_-_116687205 0.05 ENST00000288520.9
ENST00000358637.4
ENST00000341734.8
astrotactin 2
chrX_+_77910656 0.05 ENST00000343533.9
ENST00000341514.11
ENST00000645454.1
ENST00000642651.1
ENST00000644362.1
ATPase copper transporting alpha
phosphoglycerate kinase 1
chr6_+_54018910 0.05 ENST00000514921.5
ENST00000274897.9
ENST00000370877.6
muscular LMNA interacting protein
chr1_-_201171545 0.05 ENST00000367333.6
transmembrane protein 9
chr9_+_121567057 0.05 ENST00000394340.7
ENST00000436835.5
ENST00000259371.6
DAB2 interacting protein
chr6_+_26365176 0.05 ENST00000377708.7
butyrophilin subfamily 3 member A2
chr13_-_110242694 0.05 ENST00000648989.1
ENST00000647797.1
ENST00000648966.1
ENST00000649484.1
ENST00000648695.1
ENST00000650115.1
ENST00000650566.1
collagen type IV alpha 1 chain
chr6_+_26365215 0.04 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
butyrophilin subfamily 3 member A2
chr19_-_45782479 0.04 ENST00000447742.6
ENST00000354227.9
ENST00000291270.9
ENST00000683086.1
ENST00000343373.10
DM1 protein kinase
chrX_+_89921903 0.04 ENST00000283891.6
ENST00000561129.2
TGFB induced factor homeobox 2 like X-linked
chr6_+_160121859 0.04 ENST00000324965.8
ENST00000457470.6
solute carrier family 22 member 1
chr15_+_92904447 0.04 ENST00000626782.2
chromodomain helicase DNA binding protein 2
chr1_-_151831768 0.04 ENST00000318247.7
RAR related orphan receptor C
chr10_+_24466487 0.04 ENST00000396446.5
ENST00000396445.5
ENST00000376451.4
KIAA1217
chr7_+_138460238 0.04 ENST00000343526.9
tripartite motif containing 24
chr7_+_55365317 0.04 ENST00000254770.3
LanC like 2
chr15_+_92900189 0.04 ENST00000626874.2
ENST00000627622.1
ENST00000629346.2
ENST00000628375.2
ENST00000420239.7
ENST00000394196.9
chromodomain helicase DNA binding protein 2
chr14_+_21997531 0.03 ENST00000390445.2
T cell receptor alpha variable 17
chr6_+_26402237 0.03 ENST00000476549.6
ENST00000450085.6
ENST00000425234.6
ENST00000427334.5
ENST00000506698.1
ENST00000289361.11
butyrophilin subfamily 3 member A1
chr4_-_119322128 0.03 ENST00000274024.4
fatty acid binding protein 2
chr7_+_100119607 0.03 ENST00000262932.5
canopy FGF signaling regulator 4
chr9_-_5339874 0.03 ENST00000223862.2
relaxin 1
chr13_-_109786567 0.03 ENST00000375856.5
insulin receptor substrate 2
chr2_-_238288600 0.03 ENST00000254657.8
period circadian regulator 2
chrX_-_13817027 0.03 ENST00000493677.5
ENST00000355135.6
ENST00000316715.9
glycoprotein M6B
chr19_+_35748549 0.03 ENST00000301159.14
lin-37 DREAM MuvB core complex component
chr8_+_91249307 0.03 ENST00000309536.6
ENST00000276609.8
solute carrier family 26 member 7
chr19_+_49487510 0.03 ENST00000679106.1
ENST00000621674.4
ENST00000391857.9
ENST00000678510.1
ENST00000467825.2
ribosomal protein L13a
chr15_+_94355956 0.03 ENST00000557742.1
multiple C2 and transmembrane domain containing 2
chr7_+_100049765 0.03 ENST00000456748.6
ENST00000292450.9
ENST00000438937.1
ENST00000543588.2
zinc finger and SCAN domain containing 21
chr16_-_20691256 0.03 ENST00000307493.8
acyl-CoA synthetase medium chain family member 1
chr6_+_125153649 0.02 ENST00000304877.17
ENST00000368402.9
ENST00000368388.6
ENST00000534000.6
TPD52 like 1
chr14_-_99480831 0.02 ENST00000331768.10
ENST00000630307.2
SET domain containing 3, actin histidine methyltransferase
chr17_-_10469558 0.02 ENST00000255381.2
myosin heavy chain 4
chr7_-_87220567 0.02 ENST00000433078.5
transmembrane protein 243
chr6_+_29550407 0.02 ENST00000641137.1
olfactory receptor family 2 subfamily I member 1 pseudogene
chr19_-_3985451 0.02 ENST00000309311.7
eukaryotic translation elongation factor 2
chr6_-_111606260 0.02 ENST00000340026.10
TRAF3 interacting protein 2
chr12_+_8157034 0.02 ENST00000396570.7
zinc finger protein 705A
chr1_+_226063466 0.02 ENST00000666609.1
ENST00000661429.1
H3.3 histone A
chr8_+_104223320 0.02 ENST00000339750.3
regulating synaptic membrane exocytosis 2
chr19_+_49766962 0.02 ENST00000354293.10
ENST00000359032.9
adaptor related protein complex 2 subunit alpha 1
chr6_+_154039102 0.02 ENST00000360422.8
ENST00000330432.12
opioid receptor mu 1
chr19_+_54137740 0.02 ENST00000644245.1
ENST00000646002.1
ENST00000221232.11
ENST00000440571.6
ENST00000617930.2
CCR4-NOT transcription complex subunit 3
chr6_+_30720335 0.02 ENST00000327892.13
tubulin beta class I
chrX_+_77899440 0.02 ENST00000373335.4
ENST00000475465.1
ENST00000650309.2
ENST00000647835.1
cytochrome c oxidase subunit 7B
chrX_+_136536099 0.02 ENST00000440515.5
ENST00000456412.1
vestigial like family member 1
chr3_-_151316795 0.02 ENST00000260843.5
G protein-coupled receptor 87
chr2_-_86194972 0.02 ENST00000254636.9
inner membrane mitochondrial protein
chr2_+_89884740 0.02 ENST00000509129.1
immunoglobulin kappa variable 1D-37 (non-functional)
chr12_-_55296569 0.02 ENST00000358433.3
olfactory receptor family 6 subfamily C member 6
chr1_+_42682388 0.02 ENST00000321358.12
ENST00000332220.10
Y-box binding protein 1
chr2_-_89297785 0.02 ENST00000465170.1
immunoglobulin kappa variable 1-37 (non-functional)
chr17_-_4967790 0.02 ENST00000575142.5
ENST00000206020.8
sperm associated antigen 7
chr17_-_5035418 0.02 ENST00000254853.10
ENST00000424747.1
solute carrier family 52 member 1
chr1_+_100352451 0.01 ENST00000361544.11
ENST00000370124.8
ENST00000336454.5
cell division cycle 14A
chr7_-_100119323 0.01 ENST00000523306.5
ENST00000344095.8
ENST00000417349.5
ENST00000493322.5
ENST00000520135.5
ENST00000460673.2
ENST00000453269.7
ENST00000452041.5
ENST00000452438.6
ENST00000451699.5
TATA-box binding protein associated factor 6
chr16_+_3283443 0.01 ENST00000572748.1
ENST00000219069.6
ENST00000573578.1
ENST00000574253.1
zinc finger protein 263
chr1_-_152414256 0.01 ENST00000271835.3
cornulin
chr8_+_106726115 0.01 ENST00000521592.5
oxidation resistance 1
chr10_+_18260715 0.01 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
calcium voltage-gated channel auxiliary subunit beta 2
chr4_-_73620629 0.01 ENST00000342081.7
Ras association domain family member 6
chr1_+_27934980 0.01 ENST00000373894.8
sphingomyelin phosphodiesterase acid like 3B
chr12_+_16347637 0.01 ENST00000543076.5
ENST00000396210.8
microsomal glutathione S-transferase 1
chr17_-_41060109 0.01 ENST00000391418.3
keratin associated protein 2-3
chr17_+_7407838 0.01 ENST00000302926.7
neuroligin 2
chr9_-_134068012 0.01 ENST00000303407.12
bromodomain containing 3
chr9_+_34329545 0.01 ENST00000379158.7
nudix hydrolase 2
chr19_+_10111689 0.01 ENST00000321826.5
purinergic receptor P2Y11
chr6_-_111605859 0.00 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3 interacting protein 2
chr3_-_139006268 0.00 ENST00000383163.4
proline rich 23A
chr5_+_67004618 0.00 ENST00000261569.11
ENST00000436277.5
microtubule associated serine/threonine kinase family member 4
chr12_-_118359105 0.00 ENST00000541186.5
ENST00000539872.5
TAO kinase 3
chr1_+_45688165 0.00 ENST00000372025.5
transmembrane protein 69
chr2_-_74391837 0.00 ENST00000417090.1
ENST00000409868.5
ENST00000680606.1
dynactin subunit 1
chr3_-_191282383 0.00 ENST00000427544.6
urotensin 2B

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.1 0.3 GO:0061346 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 0.2 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.2 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.2 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.0 0.1 GO:2000583 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) metanephric glomerular epithelium development(GO:0072244) metanephric glomerular visceral epithelial cell differentiation(GO:0072248) metanephric glomerular visceral epithelial cell development(GO:0072249) metanephric glomerular epithelial cell differentiation(GO:0072312) metanephric glomerular epithelial cell development(GO:0072313) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.2 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.0 0.1 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.0 0.5 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.3 GO:0045176 apical protein localization(GO:0045176)
0.0 0.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.2 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.1 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.0 GO:0071284 copper ion export(GO:0060003) cellular response to lead ion(GO:0071284)
0.0 0.1 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.0 GO:0048104 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
0.0 0.0 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.0 0.0 GO:1900920 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0060187 cell pole(GO:0060187)
0.0 0.2 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.0 GO:1990032 parallel fiber(GO:1990032)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0061714 folic acid receptor activity(GO:0061714)
0.1 0.4 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.2 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.1 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.0 0.2 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.2 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.0 0.2 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.0 GO:0004618 copper-exporting ATPase activity(GO:0004008) phosphoglycerate kinase activity(GO:0004618) copper-transporting ATPase activity(GO:0043682)
0.0 0.1 GO:0052796 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.0 GO:0008513 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.5 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers