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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX2-2

Z-value: 0.91

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Transcription factors associated with NKX2-2

Gene Symbol Gene ID Gene Info
ENSG00000125820.6 NKX2-2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-2hg38_v1_chr20_-_21514046_215140700.125.3e-01Click!

Activity profile of NKX2-2 motif

Sorted Z-values of NKX2-2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr10_-_59753388 3.38 ENST00000430431.5
myoregulin
chr7_-_138627444 2.60 ENST00000463557.1
SVOP like
chr10_-_59753444 2.43 ENST00000594536.5
ENST00000414264.6
myoregulin
chr1_+_103617427 2.23 ENST00000423678.2
ENST00000414303.7
amylase alpha 2A
chr1_+_53894181 2.18 ENST00000361921.8
ENST00000322679.10
ENST00000613679.4
ENST00000617230.2
ENST00000610607.4
ENST00000532493.5
ENST00000525202.5
ENST00000524406.5
ENST00000388876.3
iodothyronine deiodinase 1
chr11_-_119196769 2.11 ENST00000415318.2
coiled-coil domain containing 153
chr13_-_35855627 2.00 ENST00000379893.5
doublecortin like kinase 1
chr15_-_56465130 1.96 ENST00000260453.4
meiosis specific nuclear structural 1
chr1_+_103750406 1.94 ENST00000370079.3
amylase alpha 1C
chr1_+_78303865 1.80 ENST00000370758.5
prostaglandin F receptor
chr13_+_30932638 1.58 ENST00000380473.8
testis expressed 26
chr2_+_38875962 1.57 ENST00000340556.11
ENST00000410014.5
ENST00000644631.3
ENST00000409665.5
ENST00000409077.2
ENST00000409131.2
MORN repeat containing 2
chr1_-_26306576 1.56 ENST00000421827.2
ENST00000374215.5
ENST00000374223.5
ENST00000357089.8
ENST00000314675.11
ENST00000423664.5
ENST00000374221.7
UBX domain protein 11
chr17_+_7688427 1.50 ENST00000396463.7
ENST00000534050.5
WD repeat containing antisense to TP53
chr12_-_71157872 1.44 ENST00000546561.2
tetraspanin 8
chr12_-_68302872 1.44 ENST00000539972.5
Mdm1 nuclear protein
chr4_-_176195563 1.43 ENST00000280191.7
spermatogenesis associated 4
chr13_-_61415508 1.31 ENST00000409204.4
protocadherin 20
chr7_-_120857124 1.23 ENST00000441017.5
ENST00000424710.5
ENST00000433758.5
tetraspanin 12
chr7_-_130441136 1.19 ENST00000675596.1
ENST00000676312.1
centrosomal protein 41
chr8_+_93754879 1.18 ENST00000453906.6
ENST00000683362.1
ENST00000682036.1
ENST00000453321.8
ENST00000409623.8
ENST00000520680.2
ENST00000521517.6
ENST00000452276.6
transmembrane protein 67
chr7_-_103074816 1.17 ENST00000379305.7
ENST00000379308.7
F-box and leucine rich repeat protein 13
chr1_-_53940100 1.14 ENST00000371376.1
heat shock protein family B (small) member 11
chr1_-_216805367 1.14 ENST00000360012.7
estrogen related receptor gamma
chr7_+_23680130 1.09 ENST00000409192.7
ENST00000409653.5
ENST00000409994.3
ENST00000344962.9
family with sequence similarity 221 member A
chr8_-_132625378 1.08 ENST00000522789.5
leucine rich repeat containing 6
chr7_-_103074725 1.08 ENST00000456695.5
ENST00000455112.6
ENST00000440067.2
F-box and leucine rich repeat protein 13
chr9_-_15510289 1.07 ENST00000397519.6
PC4 and SFRS1 interacting protein 1
chr8_-_132760548 1.04 ENST00000519187.5
ENST00000523829.5
ENST00000677595.1
ENST00000356838.7
ENST00000377901.8
ENST00000519304.1
transmembrane protein 71
chr6_-_109690515 1.01 ENST00000532976.1
adenylate kinase 9
chr5_+_141223332 1.01 ENST00000239449.7
ENST00000624896.1
ENST00000624396.1
protocadherin beta 14
novel protein
chr13_+_102656933 1.01 ENST00000650757.1
tripeptidyl peptidase 2
chr6_-_109690500 1.00 ENST00000448084.6
adenylate kinase 9
chr4_+_36281591 1.00 ENST00000639862.2
ENST00000357504.7
death domain containing 1
chr6_+_32439866 0.97 ENST00000374982.5
ENST00000395388.7
major histocompatibility complex, class II, DR alpha
chr16_+_30201057 0.92 ENST00000569485.5
sulfotransferase family 1A member 3
chr13_-_35855758 0.87 ENST00000615680.4
doublecortin like kinase 1
chr1_+_171248471 0.80 ENST00000402921.6
ENST00000617670.6
ENST00000367750.7
flavin containing dimethylaniline monoxygenase 1
chr3_-_171026709 0.80 ENST00000314251.8
solute carrier family 2 member 2
chr12_-_89656093 0.79 ENST00000359142.7
ATPase plasma membrane Ca2+ transporting 1
chr6_-_79537423 0.73 ENST00000369846.9
ENST00000392959.5
ENST00000467898.3
lebercilin LCA5
chr10_-_50279715 0.72 ENST00000395526.9
N-acylsphingosine amidohydrolase 2
chr3_-_122416035 0.70 ENST00000330689.6
WD repeat domain 5B
chr2_+_119544420 0.70 ENST00000413369.8
cilia and flagella associated protein 221
chr18_-_55321640 0.68 ENST00000637169.2
transcription factor 4
chr3_-_121660892 0.68 ENST00000428394.6
ENST00000314583.8
hematopoietic cell-specific Lyn substrate 1
chr5_+_160229499 0.68 ENST00000402432.4
fatty acid binding protein 6
chr10_-_110918934 0.67 ENST00000605742.5
BBSome interacting protein 1
chr1_+_211259932 0.67 ENST00000367005.8
REST corepressor 3
chr22_-_23751080 0.67 ENST00000341976.5
zinc finger protein 70
chr3_+_159273235 0.66 ENST00000638749.1
IQCJ-SCHIP1 readthrough
chr11_-_72721908 0.63 ENST00000426523.5
ENST00000429686.5
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr11_+_93329990 0.62 ENST00000530862.6
ENST00000531792.5
deuterosome assembly protein 1
chr2_+_169798841 0.61 ENST00000260956.9
ENST00000417292.5
small RNA binding exonuclease protection factor La
chr16_-_21278282 0.61 ENST00000572914.2
crystallin mu
chr1_-_206921987 0.58 ENST00000530505.1
ENST00000442471.4
Fc fragment of IgM receptor
chr10_-_70376779 0.57 ENST00000395011.5
leucine rich repeat containing 20
chr12_+_20810698 0.56 ENST00000540853.5
ENST00000381545.8
solute carrier organic anion transporter family member 1B3
chr20_-_57266342 0.56 ENST00000395864.7
bone morphogenetic protein 7
chr14_-_89412025 0.55 ENST00000553840.5
ENST00000556916.5
forkhead box N3
chr4_+_94757921 0.55 ENST00000515059.6
bone morphogenetic protein receptor type 1B
chrX_+_47232866 0.54 ENST00000218348.7
ENST00000377107.7
ubiquitin specific peptidase 11
chr20_+_11890785 0.54 ENST00000399006.6
ENST00000405977.5
BTB domain containing 3
chrX_-_71255060 0.54 ENST00000373988.5
ENST00000373998.5
zinc finger MYM-type containing 3
chr9_-_113340248 0.53 ENST00000341761.8
ENST00000374195.7
ENST00000374193.9
WD repeat domain 31
chr18_-_55321986 0.51 ENST00000570287.6
transcription factor 4
chr6_+_29301701 0.51 ENST00000641895.1
olfactory receptor family 14 subfamily J member 1
chr9_-_20622479 0.50 ENST00000380338.9
MLLT3 super elongation complex subunit
chr7_+_92057602 0.50 ENST00000491695.2
A-kinase anchoring protein 9
chr1_+_84164684 0.49 ENST00000370680.5
protein kinase cAMP-activated catalytic subunit beta
chr5_+_83471668 0.49 ENST00000342785.8
ENST00000343200.9
versican
chr3_+_41200080 0.47 ENST00000644524.1
catenin beta 1
chr3_-_33645253 0.47 ENST00000333778.10
cytoplasmic linker associated protein 2
chr8_+_75539862 0.46 ENST00000396423.4
hepatocyte nuclear factor 4 gamma
chr11_+_94543894 0.46 ENST00000358752.4
fucosyltransferase 4
chr10_-_27240505 0.46 ENST00000375888.5
ENST00000676732.1
acyl-CoA binding domain containing 5
chr7_-_120858066 0.46 ENST00000222747.8
tetraspanin 12
chr11_+_31650024 0.45 ENST00000638317.1
elongator acetyltransferase complex subunit 4
chr7_+_114414809 0.45 ENST00000350908.9
forkhead box P2
chr5_+_83471736 0.45 ENST00000265077.8
versican
chr8_-_121641424 0.45 ENST00000303924.5
hyaluronan synthase 2
chr3_+_41200104 0.44 ENST00000643297.1
ENST00000450969.6
catenin beta 1
chr5_+_83471764 0.44 ENST00000512590.6
ENST00000513960.5
ENST00000513984.5
versican
chr6_+_143677935 0.44 ENST00000440869.6
ENST00000367582.7
ENST00000451827.6
phosphatase and actin regulator 2
chr12_-_16600703 0.43 ENST00000616247.4
LIM domain only 3
chr5_+_83471925 0.43 ENST00000502527.2
versican
chr16_+_30200729 0.43 ENST00000563322.5
sulfotransferase family 1A member 3
chr1_+_241532121 0.42 ENST00000366558.7
kynurenine 3-monooxygenase
chr1_-_206921867 0.41 ENST00000628511.2
ENST00000367091.8
Fc fragment of IgM receptor
chr17_-_31314066 0.41 ENST00000577894.1
ecotropic viral integration site 2B
chr2_-_162152239 0.40 ENST00000418842.7
glucagon
chr8_+_75539893 0.40 ENST00000674002.1
hepatocyte nuclear factor 4 gamma
chrX_+_11760087 0.40 ENST00000649271.1
MSL complex subunit 3
chr5_-_801145 0.40 ENST00000424784.3
zinc finger DHHC-type containing 11
chrX_+_71254781 0.39 ENST00000677446.1
non-POU domain containing octamer binding
chr2_-_73233206 0.38 ENST00000258083.3
protease associated domain containing 1
chr7_+_150368189 0.38 ENST00000519397.1
ENST00000479668.5
replication initiator 1
chr2_+_161416273 0.38 ENST00000389554.8
T-box brain transcription factor 1
chrX_+_11760035 0.36 ENST00000482871.6
ENST00000648013.1
MSL complex subunit 3
chr9_-_96619783 0.36 ENST00000375241.6
cell division cycle 14B
chr2_+_202073249 0.36 ENST00000498697.3
KIAA2012
chr16_+_53207981 0.36 ENST00000565803.2
chromodomain helicase DNA binding protein 9
chr12_+_41437680 0.35 ENST00000649474.1
ENST00000539469.6
ENST00000298919.7
PDZ domain containing ring finger 4
chr2_-_162152404 0.35 ENST00000375497.3
glucagon
chr14_-_100375602 0.35 ENST00000553395.5
ENST00000553545.5
ENST00000344102.9
ENST00000556338.5
ENST00000553934.1
tryptophanyl-tRNA synthetase 1
chr13_-_19782970 0.34 ENST00000427943.1
ENST00000619300.4
paraspeckle component 1
chr12_-_57846686 0.32 ENST00000548823.1
ENST00000398073.7
CTD small phosphatase 2
chr3_-_15798184 0.32 ENST00000624145.3
ankyrin repeat domain 28
chr14_-_100375333 0.32 ENST00000557297.5
ENST00000555813.5
ENST00000392882.7
ENST00000557135.5
ENST00000556698.5
ENST00000554509.5
ENST00000555410.5
tryptophanyl-tRNA synthetase 1
chr3_-_69052309 0.31 ENST00000398559.7
ENST00000646708.1
ENST00000646304.1
TATA element modulatory factor 1
chr7_+_114414997 0.31 ENST00000462331.5
ENST00000393491.7
ENST00000403559.8
ENST00000408937.7
ENST00000393498.6
ENST00000393495.7
ENST00000378237.7
forkhead box P2
chr19_-_14835162 0.31 ENST00000322301.5
olfactory receptor family 7 subfamily A member 5
chr2_-_32039776 0.31 ENST00000342166.10
ENST00000295066.3
dpy-30 histone methyltransferase complex regulatory subunit
chr9_-_92404559 0.30 ENST00000262551.8
ENST00000375561.10
osteoglycin
chr1_-_44788168 0.29 ENST00000372207.4
bestrophin 4
chr18_+_32091849 0.29 ENST00000261593.8
ENST00000578914.1
ring finger protein 138
chr20_-_57266606 0.28 ENST00000450594.6
ENST00000395863.8
bone morphogenetic protein 7
chr1_+_14945775 0.28 ENST00000400797.3
kazrin, periplakin interacting protein
chr15_+_65550819 0.27 ENST00000569894.5
3-hydroxyacyl-CoA dehydratase 3
chr7_-_122699108 0.27 ENST00000340112.3
ring finger protein 133
chrX_-_71254527 0.27 ENST00000373978.1
ENST00000373981.5
zinc finger MYM-type containing 3
chr1_+_42846573 0.27 ENST00000372502.5
ENST00000372508.7
ENST00000651192.1
ENST00000372507.5
ENST00000372506.5
ENST00000372504.5
zinc finger protein 691
chr3_-_151203201 0.27 ENST00000480322.1
ENST00000309180.6
G protein-coupled receptor 171
chr6_-_26027274 0.27 ENST00000377745.4
H4 clustered histone 2
chr1_-_243843226 0.27 ENST00000336199.9
AKT serine/threonine kinase 3
chr1_+_180632001 0.26 ENST00000367590.9
ENST00000367589.3
xenotropic and polytropic retrovirus receptor 1
chr1_+_174700413 0.25 ENST00000529145.6
ENST00000325589.9
RAB GTPase activating protein 1 like
chrX_+_153687918 0.24 ENST00000253122.10
solute carrier family 6 member 8
chr3_-_115071333 0.24 ENST00000462705.5
zinc finger and BTB domain containing 20
chr13_-_19782923 0.23 ENST00000338910.9
paraspeckle component 1
chr12_-_27971970 0.23 ENST00000395872.5
ENST00000201015.8
parathyroid hormone like hormone
chr5_+_168291599 0.23 ENST00000265293.9
WW and C2 domain containing 1
chr7_-_99552092 0.22 ENST00000449309.2
family with sequence similarity 200 member A
chr12_+_57604598 0.22 ENST00000548804.5
ENST00000550596.5
ENST00000551835.5
ENST00000549583.5
deltex E3 ubiquitin ligase 3
chr4_-_99435396 0.22 ENST00000209665.8
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr8_+_109540075 0.22 ENST00000614147.1
ENST00000337573.10
estrogen receptor binding site associated antigen 9
chr15_+_78873030 0.22 ENST00000558502.5
mortality factor 4 like 1
chr3_+_23805941 0.21 ENST00000306627.8
ENST00000346855.7
ubiquitin conjugating enzyme E2 E1
chr17_-_69141878 0.21 ENST00000590645.1
ENST00000284425.7
ATP binding cassette subfamily A member 6
chr16_+_22490337 0.21 ENST00000415833.6
nuclear pore complex interacting protein family member B5
chr11_-_72722302 0.20 ENST00000334211.12
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr13_+_25301587 0.20 ENST00000381736.8
ENST00000463407.5
ENST00000381718.7
ENST00000381747.7
nucleoporin 58
chr1_-_246507237 0.20 ENST00000490107.6
SET and MYND domain containing 3
chr7_+_97732046 0.20 ENST00000350485.8
ENST00000346867.4
ENST00000319273.10
tachykinin precursor 1
chr17_+_50746614 0.20 ENST00000513969.5
ENST00000503728.1
LUC7 like 3 pre-mRNA splicing factor
chr17_+_54900746 0.20 ENST00000445275.6
target of myb1 like 1 membrane trafficking protein
chr8_-_61646807 0.19 ENST00000522919.5
aspartate beta-hydroxylase
chr6_+_32969345 0.19 ENST00000678250.1
bromodomain containing 2
chr18_+_44700796 0.19 ENST00000677130.1
SET binding protein 1
chr2_+_202073282 0.19 ENST00000459709.5
KIAA2012
chr14_+_22493910 0.19 ENST00000390492.1
T cell receptor alpha joining 45
chr17_-_56961014 0.18 ENST00000240316.5
coilin
chr2_+_69013379 0.18 ENST00000409349.7
ANTXR cell adhesion molecule 1
chr6_+_136038195 0.18 ENST00000615259.4
phosphodiesterase 7B
chr2_-_219571241 0.18 ENST00000373876.5
ENST00000603926.5
ENST00000373873.8
ENST00000289656.3
obscurin like cytoskeletal adaptor 1
chr8_-_18808837 0.18 ENST00000286485.12
pleckstrin and Sec7 domain containing 3
chr18_+_74534493 0.18 ENST00000358821.8
carnosine dipeptidase 1
chrX_-_71254106 0.18 ENST00000373984.7
ENST00000314425.9
ENST00000373982.5
zinc finger MYM-type containing 3
chr20_-_13784880 0.18 ENST00000202816.5
ENST00000617257.2
ESF1 nucleolar pre-rRNA processing protein homolog
chr12_+_401621 0.18 ENST00000412006.6
ENST00000239830.9
coiled-coil domain containing 77
chr22_+_21467319 0.18 ENST00000682920.1
ENST00000432134.8
ENST00000621561.5
ENST00000536718.3
transmembrane protein 191C
chr14_+_39233908 0.18 ENST00000280082.4
MIA SH3 domain ER export factor 2
chr13_-_36370171 0.17 ENST00000355182.8
spartin
chr15_+_42548810 0.17 ENST00000568876.5
ENST00000568846.6
ENST00000562398.5
ENST00000260372.8
HAUS augmin like complex subunit 2
chr9_-_83267230 0.17 ENST00000328788.5
FERM domain containing 3
chr14_-_77028663 0.17 ENST00000238647.5
interferon regulatory factor 2 binding protein like
chr18_+_74534594 0.17 ENST00000582365.1
carnosine dipeptidase 1
chr2_+_112542413 0.17 ENST00000417433.6
ENST00000263331.10
RNA polymerase I subunit B
chr3_-_64019334 0.17 ENST00000480205.5
proteasome 26S subunit, non-ATPase 6
chr8_-_133060347 0.17 ENST00000427060.6
Src like adaptor
chr3_-_123620571 0.16 ENST00000583087.5
myosin light chain kinase
chr17_-_31314040 0.16 ENST00000330927.5
ecotropic viral integration site 2B
chr6_+_32969165 0.16 ENST00000496118.2
ENST00000449085.4
bromodomain containing 2
chr3_-_123620496 0.16 ENST00000578202.1
myosin light chain kinase
chr5_+_126423176 0.16 ENST00000542322.5
ENST00000544396.5
GRAM domain containing 2B
chr8_+_109540602 0.16 ENST00000530629.5
ENST00000620557.4
estrogen receptor binding site associated antigen 9
chr2_-_75710985 0.16 ENST00000541687.5
GC-rich sequence DNA-binding factor 2
chr9_+_2159672 0.16 ENST00000634343.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr5_+_126423363 0.15 ENST00000285689.8
GRAM domain containing 2B
chr2_+_10368764 0.15 ENST00000620771.4
hippocalcin like 1
chr11_+_22668101 0.15 ENST00000630668.2
ENST00000278187.7
growth arrest specific 2
chr16_-_29926155 0.15 ENST00000567795.3
ENST00000568000.6
ENST00000561540.2
potassium channel tetramerization domain containing 13
chrX_+_11759604 0.15 ENST00000649602.1
ENST00000650215.1
ENST00000649685.1
ENST00000649649.1
ENST00000380693.8
ENST00000380692.7
ENST00000650628.1
ENST00000649851.1
ENST00000421368.3
MSL complex subunit 3
chr14_+_22479521 0.15 ENST00000390483.1
T cell receptor alpha joining 56
chr15_+_78872881 0.15 ENST00000559930.5
ENST00000426013.7
mortality factor 4 like 1
chr5_+_126423122 0.15 ENST00000515200.5
GRAM domain containing 2B
chr14_-_44507269 0.14 ENST00000340446.5
fibrous sheath CABYR binding protein
chr5_-_59356962 0.14 ENST00000405755.6
phosphodiesterase 4D
chr10_+_96000091 0.14 ENST00000424464.5
ENST00000410012.6
ENST00000344386.3
coiled-coil and C2 domain containing 2B
chr5_-_59039454 0.14 ENST00000358923.10
phosphodiesterase 4D
chr3_+_152299392 0.14 ENST00000498502.5
ENST00000545754.5
ENST00000357472.7
ENST00000324196.9
muscleblind like splicing regulator 1
chr20_+_18507520 0.14 ENST00000336714.8
ENST00000646240.1
ENST00000450074.6
ENST00000262544.6
SEC23 homolog B, COPII coat complex component
chr2_+_10368645 0.14 ENST00000613496.4
hippocalcin like 1
chr10_+_55599041 0.13 ENST00000512524.4
MT-RNR2 like 5
chr22_-_46537593 0.13 ENST00000262738.9
ENST00000674500.2
cadherin EGF LAG seven-pass G-type receptor 1
chr15_+_78872954 0.13 ENST00000558746.5
ENST00000558830.5
ENST00000559345.5
mortality factor 4 like 1
chr16_-_69132128 0.13 ENST00000398235.6
ENST00000306585.9
ENST00000519520.6
chromosome transmission fidelity factor 8
DERPC proline and glycine rich nuclear protein
chr11_+_46936710 0.13 ENST00000378618.6
ENST00000278460.12
ENST00000395460.6
ENST00000378615.7
chromosome 11 open reading frame 49
chrX_-_130903187 0.13 ENST00000432489.5
ENST00000394363.6
ENST00000338144.8
ecto-NOX disulfide-thiol exchanger 2
chr12_+_56152579 0.13 ENST00000551834.5
ENST00000552568.5
myosin light chain 6B

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 5.8 GO:1902080 regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.7 2.0 GO:0061571 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
0.3 1.0 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.3 2.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.3 0.8 GO:0021757 caudate nucleus development(GO:0021757) putamen development(GO:0021758)
0.2 1.3 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.2 1.5 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.2 0.8 GO:0072134 nephrogenic mesenchyme morphogenesis(GO:0072134)
0.2 0.8 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.2 0.8 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.2 1.7 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.2 0.6 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.2 0.9 GO:1904499 glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793)
0.1 0.7 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 2.6 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.1 2.9 GO:0070986 left/right axis specification(GO:0070986)
0.1 1.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.4 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.8 GO:0070995 NADPH oxidation(GO:0070995)
0.1 1.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.8 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.1 2.8 GO:0042403 thyroid hormone metabolic process(GO:0042403)
0.1 0.6 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.1 0.3 GO:2000845 testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845)
0.1 0.4 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 0.4 GO:0021764 amygdala development(GO:0021764)
0.1 0.7 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 1.1 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.1 0.6 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.1 1.8 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 0.4 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.2 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.1 0.5 GO:0030242 pexophagy(GO:0030242)
0.0 1.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.2 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.0 2.9 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.2 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.0 0.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.5 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.1 GO:0090646 mitochondrial RNA 5'-end processing(GO:0000964) mitochondrial tRNA processing(GO:0090646)
0.0 1.7 GO:0010842 retina layer formation(GO:0010842)
0.0 0.7 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.1 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.6 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.4 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.4 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.3 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 0.5 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.3 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0 0.1 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.0 0.1 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0 0.5 GO:0042354 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.1 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.7 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.3 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 1.0 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.2 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 0.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.0 0.6 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.3 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.1 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.2 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.1 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029)
0.0 0.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.1 GO:0009826 unidimensional cell growth(GO:0009826)
0.0 0.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.9 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 0.0 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.0 0.2 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 1.0 GO:0006968 cellular defense response(GO:0006968)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.1 0.5 GO:0044307 dendritic branch(GO:0044307)
0.1 1.0 GO:0072487 MSL complex(GO:0072487)
0.1 0.6 GO:0098536 deuterosome(GO:0098536)
0.1 1.0 GO:0042382 paraspeckles(GO:0042382)
0.1 5.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.3 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 1.2 GO:0036038 MKS complex(GO:0036038)
0.1 1.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.7 GO:0034464 BBSome(GO:0034464)
0.0 0.1 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.0 0.6 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.3 GO:1990393 3M complex(GO:1990393)
0.0 1.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.6 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.5 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 1.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.8 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.6 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 2.7 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.9 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 1.9 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 1.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.6 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.2 GO:0071004 U2-type prespliceosome(GO:0071004)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0004556 alpha-amylase activity(GO:0004556)
0.6 1.8 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.4 2.2 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.3 1.3 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.2 1.0 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.2 0.8 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.2 2.0 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.2 0.6 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 1.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 0.8 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.7 GO:0017040 ceramidase activity(GO:0017040)
0.1 0.4 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 1.1 GO:0097100 supercoiled DNA binding(GO:0097100)
0.1 1.0 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 0.3 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 1.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.8 GO:0070700 BMP receptor binding(GO:0070700)
0.1 1.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.2 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.0 0.2 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.6 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.6 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.9 GO:0070411 I-SMAD binding(GO:0070411)
0.0 1.2 GO:0031005 filamin binding(GO:0031005)
0.0 1.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.5 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.1 GO:0002113 interleukin-33 binding(GO:0002113)
0.0 0.7 GO:0032052 bile acid binding(GO:0032052)
0.0 1.5 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.3 GO:0102345 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 0.5 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.4 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.1 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.0 0.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.4 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.3 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.3 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.0 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.4 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.0 0.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.2 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID ALK2 PATHWAY ALK2 signaling events
0.0 2.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.9 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.8 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 2.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 1.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 1.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.5 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.8 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.6 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.8 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.9 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.7 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.9 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 1.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.4 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.6 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis