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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for NKX2-3
Z-value: 1.14
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Transcription factors associated with NKX2-3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX2-3 | hg38_v1_chr10_+_99532927_99532953 | 0.01 | 9.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_151025343 Show fit | 10.92 |
ENST00000521632.1
|
glutathione peroxidase 3 |
|
| chr12_+_8822610 Show fit | 6.55 |
ENST00000299698.12
|
alpha-2-macroglobulin like 1 |
|
| chr19_-_51002527 Show fit | 5.74 |
ENST00000595238.1
ENST00000600767.5 |
kallikrein related peptidase 8 |
|
| chr1_-_205422050 Show fit | 5.43 |
ENST00000367153.9
|
LEM domain containing 1 |
|
| chr19_-_51001668 Show fit | 4.15 |
ENST00000347619.8
ENST00000291726.11 ENST00000320838.9 |
kallikrein related peptidase 8 |
|
| chr5_-_111512473 Show fit | 4.09 |
ENST00000296632.8
ENST00000512160.5 ENST00000509887.5 |
StAR related lipid transfer domain containing 4 |
|
| chr11_+_35189869 Show fit | 4.00 |
ENST00000525688.5
ENST00000278385.10 ENST00000533222.5 |
CD44 molecule (Indian blood group) |
|
| chr3_-_111595339 Show fit | 3.81 |
ENST00000317012.5
|
zinc finger BED-type containing 2 |
|
| chr2_-_31217511 Show fit | 3.65 |
ENST00000403897.4
|
calpain 14 |
|
| chr19_-_18941184 Show fit | 3.51 |
ENST00000594794.5
ENST00000392351.8 ENST00000596482.5 |
homer scaffold protein 3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 13.8 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.7 | 9.9 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.5 | 6.1 | GO:1900625 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.9 | 5.4 | GO:0032487 | regulation of Rap protein signal transduction(GO:0032487) |
| 0.0 | 5.4 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 1.4 | 4.1 | GO:0070859 | positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253) |
| 0.2 | 3.8 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.0 | 3.7 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 0.1 | 3.5 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.3 | 3.2 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 6.1 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.1 | 5.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 3.8 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 3.8 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 3.7 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 3.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 2.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.6 | 2.5 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.1 | 2.5 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 2.5 | GO:0030027 | lamellipodium(GO:0030027) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.2 | 13.8 | GO:0008430 | selenium binding(GO:0008430) |
| 0.1 | 10.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 7.5 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.2 | 6.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 5.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.2 | 4.1 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 0.0 | 3.7 | GO:0070888 | E-box binding(GO:0070888) |
| 0.3 | 3.6 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.1 | 3.6 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 6.1 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 3.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.3 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 3.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 3.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.1 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 2.7 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 2.6 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 2.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 8.1 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.3 | 6.1 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 4.7 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.1 | 3.0 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 2.9 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 2.8 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 2.7 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 2.4 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 2.1 | REACTOME EICOSANOID LIGAND BINDING RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |