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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX2-4

Z-value: 0.58

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Transcription factors associated with NKX2-4

Gene Symbol Gene ID Gene Info
ENSG00000125816.5 NKX2-4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-4hg38_v1_chr20_-_21397513_21397531-0.328.9e-02Click!

Activity profile of NKX2-4 motif

Sorted Z-values of NKX2-4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-4

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_-_205449924 2.35 ENST00000367154.5
LEM domain containing 1
chr12_+_8822610 1.26 ENST00000299698.12
alpha-2-macroglobulin like 1
chr5_-_39270623 1.02 ENST00000512138.1
ENST00000646045.2
FYN binding protein 1
chr1_+_31576485 0.93 ENST00000457433.6
ENST00000271064.12
tubulointerstitial nephritis antigen like 1
chr11_+_60931744 0.86 ENST00000536409.1
transmembrane protein 132A
chr20_-_44651683 0.85 ENST00000537820.1
ENST00000372874.9
adenosine deaminase
chr12_-_84892120 0.81 ENST00000680379.1
solute carrier family 6 member 15
chr13_-_20230970 0.78 ENST00000644667.1
ENST00000646108.1
gap junction protein beta 6
chr4_-_174522791 0.76 ENST00000541923.5
ENST00000542498.5
15-hydroxyprostaglandin dehydrogenase
chr7_-_93890160 0.72 ENST00000451238.1
tissue factor pathway inhibitor 2
chr11_-_124445696 0.69 ENST00000642064.1
olfactory receptor family 8 subfamily B member 8
chr9_+_125748175 0.65 ENST00000491787.7
ENST00000447726.6
PBX homeobox 3
chr10_-_133336862 0.62 ENST00000368555.3
ENST00000252939.9
ENST00000368558.1
calcyon neuron specific vesicular protein
chr5_-_140633167 0.59 ENST00000302014.11
CD14 molecule
chr11_-_102780620 0.54 ENST00000279441.9
ENST00000539681.1
matrix metallopeptidase 10
chr1_+_153001742 0.54 ENST00000331860.7
ENST00000295367.5
ENST00000443178.1
small proline rich protein 3
chr1_-_120051714 0.53 ENST00000579475.7
notch receptor 2
chr22_-_26565362 0.53 ENST00000398110.6
tyrosylprotein sulfotransferase 2
chr4_+_3766348 0.53 ENST00000509482.1
ENST00000330055.7
adrenoceptor alpha 2C
chr20_-_37261808 0.53 ENST00000373614.7
growth hormone releasing hormone
chr17_-_28576882 0.53 ENST00000395319.7
ENST00000581807.5
ENST00000226253.9
ENST00000584086.5
ENST00000395321.6
aldolase, fructose-bisphosphate C
chr11_-_58578096 0.53 ENST00000528954.5
ENST00000528489.1
leupaxin
chr11_+_844406 0.50 ENST00000397404.5
tetraspanin 4
chr19_+_16197900 0.48 ENST00000429941.6
ENST00000291439.8
ENST00000444449.6
ENST00000589822.5
adaptor related protein complex 1 subunit mu 1
chr11_+_57338344 0.48 ENST00000263314.3
ENST00000616487.4
purinergic receptor P2X 3
chr11_-_102955705 0.47 ENST00000615555.4
ENST00000340273.4
ENST00000260302.8
matrix metallopeptidase 13
chr7_+_134843884 0.46 ENST00000445569.6
caldesmon 1
chr1_-_158554405 0.45 ENST00000641282.1
ENST00000641622.1
olfactory receptor family 6 subfamily Y member 1
chr9_+_137225166 0.45 ENST00000650725.2
cysteine rich tail 1
chr6_-_130956371 0.44 ENST00000639623.1
ENST00000525193.5
ENST00000527659.5
erythrocyte membrane protein band 4.1 like 2
chr2_+_28392802 0.44 ENST00000379619.5
ENST00000264716.9
FOS like 2, AP-1 transcription factor subunit
chr8_-_48921419 0.43 ENST00000020945.4
snail family transcriptional repressor 2
chr16_-_10774996 0.43 ENST00000572428.5
ENST00000619408.1
trans-golgi network vesicle protein 23 homolog A
chr18_-_31760864 0.41 ENST00000269205.7
ENST00000672005.1
solute carrier family 25 member 52
chr4_+_70197924 0.41 ENST00000514097.5
odontogenic, ameloblast associated
chr7_+_134866831 0.39 ENST00000435928.1
caldesmon 1
chr1_+_213989691 0.38 ENST00000607425.1
prospero homeobox 1
chr7_-_80922354 0.37 ENST00000419255.6
semaphorin 3C
chr22_+_44026283 0.37 ENST00000619710.4
parvin beta
chr19_+_48756067 0.37 ENST00000222157.5
fibroblast growth factor 21
chr8_+_31639291 0.36 ENST00000651149.1
ENST00000650866.1
neuregulin 1
chr4_+_109912877 0.36 ENST00000265171.10
ENST00000509793.5
ENST00000652245.1
epidermal growth factor
chr7_+_143477873 0.35 ENST00000408916.1
taste 2 receptor member 41
chr10_-_119536533 0.35 ENST00000392865.5
regulator of G protein signaling 10
chr2_+_100974849 0.35 ENST00000450763.1
neuronal PAS domain protein 2
chr10_+_71396905 0.34 ENST00000224721.12
ENST00000398809.9
ENST00000461841.7
ENST00000299366.11
ENST00000644511.1
ENST00000616684.4
cadherin related 23
chr19_+_39406831 0.34 ENST00000597629.3
ENST00000594442.2
ENST00000594045.2
ZFP36 ring finger protein
chr6_-_65707214 0.34 ENST00000370621.7
ENST00000393380.6
ENST00000503581.6
eyes shut homolog
chr5_-_11589019 0.33 ENST00000511377.5
catenin delta 2
chr5_-_132543513 0.33 ENST00000231454.6
interleukin 5
chr7_-_107803215 0.33 ENST00000340010.10
ENST00000453332.1
solute carrier family 26 member 3
chr8_+_31639222 0.33 ENST00000519301.6
ENST00000652698.1
neuregulin 1
chr1_-_197067234 0.32 ENST00000367412.2
coagulation factor XIII B chain
chr8_+_27311471 0.32 ENST00000397501.5
protein tyrosine kinase 2 beta
chr1_+_95117923 0.32 ENST00000455656.1
ENST00000604534.5
TLC domain containing 4
TLCD4-RWDD3 readthrough
chr11_+_35943981 0.32 ENST00000528989.5
ENST00000524419.5
ENST00000315571.6
low density lipoprotein receptor class A domain containing 3
chr15_-_55249029 0.32 ENST00000566877.5
RAB27A, member RAS oncogene family
chr15_+_67138001 0.31 ENST00000439724.7
SMAD family member 3
chr10_+_103245887 0.30 ENST00000441178.2
ribulose-5-phosphate-3-epimerase like 1
chr2_-_208190001 0.30 ENST00000451346.5
ENST00000341287.9
chromosome 2 open reading frame 80
chr17_-_44899368 0.30 ENST00000591382.5
ENST00000593072.5
ENST00000592576.5
ENST00000426333.7
ENST00000402521.7
elongation factor Tu GTP binding domain containing 2
chr20_-_23605917 0.29 ENST00000376971.4
cystatin 9
chr3_-_112610262 0.29 ENST00000479368.1
coiled-coil domain containing 80
chr15_+_41286011 0.29 ENST00000661438.1
novel protein
chr7_+_157336988 0.28 ENST00000262177.9
ENST00000417758.5
ENST00000443280.5
DnaJ heat shock protein family (Hsp40) member B6
chr5_-_11588842 0.28 ENST00000503622.5
catenin delta 2
chr6_+_7590179 0.28 ENST00000342415.6
small nuclear ribonucleoprotein U11/U12 subunit 48
chr17_+_8002610 0.28 ENST00000254854.5
guanylate cyclase 2D, retinal
chr1_-_93681829 0.27 ENST00000260502.11
BCAR3 adaptor protein, NSP family member
chr17_+_50274447 0.27 ENST00000507382.2
transmembrane protein 92
chr12_+_93574965 0.27 ENST00000551883.1
ENST00000549510.1
suppressor of cytokine signaling 2
chr5_+_138084015 0.27 ENST00000504809.5
ENST00000506684.6
ENST00000398754.1
Wnt family member 8A
chr5_-_95822711 0.27 ENST00000512469.2
ENST00000379979.8
ENST00000505427.1
ENST00000508780.5
ENST00000237858.11
glutaredoxin
chr9_-_21482313 0.26 ENST00000448696.4
interferon epsilon
chrX_-_52520803 0.26 ENST00000518075.1
X antigen family member 1B
chr18_+_58149314 0.26 ENST00000435432.6
ENST00000357895.9
ENST00000586263.5
NEDD4 like E3 ubiquitin protein ligase
chrX_-_15854791 0.26 ENST00000545766.7
ENST00000380291.5
ENST00000672987.1
ENST00000329235.6
adaptor related protein complex 1 subunit sigma 2
chr3_+_42856021 0.26 ENST00000493193.1
atypical chemokine receptor 2
chr1_+_12773738 0.25 ENST00000357726.5
PRAME family member 12
chr19_+_48755512 0.25 ENST00000593756.6
fibroblast growth factor 21
chr17_+_43483949 0.25 ENST00000540306.5
ENST00000262415.8
DEAH-box helicase 8
chr2_-_187554351 0.25 ENST00000437725.5
ENST00000409676.5
ENST00000233156.9
ENST00000339091.8
ENST00000420747.1
tissue factor pathway inhibitor
chr2_+_203706475 0.25 ENST00000374481.7
ENST00000458610.6
CD28 molecule
chr14_+_39233884 0.25 ENST00000553728.1
MIA SH3 domain ER export factor 2
chr1_-_75611109 0.25 ENST00000370859.7
solute carrier family 44 member 5
chrX_+_78945332 0.24 ENST00000544091.1
ENST00000171757.3
P2Y receptor family member 10
chr13_-_96053370 0.24 ENST00000376712.4
ENST00000397618.7
ENST00000376747.8
ENST00000376714.7
ENST00000638479.1
ENST00000621375.5
UDP-glucose glycoprotein glucosyltransferase 2
chr9_-_92482350 0.24 ENST00000375543.2
asporin
chr3_-_108757407 0.23 ENST00000295755.7
resistin like beta
chr5_-_177409535 0.23 ENST00000253496.4
coagulation factor XII
chr10_+_69220323 0.23 ENST00000354624.6
hexokinase domain containing 1
chr1_-_212414815 0.23 ENST00000261455.9
ENST00000535273.2
proton activated chloride channel 1
chr6_+_43298326 0.23 ENST00000372574.7
solute carrier family 22 member 7
chr10_+_97572771 0.23 ENST00000370655.6
ENST00000455090.1
ankyrin repeat domain 2
chr6_-_30075767 0.23 ENST00000244360.8
ENST00000376751.8
ring finger protein 39
chr3_+_149129610 0.23 ENST00000460120.5
ENST00000296051.7
HPS3 biogenesis of lysosomal organelles complex 2 subunit 1
chr4_-_144140635 0.23 ENST00000512064.5
ENST00000512789.5
ENST00000504786.5
ENST00000503627.2
ENST00000642713.1
ENST00000643148.1
ENST00000642738.1
ENST00000642295.1
ENST00000646447.1
ENST00000535709.6
glycophorin A (MNS blood group)
chr4_-_173399102 0.23 ENST00000296506.8
stimulator of chondrogenesis 1
chr4_-_57110373 0.23 ENST00000295666.6
ENST00000514062.2
insulin like growth factor binding protein 7
chr2_-_105396943 0.22 ENST00000409807.5
four and a half LIM domains 2
chr12_-_91058016 0.22 ENST00000266719.4
keratocan
chr5_-_79512794 0.22 ENST00000282260.10
ENST00000508576.5
ENST00000535690.1
homer scaffold protein 1
chr10_+_58334976 0.22 ENST00000615793.1
ubiquitin conjugating enzyme E2 D1
chr10_+_58334998 0.22 ENST00000373910.9
ubiquitin conjugating enzyme E2 D1
chr12_+_10505602 0.22 ENST00000322446.3
eukaryotic translation initiation factor 2 subunit gamma B
chr3_-_156555083 0.22 ENST00000265044.7
ENST00000476217.5
signal sequence receptor subunit 3
chr9_+_35042213 0.21 ENST00000378745.3
ENST00000312292.6
chromosome 9 open reading frame 131
chrX_-_139832235 0.21 ENST00000327569.7
ENST00000361648.6
ATPase phospholipid transporting 11C
chr16_+_31527876 0.21 ENST00000302312.9
ENST00000564707.1
alpha hemoglobin stabilizing protein
chr3_+_130560334 0.21 ENST00000358511.10
collagen type VI alpha 6 chain
chr2_+_203706614 0.21 ENST00000324106.9
CD28 molecule
chrX_-_75156272 0.21 ENST00000620875.5
ENST00000669573.1
ENST00000339447.8
ENST00000645829.3
ENST00000529949.5
ENST00000373394.8
ENST00000253577.9
ENST00000644766.1
ENST00000534524.5
ATP binding cassette subfamily B member 7
chr21_-_31558977 0.21 ENST00000286827.7
ENST00000541036.5
TIAM Rac1 associated GEF 1
chr3_+_111859180 0.21 ENST00000412622.5
ENST00000431670.7
pleckstrin homology like domain family B member 2
chr12_-_54384687 0.21 ENST00000550120.1
ENST00000547210.5
ENST00000394313.7
zinc finger protein 385A
chr9_-_92482499 0.21 ENST00000375544.7
asporin
chr19_+_7669043 0.20 ENST00000221515.6
resistin
chr12_+_95858928 0.20 ENST00000266735.9
ENST00000553192.5
ENST00000552085.1
small nuclear ribonucleoprotein polypeptide F
chrX_-_15854743 0.20 ENST00000450644.2
adaptor related protein complex 1 subunit sigma 2
chr10_-_103351133 0.20 ENST00000369847.4
polycomb group ring finger 6
chr14_-_22589157 0.20 ENST00000538631.1
ENST00000543337.1
ENST00000250498.9
defender against cell death 1
chr15_-_19988117 0.20 ENST00000558565.2
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr3_-_187291882 0.20 ENST00000392470.6
ENST00000169293.10
ENST00000439271.1
ENST00000392472.6
ENST00000392475.2
mannan binding lectin serine peptidase 1
chr1_-_12848720 0.20 ENST00000317869.7
heterogeneous nuclear ribonucleoprotein C like 1
chr1_+_4654601 0.19 ENST00000378191.5
adherens junctions associated protein 1
chr1_-_46303589 0.19 ENST00000617190.5
leucine rich repeat containing 41
chr16_+_11965234 0.19 ENST00000562385.1
TNF receptor superfamily member 17
chr2_-_102736819 0.19 ENST00000258436.10
major facilitator superfamily domain containing 9
chrX_+_74304173 0.19 ENST00000339534.4
zinc finger CCHC-type containing 13
chr19_+_10718114 0.19 ENST00000408974.8
dynamin 2
chr11_-_59845496 0.19 ENST00000257248.3
cobalamin binding intrinsic factor
chr15_-_82699893 0.19 ENST00000642989.2
adaptor related protein complex 3 subunit beta 2
chr15_-_82806054 0.19 ENST00000541889.1
ENST00000334574.12
ENST00000561368.1
fibronectin type III and SPRY domain containing 2
chr10_-_103351074 0.19 ENST00000337211.8
polycomb group ring finger 6
chr7_+_107583919 0.19 ENST00000491150.5
B cell receptor associated protein 29
chr5_-_147906530 0.18 ENST00000318315.5
ENST00000515291.1
chromosome 5 open reading frame 46
chr8_+_96584920 0.18 ENST00000521590.5
syndecan 2
chrX_+_49829260 0.18 ENST00000376141.5
ENST00000218068.7
PAGE family member 4
chr11_-_89876017 0.18 ENST00000329862.6
tripartite motif containing 64B
chr17_-_40417873 0.18 ENST00000423485.6
DNA topoisomerase II alpha
chr3_-_57693045 0.18 ENST00000311128.10
DENN domain containing 6A
chr18_-_27990256 0.18 ENST00000675173.1
cadherin 2
chr15_+_80072559 0.18 ENST00000560228.5
ENST00000559835.5
ENST00000559775.5
ENST00000558688.5
ENST00000560392.5
ENST00000560976.5
ENST00000558272.5
ENST00000558390.5
zinc finger AN1-type containing 6
chr1_-_116667668 0.18 ENST00000369486.8
ENST00000369483.5
immunoglobulin superfamily member 3
chrX_-_48356688 0.18 ENST00000298396.7
ENST00000376893.7
SSX family member 3
chr10_-_67696115 0.18 ENST00000433211.7
catenin alpha 3
chr18_-_63318674 0.18 ENST00000589955.2
BCL2 apoptosis regulator
chr5_-_135452318 0.18 ENST00000537858.2
TIFA inhibitor
chr9_-_28670285 0.18 ENST00000379992.6
ENST00000308675.5
ENST00000613945.3
leucine rich repeat and Ig domain containing 2
chr16_-_31088963 0.17 ENST00000280606.6
serine protease 53
chr1_-_70205531 0.17 ENST00000370952.4
leucine rich repeat containing 40
chr2_-_85354500 0.17 ENST00000449375.1
ENST00000409984.2
ENST00000295802.9
retinol saturase
chr10_+_49679637 0.17 ENST00000374113.3
ENST00000374111.8
ENST00000374112.7
ENST00000535836.1
chromosome 10 open reading frame 53
chr14_-_24232332 0.17 ENST00000534348.5
ENST00000524927.1
ENST00000250495.10
NEDD8-MDP1 readthrough
NEDD8 ubiquitin like modifier
chr21_+_46111434 0.17 ENST00000397763.5
ENST00000409416.6
collagen type VI alpha 2 chain
chr3_+_50617119 0.17 ENST00000430409.5
ENST00000621469.5
ENST00000357955.6
MAPK activated protein kinase 3
chr1_-_46303257 0.17 ENST00000615587.4
leucine rich repeat containing 41
chr4_-_143905529 0.17 ENST00000358615.9
ENST00000437468.2
glycophorin E (MNS blood group)
chr16_+_76309846 0.17 ENST00000478060.5
contactin associated protein family member 4
chr2_+_218245426 0.17 ENST00000456575.1
actin related protein 2/3 complex subunit 2
chr12_+_1970809 0.17 ENST00000683781.1
ENST00000682462.1
calcium voltage-gated channel subunit alpha1 C
chr11_-_11353241 0.17 ENST00000528848.3
casein kinase 2 alpha 3
chrX_+_47080855 0.17 ENST00000336169.3
regucalcin
chr2_+_161136901 0.16 ENST00000259075.6
ENST00000432002.5
TRAF family member associated NFKB activator
chr1_-_46303366 0.16 ENST00000343304.10
leucine rich repeat containing 41
chr14_+_22493910 0.16 ENST00000390492.1
T cell receptor alpha joining 45
chr12_+_1970772 0.16 ENST00000682544.1
calcium voltage-gated channel subunit alpha1 C
chr2_-_85602681 0.16 ENST00000334462.10
ENST00000306353.7
transmembrane protein 150A
chr16_+_57976435 0.16 ENST00000290871.10
ENST00000441824.4
testis, prostate and placenta expressed
chr2_-_85602351 0.16 ENST00000409668.1
transmembrane protein 150A
chr1_-_204213943 0.16 ENST00000308302.4
golgi transport 1A
chr3_+_189631373 0.16 ENST00000264731.8
ENST00000418709.6
ENST00000320472.9
ENST00000392460.7
ENST00000440651.6
tumor protein p63
chr4_+_22692906 0.16 ENST00000613293.4
ENST00000610628.4
glucosylceramidase beta 3 (gene/pseudogene)
chr10_-_102241502 0.16 ENST00000370002.8
paired like homeodomain 3
chr12_+_122527229 0.16 ENST00000450485.6
ENST00000333479.12
kinetochore associated 1
chr22_+_49918733 0.16 ENST00000407217.7
ENST00000403427.3
cysteine rich with EGF like domains 2
chr5_+_175871570 0.15 ENST00000512824.5
ENST00000393745.8
complexin 2
chr8_-_140800535 0.15 ENST00000521986.5
ENST00000523539.5
protein tyrosine kinase 2
chr6_+_82363199 0.15 ENST00000535040.4
trophoblast glycoprotein
chrX_-_120559889 0.15 ENST00000371323.3
cullin 4B
chr3_+_63443306 0.14 ENST00000472899.5
ENST00000479198.5
ENST00000460711.5
ENST00000465156.1
synaptoporin
chr11_-_60952559 0.14 ENST00000538739.2
solute carrier family 15 member 3
chr11_+_64251483 0.14 ENST00000279230.12
ENST00000540288.5
ENST00000325234.5
phospholipase C beta 3
chr14_+_24232612 0.14 ENST00000560139.5
ENST00000559910.5
ENST00000348719.11
guanosine monophosphate reductase 2
chr11_+_62671664 0.14 ENST00000377953.4
ubiquinol-cytochrome c reductase complex assembly factor 3
chr14_+_24232422 0.14 ENST00000620807.4
ENST00000355299.8
ENST00000559836.5
guanosine monophosphate reductase 2
chr18_-_36122110 0.14 ENST00000586829.1
solute carrier family 39 member 6
chrX_+_30243715 0.14 ENST00000378981.8
ENST00000397550.6
MAGE family member B1
chr1_+_116754422 0.14 ENST00000369478.4
ENST00000369477.1
CD2 molecule
chr4_-_21544650 0.14 ENST00000509207.1
potassium voltage-gated channel interacting protein 4
chr1_-_109613070 0.14 ENST00000351050.8
G protein subunit alpha transducin 2
chr4_-_102825854 0.14 ENST00000350435.11
ubiquitin conjugating enzyme E2 D3
chr16_+_81037187 0.14 ENST00000564241.5
ENST00000565237.1
ATM interactor
chr14_+_24232921 0.14 ENST00000557854.5
ENST00000399440.7
ENST00000559104.5
ENST00000456667.7
guanosine monophosphate reductase 2
chr18_+_32190033 0.14 ENST00000269202.11
meprin A subunit beta
chr14_+_96363452 0.14 ENST00000438650.5
ENST00000553699.5
ENST00000554182.5
ENST00000555181.6
ENST00000556095.5
GSK3B interacting protein
chr9_-_124415421 0.14 ENST00000259457.8
ENST00000441097.1
proteasome 20S subunit beta 7
chr18_+_32190015 0.14 ENST00000581447.1
meprin A subunit beta
chr1_-_89126066 0.14 ENST00000370466.4
guanylate binding protein 2
chr6_+_101398788 0.13 ENST00000369138.5
ENST00000413795.5
ENST00000358361.7
glutamate ionotropic receptor kainate type subunit 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0070256 germinal center B cell differentiation(GO:0002314) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) xanthine metabolic process(GO:0046110) negative regulation of mucus secretion(GO:0070256)
0.2 0.5 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.2 0.5 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.2 0.6 GO:1904640 response to methionine(GO:1904640)
0.1 0.4 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.1 0.5 GO:0032811 negative regulation of epinephrine secretion(GO:0032811) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.1 0.4 GO:2000979 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.6 GO:0071727 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.1 0.3 GO:1904580 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
0.1 0.3 GO:0045643 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.1 0.6 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.3 GO:2000538 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.1 0.3 GO:0044335 neural crest cell fate commitment(GO:0014034) canonical Wnt signaling pathway involved in neural crest cell differentiation(GO:0044335)
0.1 0.4 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.2 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.1 0.8 GO:0035524 proline transmembrane transport(GO:0035524)
0.1 0.4 GO:0090370 Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332) negative regulation of cholesterol efflux(GO:0090370) positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.1 0.5 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 0.2 GO:1903526 negative regulation of membrane tubulation(GO:1903526)
0.1 0.4 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 0.2 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.1 0.5 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.1 0.2 GO:0071626 mastication(GO:0071626) learned vocalization behavior(GO:0098583)
0.1 0.8 GO:2001300 ductus arteriosus closure(GO:0097070) lipoxin metabolic process(GO:2001300)
0.1 0.2 GO:0051919 activation of plasma proteins involved in acute inflammatory response(GO:0002541) positive regulation of fibrinolysis(GO:0051919)
0.1 0.2 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 0.2 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 0.4 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 0.3 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.2 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.1 0.7 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.1 0.3 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 0.2 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) platelet alpha granule organization(GO:0070889) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.1 0.2 GO:1903015 regulation of exo-alpha-sialidase activity(GO:1903015)
0.1 0.2 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.1 0.2 GO:2000196 positive regulation of female gonad development(GO:2000196)
0.0 0.3 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0 0.2 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 0.4 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.5 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.2 GO:0043375 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.6 GO:0019532 oxalate transport(GO:0019532)
0.0 0.2 GO:1903634 regulation of calcium-dependent ATPase activity(GO:1903610) negative regulation of calcium-dependent ATPase activity(GO:1903611) regulation of dUTP diphosphatase activity(GO:1903627) positive regulation of dUTP diphosphatase activity(GO:1903629) negative regulation of aminoacyl-tRNA ligase activity(GO:1903631) regulation of leucine-tRNA ligase activity(GO:1903633) negative regulation of leucine-tRNA ligase activity(GO:1903634)
0.0 0.3 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.2 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.0 0.3 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052) pentose catabolic process(GO:0019323)
0.0 0.4 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.0 0.5 GO:0002863 positive regulation of inflammatory response to antigenic stimulus(GO:0002863)
0.0 0.2 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.3 GO:0050957 equilibrioception(GO:0050957)
0.0 0.2 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.0 0.1 GO:2000439 positive regulation of monocyte extravasation(GO:2000439)
0.0 0.4 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.0 0.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.0 0.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.0 0.6 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.1 GO:1904387 cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387)
0.0 0.2 GO:0051414 response to cortisol(GO:0051414)
0.0 0.2 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.4 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.0 0.1 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0 0.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.1 GO:0042374 phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.0 0.1 GO:1904588 cellular response to glycoprotein(GO:1904588) response to thyrotropin-releasing hormone(GO:1905225) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.0 0.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.5 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 0.1 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.0 0.1 GO:0006288 base-excision repair, DNA ligation(GO:0006288) regulation of single strand break repair(GO:1903516)
0.0 0.2 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.0 0.7 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.0 0.2 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.6 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.4 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.2 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.2 GO:0015886 heme transport(GO:0015886)
0.0 0.5 GO:0035646 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.0 0.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.2 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.1 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.1 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.1 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0 0.3 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.0 0.6 GO:0043101 purine-containing compound salvage(GO:0043101)
0.0 0.1 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 0.3 GO:0051775 response to redox state(GO:0051775)
0.0 0.1 GO:0060523 prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.0 0.1 GO:0048840 otolith development(GO:0048840)
0.0 0.2 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.4 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.2 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.0 0.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.2 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.2 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:0003383 apical constriction(GO:0003383)
0.0 0.3 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.0 0.1 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.0 0.1 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.0 0.3 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 0.1 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.0 GO:0035698 CD8-positive, alpha-beta T cell extravasation(GO:0035697) CD8-positive, alpha-beta cytotoxic T cell extravasation(GO:0035698) regulation of T cell extravasation(GO:2000407) regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000449) regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation(GO:2000452)
0.0 0.1 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.2 GO:0044351 macropinocytosis(GO:0044351)
0.0 0.1 GO:1900133 regulation of renin secretion into blood stream(GO:1900133)
0.0 0.2 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.3 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.5 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.1 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.0 0.2 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.2 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.0 0.1 GO:1902559 3'-phosphoadenosine 5'-phosphosulfate transport(GO:0046963) 3'-phospho-5'-adenylyl sulfate transmembrane transport(GO:1902559)
0.0 0.1 GO:0018377 protein myristoylation(GO:0018377)
0.0 0.1 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:1902560 GMP reductase complex(GO:1902560)
0.1 0.2 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 0.3 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.6 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.9 GO:0030478 actin cap(GO:0030478)
0.1 0.2 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.2 GO:1990423 RZZ complex(GO:1990423)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.2 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 0.8 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.2 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.1 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.0 0.4 GO:0008091 spectrin(GO:0008091)
0.0 0.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.1 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.3 GO:0070578 RISC-loading complex(GO:0070578)
0.0 0.5 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.9 GO:0030673 axolemma(GO:0030673)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.1 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.4 GO:0005916 fascia adherens(GO:0005916)
0.0 0.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.6 GO:0001533 cornified envelope(GO:0001533)
0.0 0.1 GO:0070522 ERCC4-ERCC1 complex(GO:0070522)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.2 0.5 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.2 0.5 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.2 0.8 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.1 0.8 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.1 0.6 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1 0.3 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.1 0.3 GO:0004750 ribulose-phosphate 3-epimerase activity(GO:0004750)
0.1 0.6 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.1 0.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.2 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 0.5 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.1 0.6 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 1.0 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1 0.3 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.5 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.6 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.1 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.0 0.2 GO:0004341 gluconolactonase activity(GO:0004341)
0.0 0.4 GO:0042731 PH domain binding(GO:0042731)
0.0 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.2 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 0.4 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.9 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.8 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.2 GO:0004348 glucosylceramidase activity(GO:0004348)
0.0 0.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.8 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.1 GO:0000994 RNA polymerase III core binding(GO:0000994)
0.0 0.1 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.0 0.1 GO:0004447 iodide peroxidase activity(GO:0004447)
0.0 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.3 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.2 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.2 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.2 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.2 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.6 GO:0005549 odorant binding(GO:0005549)
0.0 0.2 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.1 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 2.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.2 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.2 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.1 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 0.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.1 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 0.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.1 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.0 0.1 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.3 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0051787 misfolded protein binding(GO:0051787)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.3 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.4 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.6 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.6 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.8 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.5 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.9 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.0 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.1 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.0 REACTOME GRB2 EVENTS IN ERBB2 SIGNALING Genes involved in GRB2 events in ERBB2 signaling
0.0 0.9 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.6 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.2 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 0.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.2 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME GAP JUNCTION TRAFFICKING Genes involved in Gap junction trafficking