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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX3-2

Z-value: 1.16

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Transcription factors associated with NKX3-2

Gene Symbol Gene ID Gene Info
NKX3-2
ENSG00000109705.8 NKX3-2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX3-2hg38_v1_chr4_-_13544506_13544513-0.202.8e-01Click!

Activity profile of NKX3-2 motif

Sorted Z-values of NKX3-2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX3-2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_-_32589833 9.47 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr1_-_161367872 9.34 ENST00000367974.2
CFAP126
cilia and flagella associated protein 126
chr13_+_42781578 7.97 ENST00000313851.3
FAM216B
family with sequence similarity 216 member B
chr13_+_42781547 7.96 ENST00000537894.5
FAM216B
family with sequence similarity 216 member B
chr5_-_150412743 7.24 ENST00000353334.11
ENST00000009530.12
ENST00000377795.7
CD74
CD74 molecule
chr17_-_76141240 6.92 ENST00000322957.7
FOXJ1
forkhead box J1
chr7_-_99971845 5.41 ENST00000419575.1
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr9_+_34458752 5.22 ENST00000614641.4
ENST00000242317.9
ENST00000437363.5
DNAI1
dynein axonemal intermediate chain 1
chr7_-_99976017 4.94 ENST00000411734.1
ENST00000292401.9
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr12_+_49961864 4.52 ENST00000293599.7
AQP5
aquaporin 5
chr14_-_106622837 4.35 ENST00000390628.3
IGHV1-58
immunoglobulin heavy variable 1-58
chr11_-_119196769 4.19 ENST00000415318.2
CCDC153
coiled-coil domain containing 153
chr16_+_57372465 3.89 ENST00000563383.1
CX3CL1
C-X3-C motif chemokine ligand 1
chr3_+_186996444 3.84 ENST00000676633.1
ST6GAL1
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
chr16_+_57372481 3.81 ENST00000006053.7
CX3CL1
C-X3-C motif chemokine ligand 1
chr16_-_21278282 3.78 ENST00000572914.2
CRYM
crystallin mu
chr7_-_131556602 3.77 ENST00000322985.9
ENST00000378555.8
PODXL
podocalyxin like
chr5_+_157269317 3.69 ENST00000618329.4
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr2_+_98087160 3.57 ENST00000477737.6
VWA3B
von Willebrand factor A domain containing 3B
chr11_-_8593940 3.42 ENST00000315204.5
ENST00000396672.5
ENST00000431279.6
ENST00000418597.5
STK33
serine/threonine kinase 33
chr9_-_110208156 3.37 ENST00000400613.5
C9orf152
chromosome 9 open reading frame 152
chr1_-_183653307 3.27 ENST00000308641.6
APOBEC4
apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4
chr6_+_32854179 3.24 ENST00000374859.3
PSMB9
proteasome 20S subunit beta 9
chr7_-_120858066 3.15 ENST00000222747.8
TSPAN12
tetraspanin 12
chr17_+_70075215 3.09 ENST00000283936.5
ENST00000615244.4
ENST00000392671.6
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr9_-_72953047 3.07 ENST00000297785.8
ENST00000376939.5
ALDH1A1
aldehyde dehydrogenase 1 family member A1
chr9_+_68705414 2.98 ENST00000541509.5
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase type 1 beta
chr19_+_40991274 2.97 ENST00000324071.10
CYP2B6
cytochrome P450 family 2 subfamily B member 6
chr11_-_26572254 2.79 ENST00000529533.6
MUC15
mucin 15, cell surface associated
chr15_-_43220989 2.52 ENST00000540029.5
ENST00000441366.7
ENST00000648595.1
EPB42
erythrocyte membrane protein band 4.2
chr12_-_113221087 2.50 ENST00000299732.6
ENST00000416617.3
IQCD
IQ motif containing D
chr11_-_26572102 2.47 ENST00000455601.6
MUC15
mucin 15, cell surface associated
chr6_-_52909666 2.46 ENST00000370968.5
ENST00000211122.4
GSTA3
glutathione S-transferase alpha 3
chr1_+_162381703 2.21 ENST00000458626.4
C1orf226
chromosome 1 open reading frame 226
chr17_+_70075317 2.19 ENST00000589377.1
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr1_-_160282458 2.19 ENST00000485079.1
ENSG00000258465.8
novel protein
chr5_-_55173173 2.19 ENST00000296733.5
ENST00000322374.10
ENST00000381375.7
CDC20B
cell division cycle 20B
chr3_-_45884685 2.18 ENST00000684620.1
LZTFL1
leucine zipper transcription factor like 1
chr5_-_160852200 2.17 ENST00000327245.10
ATP10B
ATPase phospholipid transporting 10B (putative)
chr10_+_7703300 2.11 ENST00000358415.9
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr5_-_176899332 2.06 ENST00000292432.10
HK3
hexokinase 3
chr1_+_14924100 1.94 ENST00000361144.9
KAZN
kazrin, periplakin interacting protein
chr4_-_167234426 1.91 ENST00000541354.5
ENST00000509854.5
ENST00000512681.5
ENST00000357545.9
ENST00000510741.5
ENST00000510403.5
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr4_-_167234579 1.90 ENST00000502330.5
ENST00000357154.7
ENST00000421836.6
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr11_-_107018431 1.90 ENST00000282249.6
GUCY1A2
guanylate cyclase 1 soluble subunit alpha 2
chr6_-_32763522 1.87 ENST00000435145.6
ENST00000437316.7
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr11_-_26572130 1.72 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr15_-_93073111 1.70 ENST00000557420.1
ENST00000542321.6
RGMA
repulsive guidance molecule BMP co-receptor a
chr17_+_60677822 1.69 ENST00000407086.8
ENST00000589222.5
ENST00000626960.2
ENST00000390652.9
BCAS3
BCAS3 microtubule associated cell migration factor
chr12_+_50925007 1.68 ENST00000332160.5
METTL7A
methyltransferase like 7A
chr10_-_45672708 1.62 ENST00000374366.7
ENST00000374371.6
ENST00000344646.10
ZFAND4
zinc finger AN1-type containing 4
chr15_-_93073706 1.62 ENST00000425933.6
RGMA
repulsive guidance molecule BMP co-receptor a
chr11_+_36296281 1.58 ENST00000530639.6
PRR5L
proline rich 5 like
chr7_+_90709816 1.56 ENST00000436577.3
CDK14
cyclin dependent kinase 14
chr17_+_55264952 1.56 ENST00000226067.10
HLF
HLF transcription factor, PAR bZIP family member
chr4_-_167234266 1.52 ENST00000511269.5
ENST00000506697.5
ENST00000512042.1
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr11_-_59866478 1.51 ENST00000257264.4
TCN1
transcobalamin 1
chr7_+_90709530 1.44 ENST00000406263.5
CDK14
cyclin dependent kinase 14
chr11_-_5243644 1.44 ENST00000643122.1
HBD
hemoglobin subunit delta
chr3_-_112499457 1.39 ENST00000334529.10
BTLA
B and T lymphocyte associated
chr11_-_73142308 1.38 ENST00000409418.9
FCHSD2
FCH and double SH3 domains 2
chr2_-_24972032 1.34 ENST00000534855.5
DNAJC27
DnaJ heat shock protein family (Hsp40) member C27
chr14_-_23301474 1.32 ENST00000561437.1
ENST00000559942.5
ENST00000560913.1
ENST00000559314.5
ENST00000558058.5
PPP1R3E
protein phosphatase 1 regulatory subunit 3E
chr16_+_2969548 1.29 ENST00000572687.1
PAQR4
progestin and adipoQ receptor family member 4
chr12_-_9999176 1.29 ENST00000298527.10
ENST00000348658.4
CLEC1B
C-type lectin domain family 1 member B
chr13_+_102656933 1.28 ENST00000650757.1
TPP2
tripeptidyl peptidase 2
chr7_-_101321723 1.27 ENST00000498704.6
ENST00000517481.5
ENST00000437644.2
ENST00000315322.10
ENST00000621899.4
IFT22
intraflagellar transport 22
chrX_+_48802156 1.26 ENST00000643374.1
ENST00000644068.1
ENST00000441703.6
ENST00000643934.1
ENST00000489352.5
HDAC6
histone deacetylase 6
chr1_-_216805367 1.24 ENST00000360012.7
ESRRG
estrogen related receptor gamma
chr19_-_50909328 1.23 ENST00000431178.2
KLK4
kallikrein related peptidase 4
chr14_+_20688756 1.22 ENST00000397990.5
ENST00000555597.1
ANG
RNASE4
angiogenin
ribonuclease A family member 4
chr18_-_55586092 1.21 ENST00000563888.6
ENST00000540999.5
ENST00000627685.2
TCF4
transcription factor 4
chr11_+_66278160 1.20 ENST00000311445.7
ENST00000528852.5
CNIH2
cornichon family AMPA receptor auxiliary protein 2
chr3_+_169911566 1.20 ENST00000428432.6
ENST00000335556.7
SAMD7
sterile alpha motif domain containing 7
chr3_+_121894379 1.19 ENST00000489711.6
SLC15A2
solute carrier family 15 member 2
chr2_-_24971900 1.18 ENST00000264711.7
DNAJC27
DnaJ heat shock protein family (Hsp40) member C27
chr1_-_217076889 1.17 ENST00000493748.5
ENST00000463665.5
ESRRG
estrogen related receptor gamma
chr11_-_8594140 1.16 ENST00000534493.5
ENST00000422559.6
STK33
serine/threonine kinase 33
chr10_-_5977492 1.16 ENST00000530685.5
ENST00000397255.7
ENST00000379971.5
ENST00000528354.5
ENST00000397250.6
ENST00000429135.2
IL15RA
interleukin 15 receptor subunit alpha
chr3_+_179653032 1.14 ENST00000680587.1
ENST00000681064.1
ENST00000263966.8
ENST00000681358.1
ENST00000679749.1
USP13
ubiquitin specific peptidase 13
chr19_+_17226662 1.10 ENST00000598068.5
OCEL1
occludin/ELL domain containing 1
chr1_-_204494752 1.10 ENST00000684373.1
PIK3C2B
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
chr11_+_119107335 1.10 ENST00000648610.2
ENST00000336702.7
C2CD2L
C2CD2 like
chr1_+_164559173 1.08 ENST00000420696.7
PBX1
PBX homeobox 1
chr4_+_48483324 1.05 ENST00000273861.5
SLC10A4
solute carrier family 10 member 4
chr9_+_112486819 1.05 ENST00000337530.11
KIAA1958
KIAA1958
chr19_+_16888991 1.03 ENST00000248076.4
F2RL3
F2R like thrombin or trypsin receptor 3
chr3_+_51943244 1.01 ENST00000498510.2
PARP3
poly(ADP-ribose) polymerase family member 3
chr1_+_211259932 1.01 ENST00000367005.8
RCOR3
REST corepressor 3
chr4_+_17577487 1.01 ENST00000606142.5
LAP3
leucine aminopeptidase 3
chr12_+_56080126 1.01 ENST00000411731.6
ERBB3
erb-b2 receptor tyrosine kinase 3
chr9_-_122213874 1.00 ENST00000482062.1
LHX6
LIM homeobox 6
chr12_-_22544409 0.98 ENST00000536386.5
ENST00000396028.6
ENST00000545552.5
ENST00000446597.6
ENST00000333957.8
C2CD5
C2 calcium dependent domain containing 5
chr21_-_42395943 0.97 ENST00000398405.5
TMPRSS3
transmembrane serine protease 3
chr12_-_14929116 0.95 ENST00000540097.1
ERP27
endoplasmic reticulum protein 27
chr12_+_56080155 0.93 ENST00000267101.8
ERBB3
erb-b2 receptor tyrosine kinase 3
chr9_-_122213903 0.93 ENST00000464484.3
LHX6
LIM homeobox 6
chr3_+_132597260 0.92 ENST00000249887.3
ACKR4
atypical chemokine receptor 4
chr16_-_66696680 0.92 ENST00000330687.8
ENST00000563952.1
ENST00000394106.7
CMTM4
CKLF like MARVEL transmembrane domain containing 4
chr6_-_31730198 0.91 ENST00000375787.6
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr10_-_27240505 0.91 ENST00000375888.5
ENST00000676732.1
ACBD5
acyl-CoA binding domain containing 5
chr5_+_141430565 0.91 ENST00000613314.1
PCDHGA12
protocadherin gamma subfamily A, 12
chr2_-_157874976 0.91 ENST00000682025.1
ENST00000683487.1
ENST00000682300.1
ENST00000683441.1
ENST00000684595.1
ENST00000683426.1
ENST00000683820.1
ENST00000263640.7
ACVR1
activin A receptor type 1
chr22_+_31753867 0.90 ENST00000535622.6
ENST00000645693.1
ENST00000642974.1
ENST00000645711.1
ENST00000644331.1
ENST00000645560.1
ENST00000437411.6
ENST00000433147.2
ENST00000646755.1
ENST00000382112.8
ENST00000647438.1
ENST00000400248.7
ENST00000456178.6
ENST00000646969.1
ENST00000642696.1
ENST00000647343.1
ENST00000400242.8
ENST00000651528.2
ENST00000645015.1
ENST00000645564.1
ENST00000646465.1
ENST00000400249.7
DEPDC5
DEP domain containing 5, GATOR1 subcomplex subunit
chr6_-_31729478 0.86 ENST00000436437.2
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr17_+_18476737 0.86 ENST00000581545.5
ENST00000582333.5
ENST00000328114.11
ENST00000583322.5
ENST00000584941.5
LGALS9C
galectin 9C
chr17_-_42745025 0.85 ENST00000592492.5
ENST00000585893.5
ENST00000593214.5
ENST00000590078.5
ENST00000428826.7
ENST00000586382.5
ENST00000415827.6
ENST00000592743.5
ENST00000586089.5
EZH1
enhancer of zeste 1 polycomb repressive complex 2 subunit
chr6_-_31729785 0.84 ENST00000416410.6
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr6_+_28141830 0.84 ENST00000330236.7
ZKSCAN8
zinc finger with KRAB and SCAN domains 8
chr6_-_116060859 0.84 ENST00000606080.2
FRK
fyn related Src family tyrosine kinase
chr11_+_57741451 0.82 ENST00000534355.6
SELENOH
selenoprotein H
chr20_-_57265738 0.81 ENST00000433911.1
BMP7
bone morphogenetic protein 7
chr12_-_122227491 0.79 ENST00000475784.1
ENST00000645606.1
ENSG00000284934.2
novel protein
chr5_+_73626158 0.78 ENST00000296794.10
ENST00000545377.5
ENST00000509848.5
ENST00000513042.7
ARHGEF28
Rho guanine nucleotide exchange factor 28
chr17_-_39688016 0.78 ENST00000579146.5
ENST00000300658.9
ENST00000378011.8
ENST00000429199.6
PGAP3
post-GPI attachment to proteins phospholipase 3
chr8_-_142669947 0.77 ENST00000612905.2
ENST00000615982.4
ENST00000503272.1
ENST00000571961.7
JRK
Jrk helix-turn-helix protein
chr5_+_56815534 0.77 ENST00000399503.4
MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr20_+_54475647 0.76 ENST00000395939.5
DOK5
docking protein 5
chr15_+_99105071 0.76 ENST00000328642.11
ENST00000594047.2
ENST00000336292.11
SYNM
synemin
chr20_+_2295994 0.76 ENST00000381458.6
TGM3
transglutaminase 3
chr14_-_87993159 0.75 ENST00000393568.8
ENST00000261304.7
GALC
galactosylceramidase
chr9_+_113349514 0.75 ENST00000374183.5
BSPRY
B-box and SPRY domain containing
chr14_-_67600132 0.75 ENST00000558493.1
ENST00000561272.5
PIGH
phosphatidylinositol glycan anchor biosynthesis class H
chr10_-_27240850 0.75 ENST00000426079.5
ENST00000677248.1
ENST00000375897.7
ACBD5
acyl-CoA binding domain containing 5
chr20_+_15196834 0.74 ENST00000402914.5
MACROD2
mono-ADP ribosylhydrolase 2
chr20_+_54475584 0.74 ENST00000262593.10
DOK5
docking protein 5
chr2_-_24793382 0.72 ENST00000328379.6
PTRHD1
peptidyl-tRNA hydrolase domain containing 1
chr2_-_85328262 0.72 ENST00000282120.6
TGOLN2
trans-golgi network protein 2
chr16_+_5071806 0.70 ENST00000684335.1
ENST00000684190.1
ENST00000586840.1
ENST00000262374.10
ALG1
ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase
chrX_-_72306962 0.69 ENST00000246139.9
CITED1
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
chr3_-_112499358 0.69 ENST00000383680.4
BTLA
B and T lymphocyte associated
chr20_-_2841109 0.69 ENST00000356872.7
ENST00000439542.1
PCED1A
PC-esterase domain containing 1A
chr14_+_50312311 0.69 ENST00000426751.7
ENST00000311459.12
ENST00000672419.1
ENST00000672910.1
ENST00000557421.7
ENST00000245448.11
ENST00000554204.7
DMAC2L
distal membrane arm assembly complex 2 like
chr5_+_126423176 0.68 ENST00000542322.5
ENST00000544396.5
GRAMD2B
GRAM domain containing 2B
chr15_-_43266857 0.68 ENST00000349114.8
ENST00000220420.10
TGM5
transglutaminase 5
chr5_+_170353480 0.68 ENST00000377360.8
KCNIP1
potassium voltage-gated channel interacting protein 1
chr15_-_37101205 0.68 ENST00000338564.9
ENST00000558313.5
ENST00000340545.9
MEIS2
Meis homeobox 2
chr1_+_160127672 0.67 ENST00000447527.1
ATP1A2
ATPase Na+/K+ transporting subunit alpha 2
chr20_+_21126074 0.66 ENST00000619189.5
KIZ
kizuna centrosomal protein
chr12_+_55681647 0.66 ENST00000614691.1
METTL7B
methyltransferase like 7B
chr3_-_39192584 0.65 ENST00000340369.4
ENST00000421646.1
ENST00000396251.1
XIRP1
xin actin binding repeat containing 1
chr19_+_54105923 0.65 ENST00000420296.1
NDUFA3
NADH:ubiquinone oxidoreductase subunit A3
chr10_+_96129707 0.64 ENST00000316045.9
ZNF518A
zinc finger protein 518A
chr12_+_55681711 0.63 ENST00000394252.4
METTL7B
methyltransferase like 7B
chr18_+_75210755 0.63 ENST00000322038.5
TSHZ1
teashirt zinc finger homeobox 1
chr1_-_202889099 0.63 ENST00000367262.4
RABIF
RAB interacting factor
chr15_+_90352239 0.62 ENST00000354377.8
ENST00000379090.9
ZNF774
zinc finger protein 774
chr18_+_26226417 0.62 ENST00000269142.10
TAF4B
TATA-box binding protein associated factor 4b
chr21_-_5163695 0.62 ENST00000623998.1
ENSG00000280433.1
novel protein, similar to trafficking protein particle complex 10 TRAPPC10
chr3_-_51974001 0.61 ENST00000489595.6
ENST00000461108.5
ENST00000395008.6
ENST00000361143.10
ENST00000525795.1
ENST00000488257.2
PCBP4
ABHD14B
ENSG00000272762.5
poly(rC) binding protein 4
abhydrolase domain containing 14B
novel transcript
chr2_+_119223815 0.61 ENST00000393106.6
ENST00000393110.7
ENST00000409811.5
ENST00000393107.2
STEAP3
STEAP3 metalloreductase
chr1_+_158289916 0.60 ENST00000368170.8
CD1C
CD1c molecule
chr11_+_34621109 0.60 ENST00000450654.6
EHF
ETS homologous factor
chr10_+_129467178 0.60 ENST00000306010.8
ENST00000651593.1
MGMT
O-6-methylguanine-DNA methyltransferase
chrX_+_48801949 0.60 ENST00000376610.6
ENST00000462730.5
ENST00000376619.6
ENST00000465269.5
ENST00000334136.11
ENST00000476625.5
ENST00000646703.1
HDAC6
histone deacetylase 6
chr17_+_39688079 0.60 ENST00000578199.5
ERBB2
erb-b2 receptor tyrosine kinase 2
chrX_+_22136552 0.59 ENST00000682888.1
ENST00000684356.1
PHEX
phosphate regulating endopeptidase homolog X-linked
chr2_+_86441341 0.58 ENST00000312912.10
ENST00000409064.5
KDM3A
lysine demethylase 3A
chr1_+_35268663 0.58 ENST00000314607.11
ZMYM4
zinc finger MYM-type containing 4
chrX_+_103628692 0.57 ENST00000372626.7
TCEAL1
transcription elongation factor A like 1
chr3_+_52420955 0.57 ENST00000465863.1
PHF7
PHD finger protein 7
chr11_+_63938971 0.56 ENST00000539656.5
ENST00000377793.9
NAA40
N-alpha-acetyltransferase 40, NatD catalytic subunit
chr12_-_122227449 0.56 ENST00000650715.1
DIABLO
diablo IAP-binding mitochondrial protein
chr20_-_2840623 0.56 ENST00000360652.7
ENST00000448755.5
PCED1A
PC-esterase domain containing 1A
chr10_-_48251757 0.55 ENST00000305531.3
FRMPD2
FERM and PDZ domain containing 2
chr10_-_27240743 0.55 ENST00000677901.1
ENST00000677960.1
ENST00000677440.1
ENST00000396271.8
ENST00000677141.1
ENST00000677311.1
ENST00000677667.1
ENST00000677200.1
ENST00000676997.1
ENST00000676511.1
ACBD5
acyl-CoA binding domain containing 5
chr11_-_77820706 0.54 ENST00000440064.2
ENST00000528095.5
ENST00000308488.11
RSF1
remodeling and spacing factor 1
chr10_-_125816596 0.54 ENST00000368786.5
UROS
uroporphyrinogen III synthase
chr11_+_77821125 0.54 ENST00000526415.5
ENST00000393427.6
ENST00000527134.5
ENST00000304716.12
ENST00000630098.2
AAMDC
adipogenesis associated Mth938 domain containing
chr10_+_100535927 0.54 ENST00000299163.7
HIF1AN
hypoxia inducible factor 1 subunit alpha inhibitor
chr6_-_47042306 0.54 ENST00000371253.7
ADGRF1
adhesion G protein-coupled receptor F1
chr11_-_120138104 0.54 ENST00000341846.10
TRIM29
tripartite motif containing 29
chr7_-_128775793 0.52 ENST00000249389.3
OPN1SW
opsin 1, short wave sensitive
chr19_-_6459735 0.51 ENST00000334510.9
ENST00000301454.9
SLC25A23
solute carrier family 25 member 23
chr11_+_77821105 0.50 ENST00000532481.5
AAMDC
adipogenesis associated Mth938 domain containing
chr5_+_34929524 0.50 ENST00000648817.1
DNAJC21
DnaJ heat shock protein family (Hsp40) member C21
chr19_-_44304968 0.50 ENST00000591609.1
ENST00000589799.5
ENST00000291182.9
ENST00000650576.1
ENST00000589248.5
ZNF235
zinc finger protein 235
chr11_-_102530738 0.50 ENST00000260227.5
MMP7
matrix metallopeptidase 7
chr2_+_96266211 0.50 ENST00000488633.2
CIAO1
cytosolic iron-sulfur assembly component 1
chr19_+_840991 0.50 ENST00000234347.10
PRTN3
proteinase 3
chr12_+_123973197 0.49 ENST00000392404.7
ENST00000337815.9
ENST00000538932.6
ENST00000618862.2
ENST00000389727.8
ZNF664
ENSG00000274874.2
RFLNA
zinc finger protein 664
novel protein
refilin A
chr3_+_184186023 0.49 ENST00000429586.6
ENST00000292808.5
ABCF3
ATP binding cassette subfamily F member 3
chr11_+_77821187 0.49 ENST00000525409.5
AAMDC
adipogenesis associated Mth938 domain containing
chr2_-_79159747 0.48 ENST00000409839.7
ENST00000305165.3
ENST00000393878.5
ENST00000490901.2
REG3A
regenerating family member 3 alpha
chr11_+_26188836 0.48 ENST00000672621.1
ANO3
anoctamin 3
chr11_+_61203512 0.48 ENST00000325558.11
PGA3
pepsinogen A3
chr19_+_40807112 0.47 ENST00000595621.1
ENST00000595051.1
EGLN2
egl-9 family hypoxia inducible factor 2
chr2_+_231707650 0.47 ENST00000409321.5
PTMA
prothymosin alpha
chr20_-_62926469 0.47 ENST00000354665.8
ENST00000370368.5
ENST00000395340.5
ENST00000395343.6
DIDO1
death inducer-obliterator 1
chr4_+_88007624 0.46 ENST00000237596.7
PKD2
polycystin 2, transient receptor potential cation channel
chr19_-_10333512 0.46 ENST00000617231.5
ENST00000611074.4
ENST00000615032.4
RAVER1
ribonucleoprotein, PTB binding 1
chr15_-_52652031 0.46 ENST00000546305.6
FAM214A
family with sequence similarity 214 member A
chr6_+_29306626 0.46 ENST00000377160.4
OR14J1
olfactory receptor family 14 subfamily J member 1
chr11_-_128867268 0.46 ENST00000392665.6
ENST00000392666.6
KCNJ1
potassium inwardly rectifying channel subfamily J member 1
chr1_+_205257180 0.46 ENST00000330675.12
TMCC2
transmembrane and coiled-coil domain family 2
chr22_-_17773976 0.46 ENST00000317361.11
BID
BH3 interacting domain death agonist
chr7_+_73692596 0.45 ENST00000453316.1
BUD23
BUD23 rRNA methyltransferase and ribosome maturation factor
chr1_+_107141022 0.45 ENST00000370067.5
ENST00000370068.6
NTNG1
netrin G1
chr9_+_112486954 0.45 ENST00000536272.5
KIAA1958
KIAA1958
chr13_-_40666600 0.44 ENST00000379561.6
FOXO1
forkhead box O1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.7 GO:0051040 regulation of calcium-independent cell-cell adhesion(GO:0051040)
2.4 7.2 GO:0035691 macrophage migration inhibitory factor signaling pathway(GO:0035691)
2.4 9.5 GO:0002399 MHC class II protein complex assembly(GO:0002399)
1.1 4.5 GO:0015670 carbon dioxide transport(GO:0015670)
0.9 7.4 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.7 2.2 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.6 2.6 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.6 1.9 GO:0070846 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.5 2.5 GO:0045204 MAPK export from nucleus(GO:0045204)
0.4 3.1 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.4 3.7 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.4 1.2 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.3 0.9 GO:0061445 endocardial cell fate commitment(GO:0060957) endocardial cushion cell fate commitment(GO:0061445)
0.3 3.8 GO:0070327 thyroid hormone transport(GO:0070327)
0.3 1.1 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.3 0.8 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.3 5.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.3 1.0 GO:1990166 protein localization to site of double-strand break(GO:1990166)
0.3 0.8 GO:0031443 fast-twitch skeletal muscle fiber contraction(GO:0031443)
0.3 0.8 GO:0006683 galactosylceramide catabolic process(GO:0006683)
0.2 2.2 GO:0030242 pexophagy(GO:0030242)
0.2 4.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 0.7 GO:1900920 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.2 8.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 0.8 GO:1905069 nephrogenic mesenchyme morphogenesis(GO:0072134) allantois development(GO:1905069)
0.2 3.8 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.2 0.6 GO:0046292 formaldehyde metabolic process(GO:0046292)
0.2 2.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.2 1.2 GO:0032431 diacylglycerol biosynthetic process(GO:0006651) activation of phospholipase A2 activity(GO:0032431)
0.2 0.5 GO:0097274 urea homeostasis(GO:0097274)
0.2 1.5 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.2 0.5 GO:0061182 negative regulation of chondrocyte development(GO:0061182)
0.2 0.5 GO:0070476 RNA (guanine-N7)-methylation(GO:0036265) rRNA (guanine-N7)-methylation(GO:0070476)
0.2 3.3 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.1 0.6 GO:1904383 response to sodium phosphate(GO:1904383)
0.1 1.9 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.5 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.1 0.4 GO:0033037 polysaccharide localization(GO:0033037)
0.1 1.5 GO:0006824 cobalt ion transport(GO:0006824)
0.1 3.0 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 1.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 1.2 GO:0006857 oligopeptide transport(GO:0006857)
0.1 2.6 GO:0000052 citrulline metabolic process(GO:0000052)
0.1 6.8 GO:0010107 potassium ion import(GO:0010107)
0.1 0.7 GO:0071105 response to interleukin-11(GO:0071105)
0.1 0.4 GO:1902617 response to fluoride(GO:1902617)
0.1 0.5 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.1 0.4 GO:0016259 selenocysteine metabolic process(GO:0016259)
0.1 0.4 GO:0009405 pathogenesis(GO:0009405)
0.1 0.6 GO:0060023 soft palate development(GO:0060023)
0.1 0.3 GO:0071529 cementum mineralization(GO:0071529)
0.1 1.6 GO:0038203 TORC2 signaling(GO:0038203)
0.1 0.7 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 0.6 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1 0.5 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.1 0.2 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.1 3.1 GO:0010842 retina layer formation(GO:0010842)
0.1 0.5 GO:0016584 nucleosome positioning(GO:0016584)
0.1 1.8 GO:0097186 amelogenesis(GO:0097186)
0.1 0.6 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.1 2.5 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.1 0.3 GO:0048073 regulation of eye pigmentation(GO:0048073)
0.1 0.2 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.1 5.2 GO:0016266 O-glycan processing(GO:0016266)
0.1 0.8 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.1 1.0 GO:0060155 platelet dense granule organization(GO:0060155)
0.1 1.4 GO:0015669 gas transport(GO:0015669) oxygen transport(GO:0015671)
0.1 1.7 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.6 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 1.9 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.5 GO:0061591 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.1 0.3 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.1 0.3 GO:0015853 adenine transport(GO:0015853)
0.1 0.2 GO:0048867 stem cell fate determination(GO:0048867)
0.1 0.6 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 0.2 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.1 0.2 GO:1902463 protein localization to cell leading edge(GO:1902463)
0.0 0.2 GO:0051257 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.0 0.9 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 1.5 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.6 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 1.1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.1 GO:0071469 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469)
0.0 0.6 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0 1.0 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.2 GO:0031438 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.8 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 8.8 GO:0044782 cilium organization(GO:0044782)
0.0 5.1 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 1.4 GO:0018149 peptide cross-linking(GO:0018149)
0.0 1.3 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.0 1.3 GO:0030220 platelet formation(GO:0030220) platelet morphogenesis(GO:0036344)
0.0 0.3 GO:0016139 glycoside catabolic process(GO:0016139)
0.0 1.1 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.0 0.5 GO:0010918 positive regulation of mitochondrial membrane potential(GO:0010918)
0.0 0.2 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
0.0 0.3 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.5 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.6 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.7 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.0 0.7 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 1.1 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.5 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 1.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 1.7 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 2.9 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.8 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 1.4 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.4 GO:0044849 estrous cycle(GO:0044849)
0.0 0.1 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.0 0.3 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.3 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.2 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.0 0.6 GO:0032098 regulation of appetite(GO:0032098)
0.0 0.1 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 0.2 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 2.2 GO:0070268 cornification(GO:0070268)
0.0 2.2 GO:0031295 T cell costimulation(GO:0031295)
0.0 0.6 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.8 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.3 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.3 GO:0016246 RNA interference(GO:0016246)
0.0 2.6 GO:0018210 peptidyl-threonine phosphorylation(GO:0018107) peptidyl-threonine modification(GO:0018210)
0.0 0.4 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.2 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.1 GO:0045076 regulation of interleukin-2 biosynthetic process(GO:0045076)
0.0 0.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.8 GO:0000186 activation of MAPKK activity(GO:0000186)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 18.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.5 5.2 GO:0036157 outer dynein arm(GO:0036157)
0.4 3.0 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.4 3.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.3 1.1 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.3 3.8 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 0.8 GO:0071817 MMXD complex(GO:0071817)
0.2 1.2 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.2 0.9 GO:0048179 activin receptor complex(GO:0048179)
0.1 3.0 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 0.4 GO:0008623 CHRAC(GO:0008623)
0.1 2.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.8 GO:0044305 calyx of Held(GO:0044305)
0.1 1.4 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.3 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.1 0.8 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 0.5 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.1 0.2 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 1.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 9.5 GO:0036064 ciliary basal body(GO:0036064)
0.1 0.5 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 0.8 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 2.2 GO:0030057 desmosome(GO:0030057)
0.1 1.6 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.3 GO:0043291 RAVE complex(GO:0043291)
0.1 0.7 GO:0031010 ISWI-type complex(GO:0031010)
0.1 3.8 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 3.1 GO:0009925 basal plasma membrane(GO:0009925)
0.1 4.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 7.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.2 GO:0005715 late recombination nodule(GO:0005715)
0.0 0.5 GO:0061689 tricellular tight junction(GO:0061689)
0.0 1.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.6 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 0.4 GO:0061574 ASAP complex(GO:0061574)
0.0 7.4 GO:0034705 potassium channel complex(GO:0034705)
0.0 0.3 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 3.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0 0.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 1.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.2 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 2.2 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0 1.0 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.6 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.6 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)
0.0 3.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.1 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 2.1 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 0.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.6 GO:0031941 filamentous actin(GO:0031941)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.4 GO:0035580 specific granule lumen(GO:0035580)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.2 GO:0042289 MHC class II protein binding(GO:0042289)
1.0 3.0 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.9 3.8 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.6 3.8 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.6 1.7 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.5 3.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.5 9.8 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.4 4.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.4 5.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.4 1.9 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.3 2.6 GO:0016403 dimethylargininase activity(GO:0016403)
0.3 9.2 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.3 3.3 GO:1990459 transferrin receptor binding(GO:1990459)
0.3 5.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 2.4 GO:0050682 AF-2 domain binding(GO:0050682)
0.3 1.3 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.3 0.8 GO:0004336 galactosylceramidase activity(GO:0004336)
0.3 4.5 GO:0015250 water channel activity(GO:0015250)
0.2 2.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 2.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.2 1.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 1.2 GO:0004522 ribonuclease A activity(GO:0004522)
0.2 4.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 1.4 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.2 1.2 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.2 7.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.2 1.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.2 1.9 GO:0038132 neuregulin binding(GO:0038132)
0.1 3.0 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 1.3 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.6 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.1 0.5 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.1 0.9 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 1.0 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.1 2.1 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 3.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.5 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.1 0.8 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 1.0 GO:0019826 oxygen sensor activity(GO:0019826)
0.1 3.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.1 GO:0001727 lipid kinase activity(GO:0001727) 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 1.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.7 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 1.4 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.6 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 0.4 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.1 0.3 GO:0015207 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.1 0.8 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 0.2 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.1 0.2 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.1 0.5 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.1 0.6 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 0.8 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.6 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.1 2.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.4 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 0.6 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 0.4 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.1 0.8 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.2 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.1 3.0 GO:0030332 cyclin binding(GO:0030332)
0.1 0.6 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.1 1.2 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.3 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.1 0.2 GO:0031780 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 0.7 GO:1990239 steroid hormone binding(GO:1990239)
0.1 0.5 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.9 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 2.9 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 2.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.3 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.7 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.2 GO:0097677 STAT family protein binding(GO:0097677)
0.0 0.1 GO:0097604 temperature-gated cation channel activity(GO:0097604)
0.0 0.7 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.6 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.8 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.5 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.0 0.4 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.2 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.9 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.3 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 1.5 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.6 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.2 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.9 GO:0019956 chemokine binding(GO:0019956)
0.0 0.7 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 1.6 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.5 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.5 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0032407 MutSalpha complex binding(GO:0032407)
0.0 0.5 GO:0031005 filamin binding(GO:0031005)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.5 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.5 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 7.3 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.2 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.5 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 3.9 GO:0008168 methyltransferase activity(GO:0008168)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 PID ALK2 PATHWAY ALK2 signaling events
0.1 4.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 3.0 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 5.6 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.0 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 3.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.7 PID BMP PATHWAY BMP receptor signaling
0.0 0.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 2.5 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 6.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 3.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.9 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 1.1 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 2.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 9.5 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3 10.9 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.3 4.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 3.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 3.0 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 5.4 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.4 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 7.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 4.1 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 2.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 2.0 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 2.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 3.3 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 2.9 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 6.3 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.6 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.5 REACTOME OPSINS Genes involved in Opsins
0.0 1.0 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 1.0 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.1 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.1 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.8 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.6 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.3 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 0.8 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 1.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.6 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.6 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.9 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.7 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.4 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis