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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NKX6-3

Z-value: 0.24

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Transcription factors associated with NKX6-3

Gene Symbol Gene ID Gene Info
NKX6-3
ENSG00000165066.13 NKX6-3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX6-3hg38_v1_chr8_-_41650808_41650822-0.271.5e-01Click!

Activity profile of NKX6-3 motif

Sorted Z-values of NKX6-3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr9_+_122371036 0.78 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
PTGS1
prostaglandin-endoperoxide synthase 1
chr9_+_122371014 0.59 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr5_-_140346596 0.58 ENST00000230990.7
HBEGF
heparin binding EGF like growth factor
chr6_+_130018565 0.47 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr9_+_122370523 0.47 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chrX_+_43656289 0.43 ENST00000338702.4
MAOA
monoamine oxidase A
chr3_-_142029108 0.35 ENST00000497579.5
TFDP2
transcription factor Dp-2
chr9_+_121567057 0.31 ENST00000394340.7
ENST00000436835.5
ENST00000259371.6
DAB2IP
DAB2 interacting protein
chr16_-_67483541 0.22 ENST00000290953.3
AGRP
agouti related neuropeptide
chr3_-_132684685 0.21 ENST00000512094.5
ENST00000632629.1
NPHP3
NPHP3-ACAD11
nephrocystin 3
NPHP3-ACAD11 readthrough (NMD candidate)
chrX_+_108045050 0.20 ENST00000458383.1
ENST00000217957.10
VSIG1
V-set and immunoglobulin domain containing 1
chr11_-_13496018 0.20 ENST00000529816.1
PTH
parathyroid hormone
chr6_+_113857333 0.20 ENST00000612661.2
MARCKS
myristoylated alanine rich protein kinase C substrate
chrX_+_108044967 0.19 ENST00000415430.7
VSIG1
V-set and immunoglobulin domain containing 1
chr17_-_66229380 0.15 ENST00000205948.11
APOH
apolipoprotein H
chr11_-_13495984 0.15 ENST00000282091.6
PTH
parathyroid hormone
chr19_+_4402615 0.15 ENST00000301280.10
CHAF1A
chromatin assembly factor 1 subunit A
chr15_+_92900338 0.15 ENST00000625990.3
CHD2
chromodomain helicase DNA binding protein 2
chr20_+_45416551 0.11 ENST00000639292.1
PIGT
phosphatidylinositol glycan anchor biosynthesis class T
chr14_-_50561119 0.10 ENST00000555216.5
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr1_-_113871665 0.08 ENST00000528414.5
ENST00000460620.5
ENST00000359785.10
ENST00000420377.6
ENST00000525799.1
ENST00000538253.5
PTPN22
protein tyrosine phosphatase non-receptor type 22
chr10_+_18260715 0.07 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr3_+_136930469 0.07 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr15_+_92900189 0.07 ENST00000626874.2
ENST00000627622.1
ENST00000629346.2
ENST00000628375.2
ENST00000420239.7
ENST00000394196.9
CHD2
chromodomain helicase DNA binding protein 2
chr17_-_10469558 0.06 ENST00000255381.2
MYH4
myosin heavy chain 4
chr20_-_35147285 0.06 ENST00000374491.3
ENST00000374492.8
EDEM2
ER degradation enhancing alpha-mannosidase like protein 2
chr4_+_75556048 0.05 ENST00000616557.1
ENST00000435974.2
ENST00000311623.9
ODAPH
odontogenesis associated phosphoprotein
chr7_+_130344810 0.04 ENST00000497503.5
ENST00000463587.5
ENST00000461828.5
ENST00000474905.6
ENST00000494311.1
ENST00000466363.6
CPA5
carboxypeptidase A5
chr2_-_99255107 0.04 ENST00000333017.6
ENST00000626374.2
ENST00000409679.5
ENST00000423306.1
LYG2
lysozyme g2
chr3_+_122183664 0.04 ENST00000639785.2
CASR
calcium sensing receptor
chr3_-_165078480 0.03 ENST00000264382.8
SI
sucrase-isomaltase
chr8_+_76681208 0.03 ENST00000651372.2
ZFHX4
zinc finger homeobox 4
chr20_-_31390483 0.03 ENST00000376315.2
DEFB119
defensin beta 119
chr12_-_52367478 0.02 ENST00000257901.7
KRT85
keratin 85
chr15_+_48191648 0.01 ENST00000646012.1
ENST00000561127.5
ENST00000647546.1
ENST00000559641.5
ENST00000417307.3
SLC12A1
CTXN2
solute carrier family 12 member 1
cortexin 2
chr5_-_143400716 0.00 ENST00000424646.6
ENST00000652686.1
NR3C1
nuclear receptor subfamily 3 group C member 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.3 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.1 0.6 GO:0051541 elastin metabolic process(GO:0051541)
0.1 0.3 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.0 0.2 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.4 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.0 0.1 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.1 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.0 0.4 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.2 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.2 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392) negative regulation of fibrinolysis(GO:0051918)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1990032 parallel fiber(GO:1990032)
0.1 0.2 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.2 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 1.8 GO:0001750 photoreceptor outer segment(GO:0001750)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.3 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.4 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.2 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.3 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.6 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling