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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NR1D1

Z-value: 0.38

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Transcription factors associated with NR1D1

Gene Symbol Gene ID Gene Info
NR1D1
ENSG00000126368.6 NR1D1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1D1hg38_v1_chr17_-_40100569_40100597-0.222.3e-01Click!

Activity profile of NR1D1 motif

Sorted Z-values of NR1D1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1D1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_+_20589044 1.81 ENST00000375071.4
CDA
cytidine deaminase
chr1_-_25906457 1.29 ENST00000426559.6
STMN1
stathmin 1
chr11_-_125496122 1.25 ENST00000527534.1
ENST00000278919.8
ENST00000366139.3
FEZ1
fasciculation and elongation protein zeta 1
chr19_-_42423100 0.88 ENST00000597001.1
LIPE
lipase E, hormone sensitive type
chr2_+_126898857 0.85 ENST00000643416.1
TEX51
testis expressed 51
chr1_-_6497096 0.71 ENST00000537245.6
PLEKHG5
pleckstrin homology and RhoGEF domain containing G5
chr9_-_33167296 0.69 ENST00000379731.5
ENST00000535206.5
B4GALT1
beta-1,4-galactosyltransferase 1
chr2_+_207711534 0.64 ENST00000392209.7
CCNYL1
cyclin Y like 1
chr1_-_111449209 0.61 ENST00000235090.10
WDR77
WD repeat domain 77
chr14_-_91244669 0.60 ENST00000650645.1
GPR68
G protein-coupled receptor 68
chr14_+_24070837 0.60 ENST00000537691.5
ENST00000397016.6
ENST00000560356.5
ENST00000558450.5
CPNE6
copine 6
chr14_-_94129577 0.57 ENST00000238609.4
IFI27L2
interferon alpha inducible protein 27 like 2
chr1_-_25906411 0.54 ENST00000455785.7
STMN1
stathmin 1
chr2_+_126898908 0.53 ENST00000450035.5
TEX51
testis expressed 51
chr2_+_126898876 0.52 ENST00000568484.6
ENST00000636457.1
TEX51
testis expressed 51
chr4_+_168921555 0.52 ENST00000503290.1
PALLD
palladin, cytoskeletal associated protein
chr5_-_43313473 0.51 ENST00000433297.2
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1
chr5_-_43313403 0.50 ENST00000325110.11
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1
chr3_-_182985926 0.49 ENST00000487822.5
ENST00000460412.6
ENST00000469954.5
DCUN1D1
defective in cullin neddylation 1 domain containing 1
chr1_-_25905989 0.46 ENST00000399728.5
STMN1
stathmin 1
chr22_+_22922594 0.45 ENST00000390331.3
IGLC7
immunoglobulin lambda constant 7
chr2_+_207711631 0.45 ENST00000295414.8
ENST00000420822.1
ENST00000339882.9
CCNYL1
cyclin Y like 1
chr16_+_71358713 0.42 ENST00000349553.9
ENST00000302628.9
ENST00000562305.5
CALB2
calbindin 2
chr19_-_43198079 0.41 ENST00000597374.5
ENST00000599371.1
PSG4
pregnancy specific beta-1-glycoprotein 4
chr22_-_37484505 0.38 ENST00000442496.1
MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr17_-_61863327 0.38 ENST00000584322.2
ENST00000682369.1
ENST00000683039.1
ENST00000683381.1
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr1_-_25906931 0.38 ENST00000357865.6
STMN1
stathmin 1
chr3_-_185821092 0.37 ENST00000421047.3
IGF2BP2
insulin like growth factor 2 mRNA binding protein 2
chrX_+_54920796 0.37 ENST00000442098.5
ENST00000430420.5
ENST00000453081.5
ENST00000319167.12
ENST00000622017.4
ENST00000375022.8
ENST00000399736.5
ENST00000440072.5
ENST00000173898.12
ENST00000431115.5
ENST00000440759.5
ENST00000375041.6
TRO
trophinin
chr1_+_43933277 0.36 ENST00000414809.7
ARTN
artemin
chr1_+_2467437 0.35 ENST00000449969.5
PLCH2
phospholipase C eta 2
chr19_-_14518383 0.35 ENST00000254322.3
ENST00000595139.2
DNAJB1
DnaJ heat shock protein family (Hsp40) member B1
chr6_+_31575557 0.34 ENST00000449264.3
TNF
tumor necrosis factor
chr1_-_11805924 0.34 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase
chr10_-_77140757 0.32 ENST00000637862.2
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr1_-_11805977 0.31 ENST00000376486.3
MTHFR
methylenetetrahydrofolate reductase
chr19_-_43204223 0.29 ENST00000599746.5
PSG4
pregnancy specific beta-1-glycoprotein 4
chr11_+_60924452 0.29 ENST00000453848.7
ENST00000544065.5
ENST00000005286.8
TMEM132A
transmembrane protein 132A
chr3_+_155083523 0.29 ENST00000680057.1
MME
membrane metalloendopeptidase
chr9_-_133376085 0.28 ENST00000485435.6
SURF4
surfeit 4
chr8_+_11704151 0.28 ENST00000526716.5
ENST00000532059.6
ENST00000335135.8
ENST00000622443.3
GATA4
GATA binding protein 4
chr19_-_49361475 0.27 ENST00000598810.5
TEAD2
TEA domain transcription factor 2
chr2_+_90114838 0.26 ENST00000417279.3
IGKV3D-15
immunoglobulin kappa variable 3D-15
chr3_+_172040554 0.26 ENST00000336824.8
ENST00000423424.5
FNDC3B
fibronectin type III domain containing 3B
chr8_+_104223320 0.26 ENST00000339750.3
RIMS2
regulating synaptic membrane exocytosis 2
chr16_+_3654683 0.25 ENST00000246949.10
DNASE1
deoxyribonuclease 1
chr1_-_11805949 0.22 ENST00000376590.9
MTHFR
methylenetetrahydrofolate reductase
chr1_-_11805294 0.22 ENST00000413656.5
ENST00000376592.6
ENST00000376585.6
MTHFR
methylenetetrahydrofolate reductase
chr1_+_161749762 0.22 ENST00000367943.5
DUSP12
dual specificity phosphatase 12
chr10_+_11005301 0.21 ENST00000416382.6
ENST00000631460.1
ENST00000631816.1
CELF2
CUGBP Elav-like family member 2
chr18_+_33578213 0.21 ENST00000681521.1
ENST00000269197.12
ASXL3
ASXL transcriptional regulator 3
chr7_+_45000184 0.20 ENST00000544363.5
ENST00000541586.5
ENST00000258781.11
CCM2
CCM2 scaffold protein
chr22_+_37019735 0.19 ENST00000429360.6
ENST00000341116.7
ENST00000404393.5
MPST
mercaptopyruvate sulfurtransferase
chr17_-_18644418 0.19 ENST00000575220.5
ENST00000405044.6
ENST00000573652.1
TBC1D28
TBC1 domain family member 28
chr22_+_26621952 0.17 ENST00000354760.4
CRYBA4
crystallin beta A4
chr19_+_21142058 0.17 ENST00000598331.1
ZNF431
zinc finger protein 431
chr1_+_168280872 0.17 ENST00000367821.8
TBX19
T-box transcription factor 19
chr19_+_21082140 0.16 ENST00000616183.1
ENST00000596053.5
ZNF714
zinc finger protein 714
chr10_+_88586762 0.15 ENST00000371939.7
LIPJ
lipase family member J
chr3_-_51968387 0.15 ENST00000490063.5
ENST00000468324.5
ENST00000497653.5
ENST00000484633.5
PCBP4
poly(rC) binding protein 4
chr4_+_87608529 0.14 ENST00000651931.1
DSPP
dentin sialophosphoprotein
chr1_-_226186673 0.14 ENST00000366812.6
ACBD3
acyl-CoA binding domain containing 3
chr17_+_41255384 0.14 ENST00000394008.1
KRTAP9-9
keratin associated protein 9-9
chr3_-_52826834 0.14 ENST00000441637.2
ITIH4
inter-alpha-trypsin inhibitor heavy chain 4
chr17_+_82235769 0.13 ENST00000619321.2
SLC16A3
solute carrier family 16 member 3
chr15_-_80989792 0.13 ENST00000261758.6
ENST00000561312.5
MESD
mesoderm development LRP chaperone
chr9_+_35490103 0.13 ENST00000361226.8
RUSC2
RUN and SH3 domain containing 2
chr4_-_21697755 0.13 ENST00000382148.7
KCNIP4
potassium voltage-gated channel interacting protein 4
chr17_-_78132407 0.13 ENST00000322914.7
TMC6
transmembrane channel like 6
chr19_+_21020675 0.13 ENST00000595401.1
ZNF430
zinc finger protein 430
chr17_+_42854078 0.13 ENST00000591562.1
ENST00000588033.1
AOC3
amine oxidase copper containing 3
chr1_+_203795614 0.13 ENST00000367210.3
ENST00000432282.5
ENST00000453771.5
ENST00000367214.5
ENST00000639812.1
ENST00000367212.7
ENST00000332127.8
ENST00000550078.2
ZC3H11A
ZBED6
zinc finger CCCH-type containing 11A
zinc finger BED-type containing 6
chr6_+_167111789 0.12 ENST00000400926.5
CCR6
C-C motif chemokine receptor 6
chr17_+_41237998 0.12 ENST00000254072.7
KRTAP9-8
keratin associated protein 9-8
chr10_+_133453936 0.12 ENST00000640237.1
SCART1
scavenger receptor family member expressed on T cells 1
chr1_+_109712272 0.12 ENST00000369812.6
GSTM5
glutathione S-transferase mu 5
chr14_+_100323332 0.12 ENST00000361529.5
ENST00000557052.1
SLC25A47
solute carrier family 25 member 47
chr12_-_110445540 0.12 ENST00000547365.1
ARPC3
actin related protein 2/3 complex subunit 3
chr1_+_197413827 0.11 ENST00000367397.1
ENST00000681519.1
CRB1
crumbs cell polarity complex component 1
chr15_+_65611336 0.11 ENST00000537259.5
SLC24A1
solute carrier family 24 member 1
chr1_-_12618198 0.11 ENST00000616661.5
DHRS3
dehydrogenase/reductase 3
chr9_+_136327526 0.11 ENST00000440944.6
GPSM1
G protein signaling modulator 1
chr3_-_48685835 0.10 ENST00000439518.5
ENST00000416649.6
ENST00000294129.7
NCKIPSD
NCK interacting protein with SH3 domain
chr9_-_133376111 0.09 ENST00000545297.5
ENST00000613129.4
ENST00000618229.4
SURF4
surfeit 4
chr7_-_129054869 0.09 ENST00000471166.1
TNPO3
transportin 3
chr17_+_45844875 0.08 ENST00000329196.7
SPPL2C
signal peptide peptidase like 2C
chr1_+_109712227 0.08 ENST00000256593.8
GSTM5
glutathione S-transferase mu 5
chr1_-_168543990 0.08 ENST00000367819.3
XCL2
X-C motif chemokine ligand 2
chr17_+_6070361 0.07 ENST00000317744.10
WSCD1
WSC domain containing 1
chr2_+_88885397 0.07 ENST00000390243.2
IGKV4-1
immunoglobulin kappa variable 4-1
chr10_-_102120318 0.07 ENST00000673968.1
LDB1
LIM domain binding 1
chr6_+_75749272 0.07 ENST00000653423.1
MYO6
myosin VI
chr20_+_48921775 0.06 ENST00000681021.1
ENST00000679436.1
ARFGEF2
ADP ribosylation factor guanine nucleotide exchange factor 2
chr7_+_114922561 0.06 ENST00000448022.1
MDFIC
MyoD family inhibitor domain containing
chr5_-_63962438 0.05 ENST00000323865.5
ENST00000506598.1
HTR1A
5-hydroxytryptamine receptor 1A
chr18_-_46757012 0.05 ENST00000315087.12
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr17_-_76532046 0.05 ENST00000590175.5
CYGB
cytoglobin
chr7_+_98106852 0.05 ENST00000297293.6
LMTK2
lemur tyrosine kinase 2
chr19_-_18884219 0.04 ENST00000596048.1
CERS1
ceramide synthase 1
chr7_-_144410227 0.04 ENST00000467773.1
ENST00000483238.5
NOBOX
NOBOX oogenesis homeobox
chr1_+_159826860 0.04 ENST00000289707.10
SLAMF8
SLAM family member 8
chr6_+_75749231 0.04 ENST00000664209.1
ENST00000369975.6
ENST00000627432.3
ENST00000369985.9
ENST00000369977.8
ENST00000664640.1
ENST00000662603.1
MYO6
myosin VI
chr6_+_75749192 0.03 ENST00000369981.7
MYO6
myosin VI
chr10_-_102120246 0.03 ENST00000425280.2
LDB1
LIM domain binding 1
chr12_-_7018465 0.03 ENST00000261407.9
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr6_-_169250825 0.03 ENST00000676869.1
ENST00000676760.1
THBS2
thrombospondin 2
chr11_+_66857056 0.03 ENST00000309602.5
ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr17_-_58280928 0.02 ENST00000225275.4
MPO
myeloperoxidase
chr16_+_77191173 0.02 ENST00000248248.8
ENST00000439557.6
ENST00000545553.1
MON1B
MON1 homolog B, secretory trafficking associated
chr9_-_37592564 0.02 ENST00000544379.1
ENST00000321301.7
ENST00000377773.9
ENST00000401811.3
TOMM5
translocase of outer mitochondrial membrane 5
chr13_+_27270814 0.02 ENST00000241463.5
RASL11A
RAS like family 11 member A
chr20_+_48921701 0.02 ENST00000371917.5
ARFGEF2
ADP ribosylation factor guanine nucleotide exchange factor 2
chr1_-_10947870 0.00 ENST00000468348.1
C1orf127
chromosome 1 open reading frame 127

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0019858 cytosine metabolic process(GO:0019858)
0.2 0.7 GO:0005989 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.2 2.7 GO:1905098 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.2 1.1 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.2 0.3 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.2 0.6 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1 0.9 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.4 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.1 1.3 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.1 0.4 GO:0061146 Peyer's patch morphogenesis(GO:0061146) lymphocyte migration into lymphoid organs(GO:0097021)
0.1 0.3 GO:0003290 atrial septum secundum morphogenesis(GO:0003290)
0.1 0.6 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.1 1.0 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.2 GO:0009440 cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
0.0 0.2 GO:0033133 positive regulation of glucokinase activity(GO:0033133)
0.0 0.3 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.1 GO:1902283 negative regulation of primary amine oxidase activity(GO:1902283)
0.0 0.1 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.1 GO:0035048 splicing factor protein import into nucleus(GO:0035048)
0.0 0.3 GO:0034465 response to carbon monoxide(GO:0034465)
0.0 0.5 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.5 GO:0045116 protein neddylation(GO:0045116)
0.0 0.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.4 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.1 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.0 0.7 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.2 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 1.1 GO:0030317 sperm motility(GO:0030317)
0.0 0.7 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 0.2 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 0.1 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.0 0.1 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 0.3 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.6 GO:0034709 methylosome(GO:0034709)
0.0 1.8 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.1 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.3 0.9 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.2 1.8 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 1.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.2 0.7 GO:0004461 lactose synthase activity(GO:0004461)
0.1 0.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.2 GO:0016784 3-mercaptopyruvate sulfurtransferase activity(GO:0016784)
0.1 0.3 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.0 0.1 GO:0060001 minus-end directed microfilament motor activity(GO:0060001)
0.0 0.6 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.3 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.1 GO:0052595 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.0 0.3 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.1 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.9 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.3 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.1 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.0 0.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 1.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.9 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis