ISMARA results: NR2F2

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for NR2F2

Z-value: 1.01

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Transcription factors associated with NR2F2

Gene Symbol	Gene ID	Gene Info
NR2F2 Ensembl NCBI GeneCards UniProt	ENSG00000185551.15	NR2F2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NR2F2	hg38_v1_chr15_+_96332432_96332565	0.26	1.7e-01	Click!

Activity profile of NR2F2 motif

Sorted Z-values of NR2F2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2F2

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Promoter	Score	Transcript	Gene	Gene Info
chr9_+_27109393 Show fit	1.54	ENST00000406359.8	TEK Ensembl NCBI GeneCards UniProt Show fit	TEK receptor tyrosine kinase
chr2_+_98087160 Show fit	1.31	ENST00000477737.6	VWA3B Ensembl NCBI GeneCards UniProt Show fit	von Willebrand factor A domain containing 3B
chrX_+_30653359 Show fit	1.27	ENST00000378943.7 ENST00000378946.7 ENST00000427190.6	GK Ensembl NCBI GeneCards UniProt Show fit	glycerol kinase
chr20_+_33237712 Show fit	1.20	ENST00000618484.1	BPIFA1 Ensembl NCBI GeneCards UniProt Show fit	BPI fold containing family A member 1
chr20_+_33283205 Show fit	1.13	ENST00000253354.2	BPIFB1 Ensembl NCBI GeneCards UniProt Show fit	BPI fold containing family B member 1
chr11_+_73950985 Show fit	1.08	ENST00000339764.6	DNAJB13 Ensembl NCBI GeneCards UniProt Show fit	DnaJ heat shock protein family (Hsp40) member B13
chr14_-_75069478 Show fit	1.07	ENST00000555463.1	ACYP1 Ensembl NCBI GeneCards UniProt Show fit	acylphosphatase 1
chr7_+_107660819 Show fit	1.05	ENST00000644269.2	SLC26A4 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 26 member 4
chr22_+_22380766 Show fit	1.02	ENST00000390297.3	IGLV1-44 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 1-44
chr15_+_75347727 Show fit	1.00	ENST00000565051.5 ENST00000564257.1 ENST00000567005.1	NEIL1 Ensembl NCBI GeneCards UniProt Show fit	nei like DNA glycosylase 1

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.1	GO:0046167	glycerol-3-phosphate biosynthetic process(GO:0046167)
0.2	1.9	GO:0048014	Tie signaling pathway(GO:0048014)
0.0	1.9	GO:0007340	acrosome reaction(GO:0007340)
0.1	1.8	GO:1901663	ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.2	1.5	GO:0070294	renal sodium ion absorption(GO:0070294)
0.0	1.5	GO:0006953	acute-phase response(GO:0006953)
0.2	1.4	GO:2000980	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.2	1.4	GO:0015705	iodide transport(GO:0015705)
0.1	1.3	GO:0002115	store-operated calcium entry(GO:0002115)
0.3	1.2	GO:1900190	biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)

Showing 1 to 10 of 171 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.0	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	2.4	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	1.9	GO:0009925	basal plasma membrane(GO:0009925)
0.0	1.4	GO:0036126	sperm flagellum(GO:0036126)
0.0	1.3	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.3	1.2	GO:0097196	Shu complex(GO:0097196)
0.0	1.1	GO:0031526	brush border membrane(GO:0031526)
0.3	1.0	GO:0071750	dimeric IgA immunoglobulin complex(GO:0071750) secretory dimeric IgA immunoglobulin complex(GO:0071752)
0.1	0.9	GO:0042721	mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1	0.7	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)

Showing 1 to 10 of 58 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	2.1	GO:0004714	transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0	1.9	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.2	1.8	GO:0048039	ubiquinone binding(GO:0048039)
0.0	1.8	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	1.4	GO:0019104	DNA N-glycosylase activity(GO:0019104)
0.1	1.3	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	1.3	GO:0030145	manganese ion binding(GO:0030145)
0.2	1.1	GO:0003998	acylphosphatase activity(GO:0003998)
0.1	1.1	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)

Showing 1 to 10 of 130 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
2.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
2.4	PID E2F PATHWAY	E2F transcription factor network
2.2	PID SHP2 PATHWAY	SHP2 signaling
1.5	PID FGF PATHWAY	FGF signaling pathway
0.8	PID ATM PATHWAY	ATM pathway
0.8	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.7	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.6	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.4	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.4	PID FOXM1 PATHWAY	FOXM1 transcription factor network

Showing 1 to 10 of 13 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.9	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.1	1.7	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	1.7	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.1	1.3	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation
0.0	0.9	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.9	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.0	0.9	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0	0.8	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	0.8	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	0.8	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling

Showing 1 to 10 of 32 entries

Results for NR2F2

Z-value: 1.01

Motif logo

Transcription factors associated with NR2F2

Activity-expression correlation:

Activity profile of NR2F2 motif

Sorted Z-values of NR2F2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2F2

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: