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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for NR5A2
Z-value: 1.35
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Transcription factors associated with NR5A2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR5A2 | hg38_v1_chr1_+_200027702_200027716 | -0.27 | 1.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR5A2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_59577463 Show fit | 4.47 |
ENST00000359926.7
|
phosphatase and actin regulator 3 |
|
| chr20_+_33237712 Show fit | 3.97 |
ENST00000618484.1
|
BPI fold containing family A member 1 |
|
| chr16_+_67431112 Show fit | 3.59 |
ENST00000326152.6
|
hydroxysteroid 11-beta dehydrogenase 2 |
|
| chr8_-_109691766 Show fit | 3.04 |
ENST00000529190.5
ENST00000422135.5 |
syntabulin |
|
| chr1_-_147225309 Show fit | 2.88 |
ENST00000369272.7
ENST00000254090.9 ENST00000441068.6 |
flavin containing dimethylaniline monoxygenase 5 |
|
| chr20_+_59604527 Show fit | 2.74 |
ENST00000371015.6
|
phosphatase and actin regulator 3 |
|
| chr9_-_127874964 Show fit | 2.45 |
ENST00000373156.5
|
adenylate kinase 1 |
|
| chr10_+_116427839 Show fit | 2.36 |
ENST00000369230.4
|
pancreatic lipase related protein 3 |
|
| chr3_-_122383218 Show fit | 2.14 |
ENST00000479899.5
ENST00000291458.9 ENST00000497726.5 |
mitochondrial matrix import factor 23 |
|
| chr7_-_99971845 Show fit | 2.13 |
ENST00000419575.1
|
alpha-2-glycoprotein 1, zinc-binding |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 8.3 | GO:0002386 | immune response in mucosal-associated lymphoid tissue(GO:0002386) |
| 0.1 | 6.5 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.4 | 6.4 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.0 | 4.5 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.2 | 3.6 | GO:0003084 | positive regulation of systemic arterial blood pressure(GO:0003084) |
| 0.1 | 3.3 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.0 | 3.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.2 | 2.8 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.9 | 2.6 | GO:2000276 | negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276) |
| 0.3 | 2.2 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.6 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 7.0 | GO:0030426 | growth cone(GO:0030426) |
| 0.3 | 4.5 | GO:0097433 | dense body(GO:0097433) |
| 0.1 | 4.1 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 3.9 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.9 | 2.6 | GO:0005753 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259) |
| 0.0 | 2.4 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 2.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 2.0 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.3 | 5.9 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.6 | 4.4 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.1 | 4.0 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 3.9 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.0 | 3.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.2 | 3.6 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 0.1 | 3.5 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 2.4 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.0 | 2.3 | GO:0019003 | GDP binding(GO:0019003) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 2.6 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 2.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.5 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.3 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.2 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 1.1 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 1.1 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 1.1 | PID EPHB FWD PATHWAY | EPHB forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 3.7 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 3.4 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.1 | 2.8 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 2.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 2.3 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 2.3 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 2.1 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 1.9 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 1.8 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |