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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for NRF1
Z-value: 2.94
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Transcription factors associated with NRF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NRF1 | hg38_v1_chr7_+_129611680_129611760 | 0.77 | 5.6e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NRF1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_122159886 Show fit | 14.67 |
ENST00000373764.8
ENST00000536616.5 |
MORN repeat containing 5 |
|
| chr4_-_7042931 Show fit | 14.53 |
ENST00000310085.6
|
coiled-coil domain containing 96 |
|
| chr2_-_99141517 Show fit | 13.16 |
ENST00000355053.8
|
testis specific 10 |
|
| chr17_+_410306 Show fit | 10.31 |
ENST00000360127.7
ENST00000571106.1 ENST00000491373.1 |
chromosome 17 open reading frame 97 |
|
| chr2_-_99141414 Show fit | 9.36 |
ENST00000393482.7
|
testis specific 10 |
|
| chr2_-_99141169 Show fit | 9.12 |
ENST00000674128.1
|
testis specific 10 |
|
| chr20_-_36951701 Show fit | 7.88 |
ENST00000646673.2
|
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 |
|
| chr3_+_49412203 Show fit | 7.88 |
ENST00000273590.3
|
T cell leukemia translocation altered |
|
| chr20_-_36951837 Show fit | 7.50 |
ENST00000262878.5
|
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 |
|
| chr20_-_36951637 Show fit | 7.32 |
ENST00000646066.1
|
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 30.1 | GO:0006203 | dGTP catabolic process(GO:0006203) |
| 0.5 | 28.8 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.0 | 28.1 | GO:0007283 | spermatogenesis(GO:0007283) |
| 1.0 | 20.8 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.3 | 11.6 | GO:0003341 | cilium movement(GO:0003341) |
| 0.1 | 10.6 | GO:0042733 | embryonic digit morphogenesis(GO:0042733) |
| 0.8 | 9.2 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 2.9 | 8.6 | GO:1990922 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.4 | 8.3 | GO:0060294 | cilium movement involved in cell motility(GO:0060294) |
| 0.0 | 8.3 | GO:0043687 | post-translational protein modification(GO:0043687) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 49.7 | GO:0031514 | motile cilium(GO:0031514) |
| 0.3 | 30.9 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.2 | 14.2 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 1.4 | 14.1 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.1 | 13.8 | GO:0005814 | centriole(GO:0005814) |
| 0.3 | 12.2 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.5 | 10.8 | GO:0036038 | MKS complex(GO:0036038) |
| 0.8 | 10.2 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.5 | 9.6 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.1 | 8.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 30.0 | GO:0008832 | dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793) guanyl deoxyribonucleotide binding(GO:0032560) dGTP binding(GO:0032567) |
| 0.0 | 14.6 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 1.1 | 8.7 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
| 0.3 | 8.4 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.6 | 7.8 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 7.5 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.0 | 7.2 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.5 | 6.9 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.1 | 6.1 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.4 | 5.3 | GO:0032453 | histone demethylase activity (H3-K4 specific)(GO:0032453) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.2 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 9.2 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 7.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 6.0 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 6.0 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 5.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 4.1 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 3.1 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 2.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 2.7 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.0 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 8.9 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 8.8 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 7.3 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.2 | 6.0 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.4 | 5.6 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.1 | 5.1 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 4.4 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 4.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 4.0 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |