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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 0.68

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Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Gene Symbol Gene ID Gene Info
OTP
ENSG00000171540.8 OTP
PHOX2B
ENSG00000109132.7 PHOX2B
LHX1
ENSG00000273706.5 LHX1
LMX1A
ENSG00000162761.14 LMX1A
LHX5
ENSG00000089116.4 LHX5
HOXC4
ENSG00000198353.8 HOXC4
HOXC4
ENSG00000198353.8 HOXC4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX5hg38_v1_chr12_-_113471851_1134718760.393.1e-02Click!
PHOX2Bhg38_v1_chr4_-_41748713_417487310.271.5e-01Click!
LMX1Ahg38_v1_chr1_-_165356212_165356241,
hg38_v1_chr1_-_165356703_165356721		0.261.7e-01Click!
HOXC4hg38_v1_chr12_+_54053815_540538750.125.2e-01Click!
OTPhg38_v1_chr5_-_77638713_77638713-0.077.0e-01Click!

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_130018565 3.03 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr9_+_72577939 2.72 ENST00000645773.1
TMC1
transmembrane channel like 1
chr15_+_41286011 1.89 ENST00000661438.1
ENSG00000285920.2
novel protein
chr11_-_122116215 1.89 ENST00000560104.2
BLID
BH3-like motif containing, cell death inducer
chrX_+_43656289 1.85 ENST00000338702.4
MAOA
monoamine oxidase A
chr3_-_142029108 1.70 ENST00000497579.5
TFDP2
transcription factor Dp-2
chr9_+_72577369 1.42 ENST00000651183.1
TMC1
transmembrane channel like 1
chr9_+_122371036 1.37 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
PTGS1
prostaglandin-endoperoxide synthase 1
chr9_+_72577788 1.35 ENST00000645208.2
TMC1
transmembrane channel like 1
chr17_+_59155726 1.18 ENST00000578777.5
ENST00000577457.1
ENST00000582995.5
ENST00000262293.9
ENST00000614081.1
PRR11
proline rich 11
chr11_-_107858777 1.16 ENST00000525815.6
SLC35F2
solute carrier family 35 member F2
chr6_-_32190170 1.12 ENST00000375050.6
PBX2
PBX homeobox 2
chr7_+_134843884 1.03 ENST00000445569.6
CALD1
caldesmon 1
chr11_-_5301946 1.02 ENST00000380224.2
OR51B4
olfactory receptor family 51 subfamily B member 4
chr4_+_168497066 0.97 ENST00000261509.10
PALLD
palladin, cytoskeletal associated protein
chr3_-_165078480 0.95 ENST00000264382.8
SI
sucrase-isomaltase
chr5_-_126595237 0.94 ENST00000637206.1
ENST00000553117.5
ALDH7A1
aldehyde dehydrogenase 7 family member A1
chr6_+_113857333 0.91 ENST00000612661.2
MARCKS
myristoylated alanine rich protein kinase C substrate
chr15_+_21579912 0.87 ENST00000628444.1
LINC02203
long intergenic non-protein coding RNA 2203
chr9_+_122371014 0.86 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr4_+_168497044 0.86 ENST00000505667.6
PALLD
palladin, cytoskeletal associated protein
chr12_+_26011713 0.84 ENST00000542004.5
RASSF8
Ras association domain family member 8
chr9_+_122370523 0.82 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr12_-_10826358 0.80 ENST00000240619.2
TAS2R10
taste 2 receptor member 10
chr2_+_90038848 0.75 ENST00000390270.2
IGKV3D-20
immunoglobulin kappa variable 3D-20
chr12_+_26195313 0.70 ENST00000422622.3
SSPN
sarcospan
chr15_+_22015233 0.70 ENST00000639059.1
ENST00000640156.1
ENSG00000285472.1
ENSG00000284500.3
novel protein
novel transcript
chr4_-_39032343 0.69 ENST00000381938.4
TMEM156
transmembrane protein 156
chr14_+_30577752 0.66 ENST00000547532.5
ENST00000555429.1
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chrX_-_18672101 0.66 ENST00000379984.4
RS1
retinoschisin 1
chr7_-_87713287 0.65 ENST00000416177.1
ENST00000265724.8
ENST00000543898.5
ABCB1
ATP binding cassette subfamily B member 1
chr12_+_26195647 0.65 ENST00000535504.1
SSPN
sarcospan
chr14_-_67412112 0.64 ENST00000216446.9
PLEK2
pleckstrin 2
chr12_+_26195543 0.60 ENST00000242729.7
SSPN
sarcospan
chr5_+_151020438 0.59 ENST00000622181.4
ENST00000614343.4
ENST00000388825.9
ENST00000521650.5
ENST00000517973.1
GPX3
glutathione peroxidase 3
chr17_-_9791586 0.59 ENST00000571134.2
DHRS7C
dehydrogenase/reductase 7C
chr10_-_32935511 0.57 ENST00000423113.5
ITGB1
integrin subunit beta 1
chr14_+_103385450 0.57 ENST00000416682.6
MARK3
microtubule affinity regulating kinase 3
chr7_-_111392915 0.54 ENST00000450877.5
IMMP2L
inner mitochondrial membrane peptidase subunit 2
chr7_+_107583919 0.54 ENST00000491150.5
BCAP29
B cell receptor associated protein 29
chr1_-_113871665 0.53 ENST00000528414.5
ENST00000460620.5
ENST00000359785.10
ENST00000420377.6
ENST00000525799.1
ENST00000538253.5
PTPN22
protein tyrosine phosphatase non-receptor type 22
chr10_-_104085847 0.52 ENST00000648076.2
COL17A1
collagen type XVII alpha 1 chain
chrX_-_101617921 0.52 ENST00000361910.9
ENST00000538627.5
ENST00000539247.5
ARMCX6
armadillo repeat containing X-linked 6
chr4_+_182448995 0.51 ENST00000510504.1
TENM3
teneurin transmembrane protein 3
chr14_+_34993240 0.50 ENST00000677647.1
SRP54
signal recognition particle 54
chr2_+_90172802 0.50 ENST00000390277.3
IGKV3D-11
immunoglobulin kappa variable 3D-11
chr2_-_89027700 0.48 ENST00000483158.1
IGKV3-11
immunoglobulin kappa variable 3-11
chr2_+_102337148 0.48 ENST00000311734.6
ENST00000409584.5
IL1RL1
interleukin 1 receptor like 1
chr1_-_201171545 0.47 ENST00000367333.6
TMEM9
transmembrane protein 9
chr20_-_35147285 0.47 ENST00000374491.3
ENST00000374492.8
EDEM2
ER degradation enhancing alpha-mannosidase like protein 2
chr9_+_121567057 0.46 ENST00000394340.7
ENST00000436835.5
ENST00000259371.6
DAB2IP
DAB2 interacting protein
chr3_-_20012250 0.45 ENST00000389050.5
PP2D1
protein phosphatase 2C like domain containing 1
chrX_+_154304923 0.44 ENST00000426989.5
ENST00000426203.5
ENST00000369912.2
TKTL1
transketolase like 1
chr9_-_74952904 0.43 ENST00000376854.6
C9orf40
chromosome 9 open reading frame 40
chr12_-_11134644 0.42 ENST00000539585.1
TAS2R30
taste 2 receptor member 30
chr3_-_185821092 0.42 ENST00000421047.3
IGF2BP2
insulin like growth factor 2 mRNA binding protein 2
chr20_-_57690624 0.41 ENST00000414037.5
PMEPA1
prostate transmembrane protein, androgen induced 1
chr1_+_117001744 0.41 ENST00000256652.8
ENST00000682167.1
ENST00000369470.1
CD101
CD101 molecule
chr2_+_186694007 0.40 ENST00000304698.10
FAM171B
family with sequence similarity 171 member B
chr12_-_9869345 0.40 ENST00000228438.3
CLEC2B
C-type lectin domain family 2 member B
chr1_-_157700738 0.40 ENST00000368186.9
ENST00000496769.1
ENST00000368184.8
FCRL3
Fc receptor like 3
chr17_+_41966787 0.39 ENST00000393892.8
ENST00000587679.1
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr7_-_44541262 0.39 ENST00000289547.8
ENST00000546276.5
ENST00000423141.1
NPC1L1
NPC1 like intracellular cholesterol transporter 1
chr17_+_76467597 0.38 ENST00000392492.8
AANAT
aralkylamine N-acetyltransferase
chr14_+_103385374 0.38 ENST00000678179.1
ENST00000676938.1
ENST00000678619.1
ENST00000440884.7
ENST00000560417.6
ENST00000679330.1
ENST00000556744.2
ENST00000676897.1
ENST00000677560.1
ENST00000561314.6
ENST00000677829.1
ENST00000677133.1
ENST00000676645.1
ENST00000678175.1
ENST00000429436.7
ENST00000677360.1
ENST00000678237.1
ENST00000677347.1
ENST00000677432.1
MARK3
microtubule affinity regulating kinase 3
chr12_-_21910853 0.38 ENST00000544039.5
ABCC9
ATP binding cassette subfamily C member 9
chr12_+_12357418 0.37 ENST00000298571.6
BORCS5
BLOC-1 related complex subunit 5
chr17_+_41966814 0.37 ENST00000393888.1
ENST00000441615.2
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr2_+_101839815 0.37 ENST00000421882.5
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr17_-_74776323 0.37 ENST00000582870.5
ENST00000581136.5
ENST00000579218.5
ENST00000583476.5
ENST00000580301.5
ENST00000583757.5
ENST00000357814.8
ENST00000582524.5
NAT9
N-acetyltransferase 9 (putative)
chr3_-_33645433 0.36 ENST00000635664.1
ENST00000485378.6
ENST00000313350.10
ENST00000487200.5
CLASP2
cytoplasmic linker associated protein 2
chr6_-_111793871 0.36 ENST00000368667.6
FYN
FYN proto-oncogene, Src family tyrosine kinase
chrX_+_108045050 0.36 ENST00000458383.1
ENST00000217957.10
VSIG1
V-set and immunoglobulin domain containing 1
chr17_-_445939 0.34 ENST00000329099.4
RFLNB
refilin B
chr17_+_58755821 0.34 ENST00000308249.4
PPM1E
protein phosphatase, Mg2+/Mn2+ dependent 1E
chr3_+_12287899 0.34 ENST00000643888.2
PPARG
peroxisome proliferator activated receptor gamma
chr13_-_61415508 0.34 ENST00000409204.4
PCDH20
protocadherin 20
chr6_+_29111560 0.34 ENST00000377169.2
OR2J3
olfactory receptor family 2 subfamily J member 3
chr2_-_25168571 0.32 ENST00000264708.7
ENST00000449220.1
ENST00000395826.7
POMC
proopiomelanocortin
chr20_+_45416551 0.32 ENST00000639292.1
PIGT
phosphatidylinositol glycan anchor biosynthesis class T
chrX_+_108044967 0.32 ENST00000415430.7
VSIG1
V-set and immunoglobulin domain containing 1
chr12_-_95116967 0.32 ENST00000551521.5
FGD6
FYVE, RhoGEF and PH domain containing 6
chr3_+_12287859 0.31 ENST00000309576.11
ENST00000397015.7
PPARG
peroxisome proliferator activated receptor gamma
chr2_-_20823048 0.31 ENST00000402479.6
ENST00000237822.8
ENST00000626491.2
ENST00000432947.1
ENST00000403006.6
ENST00000419825.2
ENST00000381090.7
ENST00000412261.5
ENST00000619656.4
ENST00000541941.5
ENST00000440866.6
ENST00000435420.6
LDAH
lipid droplet associated hydrolase
chr10_+_52128343 0.31 ENST00000672084.1
PRKG1
protein kinase cGMP-dependent 1
chr2_+_90234809 0.31 ENST00000443397.5
IGKV3D-7
immunoglobulin kappa variable 3D-7
chr19_-_35812838 0.29 ENST00000653904.2
PRODH2
proline dehydrogenase 2
chr4_+_118888918 0.29 ENST00000434046.6
SYNPO2
synaptopodin 2
chr20_+_58907981 0.28 ENST00000656419.1
GNAS
GNAS complex locus
chr4_+_94207596 0.28 ENST00000359052.8
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr11_-_117316230 0.28 ENST00000313005.11
ENST00000528053.5
BACE1
beta-secretase 1
chr2_+_181986015 0.28 ENST00000409702.1
PPP1R1C
protein phosphatase 1 regulatory inhibitor subunit 1C
chr1_+_157993273 0.27 ENST00000360089.8
ENST00000368173.7
KIRREL1
kirre like nephrin family adhesion molecule 1
chr12_-_56741535 0.27 ENST00000647707.1
ENSG00000285625.1
novel protein
chr10_-_93482194 0.27 ENST00000358334.9
ENST00000371488.3
MYOF
myoferlin
chr10_-_93482326 0.27 ENST00000359263.9
MYOF
myoferlin
chr12_-_54259531 0.26 ENST00000550411.5
ENST00000439541.6
CBX5
chromobox 5
chr1_-_197146620 0.26 ENST00000367409.9
ENST00000680265.1
ASPM
assembly factor for spindle microtubules
chr17_-_66229380 0.26 ENST00000205948.11
APOH
apolipoprotein H
chrX_+_80420466 0.26 ENST00000308293.5
TENT5D
terminal nucleotidyltransferase 5D
chr5_+_127649018 0.26 ENST00000379445.7
CTXN3
cortexin 3
chr13_-_35476682 0.26 ENST00000379919.6
MAB21L1
mab-21 like 1
chr9_-_28670285 0.25 ENST00000379992.6
ENST00000308675.5
ENST00000613945.3
LINGO2
leucine rich repeat and Ig domain containing 2
chr15_-_19988117 0.25 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr12_-_118359639 0.25 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAOK3
TAO kinase 3
chr4_-_39977836 0.25 ENST00000303538.13
ENST00000503396.5
PDS5A
PDS5 cohesin associated factor A
chr18_+_63587297 0.24 ENST00000269489.9
SERPINB13
serpin family B member 13
chr6_+_47781982 0.24 ENST00000489301.6
ENST00000638973.1
ENST00000371211.6
ENST00000393699.2
OPN5
opsin 5
chr2_-_89085787 0.24 ENST00000390252.2
IGKV3-15
immunoglobulin kappa variable 3-15
chr18_+_63587336 0.23 ENST00000344731.10
SERPINB13
serpin family B member 13
chr12_-_111685720 0.23 ENST00000327551.6
BRAP
BRCA1 associated protein
chr4_-_119322128 0.22 ENST00000274024.4
FABP2
fatty acid binding protein 2
chr16_-_66550005 0.22 ENST00000527284.6
TK2
thymidine kinase 2
chr16_-_66549839 0.21 ENST00000527800.6
ENST00000677555.1
ENST00000563369.6
TK2
thymidine kinase 2
chr18_-_36798482 0.21 ENST00000590258.2
TPGS2
tubulin polyglutamylase complex subunit 2
chr2_+_181985846 0.21 ENST00000682840.1
ENST00000409137.7
ENST00000280295.7
PPP1R1C
protein phosphatase 1 regulatory inhibitor subunit 1C
chr18_+_23689439 0.21 ENST00000313654.14
LAMA3
laminin subunit alpha 3
chr18_-_49492305 0.21 ENST00000615479.4
ENST00000583637.5
ENST00000618613.5
ENST00000615760.4
ENST00000578528.1
ENST00000578532.5
ENST00000580387.5
ENST00000579248.5
ENST00000580261.6
ENST00000581373.5
ENST00000618619.4
ENST00000617346.4
ENST00000583036.5
ENST00000332968.11
RPL17
RPL17-C18orf32
ribosomal protein L17
RPL17-C18orf32 readthrough
chr11_+_94768331 0.21 ENST00000317829.12
ENST00000433060.3
AMOTL1
angiomotin like 1
chr19_+_53962925 0.21 ENST00000270458.4
CACNG8
calcium voltage-gated channel auxiliary subunit gamma 8
chr19_-_51417791 0.20 ENST00000353836.9
SIGLEC10
sialic acid binding Ig like lectin 10
chr5_+_154941063 0.20 ENST00000523037.6
ENST00000265229.12
ENST00000439747.7
ENST00000522038.5
MRPL22
mitochondrial ribosomal protein L22
chr15_+_64387828 0.20 ENST00000261884.8
TRIP4
thyroid hormone receptor interactor 4
chr3_+_111999326 0.20 ENST00000494932.1
TAGLN3
transgelin 3
chr4_+_70226116 0.20 ENST00000317987.6
FDCSP
follicular dendritic cell secreted protein
chr12_+_8157034 0.20 ENST00000396570.7
ZNF705A
zinc finger protein 705A
chr14_-_106211453 0.19 ENST00000390606.3
IGHV3-20
immunoglobulin heavy variable 3-20
chr2_-_25168903 0.19 ENST00000405623.5
POMC
proopiomelanocortin
chr2_-_25168690 0.19 ENST00000380794.5
POMC
proopiomelanocortin
chr3_+_44799187 0.19 ENST00000425755.5
KIF15
kinesin family member 15
chr11_+_60056587 0.19 ENST00000395032.6
ENST00000358152.6
MS4A3
membrane spanning 4-domains A3
chr16_+_11965234 0.19 ENST00000562385.1
TNFRSF17
TNF receptor superfamily member 17
chr16_-_66550091 0.19 ENST00000564917.5
ENST00000677420.1
TK2
thymidine kinase 2
chr1_-_211134135 0.19 ENST00000638983.1
ENST00000271751.10
ENST00000639952.1
ENSG00000284299.1
KCNH1
novel protein
potassium voltage-gated channel subfamily H member 1
chr2_+_68734773 0.18 ENST00000409202.8
ARHGAP25
Rho GTPase activating protein 25
chr18_+_23689609 0.18 ENST00000399516.7
LAMA3
laminin subunit alpha 3
chr2_-_162152404 0.18 ENST00000375497.3
GCG
glucagon
chr11_+_60056653 0.18 ENST00000278865.8
MS4A3
membrane spanning 4-domains A3
chr10_+_18260715 0.18 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr15_+_94355956 0.17 ENST00000557742.1
MCTP2
multiple C2 and transmembrane domain containing 2
chr9_+_34652167 0.17 ENST00000441545.7
ENST00000553620.5
IL11RA
interleukin 11 receptor subunit alpha
chr7_+_116222804 0.17 ENST00000393481.6
TES
testin LIM domain protein
chr19_-_51417700 0.17 ENST00000529627.1
ENST00000439889.6
SIGLEC10
sialic acid binding Ig like lectin 10
chr8_+_12104389 0.16 ENST00000400085.7
ZNF705D
zinc finger protein 705D
chr6_-_82247697 0.16 ENST00000306270.12
ENST00000610980.4
IBTK
inhibitor of Bruton tyrosine kinase
chr19_-_43883964 0.16 ENST00000587539.2
ZNF404
zinc finger protein 404
chr3_+_45886501 0.16 ENST00000395963.2
CCR9
C-C motif chemokine receptor 9
chr7_-_22822829 0.16 ENST00000358435.9
ENST00000621567.1
TOMM7
translocase of outer mitochondrial membrane 7
chr9_-_26947222 0.16 ENST00000520884.5
ENST00000397292.8
PLAA
phospholipase A2 activating protein
chr9_-_111036207 0.16 ENST00000541779.5
LPAR1
lysophosphatidic acid receptor 1
chr7_-_22822779 0.16 ENST00000372879.8
TOMM7
translocase of outer mitochondrial membrane 7
chr1_-_109075944 0.16 ENST00000338366.6
TAF13
TATA-box binding protein associated factor 13
chrX_-_72239022 0.16 ENST00000373657.2
ENST00000334463.4
ERCC6L
ERCC excision repair 6 like, spindle assembly checkpoint helicase
chr3_+_111998739 0.16 ENST00000393917.6
ENST00000273368.8
TAGLN3
transgelin 3
chr8_-_85341705 0.15 ENST00000517618.5
CA1
carbonic anhydrase 1
chr14_+_71586261 0.15 ENST00000358550.6
SIPA1L1
signal induced proliferation associated 1 like 1
chr20_-_7940444 0.15 ENST00000378789.4
HAO1
hydroxyacid oxidase 1
chr6_+_26087417 0.15 ENST00000357618.10
ENST00000309234.10
HFE
homeostatic iron regulator
chr8_-_48921419 0.14 ENST00000020945.4
SNAI2
snail family transcriptional repressor 2
chr1_-_158554405 0.14 ENST00000641282.1
ENST00000641622.1
OR6Y1
olfactory receptor family 6 subfamily Y member 1
chr1_-_247760556 0.14 ENST00000641256.1
OR1C1
olfactory receptor family 1 subfamily C member 1
chr3_+_130850585 0.14 ENST00000505330.5
ENST00000504381.5
ENST00000507488.6
ATP2C1
ATPase secretory pathway Ca2+ transporting 1
chr4_-_76023489 0.14 ENST00000306602.3
CXCL10
C-X-C motif chemokine ligand 10
chr7_-_122098831 0.14 ENST00000681213.1
ENST00000679419.1
AASS
aminoadipate-semialdehyde synthase
chr10_-_49188380 0.14 ENST00000374153.7
ENST00000374148.1
ENST00000374151.7
TMEM273
transmembrane protein 273
chr3_+_111999189 0.14 ENST00000455401.6
TAGLN3
transgelin 3
chr18_+_57352541 0.14 ENST00000324000.4
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr9_+_69145463 0.14 ENST00000636438.1
TJP2
tight junction protein 2
chr5_+_90474879 0.14 ENST00000504930.5
ENST00000514483.5
POLR3G
RNA polymerase III subunit G
chr5_+_67004618 0.14 ENST00000261569.11
ENST00000436277.5
MAST4
microtubule associated serine/threonine kinase family member 4
chr4_-_151227881 0.13 ENST00000652233.1
ENST00000514152.5
SH3D19
SH3 domain containing 19
chr5_+_90474848 0.13 ENST00000651687.1
POLR3G
RNA polymerase III subunit G
chr11_-_89808575 0.13 ENST00000329758.5
TRIM49
tripartite motif containing 49
chr4_+_87650277 0.13 ENST00000339673.11
ENST00000282479.8
DMP1
dentin matrix acidic phosphoprotein 1
chr19_-_3772211 0.13 ENST00000555978.5
ENST00000555633.3
RAX2
retina and anterior neural fold homeobox 2
chr11_-_66002123 0.13 ENST00000532707.5
ENST00000526451.5
ENST00000312234.6
ENST00000533544.6
ENST00000530462.5
ENST00000525767.5
ENST00000529964.5
ENST00000527249.5
EIF1AD
eukaryotic translation initiation factor 1A domain containing
chr15_+_92900338 0.12 ENST00000625990.3
CHD2
chromodomain helicase DNA binding protein 2
chr8_-_85341659 0.12 ENST00000522389.5
CA1
carbonic anhydrase 1
chr6_-_155455830 0.12 ENST00000159060.3
NOX3
NADPH oxidase 3
chr3_-_151316795 0.12 ENST00000260843.5
GPR87
G protein-coupled receptor 87
chr7_-_150323489 0.12 ENST00000683684.1
ENST00000478393.5
ACTR3C
actin related protein 3C
chr4_+_154563003 0.12 ENST00000302068.9
ENST00000509493.1
FGB
fibrinogen beta chain
chr1_+_10450004 0.12 ENST00000377049.4
CORT
cortistatin
chr8_-_61689768 0.12 ENST00000517847.6
ENST00000389204.8
ENST00000517661.5
ENST00000517903.5
ENST00000522603.5
ENST00000541428.5
ENST00000522349.5
ENST00000522835.5
ENST00000518306.5
ASPH
aspartate beta-hydroxylase
chr10_-_73655984 0.11 ENST00000394810.3
SYNPO2L
synaptopodin 2 like
chr10_+_120851341 0.11 ENST00000263461.11
WDR11
WD repeat domain 11
chrX_-_101407893 0.11 ENST00000676156.1
ENST00000675592.1
ENST00000674634.2
ENST00000649178.1
ENST00000218516.4
GLA
galactosidase alpha
chr13_-_37598750 0.11 ENST00000379743.8
ENST00000379742.4
ENST00000379749.8
ENST00000379747.9
ENST00000541179.5
ENST00000541481.5
POSTN
periostin
chr2_-_74392025 0.11 ENST00000440727.1
ENST00000409240.5
DCTN1
dynactin subunit 1
chr6_+_124983356 0.10 ENST00000519799.5
ENST00000368414.6
ENST00000359704.2
RNF217
ring finger protein 217
chr20_+_59019397 0.10 ENST00000217133.2
TUBB1
tubulin beta 1 class VI
chr3_+_111998915 0.10 ENST00000478951.6
TAGLN3
transgelin 3
chr7_-_87475839 0.10 ENST00000359206.8
ABCB4
ATP binding cassette subfamily B member 4
chr2_+_165239388 0.10 ENST00000424833.5
ENST00000375437.7
ENST00000631182.3
SCN2A
sodium voltage-gated channel alpha subunit 2
chr21_-_14210948 0.10 ENST00000681601.1
LIPI
lipase I
chr11_-_102705737 0.10 ENST00000260229.5
MMP27
matrix metallopeptidase 27
chrM_-_14669 0.10 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6
chr9_-_128724088 0.10 ENST00000406904.2
ENST00000452105.5
ENST00000372667.9
ENST00000372663.9
ZDHHC12
zinc finger DHHC-type palmitoyltransferase 12
chr1_-_111488795 0.10 ENST00000472933.2
TMIGD3
transmembrane and immunoglobulin domain containing 3
chr10_+_18400562 0.10 ENST00000377315.5
ENST00000650685.1
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.5 GO:0060005 vestibular reflex(GO:0060005)
0.2 0.9 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.2 3.0 GO:0043249 erythrocyte maturation(GO:0043249)
0.2 0.5 GO:0061300 cerebellum vasculature development(GO:0061300)
0.2 0.8 GO:0034334 adherens junction maintenance(GO:0034334)
0.2 0.5 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.1 3.1 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 1.0 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 0.4 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.1 0.5 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.1 1.9 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.3 GO:0061182 negative regulation of chondrocyte development(GO:0061182)
0.1 0.5 GO:1902523 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.1 0.7 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.1 0.3 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.7 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1 0.6 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.1 0.5 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.4 GO:0006772 thiamine metabolic process(GO:0006772)
0.1 1.8 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.7 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.1 0.6 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161) regulation of collagen catabolic process(GO:0010710)
0.1 0.2 GO:1900390 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) regulation of T cell antigen processing and presentation(GO:0002625) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
0.1 0.9 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.5 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.1 0.4 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.1 0.5 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 0.3 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.1 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 0.1 GO:0061011 hepatic duct development(GO:0061011)
0.0 0.1 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.0 0.1 GO:0019878 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.0 0.1 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
0.0 0.5 GO:0097283 keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172)
0.0 0.1 GO:0002305 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.0 0.3 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.0 0.2 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.3 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.3 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.7 GO:0009642 response to light intensity(GO:0009642)
0.0 0.1 GO:2001025 response to cyclosporin A(GO:1905237) positive regulation of response to drug(GO:2001025)
0.0 0.9 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.7 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.2 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 1.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.9 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.4 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.0 0.5 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:1990523 bone regeneration(GO:1990523)
0.0 0.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.5 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.1 GO:0001868 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.3 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.1 GO:1900222 regulation of cell growth by extracellular stimulus(GO:0001560) negative regulation of beta-amyloid clearance(GO:1900222) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724)
0.0 0.3 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392) negative regulation of fibrinolysis(GO:0051918)
0.0 1.1 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.1 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.1 GO:0002769 natural killer cell inhibitory signaling pathway(GO:0002769)
0.0 1.1 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 0.4 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 0.3 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.3 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.2 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.0 0.1 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 0.1 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631) negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.0 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.0 0.1 GO:0048840 otolith development(GO:0048840)
0.0 0.8 GO:0021762 substantia nigra development(GO:0021762)
0.0 0.1 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0 0.1 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.1 GO:0048669 microglia differentiation(GO:0014004) microglia development(GO:0014005) collateral sprouting in absence of injury(GO:0048669) smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563) cellular response to norepinephrine stimulus(GO:0071874)
0.0 0.1 GO:0016139 glycoside catabolic process(GO:0016139)
0.0 0.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 1.5 GO:0030449 regulation of complement activation(GO:0030449)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.5 GO:0032426 stereocilium tip(GO:0032426)
0.3 0.9 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 0.6 GO:0034677 integrin alpha7-beta1 complex(GO:0034677)
0.1 0.5 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.5 GO:1990032 parallel fiber(GO:1990032)
0.1 0.6 GO:0005873 plus-end kinesin complex(GO:0005873)
0.1 0.3 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.1 1.0 GO:0030478 actin cap(GO:0030478)
0.1 0.2 GO:1990357 terminal web(GO:1990357)
0.1 0.4 GO:0005610 laminin-5 complex(GO:0005610)
0.1 0.8 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.1 0.3 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 1.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.5 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 1.8 GO:0002102 podosome(GO:0002102)
0.0 0.3 GO:0036449 microtubule minus-end(GO:0036449) meiotic spindle(GO:0072687)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.4 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 2.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.5 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.5 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.4 5.5 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.2 0.7 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.2 1.0 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.2 1.9 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 0.5 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 0.8 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.1 0.4 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.1 0.4 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 0.4 GO:0004802 transketolase activity(GO:0004802)
0.1 0.4 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 0.6 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.3 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.1 0.5 GO:0004137 deoxycytidine kinase activity(GO:0004137)
0.1 2.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.5 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 0.5 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 0.3 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 0.7 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.4 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 1.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 0.3 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.6 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0052853 (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
0.0 0.2 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.4 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.3 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.7 GO:0070492 phosphatidylinositol-5-phosphate binding(GO:0010314) oligosaccharide binding(GO:0070492)
0.0 1.0 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.5 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.9 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.3 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.3 GO:0015266 protein channel activity(GO:0015266)
0.0 0.1 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.0 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)
0.0 0.3 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.0 0.2 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.3 GO:0031005 filamin binding(GO:0031005)
0.0 1.0 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.1 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.0 0.4 GO:0051010 dystroglycan binding(GO:0002162) microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.3 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.1 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.9 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 0.9 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 0.9 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.7 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.7 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 3.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 1.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.4 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline