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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for OTX2_CRX

Z-value: 0.65

Motif logo

Transcription factors associated with OTX2_CRX

Gene Symbol Gene ID Gene Info
ENSG00000165588.18 OTX2
ENSG00000105392.16 CRX

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
OTX2hg38_v1_chr14_-_56805648_568056750.551.6e-03Click!
CRXhg38_v1_chr19_+_47821907_478219640.393.2e-02Click!

Activity profile of OTX2_CRX motif

Sorted Z-values of OTX2_CRX motif

Network of associatons between targets according to the STRING database.

First level regulatory network of OTX2_CRX

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr17_-_40703744 7.87 ENST00000264651.3
keratin 24
chr8_+_53851786 2.47 ENST00000297313.8
ENST00000344277.10
regulator of G protein signaling 20
chr19_-_51034840 2.45 ENST00000529888.5
kallikrein related peptidase 12
chr19_-_51034892 2.43 ENST00000319590.8
ENST00000250351.4
kallikrein related peptidase 12
chr19_-_51034993 2.26 ENST00000684732.1
kallikrein related peptidase 12
chr15_-_74202742 1.54 ENST00000395105.9
signaling receptor and transporter of retinol STRA6
chr5_-_150289941 1.44 ENST00000682786.1
calcium/calmodulin dependent protein kinase II alpha
chr16_+_57976435 1.21 ENST00000290871.10
ENST00000441824.4
testis, prostate and placenta expressed
chr5_-_150289764 1.13 ENST00000671881.1
ENST00000672752.1
ENST00000510347.2
ENST00000672829.1
ENST00000348628.11
calcium/calmodulin dependent protein kinase II alpha
chr1_+_180928133 1.12 ENST00000367587.1
KIAA1614
chr5_-_150289625 1.10 ENST00000683332.1
ENST00000398376.8
ENST00000672785.1
ENST00000672396.1
calcium/calmodulin dependent protein kinase II alpha
chr15_+_33310946 1.07 ENST00000415757.7
ENST00000634891.2
ENST00000389232.9
ENST00000622037.1
ryanodine receptor 3
chr2_-_65432591 1.06 ENST00000356388.9
sprouty related EVH1 domain containing 2
chr10_+_123135938 0.98 ENST00000357878.7
H6 family homeobox 3
chr12_+_6840800 0.97 ENST00000541978.5
ENST00000229264.8
ENST00000435982.6
G protein subunit beta 3
chr3_-_149377637 0.93 ENST00000305366.8
transmembrane 4 L six family member 1
chr6_+_130018565 0.89 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL histone methyl-lysine binding protein 3
chr8_-_90082871 0.88 ENST00000265431.7
calbindin 1
chr11_-_62984690 0.86 ENST00000421062.2
ENST00000458333.6
solute carrier family 22 member 6
chrX_+_70290077 0.85 ENST00000374403.4
kinesin family member 4A
chr18_-_31102411 0.77 ENST00000251081.8
ENST00000280904.11
ENST00000682357.1
ENST00000648081.1
desmocollin 2
chr14_-_94770102 0.72 ENST00000238558.5
goosecoid homeobox
chrX_+_70268324 0.70 ENST00000307959.9
ENST00000620997.4
ENST00000480877.6
arrestin 3
chr9_+_113536497 0.69 ENST00000462143.5
regulator of G protein signaling 3
chr19_-_51034727 0.67 ENST00000525263.5
kallikrein related peptidase 12
chr5_-_150290093 0.67 ENST00000672479.1
calcium/calmodulin dependent protein kinase II alpha
chrX_+_70268305 0.63 ENST00000374495.7
arrestin 3
chrX_+_136197020 0.60 ENST00000370676.7
four and a half LIM domains 1
chr10_-_84241538 0.59 ENST00000372105.4
leucine rich repeat, Ig-like and transmembrane domains 1
chr2_+_218607861 0.58 ENST00000450993.7
phospholipase C delta 4
chr17_-_55511434 0.57 ENST00000636752.1
small integral membrane protein 36
chr2_-_70553440 0.56 ENST00000450929.5
transforming growth factor alpha
chr10_-_104085847 0.55 ENST00000648076.2
collagen type XVII alpha 1 chain
chr6_-_35512863 0.55 ENST00000428978.1
ENST00000614066.4
ENST00000322263.8
TUB like protein 1
chr1_+_55039511 0.55 ENST00000302118.5
proprotein convertase subtilisin/kexin type 9
chr16_-_57971086 0.54 ENST00000564448.5
ENST00000311183.8
cyclic nucleotide gated channel subunit beta 1
chr5_-_115626161 0.54 ENST00000282382.8
TMED7-TICAM2 readthrough
chrX_-_124963768 0.50 ENST00000371130.7
ENST00000422452.2
teneurin transmembrane protein 1
chr6_+_35342535 0.49 ENST00000360694.8
ENST00000418635.6
ENST00000448077.6
peroxisome proliferator activated receptor delta
chr6_+_35342614 0.49 ENST00000337400.6
ENST00000311565.4
peroxisome proliferator activated receptor delta
chr12_-_52796110 0.48 ENST00000417996.2
keratin 3
chr12_-_52777343 0.47 ENST00000332411.2
keratin 76
chr3_+_50611871 0.47 ENST00000446044.5
MAPK activated protein kinase 3
chrX_+_136197039 0.45 ENST00000370683.6
four and a half LIM domains 1
chrX_+_136196750 0.44 ENST00000539015.5
four and a half LIM domains 1
chr3_+_130931893 0.44 ENST00000504612.5
ATPase secretory pathway Ca2+ transporting 1
chr2_-_70553638 0.44 ENST00000444975.5
ENST00000445399.5
ENST00000295400.11
ENST00000418333.6
transforming growth factor alpha
chr3_-_48188356 0.43 ENST00000351231.7
ENST00000437972.1
ENST00000302506.8
cell division cycle 25A
chr11_-_111912871 0.43 ENST00000528628.5
crystallin alpha B
chr6_+_106087580 0.42 ENST00000424894.1
ENST00000648754.1
PR/SET domain 1
chr17_-_45132505 0.41 ENST00000619929.5
phospholipase C delta 3
chr12_-_1918473 0.40 ENST00000586184.5
ENST00000587995.5
ENST00000585732.1
calcium voltage-gated channel auxiliary subunit alpha2delta 4
chr8_-_132111159 0.40 ENST00000673615.1
ENST00000434736.6
HERV-H LTR-associating 1
chr15_-_34318761 0.39 ENST00000290209.9
solute carrier family 12 member 6
chr8_-_25424260 0.39 ENST00000421054.7
gonadotropin releasing hormone 1
chr6_-_138572523 0.38 ENST00000427025.6
NHS like 1
chr11_-_62984957 0.38 ENST00000377871.7
ENST00000360421.9
solute carrier family 22 member 6
chr20_+_44355692 0.38 ENST00000316673.8
ENST00000609795.5
ENST00000457232.5
ENST00000609262.5
hepatocyte nuclear factor 4 alpha
chr12_+_53299682 0.37 ENST00000267103.10
ENST00000548632.5
MYG1 exonuclease
chr7_-_128775793 0.37 ENST00000249389.3
opsin 1, short wave sensitive
chr17_-_62808339 0.37 ENST00000583600.5
membrane associated ring-CH-type finger 10
chr14_-_63318933 0.37 ENST00000621500.2
glycoprotein hormone subunit beta 5
chr12_+_53300027 0.36 ENST00000549488.5
MYG1 exonuclease
chr17_-_62808299 0.36 ENST00000311269.10
membrane associated ring-CH-type finger 10
chr6_+_31587268 0.36 ENST00000396101.7
ENST00000490742.5
leukocyte specific transcript 1
chr1_-_150235972 0.35 ENST00000534220.1
acidic nuclear phosphoprotein 32 family member E
chr1_+_11691688 0.35 ENST00000294485.6
dorsal inhibitory axon guidance protein
chr20_-_50115935 0.33 ENST00000340309.7
ENST00000415862.6
ENST00000371677.7
ubiquitin conjugating enzyme E2 V1
chr15_+_58138368 0.32 ENST00000219919.9
ENST00000536493.1
aquaporin 9
chr1_+_159439722 0.32 ENST00000641630.1
ENST00000423932.6
olfactory receptor family 10 subfamily J member 1
chr9_+_18474206 0.32 ENST00000276935.6
ADAMTS like 1
chr19_+_47821907 0.32 ENST00000539067.5
ENST00000221996.12
ENST00000613299.1
cone-rod homeobox
chr12_+_77830886 0.31 ENST00000397909.7
ENST00000549464.5
neuron navigator 3
chr3_+_111674654 0.31 ENST00000636933.1
ENST00000393934.7
ENST00000477665.2
phosphatidylinositol specific phospholipase C X domain containing 2
chr4_-_152679984 0.31 ENST00000304385.8
ENST00000504064.1
transmembrane protein 154
chr1_-_99766620 0.30 ENST00000646001.2
ferric chelate reductase 1
chr10_+_47348351 0.30 ENST00000584701.2
retinol binding protein 3
chr8_+_69466617 0.29 ENST00000525061.5
ENST00000260128.8
ENST00000458141.6
sulfatase 1
chr11_+_73264479 0.29 ENST00000393592.7
ENST00000540342.6
ENST00000679753.1
ENST00000542092.5
ENST00000349767.6
pyrimidinergic receptor P2Y6
chr18_-_66604076 0.29 ENST00000540086.5
ENST00000580157.2
ENST00000262150.7
cadherin 19
chr6_+_34466059 0.28 ENST00000620693.4
ENST00000244458.7
ENST00000374043.6
protein kinase C and casein kinase substrate in neurons 1
chr16_-_57971121 0.28 ENST00000251102.13
cyclic nucleotide gated channel subunit beta 1
chr6_-_30690968 0.28 ENST00000376420.9
ENST00000376421.7
nurim
chr9_+_34179005 0.28 ENST00000625521.2
ENST00000379186.8
ENST00000297661.9
ENST00000626262.2
ubiquitin associated protein 1
chr6_-_65707214 0.28 ENST00000370621.7
ENST00000393380.6
ENST00000503581.6
eyes shut homolog
chr5_-_142325001 0.28 ENST00000344120.4
ENST00000434127.3
sprouty RTK signaling antagonist 4
chr1_+_18631006 0.28 ENST00000375375.7
paired box 7
chr5_-_96433214 0.28 ENST00000311106.8
proprotein convertase subtilisin/kexin type 1
chr19_+_45498439 0.28 ENST00000451287.7
protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)
chr11_+_124865425 0.27 ENST00000397801.6
roundabout guidance receptor 3
chr17_-_73644435 0.27 ENST00000392650.8
sidekick cell adhesion molecule 2
chr17_+_45241067 0.26 ENST00000587489.5
formin like 1
chr5_-_88883199 0.26 ENST00000514015.5
ENST00000503075.1
myocyte enhancer factor 2C
chr19_-_48044037 0.26 ENST00000293255.3
calcium binding protein 5
chr3_-_54928044 0.26 ENST00000273286.6
leucine rich repeats and transmembrane domains 1
chr4_-_101347327 0.25 ENST00000394853.8
protein phosphatase 3 catalytic subunit alpha
chr15_+_92900338 0.25 ENST00000625990.3
chromodomain helicase DNA binding protein 2
chr6_+_99606833 0.25 ENST00000369215.5
PR/SET domain 13
chr3_-_50611767 0.25 ENST00000443053.6
ENST00000348721.4
cytokine inducible SH2 containing protein
chr17_-_41505597 0.25 ENST00000336861.7
ENST00000246635.8
ENST00000587544.5
ENST00000587435.1
keratin 13
chrX_-_21658324 0.24 ENST00000379499.3
kelch like family member 34
chr9_+_100442271 0.24 ENST00000502978.1
MSANTD3-TMEFF1 readthrough
chr7_+_28412511 0.24 ENST00000357727.7
cAMP responsive element binding protein 5
chr9_+_69145463 0.24 ENST00000636438.1
tight junction protein 2
chr2_-_29921580 0.24 ENST00000389048.8
ALK receptor tyrosine kinase
chr11_-_111923722 0.24 ENST00000527950.5
crystallin alpha B
chr4_-_101347492 0.24 ENST00000394854.8
protein phosphatase 3 catalytic subunit alpha
chr3_-_138132381 0.24 ENST00000236709.4
alpha-1,4-N-acetylglucosaminyltransferase
chrX_-_54357993 0.23 ENST00000375169.7
ENST00000354646.6
WNK lysine deficient protein kinase 3
chr11_+_20022550 0.23 ENST00000533917.5
neuron navigator 2
chr1_-_150235995 0.23 ENST00000436748.6
acidic nuclear phosphoprotein 32 family member E
chrX_+_80420466 0.23 ENST00000308293.5
terminal nucleotidyltransferase 5D
chr2_+_191276885 0.23 ENST00000392316.5
myosin IB
chr7_-_84194781 0.23 ENST00000265362.9
semaphorin 3A
chr18_+_616672 0.23 ENST00000338387.11
clusterin like 1
chr4_-_101347471 0.23 ENST00000323055.10
ENST00000512215.5
protein phosphatase 3 catalytic subunit alpha
chr17_+_17042433 0.22 ENST00000651222.2
myosin phosphatase Rho interacting protein
chr18_+_616711 0.22 ENST00000579494.1
clusterin like 1
chr5_+_136058849 0.22 ENST00000508076.5
transforming growth factor beta induced
chr4_-_101346842 0.21 ENST00000507176.5
protein phosphatase 3 catalytic subunit alpha
chr18_+_34710249 0.21 ENST00000680346.1
ENST00000348997.9
ENST00000681274.1
ENST00000680822.1
ENST00000680767.2
ENST00000597599.5
ENST00000444659.6
dystrobrevin alpha
chr1_-_150235943 0.21 ENST00000533654.5
acidic nuclear phosphoprotein 32 family member E
chr6_+_31587185 0.21 ENST00000376092.7
ENST00000376086.7
ENST00000303757.12
ENST00000376093.6
leukocyte specific transcript 1
chr17_+_8002610 0.21 ENST00000254854.5
guanylate cyclase 2D, retinal
chr17_+_77281429 0.21 ENST00000591198.5
ENST00000427177.6
septin 9
chr6_+_31587049 0.21 ENST00000376089.6
ENST00000396112.6
leukocyte specific transcript 1
chr9_+_18474100 0.20 ENST00000327883.11
ENST00000431052.6
ENST00000380570.8
ENST00000380548.9
ADAMTS like 1
chrX_+_41447322 0.20 ENST00000378220.2
ENST00000342595.2
nyctalopin
chr9_-_128724088 0.20 ENST00000406904.2
ENST00000452105.5
ENST00000372667.9
ENST00000372663.9
zinc finger DHHC-type palmitoyltransferase 12
chr19_-_42427379 0.20 ENST00000244289.9
lipase E, hormone sensitive type
chr1_-_11691608 0.20 ENST00000376667.7
mitotic arrest deficient 2 like 2
chr12_-_110499546 0.20 ENST00000552130.6
VPS29 retromer complex component
chr9_-_92482350 0.19 ENST00000375543.2
asporin
chr18_-_37565825 0.19 ENST00000603232.6
CUGBP Elav-like family member 4
chr1_-_11691646 0.19 ENST00000235310.7
mitotic arrest deficient 2 like 2
chr3_-_197226351 0.19 ENST00000656428.1
discs large MAGUK scaffold protein 1
chr15_-_65115185 0.19 ENST00000559089.6
ubiquitin associated protein 1 like
chr5_-_36301883 0.19 ENST00000502994.5
ENST00000515759.5
ENST00000296604.8
RAN binding protein 3 like
chr10_-_75109085 0.19 ENST00000607131.5
dual specificity phosphatase 13
chr7_+_80602200 0.19 ENST00000534394.5
CD36 molecule
chr17_-_48613468 0.18 ENST00000498634.2
homeobox B8
chr7_+_80602150 0.18 ENST00000309881.11
CD36 molecule
chr19_-_3772211 0.18 ENST00000555978.5
ENST00000555633.3
retina and anterior neural fold homeobox 2
chr3_+_4493340 0.18 ENST00000357086.10
ENST00000354582.12
ENST00000649015.2
ENST00000467056.6
inositol 1,4,5-trisphosphate receptor type 1
chr3_-_98522514 0.17 ENST00000503004.5
ENST00000506575.1
ENST00000513452.5
ENST00000515620.5
claudin domain containing 1
chr9_-_92482499 0.17 ENST00000375544.7
asporin
chr1_-_11691471 0.17 ENST00000376672.5
mitotic arrest deficient 2 like 2
chr10_+_102226293 0.17 ENST00000370005.4
ELOVL fatty acid elongase 3
chr2_+_33436304 0.17 ENST00000402538.7
RAS guanyl releasing protein 3
chr5_-_11589019 0.16 ENST00000511377.5
catenin delta 2
chr2_-_55010348 0.16 ENST00000394609.6
reticulon 4
chr16_+_81238682 0.16 ENST00000258168.7
ENST00000564552.1
beta-carotene oxygenase 1
chr10_-_75109172 0.16 ENST00000372700.7
ENST00000473072.2
ENST00000491677.6
ENST00000372702.7
dual specificity phosphatase 13
chr3_+_129528632 0.16 ENST00000296271.4
rhodopsin
chr2_+_120013068 0.15 ENST00000443902.6
ENST00000263713.10
erythrocyte membrane protein band 4.1 like 5
chr13_-_35476682 0.15 ENST00000379919.6
mab-21 like 1
chr2_-_61537740 0.15 ENST00000678081.1
ENST00000676889.1
ENST00000677850.1
ENST00000676789.1
exportin 1
chr8_-_80080816 0.15 ENST00000520527.5
ENST00000517427.5
ENST00000379097.7
ENST00000448733.3
tumor protein D52
chr10_+_24239181 0.15 ENST00000438429.5
KIAA1217
chr11_-_11353241 0.15 ENST00000528848.3
casein kinase 2 alpha 3
chr3_+_191329020 0.14 ENST00000392456.4
coiled-coil domain containing 50
chr5_-_11588842 0.14 ENST00000503622.5
catenin delta 2
chr12_-_66803980 0.14 ENST00000539540.5
ENST00000540433.5
ENST00000541947.1
ENST00000538373.1
glutamate receptor interacting protein 1
chr17_-_48615261 0.14 ENST00000239144.5
homeobox B8
chr15_+_92900189 0.14 ENST00000626874.2
ENST00000627622.1
ENST00000629346.2
ENST00000628375.2
ENST00000420239.7
ENST00000394196.9
chromodomain helicase DNA binding protein 2
chr1_-_201112420 0.14 ENST00000362061.4
ENST00000681874.1
calcium voltage-gated channel subunit alpha1 S
chr7_-_126533850 0.13 ENST00000444921.3
glutamate metabotropic receptor 8
chr14_-_34630109 0.13 ENST00000396526.7
sorting nexin 6
chr21_-_33643926 0.13 ENST00000438788.1
crystallin zeta like 1
chr1_-_150236064 0.13 ENST00000532744.2
ENST00000369114.9
ENST00000369115.3
ENST00000583931.6
acidic nuclear phosphoprotein 32 family member E
chr6_+_151809105 0.13 ENST00000427531.6
estrogen receptor 1
chr10_-_110304894 0.13 ENST00000369603.10
survival motor neuron domain containing 1
chr5_-_88883420 0.13 ENST00000437473.6
myocyte enhancer factor 2C
chr10_+_93612532 0.13 ENST00000371447.4
phosphodiesterase 6C
chr3_-_170908626 0.12 ENST00000295822.7
ENST00000474096.5
eukaryotic translation initiation factor 5A2
chr5_+_150660841 0.12 ENST00000297130.4
myozenin 3
chr1_-_53142617 0.12 ENST00000371491.4
ENST00000371494.9
solute carrier family 1 member 7
chr1_-_151992571 0.12 ENST00000368809.1
S100 calcium binding protein A10
chr19_+_39498938 0.12 ENST00000356433.10
ENST00000596614.5
ENST00000205143.4
delta like canonical Notch ligand 3
chr1_-_173205543 0.11 ENST00000367718.5
TNF superfamily member 4
chr9_+_85941121 0.11 ENST00000361671.10
N-alpha-acetyltransferase 35, NatC auxiliary subunit
chr2_+_218607914 0.11 ENST00000417849.5
phospholipase C delta 4
chr2_+_120013111 0.11 ENST00000331393.8
ENST00000443124.5
erythrocyte membrane protein band 4.1 like 5
chr1_+_20070156 0.11 ENST00000375108.4
phospholipase A2 group V
chr1_+_101237009 0.11 ENST00000305352.7
sphingosine-1-phosphate receptor 1
chr10_+_100745711 0.11 ENST00000370296.6
ENST00000428433.5
paired box 2
chr10_+_50990864 0.11 ENST00000401604.8
protein kinase cGMP-dependent 1
chr4_+_125314918 0.11 ENST00000674496.2
ENST00000394329.9
FAT atypical cadherin 4
chr5_-_41510623 0.10 ENST00000328457.5
phosphatidylinositol specific phospholipase C X domain containing 3
chr10_+_102132994 0.10 ENST00000413464.6
ENST00000278070.7
PPARG related coactivator 1
chr12_+_80707625 0.10 ENST00000228641.4
myogenic factor 6
chrX_-_154097731 0.10 ENST00000628176.2
methyl-CpG binding protein 2
chr11_+_61755372 0.10 ENST00000265460.9
myelin regulatory factor
chr5_-_77776321 0.10 ENST00000380377.9
tubulin folding cofactor A
chr6_-_106975616 0.10 ENST00000610952.1
CD24 molecule
chr8_-_103501890 0.09 ENST00000649416.1
novel protein
chr8_+_64580357 0.09 ENST00000321870.3
basic helix-loop-helix family member e22
chr12_-_86256299 0.09 ENST00000552808.6
ENST00000547225.5
MGAT4 family member C
chr12_-_118190510 0.09 ENST00000540561.5
ENST00000537952.1
ENST00000537822.1
TAO kinase 3
chr9_-_28670285 0.09 ENST00000379992.6
ENST00000308675.5
ENST00000613945.3
leucine rich repeat and Ig domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0061143 alveolar primary septum development(GO:0061143)
0.2 1.2 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.2 0.7 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.2 0.9 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.2 4.3 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.2 0.5 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.1 0.4 GO:1990654 regulation of extrathymic T cell differentiation(GO:0033082) sebum secreting cell proliferation(GO:1990654)
0.1 17.7 GO:0070268 cornification(GO:0070268)
0.1 0.9 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.1 0.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.1 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.1 0.4 GO:1990637 response to prolactin(GO:1990637)
0.1 1.2 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.1 0.3 GO:0015722 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.1 0.6 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 0.4 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 0.8 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 0.9 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 0.4 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.5 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500) protein localization to photoreceptor outer segment(GO:1903546)
0.1 0.2 GO:0036269 swimming behavior(GO:0036269)
0.1 0.4 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 1.0 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 0.3 GO:0008078 mesodermal cell migration(GO:0008078) axial mesoderm morphogenesis(GO:0048319)
0.1 0.9 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.8 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 1.1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.2 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0 0.2 GO:0021634 optic nerve formation(GO:0021634) regulation of metanephros size(GO:0035566) optic chiasma development(GO:0061360) regulation of optic nerve formation(GO:2000595) positive regulation of optic nerve formation(GO:2000597)
0.0 0.2 GO:1903375 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.0 0.3 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.0 0.5 GO:0002155 regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0 0.3 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.4 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.4 GO:0072564 response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.2 GO:0016119 carotene metabolic process(GO:0016119)
0.0 0.2 GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.1 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 0.4 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.1 GO:1990451 cellular stress response to acidic pH(GO:1990451)
0.0 0.1 GO:0003245 growth involved in heart morphogenesis(GO:0003241) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.0 0.2 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.6 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.5 GO:0044351 macropinocytosis(GO:0044351)
0.0 0.3 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.1 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.0 0.1 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.7 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.5 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.2 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.1 GO:0033606 B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606)
0.0 0.3 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.2 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.2 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.2 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 1.7 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.1 GO:0048318 axial mesoderm development(GO:0048318)
0.0 0.1 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.7 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.0 0.0 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.0 0.1 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.0 1.0 GO:0043486 histone exchange(GO:0043486)
0.0 0.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.5 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.1 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 1.0 GO:0007566 embryo implantation(GO:0007566)
0.0 1.0 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.2 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.3 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0 0.1 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.7 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.4 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.0 0.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.5 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.1 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.0 GO:1903970 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) regulation of microglial cell activation(GO:1903978)
0.0 0.1 GO:0071313 cellular response to caffeine(GO:0071313)
0.0 0.0 GO:1903015 regulation of exo-alpha-sialidase activity(GO:1903015)
0.0 0.1 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.2 GO:2000172 positive regulation of mammary gland epithelial cell proliferation(GO:0033601) regulation of branching morphogenesis of a nerve(GO:2000172)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1990666 PCSK9-LDLR complex(GO:1990666) PCSK9-AnxA2 complex(GO:1990667)
0.1 0.3 GO:0035370 UBC13-UEV1A complex(GO:0035370)
0.1 1.1 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.0 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.2 GO:0060342 photoreceptor inner segment membrane(GO:0060342)
0.0 0.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 8.8 GO:0005882 intermediate filament(GO:0005882)
0.0 0.7 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.3 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.2 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.4 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.6 GO:0030056 hemidesmosome(GO:0030056)
0.0 4.5 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.8 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0035838 growing cell tip(GO:0035838) new growing cell tip(GO:0035841)
0.0 0.1 GO:0097422 tubular endosome(GO:0097422)
0.0 2.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.3 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.9 GO:1904115 axon cytoplasm(GO:1904115)
0.0 1.0 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.4 GO:0005901 caveola(GO:0005901)
0.0 0.3 GO:0030137 COPI-coated vesicle(GO:0030137)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0002046 opsin binding(GO:0002046)
0.3 1.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.3 1.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.3 4.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 0.8 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 0.9 GO:0005499 vitamin D binding(GO:0005499)
0.1 0.5 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.1 0.3 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 1.2 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.9 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.8 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.1 0.4 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.1 0.2 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.4 GO:0042835 BRE binding(GO:0042835)
0.1 0.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.3 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.4 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.3 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.5 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 1.5 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.1 GO:0008506 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 1.0 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.0 0.4 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.2 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.6 GO:0008432 JUN kinase binding(GO:0008432)
0.0 8.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.1 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.0 0.2 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.3 GO:0019841 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 1.0 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0051373 FATZ binding(GO:0051373)
0.0 0.2 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.1 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 0.1 GO:0031208 POZ domain binding(GO:0031208)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.2 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.4 GO:0005504 fatty acid binding(GO:0005504)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.1 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.0 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 1.9 PID CONE PATHWAY Visual signal transduction: Cones
0.0 2.5 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.7 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.2 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.7 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.0 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.8 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.4 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 1.2 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 3.3 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.5 REACTOME OPSINS Genes involved in Opsins
0.0 0.4 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.4 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.3 REACTOME PEPTIDE HORMONE BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 0.9 REACTOME KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion