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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for PAX1_PAX9

Z-value: 0.45

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Transcription factors associated with PAX1_PAX9

Gene Symbol Gene ID Gene Info
PAX1
ENSG00000125813.14 PAX1
PAX9
ENSG00000198807.13 PAX9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX9hg38_v1_chr14_+_36657560_366575940.441.5e-02Click!
PAX1hg38_v1_chr20_+_21705651_217056730.077.2e-01Click!

Activity profile of PAX1_PAX9 motif

Sorted Z-values of PAX1_PAX9 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX1_PAX9

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_-_23404076 4.32 ENST00000524168.1
ENST00000389131.8
ENST00000523833.2
ENST00000519243.1
LOXL2
lysyl oxidase like 2
chr4_+_74365136 3.76 ENST00000244869.3
EREG
epiregulin
chr9_+_33750669 2.16 ENST00000361005.10
ENST00000342836.9
ENST00000429677.8
PRSS3
serine protease 3
chr7_+_142770960 1.37 ENST00000632805.1
ENST00000633969.1
ENST00000539842.6
PRSS2
serine protease 2
chr7_+_36389814 0.89 ENST00000396068.6
ANLN
anillin actin binding protein
chr19_-_40285395 0.85 ENST00000424901.5
ENST00000578123.5
AKT2
AKT serine/threonine kinase 2
chr7_+_36389852 0.82 ENST00000265748.7
ANLN
anillin actin binding protein
chr19_-_40285277 0.82 ENST00000579047.5
ENST00000392038.7
AKT2
AKT serine/threonine kinase 2
chr17_+_41812974 0.78 ENST00000321562.9
FKBP10
FKBP prolyl isomerase 10
chr6_-_137173644 0.56 ENST00000296980.7
ENST00000349184.8
ENST00000339602.3
IL22RA2
interleukin 22 receptor subunit alpha 2
chr4_+_122826824 0.54 ENST00000608478.1
ENST00000644866.2
FGF2
fibroblast growth factor 2
chr8_-_124372686 0.53 ENST00000297632.8
TMEM65
transmembrane protein 65
chr4_+_122826679 0.50 ENST00000264498.8
FGF2
fibroblast growth factor 2
chr16_-_85688912 0.40 ENST00000253462.8
GINS2
GINS complex subunit 2
chr17_-_41812586 0.33 ENST00000355468.7
ENST00000590496.1
P3H4
prolyl 3-hydroxylase family member 4 (inactive)
chr14_-_68794597 0.32 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein like 1
chr6_-_137045026 0.31 ENST00000367748.4
IL20RA
interleukin 20 receptor subunit alpha
chr17_-_35487831 0.29 ENST00000260908.12
ENSG00000205045.11
schlafen family member 12 like
chr3_-_57079287 0.27 ENST00000338458.8
ENST00000468727.5
ARHGEF3
Rho guanine nucleotide exchange factor 3
chr8_-_100953331 0.26 ENST00000353245.7
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr2_+_233251571 0.25 ENST00000347464.9
ENST00000444735.5
ENST00000373525.9
ENST00000392017.9
ENST00000419681.5
ATG16L1
autophagy related 16 like 1
chr10_-_43409160 0.25 ENST00000337970.7
ENST00000682386.1
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr2_+_233251694 0.24 ENST00000417017.5
ENST00000392020.8
ENST00000392018.1
ATG16L1
autophagy related 16 like 1
chr10_+_30434176 0.22 ENST00000263056.6
ENST00000375322.2
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr10_+_30434021 0.22 ENST00000542547.5
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr11_+_6926417 0.21 ENST00000610573.4
ENST00000278319.10
ZNF215
zinc finger protein 215
chr8_-_100952918 0.21 ENST00000395957.6
ENST00000395948.6
ENST00000457309.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr10_-_97633485 0.20 ENST00000370635.3
ENST00000478953.1
ENST00000307450.11
MORN4
MORN repeat containing 4
chr14_+_64388296 0.19 ENST00000554739.5
ENST00000554768.6
ENST00000652179.1
ENST00000652337.1
ENST00000557370.3
MTHFD1
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
chr11_+_6926490 0.19 ENST00000414517.6
ZNF215
zinc finger protein 215
chr4_-_170090153 0.19 ENST00000509167.5
ENST00000353187.6
ENST00000507375.5
ENST00000515480.5
AADAT
aminoadipate aminotransferase
chr17_-_7234262 0.18 ENST00000575756.5
ENST00000575458.5
DVL2
dishevelled segment polarity protein 2
chr7_-_144835981 0.18 ENST00000360057.7
ENST00000378099.7
ENST00000639328.1
TPK1
thiamin pyrophosphokinase 1
chr1_+_31413806 0.17 ENST00000536384.2
SERINC2
serine incorporator 2
chr17_+_39200302 0.16 ENST00000579374.5
RPL19
ribosomal protein L19
chr17_+_39200507 0.15 ENST00000678573.1
RPL19
ribosomal protein L19
chr17_+_39200334 0.15 ENST00000579260.5
ENST00000582193.5
RPL19
ribosomal protein L19
chr12_+_57434778 0.15 ENST00000309668.3
INHBC
inhibin subunit beta C
chr1_-_204196482 0.15 ENST00000367194.5
KISS1
KiSS-1 metastasis suppressor
chr17_+_39200275 0.14 ENST00000225430.9
RPL19
ribosomal protein L19
chr4_-_162163989 0.14 ENST00000306100.10
ENST00000427802.2
FSTL5
follistatin like 5
chrX_-_149540900 0.14 ENST00000608355.1
ENST00000651111.1
LINC00893
ENSG00000241489.8
long intergenic non-protein coding RNA 893
novel protein
chr4_-_162163955 0.13 ENST00000379164.8
FSTL5
follistatin like 5
chr1_+_26432299 0.13 ENST00000427245.6
ENST00000236342.12
ENST00000525682.6
ENST00000526219.5
ENST00000374185.7
ENST00000360009.6
ENST00000533087.5
ENST00000531312.5
ENST00000525165.5
ENST00000525326.5
ENST00000525546.5
ENST00000436153.6
ENST00000530781.5
DHDDS
dehydrodolichyl diphosphate synthase subunit
chr17_-_3557798 0.12 ENST00000301365.8
ENST00000572519.1
ENST00000576742.6
TRPV3
transient receptor potential cation channel subfamily V member 3
chr4_-_170089930 0.11 ENST00000337664.9
AADAT
aminoadipate aminotransferase
chr14_+_24070837 0.10 ENST00000537691.5
ENST00000397016.6
ENST00000560356.5
ENST00000558450.5
CPNE6
copine 6
chr16_-_3023932 0.10 ENST00000248089.8
ENST00000574151.5
HCFC1R1
host cell factor C1 regulator 1
chr9_-_101487120 0.09 ENST00000374848.8
PGAP4
post-GPI attachment to proteins GalNAc transferase 4
chr18_-_49492305 0.08 ENST00000615479.4
ENST00000583637.5
ENST00000618613.5
ENST00000615760.4
ENST00000578528.1
ENST00000578532.5
ENST00000580387.5
ENST00000579248.5
ENST00000580261.6
ENST00000581373.5
ENST00000618619.4
ENST00000617346.4
ENST00000583036.5
ENST00000332968.11
RPL17
RPL17-C18orf32
ribosomal protein L17
RPL17-C18orf32 readthrough
chr6_-_137044959 0.06 ENST00000468393.5
ENST00000367746.3
ENST00000316649.10
IL20RA
interleukin 20 receptor subunit alpha
chr1_+_26432803 0.06 ENST00000430232.5
DHDDS
dehydrodolichyl diphosphate synthase subunit
chr5_-_134411847 0.05 ENST00000458198.3
ENST00000395009.3
CDKN2AIPNL
CDKN2A interacting protein N-terminal like
chr12_+_131929219 0.05 ENST00000322060.9
PUS1
pseudouridine synthase 1
chr7_-_113118544 0.05 ENST00000397764.8
ENST00000441359.1
SMIM30
small integral membrane protein 30
chr17_+_78378633 0.04 ENST00000262764.11
ENST00000589689.5
ENST00000592043.5
ENST00000587356.1
PGS1
phosphatidylglycerophosphate synthase 1
chr6_-_170584654 0.04 ENST00000443345.2
ENST00000614056.4
PDCD2
programmed cell death 2
chr2_-_42493970 0.03 ENST00000394973.4
ENST00000306078.2
KCNG3
potassium voltage-gated channel modifier subfamily G member 3
chr1_-_1574824 0.00 ENST00000291386.4
SSU72
SSU72 homolog, RNA polymerase II CTD phosphatase
chr22_-_41544400 0.00 ENST00000337566.9
ENST00000355209.9
ENST00000396504.6
ENST00000407461.5
POLR3H
RNA polymerase III subunit H

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:1904172 regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172)
0.6 1.7 GO:0071484 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) retinal cell apoptotic process(GO:1990009)
0.5 3.8 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 1.0 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 4.3 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.1 0.3 GO:1904580 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
0.1 0.5 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.1 2.2 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.2 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.1 0.3 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.1 0.2 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.0 0.4 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.2 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.2 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.2 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.0 0.5 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.2 GO:1904222 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.1 GO:0042636 negative regulation of hair cycle(GO:0042636)
0.0 0.3 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 1.4 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.0 GO:0070902 mitochondrial tRNA pseudouridine synthesis(GO:0070902)
0.0 0.6 GO:0097421 liver regeneration(GO:0097421)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.4 GO:0000811 GINS complex(GO:0000811)
0.0 4.3 GO:0005604 basement membrane(GO:0005604)
0.0 2.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.5 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.6 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.4 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.2 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.1 3.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.2 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 0.3 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 1.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.8 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.4 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.2 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.0 GO:0004730 pseudouridylate synthase activity(GO:0004730)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.2 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.7 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 7.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 3.8 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 1.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 1.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.5 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.4 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones