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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for PAX7_NOBOX
Z-value: 0.46
Motif logo
Transcription factors associated with PAX7_NOBOX
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
PAX7
|
ENSG00000009709.12 | PAX7 |
|
NOBOX
|
ENSG00000106410.15 | NOBOX |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NOBOX | hg38_v1_chr7_-_144403693_144403693 | -0.35 | 5.8e-02 | Click! |
| PAX7 | hg38_v1_chr1_+_18631006_18631129, hg38_v1_chr1_+_18631513_18631529 | 0.12 | 5.4e-01 | Click! |
Activity profile of PAX7_NOBOX motif
Sorted Z-values of PAX7_NOBOX motif
Network of associatons between targets according to the STRING database.
First level regulatory network of PAX7_NOBOX
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.2 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
| 0.3 | 1.3 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.2 | 0.6 | GO:0034769 | basement membrane disassembly(GO:0034769) |
| 0.2 | 0.5 | GO:0014016 | neuroblast differentiation(GO:0014016) |
| 0.1 | 0.9 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731) |
| 0.1 | 0.3 | GO:0030505 | inorganic diphosphate transport(GO:0030505) |
| 0.1 | 0.5 | GO:0071393 | propionate metabolic process(GO:0019541) cellular response to progesterone stimulus(GO:0071393) tolerance induction to lipopolysaccharide(GO:0072573) |
| 0.1 | 0.3 | GO:0061346 | non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346) |
| 0.1 | 0.2 | GO:1904862 | inhibitory synapse assembly(GO:1904862) |
| 0.1 | 0.2 | GO:1901421 | positive regulation of response to alcohol(GO:1901421) |
| 0.1 | 0.2 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.1 | 0.2 | GO:0021524 | visceral motor neuron differentiation(GO:0021524) |
| 0.1 | 0.4 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
| 0.1 | 0.2 | GO:0031247 | actin rod assembly(GO:0031247) |
| 0.1 | 0.2 | GO:2000863 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 0.1 | 0.3 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
| 0.1 | 1.6 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.0 | 0.2 | GO:0032747 | positive regulation of interleukin-23 production(GO:0032747) |
| 0.0 | 0.2 | GO:0035022 | positive regulation of Rac protein signal transduction(GO:0035022) |
| 0.0 | 0.2 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 0.0 | 0.2 | GO:0099558 | maintenance of synapse structure(GO:0099558) |
| 0.0 | 0.1 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 0.0 | 0.2 | GO:0046092 | deoxycytidine metabolic process(GO:0046092) |
| 0.0 | 0.1 | GO:0002528 | regulation of vascular permeability involved in acute inflammatory response(GO:0002528) |
| 0.0 | 0.3 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.0 | 0.3 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.0 | 0.1 | GO:0046005 | positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005) |
| 0.0 | 0.3 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
| 0.0 | 0.1 | GO:0061358 | negative regulation of Wnt protein secretion(GO:0061358) |
| 0.0 | 0.1 | GO:1903719 | regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721) |
| 0.0 | 0.1 | GO:0035425 | autocrine signaling(GO:0035425) |
| 0.0 | 0.1 | GO:0060823 | canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823) |
| 0.0 | 0.2 | GO:0010746 | regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) |
| 0.0 | 0.1 | GO:1904247 | positive regulation of polynucleotide adenylyltransferase activity(GO:1904247) |
| 0.0 | 0.1 | GO:1904908 | negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908) |
| 0.0 | 0.1 | GO:0071140 | resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140) |
| 0.0 | 0.3 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.0 | 0.1 | GO:0090119 | vesicle-mediated cholesterol transport(GO:0090119) |
| 0.0 | 0.4 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.0 | 0.6 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.0 | 0.1 | GO:0006258 | UDP-glucose catabolic process(GO:0006258) |
| 0.0 | 0.6 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.0 | 0.1 | GO:0042427 | serotonin biosynthetic process(GO:0042427) |
| 0.0 | 0.4 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.0 | 0.2 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.0 | 0.1 | GO:0046338 | phosphatidylethanolamine catabolic process(GO:0046338) |
| 0.0 | 0.2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 0.0 | 0.1 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 0.0 | 0.1 | GO:1901536 | chromatin reprogramming in the zygote(GO:0044725) regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536) |
| 0.0 | 0.2 | GO:0090080 | positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080) |
| 0.0 | 0.1 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 0.0 | 0.2 | GO:0097577 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 0.0 | 0.2 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.0 | 0.0 | GO:1902725 | negative regulation of satellite cell differentiation(GO:1902725) |
| 0.0 | 0.1 | GO:0051037 | regulation of transcription involved in meiotic cell cycle(GO:0051037) |
| 0.0 | 0.1 | GO:0048840 | otolith development(GO:0048840) |
| 0.0 | 0.6 | GO:0071801 | regulation of podosome assembly(GO:0071801) |
| 0.0 | 0.1 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) |
| 0.0 | 0.3 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.0 | 0.6 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.0 | 0.1 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
| 0.0 | 0.2 | GO:0042355 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 0.0 | 0.1 | GO:1900369 | negative regulation of RNA interference(GO:1900369) |
| 0.0 | 0.7 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
| 0.0 | 0.5 | GO:0061157 | mRNA destabilization(GO:0061157) |
| 0.0 | 0.0 | GO:0015847 | putrescine transport(GO:0015847) |
| 0.0 | 0.1 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.0 | 0.1 | GO:0044111 | development involved in symbiotic interaction(GO:0044111) |
| 0.0 | 0.1 | GO:0018076 | N-terminal peptidyl-lysine acetylation(GO:0018076) |
| 0.0 | 0.0 | GO:0003218 | cardiac left ventricle formation(GO:0003218) |
| 0.0 | 0.1 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 0.0 | 0.2 | GO:0045176 | apical protein localization(GO:0045176) |
| 0.0 | 0.2 | GO:0045792 | negative regulation of cell size(GO:0045792) |
| 0.0 | 0.2 | GO:0006552 | leucine catabolic process(GO:0006552) |
| 0.0 | 0.0 | GO:0070105 | positive regulation of interleukin-6-mediated signaling pathway(GO:0070105) |
| 0.0 | 0.8 | GO:1900739 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.0 | 0.2 | GO:0021562 | vestibulocochlear nerve development(GO:0021562) |
| 0.0 | 0.0 | GO:0060369 | positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) |
| 0.0 | 0.1 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 0.0 | 0.1 | GO:0001507 | acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581) |
| 0.0 | 0.1 | GO:0036289 | peptidyl-serine autophosphorylation(GO:0036289) |
| 0.0 | 0.1 | GO:0002331 | pre-B cell allelic exclusion(GO:0002331) |
| 0.0 | 0.1 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
| 0.0 | 0.2 | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore(GO:0051315) |
| 0.0 | 0.3 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.0 | 0.2 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.0 | 0.5 | GO:0030220 | platelet formation(GO:0030220) |
| 0.0 | 0.1 | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) |
| 0.0 | 0.2 | GO:0046548 | retinal rod cell development(GO:0046548) |
| 0.0 | 0.2 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
| 0.0 | 0.2 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.0 | 0.6 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0097196 | Shu complex(GO:0097196) |
| 0.1 | 0.3 | GO:0060187 | cell pole(GO:0060187) |
| 0.1 | 0.3 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 0.1 | 0.6 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.1 | 0.3 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
| 0.1 | 0.8 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 0.2 | GO:0000818 | nuclear MIS12/MIND complex(GO:0000818) |
| 0.0 | 0.1 | GO:0043159 | cytoskeletal calyx(GO:0033150) acrosomal matrix(GO:0043159) |
| 0.0 | 0.2 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.0 | 0.3 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.0 | 0.6 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.0 | 0.2 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.0 | 0.1 | GO:0071942 | XPC complex(GO:0071942) |
| 0.0 | 0.1 | GO:0030849 | autosome(GO:0030849) |
| 0.0 | 0.1 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.0 | 0.2 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 0.0 | 0.2 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.0 | 0.1 | GO:1990876 | cytoplasmic side of nuclear pore(GO:1990876) |
| 0.0 | 0.4 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.1 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.0 | 0.2 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.0 | 0.0 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 0.0 | 0.1 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.0 | 0.1 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.0 | 0.3 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.2 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.0 | 0.1 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.0 | 0.1 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.0 | 0.1 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.0 | 0.1 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.0 | 1.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.0 | GO:0060342 | photoreceptor inner segment membrane(GO:0060342) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.3 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
| 0.3 | 1.2 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.1 | 0.5 | GO:0033265 | acetylcholinesterase activity(GO:0003990) choline binding(GO:0033265) |
| 0.1 | 0.3 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.1 | 0.7 | GO:0004301 | epoxide hydrolase activity(GO:0004301) |
| 0.1 | 0.6 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.1 | 0.9 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.1 | 0.3 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 0.1 | 0.2 | GO:0004566 | beta-glucuronidase activity(GO:0004566) |
| 0.1 | 0.6 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.0 | 0.4 | GO:0004321 | fatty-acyl-CoA synthase activity(GO:0004321) |
| 0.0 | 0.4 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.0 | 0.1 | GO:0016608 | growth hormone-releasing hormone activity(GO:0016608) |
| 0.0 | 0.1 | GO:0052794 | exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796) |
| 0.0 | 0.1 | GO:0004979 | beta-endorphin receptor activity(GO:0004979) morphine receptor activity(GO:0038047) |
| 0.0 | 0.2 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
| 0.0 | 0.2 | GO:0004797 | deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797) |
| 0.0 | 0.2 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) nucleotide phosphatase activity, acting on free nucleotides(GO:0098519) |
| 0.0 | 0.4 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 0.3 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.0 | 0.1 | GO:0005174 | CD40 receptor binding(GO:0005174) |
| 0.0 | 0.3 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.0 | 0.1 | GO:0047374 | methylumbelliferyl-acetate deacetylase activity(GO:0047374) |
| 0.0 | 0.1 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
| 0.0 | 0.1 | GO:0050309 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
| 0.0 | 0.1 | GO:0003860 | 3-hydroxyisobutyryl-CoA hydrolase activity(GO:0003860) |
| 0.0 | 0.1 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.0 | 0.5 | GO:0043495 | protein anchor(GO:0043495) |
| 0.0 | 0.1 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.0 | 0.3 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.0 | 0.0 | GO:0015203 | polyamine transmembrane transporter activity(GO:0015203) putrescine transmembrane transporter activity(GO:0015489) |
| 0.0 | 0.2 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.0 | 0.3 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.0 | 0.1 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.0 | 0.4 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.0 | 0.1 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.0 | 0.2 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.0 | 0.6 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.0 | 0.1 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.0 | 0.2 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 0.1 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.0 | 0.2 | GO:0008417 | fucosyltransferase activity(GO:0008417) |
| 0.0 | 0.1 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.0 | 0.1 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.0 | 0.2 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 0.1 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
| 0.0 | 0.1 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.0 | 0.1 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.0 | 0.3 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.0 | 0.1 | GO:0015266 | protein channel activity(GO:0015266) |
| 0.0 | 0.3 | GO:0035497 | cAMP response element binding(GO:0035497) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.5 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 0.6 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 0.6 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.6 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.9 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.4 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.0 | 0.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.3 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |