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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for PITX1
Z-value: 1.54
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Transcription factors associated with PITX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX1 | hg38_v1_chr5_-_135034212_135034294 | 0.64 | 1.3e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PITX1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_50984028 Show fit | 15.89 |
ENST00000597707.5
|
kallikrein related peptidase 7 |
|
| chr2_+_233195433 Show fit | 7.27 |
ENST00000417661.1
|
inositol polyphosphate-5-phosphatase D |
|
| chr1_-_153375591 Show fit | 6.77 |
ENST00000368737.5
|
S100 calcium binding protein A12 |
|
| chr6_+_151341680 Show fit | 6.31 |
ENST00000359755.5
|
A-kinase anchoring protein 12 |
|
| chr9_+_72577939 Show fit | 6.29 |
ENST00000645773.1
|
transmembrane channel like 1 |
|
| chr19_-_55141889 Show fit | 6.16 |
ENST00000593194.5
|
troponin T1, slow skeletal type |
|
| chr9_+_136952896 Show fit | 5.83 |
ENST00000371632.7
|
lipocalin 12 |
|
| chr19_-_15232399 Show fit | 4.73 |
ENST00000221730.8
|
epoxide hydrolase 3 |
|
| chr7_+_48088596 Show fit | 4.69 |
ENST00000416681.5
ENST00000331803.8 ENST00000432131.5 |
uridine phosphorylase 1 |
|
| chr19_-_15232943 Show fit | 4.58 |
ENST00000435261.5
ENST00000594042.1 |
epoxide hydrolase 3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 15.9 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803) |
| 1.1 | 14.7 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 1.4 | 11.3 | GO:0060005 | vestibular reflex(GO:0060005) |
| 1.0 | 8.7 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 2.1 | 8.4 | GO:0045659 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 0.1 | 8.0 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.2 | 7.2 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.7 | 6.3 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.5 | 6.3 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.3 | 5.5 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 16.7 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 1.3 | 14.7 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.0 | 14.2 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.6 | 11.0 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.4 | 8.8 | GO:0005861 | troponin complex(GO:0005861) |
| 0.3 | 7.8 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.8 | 6.8 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.0 | 6.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 6.0 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.0 | 6.0 | GO:0005884 | actin filament(GO:0005884) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 15.2 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.4 | 14.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 12.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.8 | 11.3 | GO:0022833 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 0.0 | 10.6 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 9.2 | GO:0002020 | protease binding(GO:0002020) |
| 0.6 | 8.7 | GO:0031014 | troponin T binding(GO:0031014) |
| 1.3 | 7.9 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.3 | 7.3 | GO:0050786 | RAGE receptor binding(GO:0050786) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 11.1 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.2 | 11.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 10.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 6.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 6.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 6.0 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 6.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.8 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 5.0 | PID ATR PATHWAY | ATR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 18.5 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 8.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 8.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 7.3 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 6.0 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 6.0 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.0 | 5.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 5.2 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.3 | 5.1 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.2 | 4.6 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |