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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for PITX2

Z-value: 0.37

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Transcription factors associated with PITX2

Gene Symbol Gene ID Gene Info
PITX2
ENSG00000164093.17 PITX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PITX2hg38_v1_chr4_-_110636963_110637042,
hg38_v1_chr4_-_110641920_110642123,
hg38_v1_chr4_-_110623051_110623085		-0.441.5e-02Click!

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_-_5227063 1.73 ENST00000335295.4
ENST00000485743.1
ENST00000647020.1
HBB
hemoglobin subunit beta
chr9_+_34458752 1.68 ENST00000614641.4
ENST00000242317.9
ENST00000437363.5
DNAI1
dynein axonemal intermediate chain 1
chr13_-_35855627 1.68 ENST00000379893.5
DCLK1
doublecortin like kinase 1
chr22_-_30471986 0.94 ENST00000401751.5
ENST00000402286.5
ENST00000403066.5
ENST00000215812.9
SEC14L3
SEC14 like lipid binding 3
chr13_-_35855758 0.70 ENST00000615680.4
DCLK1
doublecortin like kinase 1
chr6_-_111483700 0.64 ENST00000435970.5
ENST00000358835.7
REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit
chr10_-_60141004 0.57 ENST00000355288.6
ANK3
ankyrin 3
chr12_-_89656051 0.57 ENST00000261173.6
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
chr12_-_89656093 0.55 ENST00000359142.7
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
chr1_-_165445088 0.46 ENST00000359842.10
RXRG
retinoid X receptor gamma
chr14_+_75522427 0.44 ENST00000286639.8
BATF
basic leucine zipper ATF-like transcription factor
chr1_-_165445220 0.43 ENST00000619224.1
RXRG
retinoid X receptor gamma
chr22_-_17258235 0.41 ENST00000649310.1
ENST00000649746.1
ADA2
adenosine deaminase 2
chr5_+_38258373 0.36 ENST00000354891.7
EGFLAM
EGF like, fibronectin type III and laminin G domains
chr11_-_119346695 0.34 ENST00000619721.6
MFRP
membrane frizzled-related protein
chr7_-_128775793 0.34 ENST00000249389.3
OPN1SW
opsin 1, short wave sensitive
chr12_-_54981838 0.33 ENST00000316577.12
TESPA1
thymocyte expressed, positive selection associated 1
chr14_+_75522531 0.31 ENST00000555504.1
BATF
basic leucine zipper ATF-like transcription factor
chr11_-_133532493 0.31 ENST00000524381.6
OPCML
opioid binding protein/cell adhesion molecule like
chr1_+_202010575 0.29 ENST00000367283.7
ENST00000367284.10
ELF3
E74 like ETS transcription factor 3
chr16_-_11976611 0.28 ENST00000538896.5
ENST00000673243.1
NPIPB2
nuclear pore complex interacting protein family member B2
chr3_-_191282383 0.27 ENST00000427544.6
UTS2B
urotensin 2B
chr12_+_69739370 0.27 ENST00000550536.5
ENST00000362025.9
RAB3IP
RAB3A interacting protein
chr10_-_48274567 0.26 ENST00000636244.1
ENST00000374201.8
FRMPD2
FERM and PDZ domain containing 2
chr17_+_4740005 0.26 ENST00000269289.10
ZMYND15
zinc finger MYND-type containing 15
chr13_+_73058993 0.25 ENST00000377687.6
KLF5
Kruppel like factor 5
chr17_+_4740042 0.25 ENST00000592813.5
ZMYND15
zinc finger MYND-type containing 15
chr6_-_41705813 0.22 ENST00000419574.6
ENST00000445214.2
TFEB
transcription factor EB
chr11_+_61755372 0.20 ENST00000265460.9
MYRF
myelin regulatory factor
chrM_+_9207 0.20 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr11_-_96343170 0.20 ENST00000524717.6
MAML2
mastermind like transcriptional coactivator 2
chr1_+_21977014 0.15 ENST00000337107.11
CELA3B
chymotrypsin like elastase 3B
chr17_-_4739866 0.15 ENST00000574412.6
ENST00000293778.12
CXCL16
C-X-C motif chemokine ligand 16
chr8_+_48008409 0.15 ENST00000523432.5
ENST00000521346.5
ENST00000523111.7
ENST00000517630.5
UBE2V2
ubiquitin conjugating enzyme E2 V2
chr4_-_67754335 0.15 ENST00000420975.2
ENST00000226413.5
GNRHR
gonadotropin releasing hormone receptor
chr13_-_94479671 0.14 ENST00000377028.10
ENST00000446125.1
DCT
dopachrome tautomerase
chr19_+_2476118 0.14 ENST00000215631.9
ENST00000587345.1
GADD45B
growth arrest and DNA damage inducible beta
chr15_+_40929338 0.12 ENST00000249749.7
DLL4
delta like canonical Notch ligand 4
chr11_-_119346655 0.12 ENST00000360167.4
MFRP
membrane frizzled-related protein
chr3_+_154121366 0.11 ENST00000465093.6
ENST00000496710.5
ENST00000465817.1
ARHGEF26
Rho guanine nucleotide exchange factor 26
chr7_+_74453790 0.11 ENST00000265755.7
ENST00000424337.7
ENST00000455841.6
GTF2IRD1
GTF2I repeat domain containing 1
chr6_-_53148822 0.11 ENST00000259803.8
GCM1
glial cells missing transcription factor 1
chr1_-_30757767 0.11 ENST00000294507.4
LAPTM5
lysosomal protein transmembrane 5
chr5_-_150758497 0.10 ENST00000521533.1
ENST00000424236.5
DCTN4
dynactin subunit 4
chr16_-_67980483 0.10 ENST00000268793.6
ENST00000672962.1
DPEP3
dipeptidase 3
chr16_+_28711417 0.09 ENST00000395587.5
ENST00000569690.5
ENST00000331666.11
ENST00000564243.5
ENST00000566866.5
EIF3C
eukaryotic translation initiation factor 3 subunit C
chr7_+_30284574 0.06 ENST00000323037.5
ZNRF2
zinc and ring finger 2
chr21_-_33542841 0.06 ENST00000381831.7
ENST00000381839.7
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr10_+_17951906 0.04 ENST00000377371.3
ENST00000377369.7
SLC39A12
solute carrier family 39 member 12
chr9_-_14300231 0.03 ENST00000636735.1
NFIB
nuclear factor I B
chr10_+_17951885 0.02 ENST00000377374.8
SLC39A12
solute carrier family 39 member 12
chr10_+_17951825 0.02 ENST00000539911.5
SLC39A12
solute carrier family 39 member 12
chr19_-_41436439 0.01 ENST00000594660.5
DMAC2
distal membrane arm assembly complex 2
chrX_+_15749848 0.00 ENST00000479740.5
ENST00000454127.2
CA5B
carbonic anhydrase 5B

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0030185 nitric oxide transport(GO:0030185)
0.1 0.6 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 1.1 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.1 1.7 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.3 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 0.4 GO:0006154 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.0 2.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.8 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.2 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.1 GO:0060018 astrocyte fate commitment(GO:0060018)
0.0 0.1 GO:0061074 regulation of neural retina development(GO:0061074)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.2 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.3 GO:0060056 mammary gland involution(GO:0060056)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.6 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.9 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.1 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.1 GO:1902416 positive regulation of mRNA binding(GO:1902416)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 1.7 GO:0036157 outer dynein arm(GO:0036157)
0.1 0.6 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 1.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.3 GO:0097381 photoreceptor disc membrane(GO:0097381)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0030492 hemoglobin binding(GO:0030492)
0.2 0.9 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 1.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.4 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 1.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME OPSINS Genes involved in Opsins
0.0 0.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors