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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for PKNOX2

Z-value: 0.52

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Transcription factors associated with PKNOX2

Gene Symbol Gene ID Gene Info
PKNOX2
ENSG00000165495.16 PKNOX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PKNOX2hg38_v1_chr11_+_125164743_125164759-0.019.6e-01Click!

Activity profile of PKNOX2 motif

Sorted Z-values of PKNOX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr16_+_2830368 2.31 ENST00000572863.1
ZG16B
zymogen granule protein 16B
chr16_+_2830295 2.29 ENST00000571723.1
ZG16B
zymogen granule protein 16B
chr16_+_2830155 2.27 ENST00000382280.7
ZG16B
zymogen granule protein 16B
chr16_+_2830179 2.27 ENST00000570670.5
ZG16B
zymogen granule protein 16B
chr4_-_148444674 2.03 ENST00000344721.8
NR3C2
nuclear receptor subfamily 3 group C member 2
chr14_-_53954470 1.25 ENST00000417573.5
BMP4
bone morphogenetic protein 4
chr19_+_7669080 1.25 ENST00000629642.1
RETN
resistin
chr11_+_6390439 1.10 ENST00000530395.1
ENST00000342245.9
ENST00000527275.5
SMPD1
sphingomyelin phosphodiesterase 1
chr4_-_82561972 0.90 ENST00000454948.3
ENST00000449862.7
TMEM150C
transmembrane protein 150C
chr18_+_3449413 0.89 ENST00000549253.5
TGIF1
TGFB induced factor homeobox 1
chr7_+_17299234 0.83 ENST00000637807.1
ENSG00000283321.1
novel protein
chr7_-_137343688 0.74 ENST00000348225.7
PTN
pleiotrophin
chr17_+_70075215 0.68 ENST00000283936.5
ENST00000615244.4
ENST00000392671.6
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr17_+_70075317 0.67 ENST00000589377.1
KCNJ16
potassium inwardly rectifying channel subfamily J member 16
chr15_+_57376497 0.64 ENST00000281282.6
CGNL1
cingulin like 1
chr14_+_103121457 0.64 ENST00000333007.8
TNFAIP2
TNF alpha induced protein 2
chr16_+_50742059 0.63 ENST00000311559.13
ENST00000564326.5
ENST00000566206.5
ENST00000427738.8
CYLD
CYLD lysine 63 deubiquitinase
chr10_+_92848461 0.60 ENST00000443748.6
ENST00000371543.5
ENST00000260762.10
EXOC6
exocyst complex component 6
chr17_-_73092657 0.57 ENST00000580557.5
ENST00000579732.5
ENST00000578620.1
ENST00000542342.6
ENST00000255559.7
ENST00000579018.5
SLC39A11
solute carrier family 39 member 11
chr6_+_137867414 0.55 ENST00000237289.8
ENST00000433680.1
TNFAIP3
TNF alpha induced protein 3
chr7_-_137343752 0.50 ENST00000393083.2
PTN
pleiotrophin
chr18_-_56638427 0.49 ENST00000586262.5
ENST00000217515.11
TXNL1
thioredoxin like 1
chr4_+_3074661 0.48 ENST00000355072.11
HTT
huntingtin
chr6_-_109094819 0.48 ENST00000436639.6
SESN1
sestrin 1
chr1_+_110034607 0.44 ENST00000369795.8
STRIP1
striatin interacting protein 1
chr5_+_126423363 0.43 ENST00000285689.8
GRAMD2B
GRAM domain containing 2B
chr9_-_83817632 0.43 ENST00000376365.7
ENST00000376371.7
GKAP1
G kinase anchoring protein 1
chr5_+_126423122 0.42 ENST00000515200.5
GRAMD2B
GRAM domain containing 2B
chr5_+_126423176 0.39 ENST00000542322.5
ENST00000544396.5
GRAMD2B
GRAM domain containing 2B
chr5_-_139904460 0.39 ENST00000340391.8
NRG2
neuregulin 2
chr19_-_43639788 0.38 ENST00000222374.3
CADM4
cell adhesion molecule 4
chr1_+_100133135 0.38 ENST00000370143.5
ENST00000370141.7
TRMT13
tRNA methyltransferase 13 homolog
chr18_+_56651335 0.34 ENST00000589935.1
ENST00000254442.8
ENST00000357574.7
WDR7
WD repeat domain 7
chr19_-_5622768 0.34 ENST00000252542.9
SAFB2
scaffold attachment factor B2
chr15_+_68054308 0.33 ENST00000249636.11
PIAS1
protein inhibitor of activated STAT 1
chr6_+_137867241 0.32 ENST00000612899.5
ENST00000420009.5
TNFAIP3
TNF alpha induced protein 3
chr16_-_30445865 0.32 ENST00000478753.5
SEPHS2
selenophosphate synthetase 2
chr14_-_21024092 0.31 ENST00000554398.5
NDRG2
NDRG family member 2
chr6_-_87095059 0.31 ENST00000369582.6
ENST00000610310.3
ENST00000630630.2
ENST00000627148.3
ENST00000625577.1
CGA
glycoprotein hormones, alpha polypeptide
chr3_+_185363129 0.31 ENST00000265026.8
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr14_-_21023954 0.31 ENST00000554094.5
NDRG2
NDRG family member 2
chr1_+_170935526 0.30 ENST00000367758.7
ENST00000367759.9
MROH9
maestro heat like repeat family member 9
chr3_+_141262614 0.30 ENST00000504264.5
PXYLP1
2-phosphoxylose phosphatase 1
chr3_-_3179674 0.30 ENST00000424814.5
ENST00000450014.1
ENST00000231948.9
ENST00000432408.6
ENST00000639284.1
CRBN
cereblon
chr16_+_2537997 0.28 ENST00000441549.7
ENST00000268673.11
ENST00000342085.9
ENST00000389224.7
PDPK1
3-phosphoinositide dependent protein kinase 1
chr14_-_21526391 0.28 ENST00000611430.4
SALL2
spalt like transcription factor 2
chr2_-_74552616 0.28 ENST00000409249.5
LOXL3
lysyl oxidase like 3
chr18_+_56651385 0.27 ENST00000615645.4
WDR7
WD repeat domain 7
chr5_-_95284535 0.27 ENST00000515393.5
MCTP1
multiple C2 and transmembrane domain containing 1
chr8_+_56211686 0.27 ENST00000521831.5
ENST00000303759.3
ENST00000517636.5
ENST00000517933.5
ENST00000355315.8
ENST00000518801.5
ENST00000523975.5
ENST00000396723.9
ENST00000523061.5
ENST00000521524.5
CHCHD7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr15_+_33968484 0.26 ENST00000383263.7
CHRM5
cholinergic receptor muscarinic 5
chr6_-_116254063 0.24 ENST00000420283.3
TSPYL4
TSPY like 4
chr20_+_36573589 0.24 ENST00000373872.9
ENST00000650844.1
TGIF2
TGFB induced factor homeobox 2
chr21_-_32813679 0.24 ENST00000487113.1
ENST00000382373.4
C21orf62
chromosome 21 open reading frame 62
chr2_-_218659468 0.22 ENST00000450560.1
ENST00000449707.5
ENST00000440934.2
ZNF142
zinc finger protein 142
chr16_+_50742037 0.22 ENST00000569418.5
CYLD
CYLD lysine 63 deubiquitinase
chr16_+_50742110 0.21 ENST00000566679.6
ENST00000564634.5
ENST00000398568.6
CYLD
CYLD lysine 63 deubiquitinase
chr14_-_21526312 0.21 ENST00000537235.2
SALL2
spalt like transcription factor 2
chr5_+_119071358 0.21 ENST00000311085.8
DMXL1
Dmx like 1
chr5_+_119071050 0.21 ENST00000539542.6
DMXL1
Dmx like 1
chr19_+_40775511 0.21 ENST00000263369.4
ENST00000597140.5
MIA
MIA SH3 domain containing
chr12_+_59596010 0.21 ENST00000547379.6
ENST00000552432.5
SLC16A7
solute carrier family 16 member 7
chr19_+_40775154 0.20 ENST00000594436.5
ENST00000597784.5
MIA
MIA SH3 domain containing
chr2_-_218659592 0.20 ENST00000411696.7
ZNF142
zinc finger protein 142
chr6_-_149545994 0.20 ENST00000253329.3
PPIL4
peptidylprolyl isomerase like 4
chr22_-_31489528 0.18 ENST00000397525.5
EIF4ENIF1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr22_+_50508216 0.18 ENST00000420993.7
ENST00000395698.7
ENST00000395701.7
ENST00000523045.5
ENST00000299821.15
NCAPH2
non-SMC condensin II complex subunit H2
chr11_-_842508 0.18 ENST00000322028.5
POLR2L
RNA polymerase II, I and III subunit L
chr20_-_3084716 0.18 ENST00000380293.3
AVP
arginine vasopressin
chr15_-_61229297 0.18 ENST00000335670.11
RORA
RAR related orphan receptor A
chr3_-_15798184 0.18 ENST00000624145.3
ANKRD28
ankyrin repeat domain 28
chr18_+_3449817 0.18 ENST00000407501.6
TGIF1
TGFB induced factor homeobox 1
chr2_-_74553049 0.18 ENST00000409549.5
LOXL3
lysyl oxidase like 3
chr6_+_110874775 0.17 ENST00000675380.1
ENST00000368882.8
ENST00000368877.9
ENST00000368885.8
ENST00000672937.2
AMD1
adenosylmethionine decarboxylase 1
chr4_+_113116676 0.16 ENST00000671971.1
ENST00000672240.1
ENST00000673240.1
ENST00000673363.1
ANK2
ankyrin 2
chr1_-_179143044 0.16 ENST00000504405.5
ENST00000512653.5
ENST00000344730.7
ABL2
ABL proto-oncogene 2, non-receptor tyrosine kinase
chr1_-_156859087 0.16 ENST00000368195.4
INSRR
insulin receptor related receptor
chr18_+_9136757 0.16 ENST00000262126.9
ENST00000577992.1
ANKRD12
ankyrin repeat domain 12
chr17_-_37609361 0.16 ENST00000614941.4
ENST00000619541.4
ENST00000622045.4
ENST00000616179.4
ENST00000621136.4
ENST00000612223.5
ENST00000620424.1
SYNRG
synergin gamma
chr9_+_129835442 0.15 ENST00000372429.8
ENST00000315480.9
ENST00000358355.5
USP20
ubiquitin specific peptidase 20
chr7_-_100656384 0.15 ENST00000461605.1
ENST00000160382.10
ACTL6B
actin like 6B
chr16_+_29973847 0.15 ENST00000308893.9
TAOK2
TAO kinase 2
chr2_+_218659749 0.15 ENST00000439945.5
ENST00000431802.5
BCS1L
BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
chr2_+_218659656 0.15 ENST00000443791.5
ENST00000359273.8
ENST00000392111.7
ENST00000392109.5
ENST00000392110.6
ENST00000423377.5
ENST00000412366.5
BCS1L
BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
chr7_-_157010615 0.14 ENST00000252971.11
MNX1
motor neuron and pancreas homeobox 1
chr9_-_129835232 0.14 ENST00000372447.7
C9orf78
chromosome 9 open reading frame 78
chr1_+_154993581 0.14 ENST00000392487.1
LENEP
lens epithelial protein
chr11_-_72099212 0.14 ENST00000544594.5
LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr7_+_6637311 0.13 ENST00000382252.6
ZNF316
zinc finger protein 316
chr19_-_39245006 0.13 ENST00000413851.3
ENST00000613087.4
IFNL3
interferon lambda 3
chr20_+_36574535 0.13 ENST00000558530.1
ENST00000558028.5
ENST00000611732.4
ENST00000560025.1
TGIF2-RAB5IF
TGIF2
TGIF2-RAB5IF readthrough
TGFB induced factor homeobox 2
chr3_-_33440343 0.13 ENST00000283629.8
UBP1
upstream binding protein 1
chr17_+_4143168 0.12 ENST00000577075.6
ENST00000301391.8
ENST00000575251.5
CYB5D2
cytochrome b5 domain containing 2
chr9_+_95875671 0.12 ENST00000683991.1
ENST00000683350.1
ENST00000653738.2
ENST00000288985.12
ENST00000665077.3
ERCC6L2
ERCC excision repair 6 like 2
chr6_+_17600273 0.12 ENST00000259963.4
FAM8A1
family with sequence similarity 8 member A1
chr2_+_128091166 0.12 ENST00000259253.11
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr19_-_48044037 0.12 ENST00000293255.3
CABP5
calcium binding protein 5
chr16_+_71808439 0.11 ENST00000683775.1
ATXN1L
ataxin 1 like
chr19_+_35651245 0.11 ENST00000590618.1
COX6B1
cytochrome c oxidase subunit 6B1
chr2_+_232406836 0.11 ENST00000295453.8
ALPG
alkaline phosphatase, germ cell
chr4_-_156970903 0.10 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr12_+_113057687 0.10 ENST00000257600.3
DTX1
deltex E3 ubiquitin ligase 1
chr2_-_61538180 0.10 ENST00000677150.1
ENST00000678182.1
ENST00000677928.1
ENST00000406957.5
XPO1
exportin 1
chr2_-_61538290 0.10 ENST00000678790.1
XPO1
exportin 1
chr1_-_35193135 0.10 ENST00000357214.6
SFPQ
splicing factor proline and glutamine rich
chr3_-_15797930 0.10 ENST00000683139.1
ANKRD28
ankyrin repeat domain 28
chr19_-_45322867 0.10 ENST00000221476.4
CKM
creatine kinase, M-type
chr18_+_59139864 0.10 ENST00000509791.7
ENST00000587834.6
ENST00000588875.2
SEC11C
SEC11 homolog C, signal peptidase complex subunit
chr18_+_3450036 0.09 ENST00000546979.5
ENST00000343820.10
ENST00000551402.1
ENST00000577543.5
TGIF1
TGFB induced factor homeobox 1
chr19_+_7669043 0.09 ENST00000221515.6
RETN
resistin
chr17_-_4142963 0.09 ENST00000381638.7
ZZEF1
zinc finger ZZ-type and EF-hand domain containing 1
chr6_+_157036315 0.09 ENST00000637904.1
ARID1B
AT-rich interaction domain 1B
chr1_+_39081410 0.09 ENST00000602421.5
ENST00000361689.7
MACF1
microtubule actin crosslinking factor 1
chr16_+_19285724 0.09 ENST00000636231.2
ENST00000493231.5
ENST00000465414.1
CLEC19A
C-type lectin domain containing 19A
chr2_-_61538313 0.08 ENST00000677803.1
ENST00000677239.1
ENST00000401558.7
XPO1
exportin 1
chr6_+_37257762 0.08 ENST00000373491.3
TBC1D22B
TBC1 domain family member 22B
chr2_-_61538516 0.08 ENST00000676771.1
ENST00000677814.1
ENST00000443240.5
ENST00000677556.1
ENST00000676553.1
XPO1
exportin 1
chr17_-_42185452 0.08 ENST00000293330.1
HCRT
hypocretin neuropeptide precursor
chr8_-_98825628 0.08 ENST00000617590.1
ENST00000518165.5
ENST00000419617.7
STK3
serine/threonine kinase 3
chr5_-_128538218 0.07 ENST00000502468.5
FBN2
fibrillin 2
chr8_+_132775340 0.07 ENST00000622263.4
ENST00000220847.8
ENST00000395379.5
ENST00000395386.7
ENST00000485595.5
ENST00000337920.8
PHF20L1
PHD finger protein 20 like 1
chr14_+_35534157 0.07 ENST00000307169.4
INSM2
INSM transcriptional repressor 2
chr3_+_31532901 0.07 ENST00000295770.4
STT3B
STT3 oligosaccharyltransferase complex catalytic subunit B
chr11_-_59615673 0.06 ENST00000263847.6
OSBP
oxysterol binding protein
chr4_+_119135825 0.06 ENST00000307128.6
MYOZ2
myozenin 2
chr18_+_9913979 0.06 ENST00000400000.7
ENST00000340541.4
VAPA
VAMP associated protein A
chr9_-_33447553 0.05 ENST00000645858.1
ENST00000297991.6
AQP3
aquaporin 3 (Gill blood group)
chr19_-_6424802 0.05 ENST00000600480.2
KHSRP
KH-type splicing regulatory protein
chr3_-_127822455 0.05 ENST00000265052.10
MGLL
monoglyceride lipase
chr6_+_31706866 0.04 ENST00000375832.5
ENST00000503322.1
LY6G6F
LY6G6F-LY6G6D
lymphocyte antigen 6 family member G6F
LY6G6F-LY6G6D readthrough
chr16_-_53503192 0.04 ENST00000568596.5
ENST00000394657.12
ENST00000570004.5
ENST00000564497.1
ENST00000300245.8
AKTIP
AKT interacting protein
chr15_+_32717994 0.04 ENST00000560677.5
ENST00000560830.1
ENST00000651154.1
GREM1
gremlin 1, DAN family BMP antagonist
chr5_-_53109733 0.04 ENST00000510818.6
ENST00000396954.8
ENST00000450852.8
ENST00000508922.5
ENST00000361377.8
ENST00000582677.5
ENST00000584946.5
MOCS2
molybdenum cofactor synthesis 2
chr2_-_178807415 0.04 ENST00000342992.10
ENST00000460472.6
ENST00000589042.5
ENST00000591111.5
ENST00000360870.10
TTN
titin
chr2_-_43676406 0.04 ENST00000475092.4
C1GALT1C1L
C1GALT1 specific chaperone 1 like
chr1_+_33864071 0.03 ENST00000681531.1
HMGB4
high mobility group box 4
chr9_-_76692181 0.03 ENST00000376717.6
ENST00000223609.10
PRUNE2
prune homolog 2 with BCH domain
chr18_-_54959391 0.03 ENST00000591504.6
CCDC68
coiled-coil domain containing 68
chr3_-_127822835 0.03 ENST00000453507.6
MGLL
monoglyceride lipase
chrX_-_129654946 0.03 ENST00000429967.3
APLN
apelin
chr1_-_145885826 0.03 ENST00000544626.2
ENST00000355594.9
ANKRD35
ankyrin repeat domain 35
chr8_-_56211257 0.03 ENST00000316981.8
ENST00000423799.6
ENST00000429357.2
PLAG1
PLAG1 zinc finger
chr7_+_100589573 0.02 ENST00000468962.5
ENST00000427939.2
FBXO24
F-box protein 24
chr12_-_91004965 0.02 ENST00000261172.8
EPYC
epiphycan
chr17_+_80545422 0.02 ENST00000544334.6
RPTOR
regulatory associated protein of MTOR complex 1
chr6_-_83709019 0.02 ENST00000519779.5
ENST00000369694.6
ENST00000195649.10
SNAP91
synaptosome associated protein 91
chrX_+_16786421 0.02 ENST00000398155.4
ENST00000380122.10
TXLNG
taxilin gamma
chr11_-_101129806 0.02 ENST00000325455.10
ENST00000617858.4
ENST00000619228.2
PGR
progesterone receptor
chr13_-_27969295 0.01 ENST00000381020.8
CDX2
caudal type homeobox 2
chr16_+_88570387 0.01 ENST00000452588.6
ENST00000301011.10
ZC3H18
zinc finger CCCH-type containing 18
chr4_-_174829212 0.01 ENST00000340217.5
ENST00000274093.8
GLRA3
glycine receptor alpha 3
chr10_-_123008687 0.01 ENST00000617859.4
IKZF5
IKAROS family zinc finger 5
chr10_-_123008784 0.01 ENST00000368886.10
IKZF5
IKAROS family zinc finger 5
chr4_+_139301478 0.01 ENST00000296543.10
ENST00000398947.1
NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit
chr5_+_79689825 0.00 ENST00000446378.3
CMYA5
cardiomyopathy associated 5
chr1_+_161766282 0.00 ENST00000680688.1
ATF6
activating transcription factor 6
chr19_-_6424772 0.00 ENST00000619396.4
ENST00000398148.7
KHSRP
KH-type splicing regulatory protein
chr4_+_143184910 0.00 ENST00000510377.5
ENST00000307017.9
USP38
ubiquitin specific peptidase 38

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:2000004 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.4 1.2 GO:1904397 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.3 1.3 GO:2000196 positive regulation of female gonad development(GO:2000196)
0.3 0.9 GO:0034147 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429)
0.3 1.1 GO:1990108 protein linear deubiquitination(GO:1990108)
0.2 0.5 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.2 1.1 GO:0023021 termination of signal transduction(GO:0023021)
0.2 0.5 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 9.1 GO:0001895 retina homeostasis(GO:0001895)
0.1 0.3 GO:0016259 selenocysteine metabolic process(GO:0016259)
0.1 0.2 GO:0002125 maternal aggressive behavior(GO:0002125)
0.1 0.2 GO:0071469 cellular response to alkaline pH(GO:0071469)
0.0 0.6 GO:0051601 exocyst localization(GO:0051601)
0.0 0.6 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.4 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.3 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.0 0.2 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.4 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.2 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.5 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 1.3 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.3 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.1 GO:0032439 endosome localization(GO:0032439) regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
0.0 0.3 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.3 GO:0010909 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.2 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.3 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.4 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.6 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.2 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.0 0.1 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.2 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.4 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0097026 dendritic cell dendrite assembly(GO:0097026)
0.0 0.1 GO:0070295 renal water absorption(GO:0070295)
0.0 0.1 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.1 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0043291 RAVE complex(GO:0043291)
0.0 1.2 GO:0000145 exocyst(GO:0000145)
0.0 1.1 GO:0042599 lamellar body(GO:0042599)
0.0 0.5 GO:0061700 GATOR2 complex(GO:0061700)
0.0 2.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.3 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.4 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.5 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.3 GO:0035580 specific granule lumen(GO:0035580)
0.0 1.2 GO:0031594 neuromuscular junction(GO:0031594)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 1.9 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 1.3 GO:0070700 BMP receptor binding(GO:0070700)
0.1 1.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.5 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 1.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.5 GO:0070728 leucine binding(GO:0070728)
0.0 0.5 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0031893 vasopressin receptor binding(GO:0031893)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 1.0 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.5 GO:0005522 profilin binding(GO:0005522)
0.0 0.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 7.8 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.3 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.3 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.8 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.8 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.2 GO:0001055 RNA polymerase II activity(GO:0001055)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 1.1 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 1.2 PID BMP PATHWAY BMP receptor signaling
0.0 0.9 PID INSULIN PATHWAY Insulin Pathway
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 1.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.3 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.3 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.4 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters