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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for POU4F2

Z-value: 0.44

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Transcription factors associated with POU4F2

Gene Symbol Gene ID Gene Info
POU4F2
ENSG00000151615.3 POU4F2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU4F2hg38_v1_chr4_+_146638890_146638894-0.193.2e-01Click!

Activity profile of POU4F2 motif

Sorted Z-values of POU4F2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_-_89352395 1.10 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr12_-_89352487 1.04 ENST00000548755.1
ENST00000279488.8
DUSP6
dual specificity phosphatase 6
chr9_+_122371036 0.99 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
PTGS1
prostaglandin-endoperoxide synthase 1
chr4_-_47981535 0.80 ENST00000402813.9
CNGA1
cyclic nucleotide gated channel subunit alpha 1
chr9_+_122371014 0.76 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr5_+_155013755 0.74 ENST00000435029.6
KIF4B
kinesin family member 4B
chr11_-_107858777 0.73 ENST00000525815.6
SLC35F2
solute carrier family 35 member F2
chr21_-_30487436 0.72 ENST00000334055.5
KRTAP19-2
keratin associated protein 19-2
chr3_+_122055355 0.58 ENST00000330540.7
ENST00000469710.5
ENST00000493101.5
CD86
CD86 molecule
chr1_-_182672232 0.54 ENST00000508450.5
RGS8
regulator of G protein signaling 8
chr2_-_70553440 0.54 ENST00000450929.5
TGFA
transforming growth factor alpha
chr4_+_143433491 0.51 ENST00000512843.1
GAB1
GRB2 associated binding protein 1
chr18_+_31318144 0.46 ENST00000257192.5
DSG1
desmoglein 1
chr9_+_122370523 0.44 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr11_+_31650024 0.43 ENST00000638317.1
ELP4
elongator acetyltransferase complex subunit 4
chr14_+_54754821 0.41 ENST00000555192.1
SAMD4A
sterile alpha motif domain containing 4A
chr12_-_30735014 0.39 ENST00000433722.6
CAPRIN2
caprin family member 2
chr21_-_30492008 0.37 ENST00000334063.6
KRTAP19-3
keratin associated protein 19-3
chr8_-_48921419 0.36 ENST00000020945.4
SNAI2
snail family transcriptional repressor 2
chr2_+_190927649 0.36 ENST00000409428.5
ENST00000409215.5
GLS
glutaminase
chr14_+_94026314 0.32 ENST00000203664.10
ENST00000553723.1
OTUB2
OTU deubiquitinase, ubiquitin aldehyde binding 2
chr4_+_158521937 0.29 ENST00000343542.9
ENST00000470033.2
RXFP1
relaxin family peptide receptor 1
chr19_+_45498439 0.27 ENST00000451287.7
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)
chr13_+_45464901 0.27 ENST00000349995.10
COG3
component of oligomeric golgi complex 3
chr10_+_97584347 0.26 ENST00000370649.3
ENST00000370646.9
ENSG00000249967.1
HOGA1
novel protein
4-hydroxy-2-oxoglutarate aldolase 1
chr11_+_31509744 0.26 ENST00000639878.1
ENST00000379163.10
ENST00000638347.1
ENST00000350638.10
ENST00000638764.1
ENST00000639570.1
ENST00000640533.1
ENST00000638482.1
ENST00000640961.2
ENST00000640342.1
ENST00000640231.1
ENST00000640954.1
ENST00000395934.2
ELP4
elongator acetyltransferase complex subunit 4
chr13_-_35476682 0.26 ENST00000379919.6
MAB21L1
mab-21 like 1
chr17_-_66229380 0.26 ENST00000205948.11
APOH
apolipoprotein H
chr21_-_30813270 0.25 ENST00000329621.6
KRTAP8-1
keratin associated protein 8-1
chr5_-_141619049 0.25 ENST00000647433.1
ENST00000253811.10
ENST00000389057.9
ENST00000398557.8
DIAPH1
diaphanous related formin 1
chr3_+_63443076 0.23 ENST00000295894.9
SYNPR
synaptoporin
chr5_-_141618914 0.22 ENST00000518047.5
DIAPH1
diaphanous related formin 1
chr5_-_141618957 0.22 ENST00000389054.8
DIAPH1
diaphanous related formin 1
chr12_-_118359639 0.20 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAOK3
TAO kinase 3
chr8_+_22999535 0.20 ENST00000251822.7
RHOBTB2
Rho related BTB domain containing 2
chr4_+_140343443 0.20 ENST00000338517.8
ENST00000394203.7
ENST00000506322.5
SCOC
short coiled-coil protein
chr4_+_75556048 0.19 ENST00000616557.1
ENST00000435974.2
ENST00000311623.9
ODAPH
odontogenesis associated phosphoprotein
chr12_-_7444139 0.17 ENST00000416109.2
ENST00000313599.8
CD163L1
CD163 molecule like 1
chr14_+_31561376 0.17 ENST00000550649.5
ENST00000281081.12
NUBPL
nucleotide binding protein like
chr4_-_168480477 0.17 ENST00000514748.5
ENST00000512371.1
ENST00000505890.5
ENST00000682922.1
ENST00000511577.5
DDX60L
DExD/H-box 60 like
chr5_+_135579193 0.17 ENST00000646290.1
SLC25A48
solute carrier family 25 member 48
chr8_-_130386864 0.16 ENST00000521426.5
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr1_+_40040720 0.16 ENST00000414893.5
ENST00000372792.7
ENST00000372805.8
ENST00000414281.5
ENST00000420216.5
ENST00000372798.5
ENST00000340450.7
ENST00000435719.5
ENST00000427843.5
ENST00000417287.5
ENST00000424977.1
CAP1
cyclase associated actin cytoskeleton regulatory protein 1
chr7_-_25228485 0.16 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr6_-_138987640 0.16 ENST00000529597.5
ENST00000415951.6
ENST00000367663.8
ENST00000409812.6
REPS1
RALBP1 associated Eps domain containing 1
chr11_-_125680869 0.15 ENST00000527795.1
ACRV1
acrosomal vesicle protein 1
chr8_+_49911801 0.15 ENST00000643809.1
SNTG1
syntrophin gamma 1
chr6_-_138499487 0.14 ENST00000343505.9
NHSL1
NHS like 1
chr1_-_44017296 0.14 ENST00000357730.6
ENST00000360584.6
ENST00000528803.1
SLC6A9
solute carrier family 6 member 9
chr2_-_157444044 0.13 ENST00000264192.8
CYTIP
cytohesin 1 interacting protein
chr17_-_81656532 0.13 ENST00000331056.10
PDE6G
phosphodiesterase 6G
chr11_-_125680831 0.12 ENST00000315608.7
ENST00000530048.5
ENST00000533904.6
ACRV1
acrosomal vesicle protein 1
chr4_+_158521872 0.12 ENST00000307765.10
RXFP1
relaxin family peptide receptor 1
chr7_-_42152396 0.12 ENST00000642432.1
ENST00000647255.1
ENST00000677288.1
GLI3
GLI family zinc finger 3
chr4_+_168497066 0.12 ENST00000261509.10
PALLD
palladin, cytoskeletal associated protein
chr2_-_69643152 0.12 ENST00000606389.7
AAK1
AP2 associated kinase 1
chr3_-_58627567 0.11 ENST00000649301.1
FAM107A
family with sequence similarity 107 member A
chr4_+_158521714 0.11 ENST00000613319.4
ENST00000423548.5
ENST00000448688.6
RXFP1
relaxin family peptide receptor 1
chr5_+_67004618 0.11 ENST00000261569.11
ENST00000436277.5
MAST4
microtubule associated serine/threonine kinase family member 4
chr14_+_41608344 0.11 ENST00000554120.5
LRFN5
leucine rich repeat and fibronectin type III domain containing 5
chr11_+_72114840 0.11 ENST00000622388.4
FOLR3
folate receptor gamma
chr1_-_193059296 0.11 ENST00000367450.7
ENST00000367451.8
ENST00000367454.6
ENST00000367448.5
ENST00000367449.5
UCHL5
ubiquitin C-terminal hydrolase L5
chr4_+_168497044 0.11 ENST00000505667.6
PALLD
palladin, cytoskeletal associated protein
chr2_+_210477676 0.11 ENST00000673510.1
ENST00000673630.1
ENST00000430249.7
CPS1
carbamoyl-phosphate synthase 1
chr17_-_41424583 0.10 ENST00000225550.4
KRT37
keratin 37
chr10_+_18260715 0.10 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr1_-_182671853 0.10 ENST00000367556.5
RGS8
regulator of G protein signaling 8
chr1_-_182671902 0.10 ENST00000483095.6
RGS8
regulator of G protein signaling 8
chr6_+_12717660 0.10 ENST00000674637.1
PHACTR1
phosphatase and actin regulator 1
chr7_-_81770122 0.10 ENST00000423064.7
HGF
hepatocyte growth factor
chr14_+_21887848 0.09 ENST00000390437.2
TRAV12-2
T cell receptor alpha variable 12-2
chr11_+_73787853 0.09 ENST00000310614.12
ENST00000497094.6
ENST00000411840.6
ENST00000535277.5
ENST00000398483.7
ENST00000542303.5
MRPL48
mitochondrial ribosomal protein L48
chr2_+_210477708 0.09 ENST00000673711.1
CPS1
carbamoyl-phosphate synthase 1
chr12_+_53954870 0.08 ENST00000243103.4
HOXC12
homeobox C12
chr6_+_118548289 0.08 ENST00000357525.6
PLN
phospholamban
chr1_-_193059489 0.08 ENST00000367455.8
ENST00000421683.1
UCHL5
ubiquitin C-terminal hydrolase L5
chrX_+_30235894 0.08 ENST00000620842.1
MAGEB3
MAGE family member B3
chrX_-_134797134 0.07 ENST00000370790.5
ENST00000493333.5
ENST00000611027.2
ENST00000343004.10
ENST00000298090.10
PABIR2
PABIR family member 2
chr1_+_50108856 0.07 ENST00000650764.1
ENST00000494555.2
ENST00000371824.7
ENST00000371823.8
ENST00000652693.1
ELAVL4
ELAV like RNA binding protein 4
chr14_-_50561119 0.07 ENST00000555216.5
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chrX_-_106903331 0.07 ENST00000411805.1
ENST00000276173.5
RIPPLY1
ripply transcriptional repressor 1
chr7_-_81770039 0.06 ENST00000222390.11
ENST00000453411.6
ENST00000457544.7
ENST00000444829.7
HGF
hepatocyte growth factor
chr3_-_9249623 0.06 ENST00000383836.8
SRGAP3
SLIT-ROBO Rho GTPase activating protein 3
chr20_+_57561103 0.06 ENST00000319441.6
PCK1
phosphoenolpyruvate carboxykinase 1
chr8_-_7486400 0.06 ENST00000335479.2
DEFB106B
defensin beta 106B
chr8_-_18684093 0.06 ENST00000428502.6
PSD3
pleckstrin and Sec7 domain containing 3
chr12_+_53454764 0.06 ENST00000439930.7
ENST00000548933.5
PCBP2
poly(rC) binding protein 2
chr8_+_49911604 0.05 ENST00000642164.1
ENST00000644093.1
ENST00000643999.1
ENST00000647073.1
ENST00000646880.1
SNTG1
syntrophin gamma 1
chr14_-_70416973 0.05 ENST00000555276.5
ENST00000617124.4
COX16
SYNJ2BP-COX16
cytochrome c oxidase assembly factor COX16
SYNJ2BP-COX16 readthrough
chrX_+_103585478 0.05 ENST00000468024.5
ENST00000415568.2
ENST00000472484.6
ENST00000613326.4
ENST00000490644.5
ENST00000459722.1
ENST00000472745.1
ENST00000494801.5
ENST00000434216.2
TCEAL4
transcription elongation factor A like 4
chr8_-_18684033 0.05 ENST00000614430.3
PSD3
pleckstrin and Sec7 domain containing 3
chr8_+_7825137 0.04 ENST00000335186.3
DEFB106A
defensin beta 106A
chr12_+_53454819 0.04 ENST00000562264.5
PCBP2
poly(rC) binding protein 2
chr10_-_97445850 0.04 ENST00000477692.6
ENST00000485122.6
ENST00000370886.9
ENST00000370885.8
ENST00000370902.8
ENST00000370884.5
EXOSC1
exosome component 1
chr8_-_18683932 0.04 ENST00000615573.4
PSD3
pleckstrin and Sec7 domain containing 3
chr1_+_193059448 0.04 ENST00000432079.5
RO60
Ro60, Y RNA binding protein
chr7_-_42152444 0.04 ENST00000479210.1
GLI3
GLI family zinc finger 3
chr17_-_41467386 0.04 ENST00000225899.4
KRT32
keratin 32
chr11_+_118304721 0.03 ENST00000361763.9
CD3E
CD3e molecule
chr6_+_130018565 0.03 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr6_-_25874212 0.03 ENST00000361703.10
ENST00000397060.8
SLC17A3
solute carrier family 17 member 3
chr1_+_193059587 0.03 ENST00000400968.7
ENST00000415442.2
ENST00000506303.1
RO60
Ro60, Y RNA binding protein
chr10_+_97446194 0.02 ENST00000370846.8
ENST00000352634.8
ENST00000353979.7
ENST00000370842.6
ENST00000345745.9
ZDHHC16
zinc finger DHHC-type palmitoyltransferase 16
chrX_-_18672101 0.02 ENST00000379984.4
RS1
retinoschisin 1
chr10_+_97446137 0.02 ENST00000370854.7
ENST00000393760.6
ENST00000414567.5
ZDHHC16
zinc finger DHHC-type palmitoyltransferase 16
chr10_+_97584314 0.01 ENST00000370647.8
HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr10_+_93612532 0.01 ENST00000371447.4
PDE6C
phosphodiesterase 6C
chr6_+_10521337 0.01 ENST00000495262.7
GCNT2
glucosaminyl (N-acetyl) transferase 2 (I blood group)
chr16_-_20404731 0.01 ENST00000302451.9
PDILT
protein disulfide isomerase like, testis expressed

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 0.6 GO:0002668 negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
0.1 0.4 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.1 2.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.3 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.1 0.2 GO:1903718 carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718)
0.1 0.4 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 0.2 GO:0022018 subpallium cell proliferation in forebrain(GO:0022012) lateral ganglionic eminence cell proliferation(GO:0022018) lambdoid suture morphogenesis(GO:0060366) sagittal suture morphogenesis(GO:0060367) anterior semicircular canal development(GO:0060873) lateral semicircular canal development(GO:0060875)
0.0 0.7 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.1 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.7 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.7 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.2 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.5 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.1 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092) regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.0 0.3 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.9 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.2 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.2 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.3 GO:0051918 negative regulation of smooth muscle cell apoptotic process(GO:0034392) negative regulation of fibrinolysis(GO:0051918)
0.0 0.1 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.0 0.1 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.5 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.2 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.2 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.2 GO:0003334 keratinocyte development(GO:0003334)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.8 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 2.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.7 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.2 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.5 GO:0030057 desmosome(GO:0030057)
0.0 0.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.0 GO:1990742 microvesicle(GO:1990742)
0.0 0.7 GO:0045171 intercellular bridge(GO:0045171)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 2.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.8 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 0.4 GO:0004359 glutaminase activity(GO:0004359)
0.1 0.7 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.2 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.3 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.3 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.5 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.0 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.9 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.6 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.9 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.6 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 2.2 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.7 REACTOME KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.5 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)