ISMARA results: POU5F1

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for POU5F1_POU2F3

Z-value: 0.83

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Transcription factors associated with POU5F1_POU2F3

Gene Symbol	Gene ID	Gene Info
POU5F1 Ensembl NCBI GeneCards UniProt	ENSG00000204531.20	POU5F1
POU2F3 Ensembl NCBI GeneCards UniProt	ENSG00000137709.10	POU2F3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
POU5F1	hg38_v1_chr6_-_31170620_31170698	0.45	1.4e-02	Click!
POU2F3	hg38_v1_chr11_+_120236635_120236642, hg38_v1_chr11_+_120240135_120240199	-0.04	8.2e-01	Click!

Activity profile of POU5F1_POU2F3 motif

Sorted Z-values of POU5F1_POU2F3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of POU5F1_POU2F3

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Promoter	Score	Transcript	Gene	Gene Info
chr14_+_79279403 Show fit	1.77	ENST00000281127.11	NRXN3 Ensembl NCBI GeneCards UniProt Show fit	neurexin 3
chr2_+_10721649 Show fit	1.47	ENST00000381661.3	ATP6V1C2 Ensembl NCBI GeneCards UniProt Show fit	ATPase H+ transporting V1 subunit C2
chr2_+_10721623 Show fit	1.46	ENST00000272238.9	ATP6V1C2 Ensembl NCBI GeneCards UniProt Show fit	ATPase H+ transporting V1 subunit C2
chr2_-_89245596 Show fit	1.37	ENST00000468494.1	IGKV2-30 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 2-30
chr2_+_89936859 Show fit	1.35	ENST00000474213.1	IGKV2D-30 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 2D-30
chr8_+_84705920 Show fit	1.25	ENST00000523850.5 ENST00000521376.1	RALYL Ensembl NCBI GeneCards UniProt Show fit	RALY RNA binding protein like
chr12_-_91180365 Show fit	1.17	ENST00000547937.5	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr19_+_52369911 Show fit	1.09	ENST00000424032.6 ENST00000422689.3 ENST00000600321.5 ENST00000344085.9 ENST00000597976.5	ZNF880 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 880
chr8_+_39902275 Show fit	1.07	ENST00000518804.5 ENST00000519154.5 ENST00000522495.5 ENST00000522840.1	IDO1 Ensembl NCBI GeneCards UniProt Show fit	indoleamine 2,3-dioxygenase 1
chr6_+_26124161 Show fit	0.91	ENST00000377791.4 ENST00000602637.1	H2AC6 Ensembl NCBI GeneCards UniProt Show fit	H2A clustered histone 6

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.4	GO:0006958	complement activation, classical pathway(GO:0006958)
0.0	5.3	GO:0002377	immunoglobulin production(GO:0002377)
0.1	3.6	GO:0090129	positive regulation of synapse maturation(GO:0090129)
0.2	3.4	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1	2.9	GO:0015991	ATP hydrolysis coupled proton transport(GO:0015991)
0.0	1.5	GO:0018149	peptide cross-linking(GO:0018149)
0.4	1.4	GO:0036269	swimming behavior(GO:0036269)
0.1	1.2	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	1.2	GO:0051973	positive regulation of telomerase activity(GO:0051973)
0.1	1.1	GO:0055095	lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)

Showing 1 to 10 of 226 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.2	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	3.2	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.5	2.9	GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0	1.9	GO:0072562	blood microparticle(GO:0072562)
0.0	1.4	GO:0005771	multivesicular body(GO:0005771)
0.0	1.3	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.0	1.2	GO:0001533	cornified envelope(GO:0001533)
0.2	1.1	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.0	0.9	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.7	GO:0043198	dendritic shaft(GO:0043198)

Showing 1 to 10 of 53 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	14.5	GO:0003823	antigen binding(GO:0003823)
0.1	3.6	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	3.4	GO:0050840	extracellular matrix binding(GO:0050840)
0.3	2.9	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1	1.6	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.4	1.1	GO:0033754	indoleamine 2,3-dioxygenase activity(GO:0033754)
0.1	0.8	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.8	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.8	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.8	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)

Showing 1 to 10 of 125 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	1.4	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	0.9	NABA COLLAGENS	Genes encoding collagen proteins
0.0	0.8	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.7	PID IGF1 PATHWAY	IGF1 pathway
0.0	0.6	PID RAS PATHWAY	Regulation of Ras family activation
0.0	0.3	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	0.3	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.2	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.2	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	2.9	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.1	1.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.7	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.0	0.6	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.6	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.5	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	0.5	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.4	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases

Showing 1 to 10 of 26 entries

Results for POU5F1_POU2F3

Z-value: 0.83

Motif logo

Transcription factors associated with POU5F1_POU2F3

Activity-expression correlation:

Activity profile of POU5F1_POU2F3 motif

Sorted Z-values of POU5F1_POU2F3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of POU5F1_POU2F3

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: