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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for PRDM14

Z-value: 0.33

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Transcription factors associated with PRDM14

Gene Symbol Gene ID Gene Info
PRDM14
ENSG00000147596.4 PRDM14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM14hg38_v1_chr8_-_70071226_700712580.154.3e-01Click!

Activity profile of PRDM14 motif

Sorted Z-values of PRDM14 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM14

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_153094521 1.10 ENST00000368750.8
SPRR2E
small proline rich protein 2E
chr1_-_153113507 0.82 ENST00000468739.2
SPRR2F
small proline rich protein 2F
chr22_+_31093358 0.64 ENST00000404574.5
SMTN
smoothelin
chr1_-_113887375 0.40 ENST00000471267.1
ENST00000393320.3
BCL2L15
BCL2 like 15
chr4_-_102345469 0.33 ENST00000356736.5
ENST00000682932.1
SLC39A8
solute carrier family 39 member 8
chr1_+_155033824 0.28 ENST00000295542.6
ENST00000423025.6
ENST00000368419.2
DCST1
DC-STAMP domain containing 1
chr13_+_108629605 0.28 ENST00000457511.7
MYO16
myosin XVI
chr12_+_55932028 0.28 ENST00000394147.5
ENST00000551156.5
ENST00000553783.5
ENST00000557080.5
ENST00000432422.7
ENST00000556001.5
DGKA
diacylglycerol kinase alpha
chr2_-_68871382 0.27 ENST00000295379.2
BMP10
bone morphogenetic protein 10
chr7_-_30026617 0.25 ENST00000222803.10
FKBP14
FKBP prolyl isomerase 14
chr19_-_50513870 0.24 ENST00000389208.9
ASPDH
aspartate dehydrogenase domain containing
chr1_-_155033778 0.24 ENST00000368424.4
DCST2
DC-STAMP domain containing 2
chr4_-_10457385 0.22 ENST00000507515.1
ENST00000326756.4
ZNF518B
zinc finger protein 518B
chr1_-_6261053 0.22 ENST00000377893.3
GPR153
G protein-coupled receptor 153
chr1_+_21570303 0.20 ENST00000374830.2
ALPL
alkaline phosphatase, biomineralization associated
chr1_+_145927105 0.20 ENST00000437797.5
ENST00000601726.3
ENST00000599626.5
ENST00000599147.5
ENST00000595494.5
ENST00000595518.5
ENST00000597144.5
ENST00000599469.5
ENST00000598354.5
ENST00000598103.5
ENST00000600340.5
ENST00000630257.2
ENST00000625258.1
LIX1L-AS1
ENSG00000280778.1
LIX1L antisense RNA 1
novel protein, lncRNA-POLR3GL readthrough
chr17_-_48615261 0.19 ENST00000239144.5
HOXB8
homeobox B8
chr1_-_41918858 0.17 ENST00000372583.6
HIVEP3
HIVEP zinc finger 3
chr1_-_41918666 0.16 ENST00000372584.5
HIVEP3
HIVEP zinc finger 3
chr5_-_168883333 0.16 ENST00000404867.7
SLIT3
slit guidance ligand 3
chr17_-_17582417 0.16 ENST00000395783.5
PEMT
phosphatidylethanolamine N-methyltransferase
chr12_+_54008961 0.15 ENST00000040584.6
HOXC8
homeobox C8
chr17_-_48614628 0.14 ENST00000576562.1
HOXB8
homeobox B8
chrX_+_120158600 0.14 ENST00000371388.5
RHOXF2
Rhox homeobox family member 2
chr1_+_36155930 0.13 ENST00000316156.8
MAP7D1
MAP7 domain containing 1
chrX_-_120077690 0.13 ENST00000371402.5
RHOXF2B
Rhox homeobox family member 2B
chr5_+_32710630 0.13 ENST00000326958.5
NPR3
natriuretic peptide receptor 3
chr19_+_3572777 0.12 ENST00000416526.5
HMG20B
high mobility group 20B
chr2_-_191847068 0.12 ENST00000304141.5
CAVIN2
caveolae associated protein 2
chr5_+_32711313 0.11 ENST00000265074.13
NPR3
natriuretic peptide receptor 3
chr11_+_62707668 0.11 ENST00000294117.6
GNG3
G protein subunit gamma 3
chr11_-_65857543 0.10 ENST00000534784.1
CFL1
cofilin 1
chr5_-_16936231 0.10 ENST00000507288.1
ENST00000274203.13
ENST00000513610.6
MYO10
myosin X
chr17_+_43847142 0.10 ENST00000377203.8
ENST00000539718.5
ENST00000588884.1
ENST00000293396.12
ENST00000586233.5
CD300LG
CD300 molecule like family member g
chr18_+_59899988 0.10 ENST00000316660.7
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr12_-_48957445 0.09 ENST00000541959.5
ENST00000447318.6
ENST00000256682.9
ARF3
ADP ribosylation factor 3
chr12_-_48957365 0.09 ENST00000398092.4
ENST00000539611.1
ENSG00000272822.2
ARF3
novel protein
ADP ribosylation factor 3
chr12_+_64497968 0.08 ENST00000676593.1
ENST00000677093.1
TBK1
ENSG00000288665.1
TANK binding kinase 1
novel transcript
chr15_+_74788542 0.08 ENST00000567571.5
CSK
C-terminal Src kinase
chr11_-_65856944 0.08 ENST00000524553.5
CFL1
cofilin 1
chr1_-_33182030 0.08 ENST00000291416.10
TRIM62
tripartite motif containing 62
chr10_+_12129637 0.08 ENST00000379051.5
ENST00000379033.7
ENST00000441368.5
ENST00000298428.14
ENST00000304267.12
ENST00000379020.8
ENST00000379017.7
SEC61A2
SEC61 translocon subunit alpha 2
chr11_-_65857007 0.08 ENST00000527344.5
CFL1
cofilin 1
chr1_+_93079234 0.07 ENST00000540243.5
ENST00000545708.5
MTF2
metal response element binding transcription factor 2
chr20_-_50153637 0.07 ENST00000341698.2
ENST00000371652.9
ENST00000371650.9
PEDS1-UBE2V1
PEDS1
PEDS1-UBE2V1 readthrough
plasmanylethanolamine desaturase 1
chr6_+_31946086 0.07 ENST00000425368.7
CFB
complement factor B
chr19_+_42284483 0.07 ENST00000575354.6
CIC
capicua transcriptional repressor
chr4_+_80266639 0.07 ENST00000456523.3
ENST00000312465.12
FGF5
fibroblast growth factor 5
chr1_+_93079264 0.07 ENST00000370298.9
ENST00000370303.4
MTF2
metal response element binding transcription factor 2
chr15_+_45402324 0.06 ENST00000305560.11
SPATA5L1
spermatogenesis associated 5 like 1
chr11_+_85855377 0.06 ENST00000342404.8
CCDC83
coiled-coil domain containing 83
chr17_+_77453993 0.06 ENST00000592951.5
SEPTIN9
septin 9
chr10_+_88664439 0.06 ENST00000394375.7
ENST00000608620.5
ENST00000238983.9
ENST00000355843.2
LIPF
lipase F, gastric type
chr19_+_38619082 0.06 ENST00000614624.4
ENST00000593149.5
ENST00000538434.5
ENST00000588934.5
ENST00000248342.9
ENST00000545173.6
ENST00000591409.5
ENST00000592558.1
EIF3K
eukaryotic translation initiation factor 3 subunit K
chr3_-_71132099 0.06 ENST00000650188.1
ENST00000648121.1
ENST00000648794.1
ENST00000649592.1
FOXP1
forkhead box P1
chr7_-_124765753 0.06 ENST00000303921.3
GPR37
G protein-coupled receptor 37
chr7_+_150514851 0.05 ENST00000313543.5
GIMAP7
GTPase, IMAP family member 7
chrX_+_41334154 0.05 ENST00000441189.4
ENST00000644513.1
ENST00000644109.1
ENST00000646122.1
ENST00000644074.1
ENST00000644876.2
ENST00000399959.7
ENST00000646319.1
DDX3X
DEAD-box helicase 3 X-linked
chr17_+_41837817 0.05 ENST00000438813.1
ENST00000293303.5
KLHL10
kelch like family member 10
chr9_+_97633811 0.04 ENST00000375147.8
NCBP1
nuclear cap binding protein subunit 1
chr1_+_23959109 0.04 ENST00000471915.5
PNRC2
proline rich nuclear receptor coactivator 2
chr3_-_143848442 0.04 ENST00000474151.1
ENST00000316549.11
SLC9A9
solute carrier family 9 member A9
chr1_-_26890237 0.04 ENST00000431781.2
ENST00000374135.9
GPN2
GPN-loop GTPase 2
chr6_-_46080332 0.03 ENST00000185206.12
CLIC5
chloride intracellular channel 5
chr3_+_36993798 0.03 ENST00000455445.6
ENST00000539477.6
ENST00000435176.5
ENST00000429117.5
ENST00000441265.6
MLH1
mutL homolog 1
chr3_-_155676363 0.03 ENST00000494598.5
PLCH1
phospholipase C eta 1
chr3_+_36993764 0.03 ENST00000674019.1
ENST00000458205.6
MLH1
mutL homolog 1
chr1_+_27342014 0.03 ENST00000618673.4
ENST00000318074.9
ENST00000616558.5
SYTL1
synaptotagmin like 1
chr5_-_160685379 0.03 ENST00000642502.1
ATP10B
ATPase phospholipid transporting 10B (putative)
chr1_-_167914089 0.03 ENST00000476818.2
ENST00000367848.1
ENST00000367851.9
ENST00000545172.5
ADCY10
adenylate cyclase 10
chr12_-_52573816 0.03 ENST00000549343.5
ENST00000305620.3
KRT74
keratin 74
chr3_-_47475811 0.03 ENST00000265565.10
ENST00000428413.5
SCAP
SREBF chaperone
chr1_+_50105666 0.03 ENST00000651347.1
ELAVL4
ELAV like RNA binding protein 4
chr19_-_48810900 0.02 ENST00000597011.5
ENST00000601681.5
BCAT2
branched chain amino acid transaminase 2
chr16_-_67483541 0.02 ENST00000290953.3
AGRP
agouti related neuropeptide
chr19_-_48811012 0.02 ENST00000545387.6
ENST00000402551.5
ENST00000598162.5
ENST00000316273.11
ENST00000599246.5
BCAT2
branched chain amino acid transaminase 2
chr17_-_19748341 0.02 ENST00000395555.7
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr11_-_46593948 0.02 ENST00000533727.5
ENST00000534300.5
ENST00000683756.1
ENST00000528950.1
ENST00000526606.1
AMBRA1
autophagy and beclin 1 regulator 1
chr17_-_19748285 0.02 ENST00000570414.1
ENST00000225740.11
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr17_-_19748355 0.02 ENST00000494157.6
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr2_-_144520315 0.01 ENST00000465070.5
ENST00000465308.5
ENST00000636471.1
ENST00000629520.2
ENST00000675069.1
ENST00000636026.2
ENST00000444559.5
ZEB2
zinc finger E-box binding homeobox 2
chr9_+_84668485 0.01 ENST00000359847.4
ENST00000395882.6
ENST00000376208.6
ENST00000376213.6
NTRK2
neurotrophic receptor tyrosine kinase 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0019364 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.1 0.2 GO:0071529 cementum mineralization(GO:0071529)
0.0 0.3 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.3 GO:2000814 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.3 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 1.9 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.2 GO:0061364 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834) apoptotic process involved in luteolysis(GO:0061364)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686) positive regulation of lipoprotein metabolic process(GO:0050747)
0.0 0.1 GO:0044565 dendritic cell proliferation(GO:0044565)
0.0 0.1 GO:0051311 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.0 0.2 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.3 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.0 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.0 0.0 GO:0090598 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.0 GO:0006550 isoleucine catabolic process(GO:0006550)
0.0 0.1 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 GO:0001533 cornified envelope(GO:0001533)
0.0 0.2 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.1 GO:0005715 late recombination nodule(GO:0005715)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 0.2 GO:0004608 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.1 GO:0036505 prosaposin receptor activity(GO:0036505)
0.0 0.3 GO:0031433 telethonin binding(GO:0031433)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.0 GO:0043273 CTPase activity(GO:0043273)
0.0 0.1 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters