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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for RAD21_SMC3

Z-value: 1.04

Motif logo

Transcription factors associated with RAD21_SMC3

Gene Symbol Gene ID Gene Info
ENSG00000164754.15 RAD21
ENSG00000108055.10 SMC3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMC3hg38_v1_chr10_+_110567666_110567765-0.523.2e-03Click!
RAD21hg38_v1_chr8_-_116874746_116874828-0.222.5e-01Click!

Activity profile of RAD21_SMC3 motif

Sorted Z-values of RAD21_SMC3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RAD21_SMC3

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr5_+_149141817 4.09 ENST00000504238.5
actin binding LIM protein family member 3
chr5_+_149141483 3.97 ENST00000326685.11
ENST00000309868.12
actin binding LIM protein family member 3
chr5_+_149141573 3.94 ENST00000506113.5
actin binding LIM protein family member 3
chr4_+_74933095 2.39 ENST00000513238.5
prostate androgen-regulated mucin-like protein 1
chr4_+_74933108 2.36 ENST00000307428.7
prostate androgen-regulated mucin-like protein 1
chr4_+_7192519 2.18 ENST00000507866.6
sortilin related VPS10 domain containing receptor 2
chr19_-_1513003 1.46 ENST00000330475.9
ENST00000586272.5
ENST00000590562.5
ADAMTS like 5
chr7_+_90154442 1.43 ENST00000297205.7
STEAP family member 1
chr17_-_74361860 1.36 ENST00000375366.4
BTB domain containing 17
chr15_+_45430579 1.35 ENST00000558435.5
ENST00000344300.3
ENST00000396650.7
chromosome 15 open reading frame 48
chr19_-_18941117 1.27 ENST00000600077.5
homer scaffold protein 3
chr11_-_17389323 1.24 ENST00000528731.1
potassium inwardly rectifying channel subfamily J member 11
chr3_-_184017863 1.23 ENST00000427120.6
ENST00000334444.11
ENST00000392579.6
ENST00000382494.6
ENST00000265586.10
ENST00000446941.2
ATP binding cassette subfamily C member 5
chr15_+_73873604 1.19 ENST00000535547.6
ENST00000562056.1
TBC1 domain family member 21
chr12_-_51269949 1.18 ENST00000603864.5
ENST00000605426.5
small cell adhesion glycoprotein
chr14_-_93115812 1.10 ENST00000553452.5
inositol-tetrakisphosphate 1-kinase
chr19_-_18941184 1.07 ENST00000594794.5
ENST00000392351.8
ENST00000596482.5
homer scaffold protein 3
chr16_+_30748241 1.02 ENST00000565924.5
ENST00000424889.7
phosphorylase kinase catalytic subunit gamma 2
chr6_+_137867241 0.99 ENST00000612899.5
ENST00000420009.5
TNF alpha induced protein 3
chr5_-_77492309 0.99 ENST00000296679.9
ENST00000507029.5
WD repeat domain 41
chr11_-_117232033 0.97 ENST00000524507.6
ENST00000320934.8
ENST00000532301.5
ENST00000676339.1
ENST00000540028.5
proprotein convertase subtilisin/kexin type 7
chr15_-_65422894 0.96 ENST00000352385.3
immunoglobulin superfamily DCC subclass member 4
chr19_-_4400418 0.94 ENST00000598564.5
ENST00000417295.6
ENST00000269886.7
SH3 domain containing GRB2 like 1, endophilin A2
chr6_+_137867414 0.94 ENST00000237289.8
ENST00000433680.1
TNF alpha induced protein 3
chr19_-_48835823 0.92 ENST00000595764.1
hydroxysteroid 17-beta dehydrogenase 14
chr12_-_51270175 0.91 ENST00000604188.1
ENST00000398453.7
small cell adhesion glycoprotein
chr19_-_15479469 0.89 ENST00000292609.8
ENST00000340880.5
peptidoglycan recognition protein 2
chr14_+_21841182 0.89 ENST00000390433.1
T cell receptor alpha variable 12-1
chr20_-_31723491 0.88 ENST00000676582.1
ENST00000422920.2
BCL2 like 1
chr5_-_140346596 0.86 ENST00000230990.7
heparin binding EGF like growth factor
chr17_+_76868410 0.86 ENST00000301618.8
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
chr3_+_5122276 0.85 ENST00000256496.8
ENST00000419534.2
ADP ribosylation factor like GTPase 8B
chr8_-_27992624 0.84 ENST00000524352.5
scavenger receptor class A member 5
chr10_-_29735787 0.84 ENST00000375400.7
supervillin
chr3_+_126983035 0.83 ENST00000393409.3
plexin A1
chr20_-_31723902 0.83 ENST00000676942.1
ENST00000450273.2
ENST00000678563.1
ENST00000456404.6
ENST00000420488.6
ENST00000439267.2
BCL2 like 1
chr19_-_45815303 0.82 ENST00000221538.8
radial spoke head 6 homolog A
chr17_+_78232006 0.82 ENST00000550981.7
ENST00000591033.2
transmembrane protein 235
chr11_+_118956289 0.80 ENST00000264031.3
uroplakin 2
chr5_-_137499293 0.80 ENST00000510689.5
ENST00000394945.6
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
chr1_+_47438036 0.80 ENST00000334793.6
forkhead box D2
chr1_+_37474572 0.80 ENST00000373087.7
zinc finger CCCH-type containing 12A
chr1_-_159945596 0.79 ENST00000361509.7
ENST00000611023.1
ENST00000368094.6
immunoglobulin superfamily member 9
chr19_-_55140922 0.78 ENST00000589745.5
troponin T1, slow skeletal type
chr19_-_45815228 0.78 ENST00000597055.1
radial spoke head 6 homolog A
chr8_+_22165140 0.77 ENST00000397814.7
ENST00000354870.5
bone morphogenetic protein 1
chr17_+_76868396 0.76 ENST00000569840.7
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
chr17_+_47733228 0.74 ENST00000177694.2
T-box transcription factor 21
chr15_-_38564635 0.72 ENST00000450598.6
ENST00000559830.5
ENST00000558164.5
ENST00000539159.5
ENST00000310803.10
RAS guanyl releasing protein 1
chr19_-_1513189 0.71 ENST00000395467.6
ADAMTS like 5
chr16_+_66604782 0.71 ENST00000565003.5
CKLF like MARVEL transmembrane domain containing 3
chr5_-_77492199 0.70 ENST00000515253.5
ENST00000507654.5
ENST00000514559.5
ENST00000511791.1
WD repeat domain 41
chr19_+_57830288 0.69 ENST00000442832.8
ENST00000594901.2
zinc finger protein 587B
chr16_-_88785210 0.69 ENST00000301015.14
piezo type mechanosensitive ion channel component 1
chr9_+_137423350 0.69 ENST00000341349.6
ENST00000683555.1
ENST00000392815.2
ENST00000683683.1
NADPH oxidase activator 1
chr19_+_47713412 0.68 ENST00000538399.1
ENST00000263277.8
EH domain containing 2
chr3_+_141876124 0.67 ENST00000475483.5
ATPase Na+/K+ transporting subunit beta 3
chr22_-_21938557 0.67 ENST00000424647.1
ENST00000407142.5
protein phosphatase, Mg2+/Mn2+ dependent 1F
chr5_+_177087412 0.66 ENST00000513166.1
fibroblast growth factor receptor 4
chr14_+_21797272 0.66 ENST00000390430.2
T cell receptor alpha variable 8-1
chr3_+_58306236 0.66 ENST00000295959.10
ENST00000445193.7
ENST00000466547.1
ENST00000475412.5
ENST00000474660.5
ENST00000477305.5
ENST00000481972.5
ribonuclease P/MRP subunit p14
hydroxyacyl-thioester dehydratase type 2
chr19_-_55141889 0.65 ENST00000593194.5
troponin T1, slow skeletal type
chr20_+_31514410 0.65 ENST00000335574.10
ENST00000340852.9
ENST00000398174.9
ENST00000466766.2
ENST00000498035.5
ENST00000344042.5
histocompatibility minor 13
chr7_-_38349972 0.65 ENST00000390344.2
T cell receptor gamma variable 5
chr10_+_97572771 0.65 ENST00000370655.6
ENST00000455090.1
ankyrin repeat domain 2
chr3_+_58306505 0.64 ENST00000461393.7
hydroxyacyl-thioester dehydratase type 2
chr1_+_92029971 0.64 ENST00000370383.5
epoxide hydrolase 4
chr10_+_97572493 0.63 ENST00000307518.9
ENST00000298808.9
ankyrin repeat domain 2
chr19_-_19643547 0.63 ENST00000587238.5
GEM interacting protein
chr19_+_10013468 0.62 ENST00000591589.3
retinol dehydrogenase 8
chr1_+_17755307 0.61 ENST00000375406.2
actin like 8
chr14_+_22040576 0.61 ENST00000390448.3
T cell receptor alpha variable 20
chr19_-_41353904 0.61 ENST00000221930.6
transforming growth factor beta 1
chr2_-_165953750 0.61 ENST00000243344.8
ENST00000679799.1
ENST00000679840.1
ENST00000681606.1
ENST00000680448.1
tetratricopeptide repeat domain 21B
chr3_-_128493173 0.61 ENST00000498200.1
ENST00000341105.7
GATA binding protein 2
chr14_+_21887848 0.60 ENST00000390437.2
T cell receptor alpha variable 12-2
chr1_-_74733253 0.60 ENST00000417775.5
crystallin zeta
chr17_-_42681840 0.59 ENST00000332438.4
C-C motif chemokine receptor 10
chr15_-_78811415 0.59 ENST00000388820.5
ADAM metallopeptidase with thrombospondin type 1 motif 7
chr22_+_31082860 0.59 ENST00000619644.4
smoothelin
chr16_-_30021288 0.59 ENST00000574405.5
double C2 domain alpha
chr8_-_144326842 0.58 ENST00000528718.6
diacylglycerol O-acyltransferase 1
chr11_-_66336396 0.58 ENST00000627248.1
ENST00000311320.9
Ras and Rab interactor 1
chr15_-_34210011 0.58 ENST00000557877.5
katanin regulatory subunit B1 like 1
chr17_-_74923222 0.58 ENST00000614341.5
USH1 protein network component sans
chr17_-_45132505 0.58 ENST00000619929.5
phospholipase C delta 3
chr14_+_51651858 0.57 ENST00000395718.6
FERM domain containing 6
chr14_+_21852457 0.57 ENST00000390435.1
T cell receptor alpha variable 8-3
chr11_+_60924452 0.57 ENST00000453848.7
ENST00000544065.5
ENST00000005286.8
transmembrane protein 132A
chr7_+_112480853 0.57 ENST00000439068.6
ENST00000312849.4
leucine rich single-pass membrane protein 1
chr10_-_48524236 0.57 ENST00000374170.5
Rho GTPase activating protein 22
chr1_-_156705764 0.56 ENST00000621784.4
ENST00000368220.1
cellular retinoic acid binding protein 2
chr1_-_156705742 0.56 ENST00000368221.1
cellular retinoic acid binding protein 2
chr2_-_24084292 0.56 ENST00000413037.1
ENST00000407482.5
tumor protein p53 inducible protein 3
chr20_+_45363454 0.56 ENST00000453003.1
SYS1 golgi trafficking protein
chr8_+_22589240 0.55 ENST00000450780.6
ENST00000430850.6
ENST00000447849.2
ENST00000614502.4
ENST00000443561.3
novel protein
PDZ and LIM domain 2
chr1_-_211133945 0.54 ENST00000640044.1
ENST00000640566.1
potassium voltage-gated channel subfamily H member 1
chr14_+_51651901 0.54 ENST00000344768.10
FERM domain containing 6
chr7_+_1086800 0.54 ENST00000413368.5
ENST00000397092.5
ENST00000297469.3
G protein-coupled estrogen receptor 1
chr10_-_88583304 0.54 ENST00000331772.9
renalase, FAD dependent amine oxidase
chr1_+_203682734 0.53 ENST00000341360.6
ATPase plasma membrane Ca2+ transporting 4
chr18_+_46174055 0.52 ENST00000615553.1
chromosome 18 open reading frame 25
chr17_-_47831509 0.51 ENST00000414011.1
ENST00000351111.7
mitochondrial ribosomal protein L10
chr2_+_227813834 0.51 ENST00000358813.5
ENST00000409189.7
C-C motif chemokine ligand 20
chr6_+_35342614 0.51 ENST00000337400.6
ENST00000311565.4
peroxisome proliferator activated receptor delta
chr17_+_74203582 0.50 ENST00000439590.6
ENST00000311111.11
ENST00000584577.5
ENST00000534490.5
ENST00000528433.2
ENST00000533498.1
ribosomal protein L38
chr6_-_11044275 0.50 ENST00000354666.4
ELOVL fatty acid elongase 2
chr16_+_30748378 0.50 ENST00000563588.6
ENST00000328273.11
phosphorylase kinase catalytic subunit gamma 2
chr10_+_102394488 0.50 ENST00000369966.8
nuclear factor kappa B subunit 2
chr12_-_95116967 0.49 ENST00000551521.5
FYVE, RhoGEF and PH domain containing 6
chr16_+_67645100 0.49 ENST00000334583.11
capping protein regulator and myosin 1 linker 2
chr9_+_136844415 0.48 ENST00000436881.2
apical junction component 1 homolog
chr16_-_70680025 0.48 ENST00000576338.1
MTSS I-BAR domain containing 2
chr1_-_145910031 0.47 ENST00000369304.8
integrin subunit alpha 10
chr2_-_218292496 0.47 ENST00000258412.8
ENST00000445635.5
ENST00000413976.1
transmembrane BAX inhibitor motif containing 1
chr7_+_73667824 0.46 ENST00000324941.5
ENST00000451519.1
VPS37D subunit of ESCRT-I
chr9_-_109321041 0.46 ENST00000374566.8
erythrocyte membrane protein band 4.1 like 4B
chr8_+_28622729 0.46 ENST00000523149.5
exostosin like glycosyltransferase 3
chr9_-_21141832 0.46 ENST00000380229.4
interferon omega 1
chr12_-_120265719 0.46 ENST00000637617.2
ENST00000267257.11
ENST00000228307.11
ENST00000424649.6
paxillin
chr22_+_22594528 0.45 ENST00000390303.3
immunoglobulin lambda variable 3-32 (non-functional)
chr1_-_145910066 0.45 ENST00000539363.2
integrin subunit alpha 10
chr3_+_49171590 0.45 ENST00000332780.4
kelch domain containing 8B
chr22_-_22559229 0.44 ENST00000405655.8
ENST00000406503.1
ENST00000439106.5
ENST00000402697.5
ENST00000543184.5
ENST00000398743.6
PRAME nuclear receptor transcriptional regulator
chr12_+_112418976 0.44 ENST00000635625.1
protein tyrosine phosphatase non-receptor type 11
chr18_-_50819982 0.44 ENST00000398439.8
ENST00000431965.6
ENST00000436348.6
maestro
chr16_+_67645166 0.43 ENST00000545661.5
capping protein regulator and myosin 1 linker 2
chr10_-_15719885 0.43 ENST00000378076.4
integrin subunit alpha 8
chr18_+_596973 0.43 ENST00000579912.5
ENST00000400606.6
ENST00000540035.5
clusterin like 1
chr19_-_19643597 0.42 ENST00000587205.1
ENST00000203556.9
GEM interacting protein
chr2_-_24084822 0.42 ENST00000238721.9
tumor protein p53 inducible protein 3
chr16_-_11256192 0.42 ENST00000644787.1
ENST00000332029.4
suppressor of cytokine signaling 1
chr17_+_45135640 0.42 ENST00000586346.5
ENST00000321854.13
ENST00000398322.7
ENST00000592162.5
ENST00000376955.8
acyl-CoA binding domain containing 4
chr16_+_66604696 0.42 ENST00000567572.6
ENST00000564060.5
ENST00000565922.1
CKLF like MARVEL transmembrane domain containing 3
chr3_-_197029775 0.41 ENST00000439320.1
ENST00000296351.8
ENST00000296350.10
melanotransferrin
chr11_+_61752603 0.41 ENST00000278836.10
myelin regulatory factor
chr17_+_7717727 0.41 ENST00000570791.5
dynein axonemal heavy chain 2
chr6_+_35342535 0.40 ENST00000360694.8
ENST00000418635.6
ENST00000448077.6
peroxisome proliferator activated receptor delta
chr8_-_144326908 0.40 ENST00000332324.5
diacylglycerol O-acyltransferase 1
chr9_+_128203371 0.40 ENST00000475805.5
ENST00000372923.8
ENST00000341179.11
ENST00000393594.7
dynamin 1
chr17_-_44363839 0.39 ENST00000293443.12
family with sequence similarity 171 member A2
chr19_-_35135180 0.39 ENST00000392225.7
leucine rich repeat LGI family member 4
chr16_+_23557714 0.38 ENST00000567212.5
ENST00000567264.1
ENST00000395878.8
ubiquitin family domain containing 1
chr22_-_21952827 0.38 ENST00000397495.8
ENST00000263212.10
protein phosphatase, Mg2+/Mn2+ dependent 1F
chr3_-_136752361 0.38 ENST00000480733.1
ENST00000629124.2
ENST00000383202.7
ENST00000236698.9
ENST00000434713.6
stromal antigen 1
chr17_-_8079903 0.38 ENST00000649809.1
arachidonate 12-lipoxygenase, 12R type
chr1_+_21509415 0.37 ENST00000374840.8
ENST00000539907.5
ENST00000540617.5
alkaline phosphatase, biomineralization associated
chr17_-_7614824 0.37 ENST00000571597.1
ENST00000250113.12
FMR1 autosomal homolog 2
chr3_-_49719668 0.37 ENST00000320431.8
adhesion molecule with Ig like domain 3
chr10_-_75109172 0.37 ENST00000372700.7
ENST00000473072.2
ENST00000491677.6
ENST00000372702.7
dual specificity phosphatase 13
chr16_+_16232516 0.37 ENST00000399336.9
ENST00000678538.1
ENST00000678192.1
ENST00000677777.1
ENST00000677260.1
ENST00000676550.1
ENST00000263012.10
NODAL modulator 3
chr19_+_1941118 0.37 ENST00000255641.13
casein kinase 1 gamma 2
chr1_-_151716052 0.36 ENST00000290585.8
CUGBP Elav-like family member 3
chr20_+_31440626 0.36 ENST00000376309.4
defensin beta 123
chr14_-_64823148 0.36 ENST00000389722.7
spectrin beta, erythrocytic
chr1_+_145845608 0.36 ENST00000334513.6
nudix hydrolase 17
chr11_+_117232625 0.36 ENST00000534428.5
ENST00000300650.9
ring finger protein 214
chr6_+_31137646 0.36 ENST00000547221.1
psoriasis susceptibility 1 candidate 1
chr19_+_55654115 0.35 ENST00000450554.6
U2 small nuclear RNA auxiliary factor 2
chr17_+_2055094 0.35 ENST00000399849.4
ENST00000619757.5
HIC ZBTB transcriptional repressor 1
chr15_-_44195210 0.35 ENST00000402883.5
ENST00000417257.6
FERM domain containing 5
chr10_-_90857680 0.35 ENST00000277874.10
ENST00000371719.2
5-hydroxytryptamine receptor 7
chr7_-_22500152 0.34 ENST00000406890.6
ENST00000678116.1
ENST00000424363.5
STEAP family member 1B
chr18_-_50819764 0.34 ENST00000592966.5
maestro
chr10_-_75235917 0.34 ENST00000469299.1
ENST00000372538.8
catechol-O-methyltransferase domain containing 1
chr10_-_90857983 0.34 ENST00000336152.8
5-hydroxytryptamine receptor 7
chr10_-_101843920 0.33 ENST00000358038.7
potassium voltage-gated channel interacting protein 2
chr10_-_75109085 0.33 ENST00000607131.5
dual specificity phosphatase 13
chrX_-_132219473 0.33 ENST00000620646.4
RAP2C, member of RAS oncogene family
chr11_+_85855377 0.33 ENST00000342404.8
coiled-coil domain containing 83
chr2_-_231530427 0.33 ENST00000305141.5
neuromedin U receptor 1
chr9_+_126860625 0.33 ENST00000319119.4
zinc finger and BTB domain containing 34
chr11_+_61680373 0.33 ENST00000257215.10
diacylglycerol lipase alpha
chr13_+_87671354 0.33 ENST00000683689.1
SLIT and NTRK like family member 5
chrX_-_132219439 0.32 ENST00000370874.2
RAP2C, member of RAS oncogene family
chr19_-_4558417 0.32 ENST00000586965.1
semaphorin 6B
chr5_+_140821598 0.32 ENST00000614258.1
ENST00000529859.2
ENST00000529619.5
protocadherin alpha 5
chr16_+_3654683 0.32 ENST00000246949.10
deoxyribonuclease 1
chr3_+_134795277 0.30 ENST00000647596.1
EPH receptor B1
chr11_+_126269110 0.30 ENST00000263578.10
ENST00000532125.1
FAD dependent oxidoreductase domain containing 1
chr10_+_100999287 0.30 ENST00000370220.1
leucine zipper tumor suppressor 2
chr11_+_119206298 0.30 ENST00000634586.1
ENST00000634840.1
ENST00000264033.6
ENST00000637974.1
Cbl proto-oncogene
chr3_+_184561768 0.30 ENST00000330394.3
EPH receptor B3
chr17_+_16690223 0.29 ENST00000340621.9
ENST00000399273.5
ENST00000456009.4
ENST00000360524.12
coiled-coil domain containing 144A
chr15_+_31978056 0.29 ENST00000637183.1
cholinergic receptor nicotinic alpha 7 subunit
chr19_-_1848452 0.29 ENST00000170168.9
RNA exonuclease 1 homolog
chr3_-_138947095 0.29 ENST00000648323.1
forkhead box L2
chr12_+_50504970 0.29 ENST00000301180.10
disco interacting protein 2 homolog B
chr22_+_23070496 0.29 ENST00000615612.2
G protein subunit alpha z
chr22_-_22559073 0.29 ENST00000420709.5
ENST00000398741.5
PRAME nuclear receptor transcriptional regulator
chr3_+_39809602 0.28 ENST00000302541.11
ENST00000396217.7
myosin VIIA and Rab interacting protein
chr4_-_170090153 0.28 ENST00000509167.5
ENST00000353187.6
ENST00000507375.5
ENST00000515480.5
aminoadipate aminotransferase
chr7_-_5529949 0.28 ENST00000642480.2
ENST00000417101.2
actin beta
chr1_-_34859717 0.28 ENST00000423898.1
ENST00000521580.3
ENST00000456842.1
small integral membrane protein 12
chr20_+_45363114 0.27 ENST00000426004.5
ENST00000243918.10
SYS1 golgi trafficking protein
chr9_+_131009141 0.27 ENST00000361069.9
laminin subunit gamma 3
chr17_+_43483949 0.27 ENST00000540306.5
ENST00000262415.8
DEAH-box helicase 8
chr9_+_128203397 0.27 ENST00000628346.2
ENST00000486160.3
ENST00000627061.2
ENST00000627543.2
ENST00000634267.2
dynamin 1
chr13_-_52450590 0.27 ENST00000378060.9
vacuolar protein sorting 36 homolog
chr2_+_69013414 0.26 ENST00000681816.1
ENST00000482235.2
ANTXR cell adhesion molecule 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0070429 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429)
0.3 0.9 GO:0002325 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.3 1.8 GO:0097461 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.3 1.5 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.2 0.7 GO:0051463 negative regulation of cortisol secretion(GO:0051463)
0.2 0.7 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.2 1.7 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.2 1.1 GO:0003383 apical constriction(GO:0003383)
0.2 0.7 GO:0052031 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
0.2 0.5 GO:0031959 mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724)
0.2 0.5 GO:0033241 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.2 0.7 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.2 0.5 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.2 0.7 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.2 0.5 GO:0099557 trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission(GO:0099557)
0.2 1.4 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.2 0.8 GO:1904637 miRNA catabolic process(GO:0010587) negative regulation by host of viral genome replication(GO:0044828) response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.2 0.6 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725) eosinophil fate commitment(GO:0035854)
0.1 1.8 GO:0071316 cellular response to nicotine(GO:0071316)
0.1 0.7 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.1 0.4 GO:0071529 cementum mineralization(GO:0071529)
0.1 0.5 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.1 0.4 GO:0034970 regulation of growth plate cartilage chondrocyte proliferation(GO:0003420) histone H3-R2 methylation(GO:0034970)
0.1 2.2 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.1 0.7 GO:0032252 secretory granule localization(GO:0032252)
0.1 1.2 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.1 0.4 GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.1 0.4 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.1 0.7 GO:1903412 response to bile acid(GO:1903412)
0.1 0.3 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.1 2.7 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 1.1 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 1.1 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 0.5 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.1 0.8 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.4 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1 0.3 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.1 1.5 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 1.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.6 GO:1904098 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.1 1.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 12.5 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 0.7 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.1 0.8 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 0.4 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.1 1.1 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.1 0.9 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 1.3 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.1 0.6 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.1 1.0 GO:0036155 acylglycerol acyl-chain remodeling(GO:0036155)
0.1 0.8 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.5 GO:0048318 axial mesoderm development(GO:0048318)
0.1 0.3 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.1 0.2 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.1 0.3 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.1 0.6 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 0.6 GO:0050957 equilibrioception(GO:0050957)
0.1 3.6 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.1 0.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.3 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 0.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.1 0.2 GO:1902164 regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.1 0.7 GO:0060263 regulation of respiratory burst(GO:0060263)
0.1 0.2 GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.0 0.1 GO:0071344 diphosphate metabolic process(GO:0071344)
0.0 0.1 GO:1903028 positive regulation of opsonization(GO:1903028)
0.0 0.1 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0 0.7 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.5 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.7 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.1 GO:1903348 establishment of blood-nerve barrier(GO:0008065) positive regulation of bicellular tight junction assembly(GO:1903348)
0.0 0.2 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.0 0.1 GO:0046108 uridine metabolic process(GO:0046108)
0.0 0.4 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533)
0.0 0.2 GO:1902559 3'-phosphoadenosine 5'-phosphosulfate transport(GO:0046963) 3'-phospho-5'-adenylyl sulfate transmembrane transport(GO:1902559)
0.0 0.4 GO:0051121 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.3 GO:0050893 sensory processing(GO:0050893)
0.0 0.1 GO:0035992 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.0 0.4 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.6 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.6 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.0 0.9 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 0.3 GO:0035865 cellular response to potassium ion(GO:0035865)
0.0 0.1 GO:1904562 phosphatidylinositol 5-phosphate metabolic process(GO:1904562)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 2.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.3 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.1 GO:1990834 response to odorant(GO:1990834)
0.0 0.1 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.0 0.1 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.1 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051) positive regulation of saliva secretion(GO:0046878)
0.0 0.2 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.0 0.3 GO:0090650 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.0 0.8 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.1 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.0 0.1 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.0 0.1 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.2 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.1 GO:0009631 cold acclimation(GO:0009631)
0.0 0.1 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0 0.1 GO:1903259 exon-exon junction complex disassembly(GO:1903259)
0.0 0.1 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.0 0.2 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.0 0.7 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.1 GO:0090289 regulation of osteoclast proliferation(GO:0090289)
0.0 0.3 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.2 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.5 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.7 GO:0001502 cartilage condensation(GO:0001502)
0.0 0.1 GO:0044313 protein K6-linked deubiquitination(GO:0044313) protein K27-linked deubiquitination(GO:1990167)
0.0 0.4 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.6 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.1 GO:1902966 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.0 0.2 GO:0045988 negative regulation of striated muscle contraction(GO:0045988)
0.0 0.1 GO:1904806 regulation of protein oxidation(GO:1904806) positive regulation of protein oxidation(GO:1904808)
0.0 0.1 GO:1903677 regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
0.0 0.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 1.0 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.6 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.0 0.5 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.4 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.2 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.0 0.1 GO:0007174 epidermal growth factor catabolic process(GO:0007174)
0.0 0.2 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.2 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 0.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 1.0 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.4 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0 0.2 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.1 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.0 0.0 GO:1900239 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.0 0.5 GO:0039702 viral budding via host ESCRT complex(GO:0039702)
0.0 0.1 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100) cellular magnesium ion homeostasis(GO:0010961)
0.0 1.9 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.2 GO:1904263 positive regulation of cytolysis(GO:0045919) positive regulation of TORC1 signaling(GO:1904263)
0.0 0.4 GO:0030575 nuclear body organization(GO:0030575)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.2 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.9 GO:0006739 NADP metabolic process(GO:0006739)
0.0 1.4 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.2 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.1 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.1 GO:1990504 dense core granule exocytosis(GO:1990504)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.2 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.1 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
0.0 0.2 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.4 GO:0022011 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.2 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.0 0.3 GO:0021756 striatum development(GO:0021756)
0.0 0.2 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 1.3 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.1 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.2 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.2 GO:0048266 behavioral response to pain(GO:0048266)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.2 1.7 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 1.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.2 1.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 1.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.5 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.1 12.5 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.7 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.1 0.4 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
0.1 2.2 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.8 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 0.3 GO:0000814 ESCRT II complex(GO:0000814)
0.1 0.8 GO:0036449 microtubule minus-end(GO:0036449)
0.1 1.4 GO:0005861 troponin complex(GO:0005861)
0.1 0.8 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.6 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 0.7 GO:0030681 multimeric ribonuclease P complex(GO:0030681)
0.1 0.7 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.4 GO:0089701 U2AF(GO:0089701)
0.0 0.5 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.5 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.1 GO:0016938 kinesin I complex(GO:0016938)
0.0 0.4 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.3 GO:0043196 varicosity(GO:0043196)
0.0 0.8 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 2.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.2 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.2 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.5 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 0.2 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.0 0.9 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.0 2.6 GO:0045178 basal part of cell(GO:0045178)
0.0 0.1 GO:0031905 early endosome lumen(GO:0031905)
0.0 0.1 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0 0.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0032419 extrinsic component of lysosome membrane(GO:0032419)
0.0 0.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.7 GO:0042629 mast cell granule(GO:0042629)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 1.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.3 GO:0030008 TRAPP complex(GO:0030008)
0.0 10.0 GO:0010008 endosome membrane(GO:0010008)
0.0 2.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.0 GO:0098855 HCN channel complex(GO:0098855)
0.0 0.3 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)
0.0 0.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.1 GO:0033269 internode region of axon(GO:0033269)
0.0 0.6 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.9 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.2 GO:0000322 storage vacuole(GO:0000322)
0.0 0.6 GO:0000791 euchromatin(GO:0000791)
0.0 0.2 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.5 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.2 GO:0005858 axonemal dynein complex(GO:0005858)
0.0 0.2 GO:0030914 STAGA complex(GO:0030914)
0.0 0.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0052825 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835)
0.4 1.3 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.3 1.8 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 1.0 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.2 1.6 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.2 0.9 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.2 1.6 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.2 0.5 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.2 0.5 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.2 1.5 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 1.3 GO:0018812 3-hydroxyacyl-CoA dehydratase activity(GO:0018812)
0.1 0.9 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.1 1.7 GO:0051434 BH3 domain binding(GO:0051434)
0.1 1.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 2.3 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 1.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.9 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.8 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 1.4 GO:0031014 troponin T binding(GO:0031014)
0.1 1.9 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.6 GO:0010465 neurotrophin p75 receptor binding(GO:0005166) nerve growth factor receptor activity(GO:0010465)
0.1 0.7 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.4 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 0.3 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.1 0.5 GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888)
0.1 0.2 GO:0097677 STAT family protein binding(GO:0097677)
0.1 0.6 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 0.8 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 1.2 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.1 0.4 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.1 0.4 GO:0047280 nicotinamide phosphoribosyltransferase activity(GO:0047280)
0.1 0.3 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.5 GO:1990239 steroid hormone binding(GO:1990239)
0.1 0.2 GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity(GO:0004577)
0.1 0.3 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.1 0.4 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.1 0.7 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 1.1 GO:0019841 retinol binding(GO:0019841)
0.1 0.4 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 2.4 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 0.2 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 0.4 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.1 0.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.7 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.7 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.6 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.1 GO:0035650 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.2 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.5 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.9 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.9 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.1 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.0 0.4 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.2 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.0 0.7 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.6 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.5 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.1 GO:0031755 endothelial differentiation G-protein coupled receptor binding(GO:0031753) Edg-2 lysophosphatidic acid receptor binding(GO:0031755)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.9 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.6 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.5 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.9 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.0 1.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.5 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.1 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 3.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0016154 thymidine phosphorylase activity(GO:0009032) pyrimidine-nucleoside phosphorylase activity(GO:0016154)
0.0 0.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.2 GO:0043426 MRF binding(GO:0043426)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.4 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.3 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 2.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.5 GO:0017166 vinculin binding(GO:0017166)
0.0 0.6 GO:0030507 spectrin binding(GO:0030507)
0.0 0.6 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.2 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.8 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.7 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 0.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.0 GO:0031862 prostanoid receptor binding(GO:0031862)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 11.5 GO:0003779 actin binding(GO:0003779)
0.0 0.0 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.3 GO:0008494 translation activator activity(GO:0008494)
0.0 0.5 GO:0005123 death receptor binding(GO:0005123)
0.0 1.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.2 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.7 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.5 PID IL27 PATHWAY IL27-mediated signaling events
0.0 1.7 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.7 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.8 PID RAS PATHWAY Regulation of Ras family activation
0.0 2.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.6 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.4 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.3 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.9 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 5.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.7 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 1.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.0 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.3 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.4 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.8 PID RHOA PATHWAY RhoA signaling pathway
0.0 1.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 3.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.1 PID NECTIN PATHWAY Nectin adhesion pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 12.0 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.7 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 1.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 0.8 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.6 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 1.1 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 1.7 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.5 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.7 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.7 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.5 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 1.1 REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.0 0.9 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.5 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.2 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.1 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.3 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 1.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.7 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.1 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.4 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.7 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.3 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 2.3 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 2.2 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.0 0.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events