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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for RELA
Z-value: 1.24
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Transcription factors associated with RELA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RELA | hg38_v1_chr11_-_65662931_65662972 | 0.44 | 1.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RELA
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_227813834 Show fit | 4.58 |
ENST00000358813.5
ENST00000409189.7 |
C-C motif chemokine ligand 20 |
|
| chr4_-_74099187 Show fit | 3.79 |
ENST00000508487.3
|
C-X-C motif chemokine ligand 2 |
|
| chr6_+_137867241 Show fit | 3.67 |
ENST00000612899.5
ENST00000420009.5 |
TNF alpha induced protein 3 |
|
| chr11_+_102317492 Show fit | 3.36 |
ENST00000673846.1
|
baculoviral IAP repeat containing 3 |
|
| chr6_+_137867414 Show fit | 3.35 |
ENST00000237289.8
ENST00000433680.1 |
TNF alpha induced protein 3 |
|
| chr4_-_74038681 Show fit | 3.23 |
ENST00000296026.4
|
C-X-C motif chemokine ligand 3 |
|
| chr4_-_73998669 Show fit | 3.19 |
ENST00000296027.5
|
C-X-C motif chemokine ligand 5 |
|
| chr6_-_29559724 Show fit | 2.95 |
ENST00000377050.5
|
ubiquitin D |
|
| chr7_+_107660819 Show fit | 2.91 |
ENST00000644269.2
|
solute carrier family 26 member 4 |
|
| chr11_+_102317542 Show fit | 2.85 |
ENST00000532808.5
|
baculoviral IAP repeat containing 3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.3 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.7 | 8.7 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 2.3 | 7.0 | GO:0034147 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) |
| 1.5 | 4.6 | GO:0045362 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.4 | 4.3 | GO:1904996 | positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996) |
| 0.0 | 3.6 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.8 | 3.2 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 0.4 | 3.0 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.4 | 2.9 | GO:0015705 | iodide transport(GO:0015705) |
| 0.2 | 2.9 | GO:0016540 | protein autoprocessing(GO:0016540) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.5 | GO:0045121 | membrane raft(GO:0045121) |
| 0.5 | 4.8 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.8 | 3.2 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 3.0 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 2.9 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 2.4 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 2.0 | GO:0045180 | basal cortex(GO:0045180) |
| 0.1 | 1.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 1.6 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 1.6 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 13.4 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.2 | 8.5 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.4 | 7.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 1.5 | 4.6 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.0 | 3.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 3.5 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 3.1 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 3.0 | GO:0019003 | GDP binding(GO:0019003) |
| 0.7 | 2.9 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
| 0.6 | 2.8 | GO:0050473 | prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 22.6 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 9.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 4.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 4.1 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 2.8 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 2.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 2.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 1.8 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 1.7 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 1.7 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 16.3 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.3 | 7.4 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.0 | 3.2 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 2.5 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 2.2 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 2.1 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 1.8 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.0 | 1.7 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.1 | 1.6 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |