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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for RELA

Z-value: 1.24

Motif logo

Transcription factors associated with RELA

Gene Symbol Gene ID Gene Info
ENSG00000173039.19 RELA

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RELAhg38_v1_chr11_-_65662931_656629720.441.4e-02Click!

Activity profile of RELA motif

Sorted Z-values of RELA motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RELA

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr2_+_227813834 4.58 ENST00000358813.5
ENST00000409189.7
C-C motif chemokine ligand 20
chr4_-_74099187 3.79 ENST00000508487.3
C-X-C motif chemokine ligand 2
chr6_+_137867241 3.67 ENST00000612899.5
ENST00000420009.5
TNF alpha induced protein 3
chr11_+_102317492 3.36 ENST00000673846.1
baculoviral IAP repeat containing 3
chr6_+_137867414 3.35 ENST00000237289.8
ENST00000433680.1
TNF alpha induced protein 3
chr4_-_74038681 3.23 ENST00000296026.4
C-X-C motif chemokine ligand 3
chr4_-_73998669 3.19 ENST00000296027.5
C-X-C motif chemokine ligand 5
chr6_-_29559724 2.95 ENST00000377050.5
ubiquitin D
chr7_+_107660819 2.91 ENST00000644269.2
solute carrier family 26 member 4
chr11_+_102317542 2.85 ENST00000532808.5
baculoviral IAP repeat containing 3
chr1_-_186680411 2.82 ENST00000367468.10
prostaglandin-endoperoxide synthase 2
chr14_-_35404650 2.57 ENST00000553342.1
ENST00000557140.5
ENST00000216797.10
NFKB inhibitor alpha
chr11_+_102317450 2.49 ENST00000615299.4
ENST00000527309.2
ENST00000526421.6
ENST00000263464.9
baculoviral IAP repeat containing 3
chr14_+_103123452 2.39 ENST00000558056.1
ENST00000560869.6
TNF alpha induced protein 2
chr10_+_102394488 2.35 ENST00000369966.8
nuclear factor kappa B subunit 2
chr19_-_50968125 1.82 ENST00000594641.1
kallikrein related peptidase 6
chr6_+_32637419 1.79 ENST00000374949.2
major histocompatibility complex, class II, DQ alpha 1
chr3_+_101827982 1.65 ENST00000461724.5
ENST00000483180.5
ENST00000394054.6
NFKB inhibitor zeta
chr19_+_45001430 1.57 ENST00000625761.2
ENST00000505236.1
ENST00000221452.13
RELB proto-oncogene, NF-kB subunit
chr9_-_133479075 1.56 ENST00000414172.1
ENST00000371897.8
ENST00000371899.9
solute carrier family 2 member 6
chr19_+_10271093 1.42 ENST00000423829.2
ENST00000588645.1
ENST00000264832.8
intercellular adhesion molecule 1
chr12_-_48865863 1.38 ENST00000309739.6
Rho family GTPase 1
chr4_-_76023489 1.30 ENST00000306602.3
C-X-C motif chemokine ligand 10
chr5_+_151212117 1.25 ENST00000523466.5
GM2 ganglioside activator
chr19_+_2476118 1.20 ENST00000215631.9
ENST00000587345.1
growth arrest and DNA damage inducible beta
chr7_-_93890744 1.18 ENST00000650573.1
ENST00000222543.11
ENST00000649913.1
ENST00000647793.1
tissue factor pathway inhibitor 2
chr19_+_41219177 1.08 ENST00000301178.9
AXL receptor tyrosine kinase
chr11_-_128522189 1.06 ENST00000526145.6
ETS proto-oncogene 1, transcription factor
chr14_+_22515623 1.04 ENST00000390509.1
T cell receptor alpha joining 28
chr19_-_50968775 1.04 ENST00000391808.5
kallikrein related peptidase 6
chr4_+_73869385 1.03 ENST00000395761.4
C-X-C motif chemokine ligand 1
chr11_-_128522264 1.01 ENST00000531611.5
ETS proto-oncogene 1, transcription factor
chr2_+_64454506 0.99 ENST00000409537.2
galectin like
chr16_+_29812150 0.98 ENST00000647876.1
ENST00000567551.2
ENST00000567659.3
ENST00000637565.1
ENST00000358758.12
ENST00000636619.1
proline rich transmembrane protein 2
chr10_-_29634964 0.96 ENST00000375398.6
ENST00000355867.8
supervillin
chr12_-_76031588 0.94 ENST00000602540.5
pleckstrin homology like domain family A member 1
chr17_-_7205116 0.91 ENST00000649520.1
ENST00000649186.1
discs large MAGUK scaffold protein 4
chr10_+_30434021 0.91 ENST00000542547.5
mitogen-activated protein kinase kinase kinase 8
chr9_-_32526185 0.90 ENST00000379883.3
ENST00000379868.6
ENST00000679859.1
DExD/H-box helicase 58
chr10_+_102395693 0.87 ENST00000652277.1
ENST00000189444.11
ENST00000661543.1
nuclear factor kappa B subunit 2
chr6_+_106086316 0.86 ENST00000369091.6
ENST00000369096.9
PR/SET domain 1
chr10_-_98415143 0.86 ENST00000370575.5
pyridine nucleotide-disulphide oxidoreductase domain 2
chr11_-_128522285 0.86 ENST00000319397.6
ENST00000535549.5
ETS proto-oncogene 1, transcription factor
chr7_+_22727147 0.84 ENST00000426291.5
ENST00000401651.5
ENST00000258743.10
ENST00000407492.5
ENST00000401630.7
ENST00000406575.1
interleukin 6
chr10_+_30434176 0.84 ENST00000263056.6
ENST00000375322.2
mitogen-activated protein kinase kinase kinase 8
chr22_-_37244237 0.83 ENST00000401529.3
ENST00000249071.11
Rac family small GTPase 2
chr19_+_2096937 0.82 ENST00000395296.5
IZUMO family member 4
chr19_+_2097010 0.82 ENST00000610800.1
IZUMO family member 4
chr12_-_27971970 0.82 ENST00000395872.5
ENST00000201015.8
parathyroid hormone like hormone
chr1_-_209652329 0.80 ENST00000367030.7
ENST00000356082.9
laminin subunit beta 3
chr15_+_41774539 0.78 ENST00000514566.5
mitogen-activated protein kinase binding protein 1
chr6_-_32853618 0.77 ENST00000354258.5
transporter 1, ATP binding cassette subfamily B member
chr6_-_32853813 0.77 ENST00000643049.2
transporter 1, ATP binding cassette subfamily B member
chr19_-_4831689 0.77 ENST00000248244.6
toll like receptor adaptor molecule 1
chr9_+_17579059 0.77 ENST00000380607.5
SH3 domain containing GRB2 like 2, endophilin A1
chr19_-_49640092 0.76 ENST00000246792.4
RAS related
chr11_+_18266254 0.76 ENST00000532858.5
ENST00000649195.1
ENST00000356524.9
ENST00000405158.2
serum amyloid A1
chr14_+_51847145 0.75 ENST00000615906.4
G protein subunit gamma 2
chr11_+_94768331 0.73 ENST00000317829.12
ENST00000433060.3
angiomotin like 1
chr1_-_37634864 0.72 ENST00000356545.7
R-spondin 1
chr22_-_37244417 0.72 ENST00000405484.5
ENST00000441619.5
ENST00000406508.5
Rac family small GTPase 2
chr1_+_206470463 0.72 ENST00000581977.7
ENST00000578328.6
ENST00000584998.5
ENST00000579827.6
inhibitor of nuclear factor kappa B kinase subunit epsilon
chr21_+_42403856 0.70 ENST00000291535.11
ubiquitin associated and SH3 domain containing A
chr10_+_100997040 0.69 ENST00000370223.7
leucine zipper tumor suppressor 2
chr11_-_58578096 0.68 ENST00000528954.5
ENST00000528489.1
leupaxin
chr3_-_157160751 0.67 ENST00000461804.5
cyclin L1
chr4_+_41612702 0.67 ENST00000509277.5
LIM and calponin homology domains 1
chr14_+_73237493 0.67 ENST00000340738.9
ENST00000644200.2
papilin, proteoglycan like sulfated glycoprotein
chr6_+_32637396 0.66 ENST00000395363.5
ENST00000496318.5
ENST00000343139.11
major histocompatibility complex, class II, DQ alpha 1
chr11_+_118607598 0.65 ENST00000600882.6
ENST00000356063.9
pleckstrin homology like domain family B member 1
chr2_+_218880844 0.65 ENST00000258411.8
Wnt family member 10A
chr16_+_29812230 0.64 ENST00000300797.7
ENST00000637403.1
ENST00000572820.2
ENST00000637064.1
ENST00000636246.1
proline rich transmembrane protein 2
chr4_-_121164314 0.64 ENST00000057513.8
TNFAIP3 interacting protein 3
chr7_-_24757926 0.62 ENST00000342947.9
ENST00000419307.6
gasdermin E
chr7_-_24757413 0.62 ENST00000645220.1
ENST00000409970.6
gasdermin E
chr3_+_172039556 0.62 ENST00000415807.7
ENST00000421757.5
fibronectin type III domain containing 3B
chr21_+_33403466 0.62 ENST00000405436.5
interferon gamma receptor 2
chr1_-_209651291 0.61 ENST00000391911.5
ENST00000415782.1
laminin subunit beta 3
chr19_+_2096960 0.60 ENST00000588003.5
IZUMO family member 4
chr5_-_151080978 0.59 ENST00000520931.5
ENST00000521591.6
ENST00000520695.5
ENST00000610535.5
ENST00000518977.5
ENST00000389378.6
ENST00000610874.4
TNFAIP3 interacting protein 1
chr10_+_13099585 0.59 ENST00000378764.6
optineurin
chr15_+_57591891 0.59 ENST00000267853.10
ENST00000380569.6
myocardial zonula adherens protein
GRINL1A complex locus 1
chr7_+_151114597 0.58 ENST00000335367.7
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr21_+_33403391 0.58 ENST00000290219.11
ENST00000381995.5
interferon gamma receptor 2
chr7_-_111562455 0.57 ENST00000452895.5
ENST00000405709.7
ENST00000452753.1
ENST00000331762.7
inner mitochondrial membrane peptidase subunit 2
chr7_+_143381561 0.57 ENST00000354434.8
zyxin
chr10_+_13100075 0.57 ENST00000378747.8
ENST00000378757.6
ENST00000378752.7
ENST00000378748.7
optineurin
chr1_+_24319342 0.56 ENST00000361548.9
grainyhead like transcription factor 3
chr12_+_93572664 0.56 ENST00000551556.2
suppressor of cytokine signaling 2
chr1_+_24319511 0.56 ENST00000356046.6
grainyhead like transcription factor 3
chr13_-_51453015 0.55 ENST00000442263.4
ENST00000311234.9
integrator complex subunit 6
chr15_+_57592003 0.54 ENST00000587652.5
ENST00000649429.1
ENST00000380568.7
ENST00000380565.8
GRINL1A complex locus 1
myocardial zonula adherens protein
chr11_-_73142308 0.54 ENST00000409418.9
FCH and double SH3 domains 2
chr7_+_146116772 0.53 ENST00000361727.8
contactin associated protein 2
chr14_+_102777555 0.53 ENST00000539721.5
ENST00000560463.5
TNF receptor associated factor 3
chr4_+_41612892 0.53 ENST00000509454.5
ENST00000396595.7
ENST00000381753.8
LIM and calponin homology domains 1
chr6_-_31582415 0.53 ENST00000429299.3
ENST00000446745.2
lymphotoxin beta
chr7_+_143381286 0.52 ENST00000449630.5
ENST00000322764.10
ENST00000457235.5
zyxin
chr11_+_118607579 0.52 ENST00000530708.4
pleckstrin homology like domain family B member 1
chr7_+_134779663 0.52 ENST00000361901.6
caldesmon 1
chr17_+_8002610 0.52 ENST00000254854.5
guanylate cyclase 2D, retinal
chr5_-_151087131 0.51 ENST00000315050.11
ENST00000523338.5
ENST00000522100.5
TNFAIP3 interacting protein 1
chr17_-_7251691 0.51 ENST00000574322.6
CTD nuclear envelope phosphatase 1
chr2_-_191020960 0.50 ENST00000432058.1
signal transducer and activator of transcription 1
chr14_+_102777433 0.49 ENST00000392745.8
TNF receptor associated factor 3
chr19_-_11577632 0.49 ENST00000590420.1
ENST00000648477.1
acid phosphatase 5, tartrate resistant
chr15_+_85380625 0.49 ENST00000560302.5
A-kinase anchoring protein 13
chr7_+_134779625 0.49 ENST00000454108.5
ENST00000361675.7
caldesmon 1
chr2_-_89143133 0.48 ENST00000492167.1
immunoglobulin kappa variable 3-20
chr19_+_36851645 0.47 ENST00000331800.8
ENST00000612719.4
ENST00000586646.1
zinc finger protein 345
chr1_+_151198536 0.47 ENST00000349792.9
ENST00000409426.5
ENST00000368888.9
ENST00000441902.6
ENST00000368890.8
ENST00000424999.1
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
chr2_+_68467544 0.47 ENST00000303795.9
aprataxin and PNKP like factor
chr19_+_38899680 0.47 ENST00000576510.5
ENST00000392079.7
NFKB inhibitor beta
chr16_+_50742037 0.46 ENST00000569418.5
CYLD lysine 63 deubiquitinase
chr3_+_5122276 0.46 ENST00000256496.8
ENST00000419534.2
ADP ribosylation factor like GTPase 8B
chr15_+_67138001 0.46 ENST00000439724.7
SMAD family member 3
chr3_+_111859180 0.46 ENST00000412622.5
ENST00000431670.7
pleckstrin homology like domain family B member 2
chr19_+_38899946 0.43 ENST00000572515.5
ENST00000313582.6
ENST00000575359.5
NFKB inhibitor beta
chr19_-_4338786 0.43 ENST00000601482.1
ENST00000600324.5
ENST00000594605.6
signal transducing adaptor family member 2
chr7_-_99144053 0.42 ENST00000361125.1
ENST00000361368.7
SMAD specific E3 ubiquitin protein ligase 1
chr4_+_73836667 0.42 ENST00000226317.10
C-X-C motif chemokine ligand 6
chr5_+_31639104 0.41 ENST00000438447.2
PDZ domain containing 2
chr14_+_102777461 0.41 ENST00000560371.5
ENST00000347662.8
TNF receptor associated factor 3
chr8_-_39838201 0.41 ENST00000347580.8
ENST00000379853.6
ENST00000265708.9
ENST00000521880.5
ADAM metallopeptidase domain 2
chr2_-_74441882 0.41 ENST00000272430.10
rhotekin
chr16_+_1309136 0.41 ENST00000325437.9
ubiquitin conjugating enzyme E2 I
chr16_+_50742110 0.41 ENST00000566679.6
ENST00000564634.5
ENST00000398568.6
CYLD lysine 63 deubiquitinase
chr2_+_207529731 0.41 ENST00000430624.5
cAMP responsive element binding protein 1
chr6_+_20401864 0.40 ENST00000346618.8
ENST00000613242.4
E2F transcription factor 3
chr14_-_21536928 0.40 ENST00000613414.4
spalt like transcription factor 2
chr2_+_233693659 0.40 ENST00000406651.1
UDP glucuronosyltransferase family 1 member A6
chr11_-_64803152 0.40 ENST00000439069.5
ENST00000294066.7
ENST00000377350.7
mitogen-activated protein kinase kinase kinase kinase 2
chrX_-_132218124 0.40 ENST00000342983.6
RAP2C, member of RAS oncogene family
chr1_-_93614091 0.40 ENST00000370247.7
BCAR3 adaptor protein, NSP family member
chr1_-_205775449 0.40 ENST00000235932.8
ENST00000437324.6
ENST00000414729.1
ENST00000367139.8
RAB29, member RAS oncogene family
chrX_-_135052114 0.39 ENST00000370775.3
retrotransposon Gag like 8A
chr5_-_55173173 0.38 ENST00000296733.5
ENST00000322374.10
ENST00000381375.7
cell division cycle 20B
chr5_-_132777215 0.38 ENST00000458488.2
septin 8
chr20_-_45124463 0.38 ENST00000372785.3
WAP four-disulfide core domain 12
chr6_+_46652914 0.38 ENST00000411689.6
solute carrier family 25 member 27
chr3_-_134651011 0.37 ENST00000508956.5
ENST00000503669.1
ENST00000423778.7
kyphoscoliosis peptidase
chr9_+_100429511 0.37 ENST00000613183.1
Myb/SANT DNA binding domain containing 3
chr6_-_30744537 0.37 ENST00000259874.6
ENST00000376377.2
immediate early response 3
chr6_+_32154131 0.36 ENST00000375143.6
ENST00000324816.11
ENST00000424499.1
palmitoyl-protein thioesterase 2
chrX_-_132219439 0.36 ENST00000370874.2
RAP2C, member of RAS oncogene family
chrX_-_132219473 0.36 ENST00000620646.4
RAP2C, member of RAS oncogene family
chr1_-_233295712 0.35 ENST00000258229.14
pecanex 2
chr3_+_111859284 0.35 ENST00000498699.5
pleckstrin homology like domain family B member 2
chr1_-_41484680 0.35 ENST00000372587.5
endothelin 2
chr5_-_178627001 0.35 ENST00000611575.4
ENST00000520957.1
ENST00000316308.9
ENST00000611733.4
CDC like kinase 4
chr6_+_32154010 0.34 ENST00000375137.6
palmitoyl-protein thioesterase 2
chr17_-_35880350 0.34 ENST00000605140.6
ENST00000651122.1
ENST00000603197.6
C-C motif chemokine ligand 5
chr15_+_47184076 0.34 ENST00000558014.5
semaphorin 6D
chr1_+_231162052 0.34 ENST00000366653.6
ENST00000444294.7
tripartite motif containing 67
chr1_-_153963462 0.34 ENST00000368621.5
ENST00000368623.7
ENST00000621013.4
solute carrier family 39 member 1
chr15_+_41774459 0.34 ENST00000457542.7
ENST00000456763.6
mitogen-activated protein kinase binding protein 1
chr2_-_162318475 0.33 ENST00000648433.1
interferon induced with helicase C domain 1
chr19_+_40717091 0.32 ENST00000263370.3
inositol-trisphosphate 3-kinase C
chr9_-_114806031 0.32 ENST00000374045.5
TNF superfamily member 15
chr1_-_153963505 0.32 ENST00000356205.9
ENST00000537590.5
solute carrier family 39 member 1
chr22_-_27919199 0.32 ENST00000634017.1
ENST00000436663.1
ENST00000320996.14
ENST00000335272.10
ENST00000455418.7
phosphatidylinositol transfer protein beta
chr1_-_205775182 0.32 ENST00000446390.6
RAB29, member RAS oncogene family
chr7_-_123748902 0.32 ENST00000223023.5
WASP like actin nucleation promoting factor
chr11_-_73142032 0.31 ENST00000311172.11
ENST00000409314.5
FCH and double SH3 domains 2
chr4_-_102828048 0.31 ENST00000508249.1
ubiquitin conjugating enzyme E2 D3
chr11_+_118883884 0.30 ENST00000292174.5
C-X-C motif chemokine receptor 5
chr17_-_41811930 0.30 ENST00000393928.6
prolyl 3-hydroxylase family member 4 (inactive)
chr19_-_47231191 0.30 ENST00000439096.3
BCL2 binding component 3
chr15_+_100602519 0.30 ENST00000332783.12
ENST00000558747.5
ENST00000343276.4
ankyrin repeat and SOCS box containing 7
chr2_+_42494547 0.30 ENST00000405592.5
metastasis associated 1 family member 3
chr13_+_108269880 0.29 ENST00000542136.1
TNF superfamily member 13b
chr10_+_18659382 0.29 ENST00000377275.4
ADP ribosylation factor like GTPase 5B
chr12_+_6944065 0.29 ENST00000540506.2
chromosome 12 open reading frame 57
chr11_+_119185469 0.28 ENST00000525131.5
ENST00000355547.10
ENST00000531114.5
ENST00000322712.4
PDZ domain containing 3
chr4_-_76007501 0.28 ENST00000264888.6
C-X-C motif chemokine ligand 9
chrX_-_20266606 0.28 ENST00000643085.1
ENST00000645270.1
ENST00000644368.1
ribosomal protein S6 kinase A3
chr1_+_247416166 0.28 ENST00000391827.3
ENST00000336119.8
NLR family pyrin domain containing 3
chr12_-_57110284 0.28 ENST00000543873.6
ENST00000554663.5
ENST00000557635.5
signal transducer and activator of transcription 6
chr14_-_50830479 0.27 ENST00000382043.8
ninein
chr4_-_186723776 0.27 ENST00000614102.4
ENST00000441802.7
FAT atypical cadherin 1
chr9_-_127930777 0.27 ENST00000388747.9
phosphatidylinositol-4-phosphate 5-kinase like 1
chr17_-_7687427 0.27 ENST00000514944.5
ENST00000503591.1
ENST00000610292.4
ENST00000420246.6
ENST00000455263.6
ENST00000610538.4
ENST00000622645.4
ENST00000445888.6
ENST00000619485.4
ENST00000509690.5
ENST00000604348.5
ENST00000269305.9
ENST00000620739.4
tumor protein p53
chr12_+_6943811 0.27 ENST00000544681.1
ENST00000537087.5
chromosome 12 open reading frame 57
chr2_+_60881553 0.27 ENST00000394479.4
REL proto-oncogene, NF-kB subunit
chr16_+_67537439 0.25 ENST00000428437.6
ENST00000569253.5
RHO family interacting cell polarization regulator 1
chrX_-_139932994 0.25 ENST00000682941.1
ENST00000370557.5
ATPase phospholipid transporting 11C
chr12_+_48106094 0.25 ENST00000546755.5
ENST00000549366.5
ENST00000642730.1
ENST00000552792.5
phosphofructokinase, muscle
chr2_-_162318613 0.25 ENST00000649979.2
ENST00000421365.2
interferon induced with helicase C domain 1
chr12_+_6944009 0.25 ENST00000229281.6
chromosome 12 open reading frame 57
chr6_-_46652786 0.25 ENST00000275016.3
ENST00000619708.4
cytochrome P450 family 39 subfamily A member 1
chr19_-_4182527 0.24 ENST00000601571.1
ENST00000601488.5
ENST00000305232.10
ENST00000337491.7
sirtuin 6
chr2_+_60881515 0.24 ENST00000295025.12
REL proto-oncogene, NF-kB subunit
chr1_-_155688294 0.24 ENST00000311573.9
YY1 associated protein 1
chr1_+_247416149 0.24 ENST00000366497.6
ENST00000391828.8
NLR family pyrin domain containing 3
chr5_-_35230332 0.24 ENST00000504500.5
prolactin receptor
chr2_-_68467272 0.24 ENST00000377957.4
F-box protein 48
chr10_-_6062349 0.24 ENST00000379959.8
interleukin 2 receptor subunit alpha
chrX_-_30577759 0.24 ENST00000378962.4
TLR adaptor interacting with endolysosomal SLC15A4
chr12_-_48106042 0.24 ENST00000551798.1
ENST00000549518.6
SUMO specific peptidase 1
chr16_-_28211476 0.23 ENST00000569951.1
ENST00000565698.5
exportin 6

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 7.0 GO:0034147 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429)
1.5 4.6 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.9 2.8 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.8 3.2 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.7 8.7 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.6 2.6 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.5 1.5 GO:0046967 cytosol to ER transport(GO:0046967)
0.4 4.3 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.4 3.0 GO:0070842 aggresome assembly(GO:0070842)
0.4 1.1 GO:0052027 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.4 2.9 GO:0015705 iodide transport(GO:0015705)
0.3 11.3 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.3 1.5 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.3 0.9 GO:1990654 regulation of extrathymic T cell differentiation(GO:0033082) sebum secreting cell proliferation(GO:1990654)
0.2 0.7 GO:2000669 negative regulation of dendritic cell apoptotic process(GO:2000669)
0.2 0.9 GO:1990108 protein linear deubiquitination(GO:1990108)
0.2 0.8 GO:1990637 hepatic immune response(GO:0002384) response to prolactin(GO:1990637)
0.2 1.6 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.2 0.6 GO:0061300 cerebellum vasculature development(GO:0061300)
0.2 1.8 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.2 0.3 GO:0003099 positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.2 0.5 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.2 1.3 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.2 2.9 GO:0016540 protein autoprocessing(GO:0016540)
0.1 2.4 GO:0051601 exocyst localization(GO:0051601)
0.1 1.3 GO:0006689 ganglioside catabolic process(GO:0006689)
0.1 0.3 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
0.1 0.8 GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
0.1 0.5 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1 0.5 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.1 0.3 GO:0038158 granulocyte colony-stimulating factor signaling pathway(GO:0038158)
0.1 2.1 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 1.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 0.5 GO:0071109 superior temporal gyrus development(GO:0071109)
0.1 0.3 GO:1903526 negative regulation of membrane tubulation(GO:1903526)
0.1 2.0 GO:1904261 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.1 0.4 GO:1903755 regulation of SUMO transferase activity(GO:1903182) positive regulation of SUMO transferase activity(GO:1903755)
0.1 0.8 GO:0021678 third ventricle development(GO:0021678)
0.1 0.5 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.4 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.1 0.3 GO:0090222 centrosome-templated microtubule nucleation(GO:0090222)
0.1 0.3 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.1 0.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.3 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 0.2 GO:0030573 bile acid catabolic process(GO:0030573)
0.1 0.4 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.1 0.2 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) regulation of chromatin silencing at telomere(GO:0031938)
0.1 1.4 GO:0016322 neuron remodeling(GO:0016322)
0.1 0.5 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 0.5 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.1 0.5 GO:2000321 positive regulation of T-helper 17 cell differentiation(GO:2000321)
0.1 1.6 GO:0050884 neuromuscular process controlling posture(GO:0050884)
0.1 0.8 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.3 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.1 0.3 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916) chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.1 0.8 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 0.7 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 0.2 GO:0038161 prolactin signaling pathway(GO:0038161)
0.1 1.1 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.1 0.7 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.1 1.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.1 0.4 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 0.9 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.1 0.8 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.1 0.2 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.3 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.1 0.2 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 0.3 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.1 1.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.6 GO:0048733 sebaceous gland development(GO:0048733)
0.0 1.6 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.0 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180)
0.0 0.1 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536) regulation of respiratory burst involved in inflammatory response(GO:0060264) negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0 0.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.3 GO:0032417 positive regulation of sodium:proton antiporter activity(GO:0032417)
0.0 0.5 GO:0051106 positive regulation of DNA ligation(GO:0051106)
0.0 0.3 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956)
0.0 0.2 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.7 GO:1903441 protein localization to ciliary membrane(GO:1903441)
0.0 1.6 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.2 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:1903015 regulation of exo-alpha-sialidase activity(GO:1903015)
0.0 0.1 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.3 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 1.3 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 1.2 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.0 0.4 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.2 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.7 GO:0071380 cellular response to prostaglandin E stimulus(GO:0071380)
0.0 0.3 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 1.5 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0 0.5 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 3.6 GO:0031295 T cell costimulation(GO:0031295)
0.0 0.1 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.2 GO:0060613 fat pad development(GO:0060613)
0.0 0.5 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 0.3 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.8 GO:0002076 osteoblast development(GO:0002076)
0.0 0.1 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.2 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.2 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.4 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.1 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.2 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.2 GO:1904628 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012) response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.0 0.6 GO:0016180 snRNA processing(GO:0016180)
0.0 1.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0039526 suppression by virus of host apoptotic process(GO:0019050) modulation by virus of host apoptotic process(GO:0039526)
0.0 0.2 GO:0032782 bile acid secretion(GO:0032782)
0.0 0.3 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.3 GO:0051683 establishment of Golgi localization(GO:0051683)
0.0 0.7 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.1 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
0.0 0.1 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.0 0.3 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.2 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.8 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.2 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.4 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.5 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.1 GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0 0.2 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.0 GO:2000152 regulation of ubiquitin-specific protease activity(GO:2000152)
0.0 0.7 GO:0035329 hippo signaling(GO:0035329)
0.0 0.7 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.3 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.2 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.5 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.5 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.2 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.0 0.1 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.4 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.5 GO:0060325 face morphogenesis(GO:0060325)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.5 4.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.3 1.3 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.2 1.5 GO:0042825 TAP complex(GO:0042825)
0.2 1.4 GO:0005610 laminin-5 complex(GO:0005610)
0.2 0.9 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.2 0.7 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.2 0.5 GO:0071753 IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756)
0.1 0.6 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 2.0 GO:0045180 basal cortex(GO:0045180)
0.1 1.2 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.4 GO:1990356 sumoylated E2 ligase complex(GO:1990356)
0.1 0.5 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 1.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.3 GO:0030478 actin cap(GO:0030478)
0.1 2.4 GO:0000145 exocyst(GO:0000145)
0.1 1.4 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 0.2 GO:0016938 kinesin I complex(GO:0016938)
0.1 0.2 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 0.3 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 0.2 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.1 0.9 GO:0098839 postsynaptic density membrane(GO:0098839)
0.1 1.0 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 0.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.5 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.0 0.7 GO:0033643 host cell part(GO:0033643)
0.0 3.0 GO:0016235 aggresome(GO:0016235)
0.0 0.3 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 1.0 GO:0097342 ripoptosome(GO:0097342)
0.0 0.7 GO:0033010 paranodal junction(GO:0033010)
0.0 0.6 GO:0032039 integrator complex(GO:0032039)
0.0 2.9 GO:0031526 brush border membrane(GO:0031526)
0.0 0.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.8 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 12.5 GO:0045121 membrane raft(GO:0045121)
0.0 0.4 GO:0008091 spectrin(GO:0008091)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.5 GO:0005861 troponin complex(GO:0005861)
0.0 1.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.1 GO:0002102 podosome(GO:0002102)
0.0 1.6 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 1.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.1 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.9 GO:0097542 ciliary tip(GO:0097542)
0.0 0.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.5 GO:0051233 spindle midzone(GO:0051233)
0.0 0.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.3 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 1.1 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.9 13.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.7 2.9 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.6 2.8 GO:0050473 prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473)
0.4 7.9 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.4 1.3 GO:0032428 sphingolipid activator protein activity(GO:0030290) beta-N-acetylgalactosaminidase activity(GO:0032428)
0.3 1.2 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.3 0.8 GO:0008384 IkappaB kinase activity(GO:0008384)
0.2 1.5 GO:0023029 peptide-transporting ATPase activity(GO:0015440) MHC class Ib protein binding(GO:0023029)
0.2 8.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 0.5 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.1 1.9 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 0.9 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 2.7 GO:0070628 proteasome binding(GO:0070628)
0.1 0.5 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.1 1.6 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.1 0.4 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.1 0.2 GO:0097199 death effector domain binding(GO:0035877) cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 0.9 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 1.4 GO:0031996 thioesterase binding(GO:0031996)
0.1 0.5 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 0.6 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.3 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298) CCR1 chemokine receptor binding(GO:0031726)
0.1 0.2 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.1 0.2 GO:0004925 prolactin receptor activity(GO:0004925)
0.1 2.6 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 0.2 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.7 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 3.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 0.5 GO:0031014 troponin T binding(GO:0031014)
0.1 0.3 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 3.1 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.3 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 1.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.1 GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223)
0.0 0.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.2 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.0 1.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.4 GO:0042731 PH domain binding(GO:0042731)
0.0 0.2 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.0 0.3 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 1.0 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.7 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.0 GO:0070004 cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004)
0.0 0.2 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 3.0 GO:0019003 GDP binding(GO:0019003)
0.0 0.5 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.3 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.4 GO:0010851 cyclase regulator activity(GO:0010851)
0.0 0.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.3 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.3 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.5 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.1 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.4 GO:0070411 activin binding(GO:0048185) I-SMAD binding(GO:0070411)
0.0 0.1 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0 0.8 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.9 GO:0061650 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 2.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 1.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.1 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0 0.2 GO:0004568 chitinase activity(GO:0004568)
0.0 0.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 3.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.4 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 22.6 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 1.6 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 1.7 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 4.1 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 2.8 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 1.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 0.9 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 2.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 0.5 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 1.8 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 1.2 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.0 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.6 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.7 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.6 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 1.6 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 2.2 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.7 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 1.0 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.8 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 9.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 4.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.3 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.4 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.3 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.2 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.5 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.9 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.4 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.3 16.3 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.3 18.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 1.5 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.1 2.2 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 2.5 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 2.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.6 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 0.8 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 1.6 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 0.1 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1 0.2 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 0.8 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 1.8 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 1.7 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.5 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.3 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.1 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 3.2 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.8 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.7 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.7 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.6 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.3 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.5 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.2 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 1.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 1.5 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.6 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 0.1 REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways