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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for REST

Z-value: 0.86

Motif logo

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.19 REST

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg38_v1_chr4_+_56908094_56908134-0.154.3e-01Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr20_+_63696643 1.85 ENST00000369996.3
TNFRSF6B
TNF receptor superfamily member 6b
chr5_+_33936386 1.82 ENST00000330120.5
RXFP3
relaxin family peptide receptor 3
chr8_-_90082871 1.71 ENST00000265431.7
CALB1
calbindin 1
chr9_+_132582581 1.60 ENST00000263610.7
BARHL1
BarH like homeobox 1
chr19_-_51342130 1.50 ENST00000335624.5
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr4_+_8580387 1.38 ENST00000382487.5
GPR78
G protein-coupled receptor 78
chr6_+_35805347 1.18 ENST00000360215.3
LHFPL5
LHFPL tetraspan subfamily member 5
chr12_+_71439976 1.10 ENST00000536515.5
ENST00000540815.2
LGR5
leucine rich repeat containing G protein-coupled receptor 5
chr7_+_155070317 1.03 ENST00000287907.3
HTR5A
5-hydroxytryptamine receptor 5A
chr20_+_31968141 0.99 ENST00000562532.3
XKR7
XK related 7
chr5_-_151924846 0.93 ENST00000274576.9
GLRA1
glycine receptor alpha 1
chr5_-_151924824 0.90 ENST00000455880.2
GLRA1
glycine receptor alpha 1
chrX_+_7147675 0.81 ENST00000674429.1
STS
steroid sulfatase
chr10_-_77638369 0.81 ENST00000372443.6
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr14_-_106627685 0.81 ENST00000390629.3
IGHV4-59
immunoglobulin heavy variable 4-59
chr17_+_32486975 0.80 ENST00000313401.4
CDK5R1
cyclin dependent kinase 5 regulatory subunit 1
chr3_-_42701513 0.78 ENST00000310417.9
HHATL
hedgehog acyltransferase like
chr12_-_29783798 0.78 ENST00000552618.5
ENST00000551659.5
ENST00000539277.6
TMTC1
transmembrane O-mannosyltransferase targeting cadherins 1
chr15_-_21742799 0.74 ENST00000622410.2
ENSG00000278263.2
novel protein, identical to IGHV4-4
chr11_+_62613236 0.73 ENST00000278833.4
ROM1
retinal outer segment membrane protein 1
chr2_+_114442616 0.68 ENST00000410059.6
DPP10
dipeptidyl peptidase like 10
chrX_+_7147237 0.67 ENST00000666110.2
STS
steroid sulfatase
chr14_+_92923143 0.65 ENST00000216492.10
ENST00000334654.4
CHGA
chromogranin A
chr4_+_157220691 0.65 ENST00000509417.5
ENST00000645636.1
ENST00000296526.12
ENST00000264426.14
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr15_-_72320149 0.62 ENST00000287202.10
CELF6
CUGBP Elav-like family member 6
chr9_-_71446835 0.60 ENST00000357533.6
TRPM3
transient receptor potential cation channel subfamily M member 3
chr15_-_31870651 0.59 ENST00000307050.6
ENST00000560598.2
OTUD7A
OTU deubiquitinase 7A
chr3_+_9703826 0.59 ENST00000613455.4
ENST00000383831.7
ENST00000383832.8
CPNE9
copine family member 9
chr10_+_97849824 0.58 ENST00000370602.6
GOLGA7B
golgin A7 family member B
chr20_+_46029206 0.57 ENST00000243964.7
SLC12A5
solute carrier family 12 member 5
chr6_+_109978297 0.56 ENST00000275169.5
GPR6
G protein-coupled receptor 6
chr17_-_3398410 0.56 ENST00000322608.2
OR1E1
olfactory receptor family 1 subfamily E member 1
chr6_+_109978256 0.54 ENST00000414000.3
GPR6
G protein-coupled receptor 6
chr15_-_82709823 0.52 ENST00000666973.1
ENST00000664460.1
ENST00000669930.1
AP3B2
adaptor related protein complex 3 subunit beta 2
chr20_+_46029165 0.52 ENST00000616201.4
ENST00000616202.4
ENST00000616933.4
ENST00000626937.2
SLC12A5
solute carrier family 12 member 5
chr4_+_157220654 0.52 ENST00000393815.6
GRIA2
glutamate ionotropic receptor AMPA type subunit 2
chr11_+_125903320 0.49 ENST00000525943.1
DDX25
DEAD-box helicase 25
chr15_-_82709775 0.49 ENST00000535348.5
AP3B2
adaptor related protein complex 3 subunit beta 2
chr12_+_113358542 0.48 ENST00000545182.6
ENST00000280800.5
PLBD2
phospholipase B domain containing 2
chr2_-_51032390 0.48 ENST00000404971.5
NRXN1
neurexin 1
chr2_-_51032536 0.47 ENST00000626899.1
ENST00000406316.6
NRXN1
neurexin 1
chr7_-_101165114 0.44 ENST00000445482.2
VGF
VGF nerve growth factor inducible
chr3_-_48662877 0.44 ENST00000164024.5
CELSR3
cadherin EGF LAG seven-pass G-type receptor 3
chr19_-_3971051 0.43 ENST00000545797.7
ENST00000596311.5
DAPK3
death associated protein kinase 3
chr1_-_101996919 0.42 ENST00000370103.9
OLFM3
olfactomedin 3
chr14_+_93430853 0.41 ENST00000553484.5
UNC79
unc-79 homolog, NALCN channel complex subunit
chr4_-_174829212 0.40 ENST00000340217.5
ENST00000274093.8
GLRA3
glycine receptor alpha 3
chr5_+_175871570 0.38 ENST00000512824.5
ENST00000393745.8
CPLX2
complexin 2
chr6_+_152750789 0.38 ENST00000367244.8
ENST00000367243.7
VIP
vasoactive intestinal peptide
chr15_-_82709859 0.38 ENST00000542200.2
ENST00000535359.6
ENST00000668990.2
ENST00000652847.1
AP3B2
adaptor related protein complex 3 subunit beta 2
chr9_-_101594995 0.37 ENST00000636434.1
PPP3R2
protein phosphatase 3 regulatory subunit B, beta
chrX_-_47619850 0.37 ENST00000295987.13
ENST00000340666.5
SYN1
synapsin I
chr12_+_118981531 0.35 ENST00000267260.5
SRRM4
serine/arginine repetitive matrix 4
chr2_-_51032151 0.35 ENST00000628515.2
NRXN1
neurexin 1
chr1_-_241357085 0.35 ENST00000366564.5
RGS7
regulator of G protein signaling 7
chr10_-_101031095 0.35 ENST00000645349.1
ENST00000619208.6
ENST00000644782.1
ENST00000370215.7
ENST00000646029.1
PDZD7
PDZ domain containing 7
chr1_+_209938169 0.34 ENST00000367019.5
ENST00000537238.5
ENST00000637265.1
SYT14
synaptotagmin 14
chr1_-_241357171 0.34 ENST00000440928.6
RGS7
regulator of G protein signaling 7
chr9_-_101594918 0.34 ENST00000374806.2
PPP3R2
protein phosphatase 3 regulatory subunit B, beta
chr16_+_31459950 0.33 ENST00000564900.1
ARMC5
armadillo repeat containing 5
chr9_+_137139139 0.32 ENST00000371561.8
GRIN1
glutamate ionotropic receptor NMDA type subunit 1
chr1_+_209938207 0.32 ENST00000472886.5
SYT14
synaptotagmin 14
chr6_+_25652272 0.32 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr15_-_82709886 0.30 ENST00000666055.1
ENST00000261722.8
ENST00000535513.2
AP3B2
adaptor related protein complex 3 subunit beta 2
chr12_+_112791738 0.30 ENST00000389385.9
RPH3A
rabphilin 3A
chr9_+_137139481 0.30 ENST00000371546.8
ENST00000371550.8
ENST00000371553.7
ENST00000371555.8
ENST00000371559.8
ENST00000371560.4
GRIN1
glutamate ionotropic receptor NMDA type subunit 1
chr7_-_101165558 0.30 ENST00000611537.1
ENST00000249330.3
VGF
VGF nerve growth factor inducible
chr3_-_114179052 0.30 ENST00000383673.5
ENST00000295881.9
DRD3
dopamine receptor D3
chr10_-_49762276 0.28 ENST00000374103.9
OGDHL
oxoglutarate dehydrogenase L
chr14_-_106639589 0.27 ENST00000390630.3
IGHV4-61
immunoglobulin heavy variable 4-61
chr2_-_51032091 0.27 ENST00000637511.1
ENST00000405472.7
ENST00000405581.3
ENST00000401669.7
NRXN1
neurexin 1
chr1_+_154567820 0.26 ENST00000637900.1
CHRNB2
cholinergic receptor nicotinic beta 2 subunit
chr9_-_136205122 0.26 ENST00000371748.10
LHX3
LIM homeobox 3
chr20_-_63653413 0.25 ENST00000370053.3
STMN3
stathmin 3
chr1_+_65309517 0.25 ENST00000371069.5
DNAJC6
DnaJ heat shock protein family (Hsp40) member C6
chr17_+_58148384 0.24 ENST00000268912.6
ENST00000641449.1
OR4D1
olfactory receptor family 4 subfamily D member 1
chr14_-_74426102 0.24 ENST00000554953.1
ENST00000331628.8
SYNDIG1L
synapse differentiation inducing 1 like
chr10_-_44385043 0.23 ENST00000374426.6
ENST00000395794.2
ENST00000374429.6
ENST00000395793.7
ENST00000343575.10
ENST00000395795.5
CXCL12
C-X-C motif chemokine ligand 12
chrX_-_153971810 0.23 ENST00000310441.12
HCFC1
host cell factor C1
chr20_+_37383648 0.23 ENST00000373567.6
SRC
SRC proto-oncogene, non-receptor tyrosine kinase
chrX_-_153875847 0.23 ENST00000361699.8
ENST00000361981.7
L1CAM
L1 cell adhesion molecule
chrX_-_49200174 0.22 ENST00000472598.5
ENST00000263233.9
ENST00000479808.5
SYP
synaptophysin
chr15_-_26773737 0.21 ENST00000299267.8
GABRB3
gamma-aminobutyric acid type A receptor subunit beta3
chr12_+_112791933 0.20 ENST00000551052.5
ENST00000415485.7
RPH3A
rabphilin 3A
chr17_+_44308573 0.20 ENST00000590941.5
ENST00000225441.11
ENST00000426726.8
RUNDC3A
RUN domain containing 3A
chr8_-_56445941 0.20 ENST00000517415.1
ENST00000314922.3
PENK
proenkephalin
chr5_+_64505981 0.20 ENST00000334025.3
RGS7BP
regulator of G protein signaling 7 binding protein
chr10_+_26216766 0.20 ENST00000376261.8
GAD2
glutamate decarboxylase 2
chr14_-_94293071 0.19 ENST00000554723.5
SERPINA10
serpin family A member 10
chr8_-_144336451 0.19 ENST00000569446.3
SCRT1
scratch family transcriptional repressor 1
chr14_-_94293024 0.19 ENST00000393096.5
SERPINA10
serpin family A member 10
chr19_+_40530464 0.18 ENST00000392023.1
SPTBN4
spectrin beta, non-erythrocytic 4
chr1_+_154567770 0.18 ENST00000368476.4
CHRNB2
cholinergic receptor nicotinic beta 2 subunit
chr2_-_27308445 0.18 ENST00000296099.2
UCN
urocortin
chr14_-_94293260 0.18 ENST00000261994.9
SERPINA10
serpin family A member 10
chr11_-_6655788 0.18 ENST00000299441.5
DCHS1
dachsous cadherin-related 1
chr19_-_45423481 0.17 ENST00000589381.5
ERCC1
ERCC excision repair 1, endonuclease non-catalytic subunit
chr5_-_176610104 0.17 ENST00000303991.5
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr2_+_225399684 0.16 ENST00000636099.1
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr2_+_130756291 0.16 ENST00000458606.5
ENST00000423981.1
AMER3
APC membrane recruitment protein 3
chr10_-_49762335 0.16 ENST00000419399.4
ENST00000432695.2
OGDHL
oxoglutarate dehydrogenase L
chr9_+_114329869 0.16 ENST00000431067.4
ORM2
orosomucoid 2
chr6_+_138404206 0.16 ENST00000607197.6
ENST00000367697.7
HEBP2
heme binding protein 2
chr17_-_3433841 0.16 ENST00000248384.1
OR1E2
olfactory receptor family 1 subfamily E member 2
chr20_-_62220267 0.16 ENST00000317393.10
ENST00000611492.1
ENST00000340177.10
HRH3
histamine receptor H3
chr6_+_25652201 0.15 ENST00000612225.4
ENST00000377961.3
SCGN
secretagogin, EF-hand calcium binding protein
chr19_-_45423501 0.15 ENST00000591636.5
ENST00000013807.9
ENST00000592023.5
ERCC1
ERCC excision repair 1, endonuclease non-catalytic subunit
chr14_-_51095091 0.14 ENST00000684578.1
TRIM9
tripartite motif containing 9
chr1_-_151716782 0.14 ENST00000420342.1
ENST00000290583.9
CELF3
CUGBP Elav-like family member 3
chr3_+_75906666 0.14 ENST00000487694.7
ENST00000602589.5
ROBO2
roundabout guidance receptor 2
chr1_+_212432891 0.14 ENST00000366988.5
NENF
neudesin neurotrophic factor
chr17_-_29006145 0.13 ENST00000360295.13
SEZ6
seizure related 6 homolog
chr22_+_22711689 0.12 ENST00000390308.2
IGLV3-21
immunoglobulin lambda variable 3-21
chr17_-_29005913 0.11 ENST00000442608.7
ENST00000317338.17
ENST00000335960.10
SEZ6
seizure related 6 homolog
chr11_+_637244 0.11 ENST00000176183.6
DRD4
dopamine receptor D4
chr9_-_128275935 0.11 ENST00000610329.4
GOLGA2
golgin A2
chr5_-_136365476 0.11 ENST00000378459.7
ENST00000502753.4
ENST00000513104.6
ENST00000352189.8
TRPC7
transient receptor potential cation channel subfamily C member 7
chr8_+_67952028 0.11 ENST00000288368.5
PREX2
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
chr11_-_66347560 0.11 ENST00000311181.5
B4GAT1
beta-1,4-glucuronyltransferase 1
chr12_-_12684490 0.10 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr3_+_120908072 0.09 ENST00000273666.10
ENST00000471454.6
ENST00000472879.5
ENST00000497029.5
ENST00000492541.5
STXBP5L
syntaxin binding protein 5 like
chr12_+_71439789 0.09 ENST00000266674.10
LGR5
leucine rich repeat containing G protein-coupled receptor 5
chr10_+_26216665 0.09 ENST00000259271.7
GAD2
glutamate decarboxylase 2
chr9_-_128275987 0.09 ENST00000490628.2
ENST00000421699.7
ENST00000611957.4
ENST00000450617.6
GOLGA2
golgin A2
chr6_+_154039480 0.09 ENST00000229768.9
ENST00000419506.6
ENST00000524163.5
ENST00000414028.6
ENST00000435918.6
ENST00000337049.8
OPRM1
opioid receptor mu 1
chr10_+_59177161 0.07 ENST00000373878.3
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein like
chr3_-_114178698 0.07 ENST00000467632.5
DRD3
dopamine receptor D3
chr3_+_194136138 0.06 ENST00000232424.4
HES1
hes family bHLH transcription factor 1
chr16_+_4958289 0.06 ENST00000251170.12
SEC14L5
SEC14 like lipid binding 5
chr20_-_45515612 0.06 ENST00000217428.7
SPINT3
serine peptidase inhibitor, Kunitz type 3
chr14_-_51095066 0.06 ENST00000360392.4
TRIM9
tripartite motif containing 9
chr3_-_132035004 0.06 ENST00000429747.6
CPNE4
copine 4
chr8_+_6708626 0.05 ENST00000285518.11
AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5
chr9_-_121050264 0.04 ENST00000223642.3
C5
complement C5
chrX_+_153972729 0.04 ENST00000369982.5
TMEM187
transmembrane protein 187
chr1_+_32886456 0.04 ENST00000373467.4
HPCA
hippocalcin
chr19_-_45423891 0.03 ENST00000300853.8
ERCC1
ERCC excision repair 1, endonuclease non-catalytic subunit
chr6_+_154039333 0.03 ENST00000428397.6
OPRM1
opioid receptor mu 1
chr5_+_71719267 0.03 ENST00000296777.5
CARTPT
CART prepropeptide
chr6_+_154039416 0.02 ENST00000452687.6
OPRM1
opioid receptor mu 1
chr19_-_45423839 0.00 ENST00000340192.11
ERCC1
ERCC excision repair 1, endonuclease non-catalytic subunit
chr11_-_125903190 0.00 ENST00000227474.8
ENST00000613398.4
ENST00000534158.5
ENST00000529801.1
PUS3
pseudouridine synthase 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0021586 pons maturation(GO:0021586)
0.3 1.8 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.3 0.8 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
0.2 0.7 GO:1901899 positive regulation of relaxation of cardiac muscle(GO:1901899)
0.2 1.7 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.2 1.0 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.2 1.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 1.6 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.6 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.1 0.6 GO:0008218 bioluminescence(GO:0008218)
0.1 0.4 GO:0050883 negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883)
0.1 1.2 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1 1.5 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 0.4 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.1 0.3 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.1 0.7 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.1 0.2 GO:0019046 release from viral latency(GO:0019046)
0.1 0.8 GO:0034465 response to carbon monoxide(GO:0034465)
0.1 0.6 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.4 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.1 0.2 GO:0003192 mitral valve formation(GO:0003192)
0.1 1.7 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 0.2 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.1 1.1 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.0 0.3 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 0.3 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0 0.2 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.0 1.8 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 1.5 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.2 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.1 GO:0060164 negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974)
0.0 0.4 GO:0070459 prolactin secretion(GO:0070459)
0.0 0.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.7 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.1 GO:0051944 positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.0 0.2 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.0 0.0 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.0 0.2 GO:0090166 Golgi disassembly(GO:0090166)
0.0 1.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.4 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0 0.7 GO:0002021 response to dietary excess(GO:0002021)
0.0 0.2 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.0 0.6 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.4 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.2 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.1 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.3 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.3 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.2 GO:0010940 positive regulation of necrotic cell death(GO:0010940)
0.0 0.0 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 0.2 GO:0031282 regulation of guanylate cyclase activity(GO:0031282)
0.0 1.4 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 0.1 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.0 1.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.5 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.2 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 1.6 GO:0030901 midbrain development(GO:0030901)
0.0 1.9 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.2 GO:1904469 positive regulation of tumor necrosis factor secretion(GO:1904469)
0.0 0.4 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.7 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.0 0.1 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.2 0.8 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 1.7 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 2.1 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.3 GO:0002139 stereocilia coupling link(GO:0002139)
0.1 1.2 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.3 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.4 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.6 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.6 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.7 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.3 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.4 GO:0070852 cell body fiber(GO:0070852)
0.0 0.5 GO:0033391 chromatoid body(GO:0033391)
0.0 0.2 GO:0043196 varicosity(GO:0043196)
0.0 2.2 GO:0043195 terminal bouton(GO:0043195)
0.0 1.3 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 1.2 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.4 1.5 GO:0004773 steryl-sulfatase activity(GO:0004773)
0.3 1.8 GO:0004966 galanin receptor activity(GO:0004966)
0.3 1.7 GO:0005499 vitamin D binding(GO:0005499)
0.3 0.8 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 1.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.6 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 1.0 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 0.8 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 1.1 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 0.4 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 1.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 0.5 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 1.6 GO:0033130 acetylcholine receptor binding(GO:0033130) neuroligin family protein binding(GO:0097109)
0.1 1.9 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.2 GO:0051431 histone deacetylase regulator activity(GO:0035033) corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.0 0.5 GO:0008430 selenium binding(GO:0008430)
0.0 0.2 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.3 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 1.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.3 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.2 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.2 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.1 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.6 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0097322 7SK snRNA binding(GO:0097322)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.2 ST STAT3 PATHWAY STAT3 Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.0 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 2.4 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.8 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.8 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.4 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.5 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.3 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 2.9 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events