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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for RFX3_RFX2
Z-value: 14.13
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Transcription factors associated with RFX3_RFX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX2 | hg38_v1_chr19_-_6110463_6110541 | 0.99 | 1.0e-23 | Click! |
| RFX3 | hg38_v1_chr9_-_3525968_3526017 | 0.97 | 2.5e-19 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX3_RFX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 24.7 | 889.0 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 10.2 | 530.6 | GO:0035082 | axoneme assembly(GO:0035082) |
| 1.2 | 286.4 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 5.0 | 258.9 | GO:0042073 | intraciliary transport(GO:0042073) |
| 11.3 | 147.2 | GO:0060294 | cilium movement involved in cell motility(GO:0060294) |
| 0.8 | 124.0 | GO:0007286 | spermatid development(GO:0007286) |
| 2.4 | 123.7 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 1.3 | 116.0 | GO:0021795 | cerebral cortex cell migration(GO:0021795) |
| 0.8 | 113.0 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 1.0 | 107.7 | GO:0032418 | lysosome localization(GO:0032418) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 810.5 | GO:0005929 | cilium(GO:0005929) |
| 6.5 | 659.3 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 11.3 | 349.1 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.6 | 308.4 | GO:0005874 | microtubule(GO:0005874) |
| 39.8 | 278.8 | GO:0002177 | manchette(GO:0002177) |
| 5.7 | 237.5 | GO:0034451 | centriolar satellite(GO:0034451) |
| 22.6 | 225.9 | GO:0072687 | meiotic spindle(GO:0072687) |
| 9.3 | 213.0 | GO:0036038 | MKS complex(GO:0036038) |
| 15.9 | 158.6 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 1.3 | 148.6 | GO:0001669 | acrosomal vesicle(GO:0001669) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 490.6 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.4 | 415.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 206.3 | GO:0003677 | DNA binding(GO:0003677) |
| 0.3 | 163.9 | GO:0005525 | GTP binding(GO:0005525) |
| 4.8 | 144.7 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 2.9 | 132.5 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 7.6 | 106.2 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.7 | 93.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.6 | 91.5 | GO:0005254 | chloride channel activity(GO:0005254) |
| 3.2 | 90.2 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 68.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 2.5 | 50.7 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 43.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.7 | 38.3 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.5 | 31.0 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.3 | 30.2 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.2 | 25.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.3 | 22.6 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 18.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 17.3 | PID EPHA FWDPATHWAY | EPHA forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 80.2 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.9 | 60.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 2.0 | 57.1 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 1.4 | 38.3 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 1.6 | 32.5 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 1.4 | 28.4 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.4 | 27.4 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 1.5 | 24.6 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.2 | 20.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 18.0 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |