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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for RFX5
Z-value: 1.61
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Transcription factors associated with RFX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX5 | hg38_v1_chr1_-_151347234_151347326 | 0.39 | 3.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.9 | 35.5 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 0.3 | 34.8 | GO:0031295 | T cell costimulation(GO:0031295) |
| 5.4 | 16.3 | GO:0035691 | macrophage migration inhibitory factor signaling pathway(GO:0035691) |
| 0.2 | 16.2 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.4 | 14.6 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
| 1.1 | 13.6 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 0.1 | 12.3 | GO:0042733 | embryonic digit morphogenesis(GO:0042733) |
| 0.3 | 8.1 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.1 | 5.0 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.2 | 3.5 | GO:0006069 | ethanol oxidation(GO:0006069) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 85.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 2.1 | 16.9 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.7 | 13.6 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.5 | 12.3 | GO:0036038 | MKS complex(GO:0036038) |
| 0.2 | 10.1 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.1 | 5.1 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.2 | 5.0 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 3.0 | GO:1902911 | protein kinase complex(GO:1902911) |
| 0.0 | 3.0 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.2 | 1.9 | GO:0042612 | MHC class I protein complex(GO:0042612) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 52.1 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.6 | 16.9 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 2.3 | 16.3 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.7 | 16.3 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.6 | 13.6 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 1.5 | 12.3 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
| 0.0 | 10.1 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 9.8 | GO:0005525 | GTP binding(GO:0005525) |
| 0.8 | 4.2 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.0 | 4.0 | GO:0008022 | protein C-terminus binding(GO:0008022) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 20.0 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 2.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 2.6 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.0 | PID CD40 PATHWAY | CD40/CD40L signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 44.4 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.2 | 29.4 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.2 | 16.2 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.3 | 3.5 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.3 | 3.3 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 2.6 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 1.4 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.0 | 1.2 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 1.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |