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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for RFX5

Z-value: 1.61

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Transcription factors associated with RFX5

Gene Symbol Gene ID Gene Info
RFX5
ENSG00000143390.18 RFX5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX5hg38_v1_chr1_-_151347234_1513473260.393.4e-02Click!

Activity profile of RFX5 motif

Sorted Z-values of RFX5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX5

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_-_32589833 20.00 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr6_-_32530268 16.96 ENST00000374975.4
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr5_-_150412743 16.34 ENST00000353334.11
ENST00000009530.12
ENST00000377795.7
CD74
CD74 molecule
chr6_-_32953017 10.79 ENST00000395305.7
ENST00000374843.9
ENST00000395303.7
ENST00000429234.1
HLA-DMA
ENSG00000248993.1
major histocompatibility complex, class II, DM alpha
novel protein
chr10_-_25062279 10.12 ENST00000615958.4
ENKUR
enkurin, TRPC channel interacting protein
chr11_+_111514772 10.07 ENST00000375618.9
ENST00000529167.5
ENST00000332814.6
HOATZ
HOATZ cilia and flagella associated protein
chr10_+_80356754 9.10 ENST00000616870.4
ENST00000411538.5
ENST00000256039.3
DYDC2
DPY30 domain containing 2
chr6_+_32854179 8.56 ENST00000374859.3
PSMB9
proteasome 20S subunit beta 9
chr6_+_33075952 7.39 ENST00000418931.7
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr1_+_85062304 6.94 ENST00000326813.12
ENST00000528899.5
ENST00000294664.11
DNAI3
dynein axonemal intermediate chain 3
chr6_+_32844789 6.03 ENST00000414474.5
PSMB9
proteasome 20S subunit beta 9
chr17_-_19362732 5.67 ENST00000395616.7
B9D1
B9 domain containing 1
chr6_-_32666648 5.37 ENST00000399082.7
ENST00000399079.7
ENST00000374943.8
ENST00000434651.6
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chrX_+_126819720 5.14 ENST00000371125.4
PRR32
proline rich 32
chr1_+_36084079 5.10 ENST00000207457.8
TEKT2
tektin 2
chr8_+_100158576 4.91 ENST00000388798.7
SPAG1
sperm associated antigen 1
chr8_+_100158029 4.91 ENST00000251809.4
SPAG1
sperm associated antigen 1
chr6_-_32941018 4.71 ENST00000418107.3
HLA-DMB
major histocompatibility complex, class II, DM beta
chr10_-_80356710 4.54 ENST00000454362.5
ENST00000372204.7
ENST00000372202.6
ENST00000453477.1
DYDC1
DPY30 domain containing 1
chr6_-_32763522 4.42 ENST00000435145.6
ENST00000437316.7
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr17_-_19362669 4.34 ENST00000268841.10
ENST00000663089.1
ENST00000675510.1
ENST00000647252.1
ENST00000477683.5
ENST00000575478.7
ENST00000261499.10
B9D1
B9 domain containing 1
chr1_-_27012837 3.59 ENST00000289166.6
TENT5B
terminal nucleotidyltransferase 5B
chr4_-_99290975 3.50 ENST00000209668.3
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr3_-_27369355 3.02 ENST00000429845.6
ENST00000341435.9
ENST00000435750.1
NEK10
NIMA related kinase 10
chr6_-_31357171 2.77 ENST00000412585.7
ENST00000434333.1
HLA-B
major histocompatibility complex, class I, B
chr9_+_83980757 2.74 ENST00000325875.7
ENST00000445877.6
RMI1
RecQ mediated genome instability 1
chr11_+_45847406 2.61 ENST00000443527.6
ENST00000616623.4
ENST00000616080.2
CRY2
cryptochrome circadian regulator 2
chr11_-_118565810 2.55 ENST00000672656.2
ENST00000530872.5
ENST00000264021.8
IFT46
intraflagellar transport 46
chr6_+_26402237 2.43 ENST00000476549.6
ENST00000450085.6
ENST00000425234.6
ENST00000427334.5
ENST00000506698.1
ENST00000289361.11
BTN3A1
butyrophilin subfamily 3 member A1
chr11_-_118565992 2.40 ENST00000264020.6
IFT46
intraflagellar transport 46
chr19_-_48615050 2.35 ENST00000263266.4
FAM83E
family with sequence similarity 83 member E
chr6_-_32844643 2.27 ENST00000374881.3
PSMB8
proteasome 20S subunit beta 8
chr17_-_19362542 2.26 ENST00000440841.1
ENST00000671102.1
ENST00000461069.6
B9D1
B9 domain containing 1
chr22_-_23751080 2.01 ENST00000341976.5
ZNF70
zinc finger protein 70
chr6_+_26440472 1.99 ENST00000494393.5
ENST00000482451.5
ENST00000471353.5
ENST00000361232.7
ENST00000487627.5
ENST00000496719.1
ENST00000244519.7
ENST00000490254.5
ENST00000487272.1
BTN3A3
butyrophilin subfamily 3 member A3
chr1_+_45583846 1.94 ENST00000437901.6
ENST00000537798.5
ENST00000350030.8
ENST00000527470.5
ENST00000525515.5
ENST00000528238.5
ENST00000470768.5
ENST00000372052.8
ENST00000629893.1
ENST00000351223.7
NASP
nuclear autoantigenic sperm protein
chr6_+_26365215 1.63 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
BTN3A2
butyrophilin subfamily 3 member A2
chr6_+_26365159 1.58 ENST00000532865.5
ENST00000396934.7
ENST00000508906.6
ENST00000530653.5
ENST00000527417.5
BTN3A2
butyrophilin subfamily 3 member A2
chr6_+_26365176 1.54 ENST00000377708.7
BTN3A2
butyrophilin subfamily 3 member A2
chr13_-_29850605 1.44 ENST00000380680.5
UBL3
ubiquitin like 3
chr12_-_110403657 1.41 ENST00000455511.9
ENST00000450008.3
ANAPC7
anaphase promoting complex subunit 7
chr6_-_32763466 1.31 ENST00000427449.1
ENST00000411527.5
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr22_+_31122923 1.28 ENST00000620191.4
ENST00000412277.6
ENST00000412985.5
ENST00000331075.10
ENST00000420017.5
ENST00000400294.6
ENST00000405300.5
ENST00000404390.7
INPP5J
inositol polyphosphate-5-phosphatase J
chr5_-_60488055 1.25 ENST00000505507.6
ENST00000515835.2
ENST00000502484.6
PDE4D
phosphodiesterase 4D
chr15_-_44711306 1.19 ENST00000682850.1
PATL2
PAT1 homolog 2
chr16_+_67347358 1.13 ENST00000563189.5
LRRC36
leucine rich repeat containing 36
chr11_-_6619353 1.12 ENST00000642892.1
ENST00000645620.1
ENST00000533371.6
ENST00000647152.1
ENST00000644810.1
ENST00000299427.12
ENST00000682424.1
ENST00000644218.1
ENST00000528657.2
ENST00000531754.2
TPP1
tripeptidyl peptidase 1
chr11_-_85719045 1.11 ENST00000533057.6
ENST00000533892.5
SYTL2
synaptotagmin like 2
chr11_+_7987314 1.05 ENST00000531572.2
ENST00000651655.1
EIF3F
eukaryotic translation initiation factor 3 subunit F
chr16_+_67347391 0.96 ENST00000435835.3
LRRC36
leucine rich repeat containing 36
chr1_+_150282526 0.93 ENST00000447007.5
ENST00000369095.5
ENST00000369094.5
ENST00000290363.6
CIART
circadian associated repressor of transcription
chr6_+_26402289 0.89 ENST00000414912.2
BTN3A1
butyrophilin subfamily 3 member A1
chr6_+_30489501 0.86 ENST00000376630.5
HLA-E
major histocompatibility complex, class I, E
chr10_-_80172839 0.82 ENST00000265447.8
ANXA11
annexin A11
chr6_+_26457904 0.79 ENST00000541522.5
BTN2A1
butyrophilin subfamily 2 member A1
chr11_-_72722302 0.76 ENST00000334211.12
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr2_-_241149435 0.67 ENST00000358649.8
ENST00000452907.1
ENST00000403638.7
ENST00000234040.9
ENST00000415234.1
PASK
PAS domain containing serine/threonine kinase
chr9_-_34895722 0.64 ENST00000603640.6
ENST00000603592.1
ENST00000340783.11
FAM205C
family with sequence similarity 205 member C
chr6_-_24666854 0.58 ENST00000378198.9
TDP2
tyrosyl-DNA phosphodiesterase 2
chr15_+_44711487 0.54 ENST00000544417.5
ENST00000559916.1
ENST00000648006.3
B2M
beta-2-microglobulin
chr8_-_98294195 0.53 ENST00000430223.7
NIPAL2
NIPA like domain containing 2
chrX_+_19343893 0.46 ENST00000540249.5
ENST00000545074.5
ENST00000379806.9
ENST00000423505.5
ENST00000422285.7
ENST00000417819.5
ENST00000355808.9
ENST00000379805.3
PDHA1
pyruvate dehydrogenase E1 subunit alpha 1
chr8_-_98294339 0.42 ENST00000341166.3
NIPAL2
NIPA like domain containing 2
chr6_-_24666591 0.42 ENST00000341060.3
TDP2
tyrosyl-DNA phosphodiesterase 2
chr1_+_248838211 0.41 ENST00000306562.8
ZNF672
zinc finger protein 672
chr6_-_30213379 0.40 ENST00000418026.1
ENST00000454678.7
ENST00000416596.5
ENST00000453195.5
TRIM26
tripartite motif containing 26
chr8_-_74321532 0.33 ENST00000342232.5
JPH1
junctophilin 1
chr6_+_26383090 0.31 ENST00000469230.5
ENST00000490025.5
ENST00000352867.6
ENST00000356709.9
ENST00000493275.5
ENST00000472507.5
ENST00000482536.5
ENST00000432533.6
ENST00000482842.1
BTN2A2
butyrophilin subfamily 2 member A2
chr6_+_26383176 0.29 ENST00000416795.6
ENST00000494184.1
BTN2A2
butyrophilin subfamily 2 member A2
chr5_-_56116946 0.26 ENST00000434982.2
ANKRD55
ankyrin repeat domain 55
chr6_+_26457941 0.18 ENST00000493173.1
ENST00000312541.10
ENST00000429381.5
ENST00000469185.5
BTN2A1
butyrophilin subfamily 2 member A1
chr11_+_57667974 0.15 ENST00000528177.5
ENST00000287169.8
ZDHHC5
zinc finger DHHC-type palmitoyltransferase 5
chr9_+_130172343 0.06 ENST00000372398.6
NCS1
neuronal calcium sensor 1
chr20_+_44247252 0.03 ENST00000537864.5
ENST00000612599.4
GDAP1L1
ganglioside induced differentiation associated protein 1 like 1
chr11_+_85628573 0.03 ENST00000393375.5
ENST00000358867.11
ENST00000534341.1
ENST00000531274.1
TMEM126B
transmembrane protein 126B

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.9 35.5 GO:0002399 MHC class II protein complex assembly(GO:0002399)
5.4 16.3 GO:0035691 macrophage migration inhibitory factor signaling pathway(GO:0035691)
1.1 13.6 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.9 2.7 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.9 2.6 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.5 1.4 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
0.4 1.2 GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly(GO:0010607)
0.4 14.6 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.3 2.8 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.3 8.1 GO:0072643 interferon-gamma secretion(GO:0072643)
0.3 34.8 GO:0031295 T cell costimulation(GO:0031295)
0.2 1.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 3.5 GO:0006069 ethanol oxidation(GO:0006069)
0.2 0.8 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.2 16.2 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 12.3 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.1 1.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 5.0 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 0.7 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.1 3.0 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 1.1 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 1.0 GO:0015693 magnesium ion transport(GO:0015693)
0.1 1.0 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.1 0.9 GO:0045475 locomotor rhythm(GO:0045475)
0.1 1.3 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.5 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.6 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 1.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.8 GO:0032506 cytokinetic process(GO:0032506)
0.0 1.1 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.4 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 2.0 GO:0002456 T cell mediated immunity(GO:0002456)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 85.8 GO:0042613 MHC class II protein complex(GO:0042613)
2.1 16.9 GO:1990111 spermatoproteasome complex(GO:1990111)
0.7 13.6 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.5 12.3 GO:0036038 MKS complex(GO:0036038)
0.2 10.1 GO:0097228 sperm principal piece(GO:0097228)
0.2 5.0 GO:0030992 intraciliary transport particle B(GO:0030992)
0.2 1.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.0 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 5.1 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.5 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 1.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.3 GO:0030314 junctional membrane complex(GO:0030314)
0.0 3.0 GO:1902911 protein kinase complex(GO:1902911)
0.0 1.3 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.0 GO:0016235 aggresome(GO:0016235)
0.0 3.0 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 16.3 GO:0042289 MHC class II protein binding(GO:0042289)
1.5 12.3 GO:0008158 hedgehog receptor activity(GO:0008158)
1.3 52.1 GO:0042605 peptide antigen binding(GO:0042605)
0.8 4.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.7 16.3 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.6 13.6 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.6 16.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4 3.5 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.3 1.0 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.2 1.1 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.1 2.6 GO:0009881 photoreceptor activity(GO:0009881)
0.1 1.3 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.1 0.5 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 1.0 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 10.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.8 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 1.9 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 1.0 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 9.8 GO:0005525 GTP binding(GO:0005525)
0.0 0.9 GO:0070888 E-box binding(GO:0070888)
0.0 4.0 GO:0008022 protein C-terminus binding(GO:0008022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 20.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 2.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 2.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 1.0 PID CD40 PATHWAY CD40/CD40L signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 44.4 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3 3.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 3.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 16.2 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 29.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.4 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.5 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex