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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for RFX7_RFX4_RFX1
Z-value: 10.66
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Transcription factors associated with RFX7_RFX4_RFX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX7 | hg38_v1_chr15_-_56245074_56245088, hg38_v1_chr15_-_56243829_56243891 | -0.50 | 4.8e-03 | Click! |
| RFX4 | hg38_v1_chr12_+_106684696_106684755, hg38_v1_chr12_+_106582996_106583010 | -0.30 | 1.0e-01 | Click! |
| RFX1 | hg38_v1_chr19_-_14006262_14006330 | -0.25 | 1.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX7_RFX4_RFX1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_55376818 Show fit | 195.99 |
ENST00000291934.4
|
transmembrane protein 190 |
|
| chr1_-_109112733 Show fit | 124.87 |
ENST00000369948.8
ENST00000369945.7 |
chromosome 1 open reading frame 194 |
|
| chr1_-_161367872 Show fit | 119.51 |
ENST00000367974.2
|
cilia and flagella associated protein 126 |
|
| chr9_-_135499846 Show fit | 116.50 |
ENST00000429260.7
|
chromosome 9 open reading frame 116 |
|
| chr5_-_7851111 Show fit | 100.18 |
ENST00000399810.7
|
chromosome 5 open reading frame 49 |
|
| chr10_+_22928010 Show fit | 97.92 |
ENST00000376528.8
|
armadillo repeat containing 3 |
|
| chr10_+_22928030 Show fit | 97.35 |
ENST00000409983.7
ENST00000298032.10 ENST00000409049.7 |
armadillo repeat containing 3 |
|
| chr17_+_41930599 Show fit | 95.11 |
ENST00000377540.6
|
outer dynein arm docking complex subunit 4 |
|
| chr10_-_25016105 Show fit | 92.54 |
ENST00000376363.5
ENST00000331161.9 |
enkurin, TRPC channel interacting protein |
|
| chr16_+_80540980 Show fit | 88.33 |
ENST00000568035.5
ENST00000305904.11 |
dynein light chain roadblock-type 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.4 | 375.0 | GO:0035082 | axoneme assembly(GO:0035082) |
| 4.3 | 298.1 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.7 | 240.7 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 12.0 | 240.2 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 41.3 | 165.1 | GO:0090301 | regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 1.1 | 149.3 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 1.0 | 141.7 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 14.2 | 127.6 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 6.4 | 121.3 | GO:0042424 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 6.8 | 115.7 | GO:0003351 | epithelial cilium movement(GO:0003351) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 379.2 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 3.3 | 321.2 | GO:0036064 | ciliary basal body(GO:0036064) |
| 3.5 | 276.6 | GO:0036126 | sperm flagellum(GO:0036126) |
| 25.0 | 250.1 | GO:0036157 | outer dynein arm(GO:0036157) |
| 10.5 | 241.8 | GO:0036038 | MKS complex(GO:0036038) |
| 32.7 | 196.0 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
| 0.6 | 191.4 | GO:0005929 | cilium(GO:0005929) |
| 4.8 | 147.5 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.2 | 135.8 | GO:0005813 | centrosome(GO:0005813) |
| 5.4 | 108.6 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 222.9 | GO:0005525 | GTP binding(GO:0005525) |
| 0.6 | 210.2 | GO:0008017 | microtubule binding(GO:0008017) |
| 1.7 | 184.4 | GO:0043621 | protein self-association(GO:0043621) |
| 5.3 | 163.6 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 11.3 | 158.0 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 13.5 | 121.3 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 4.0 | 112.9 | GO:0031005 | filamin binding(GO:0031005) |
| 4.7 | 108.6 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 2.4 | 106.9 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.4 | 91.0 | GO:0017124 | SH3 domain binding(GO:0017124) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 62.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.9 | 50.1 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.4 | 42.0 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.4 | 30.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.4 | 29.9 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.4 | 29.4 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.3 | 11.6 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 10.5 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.7 | 9.8 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 7.2 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 69.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.5 | 32.8 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.8 | 30.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 1.0 | 27.6 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.5 | 14.9 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 14.1 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.4 | 13.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.4 | 12.5 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.5 | 11.6 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.5 | 10.1 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |