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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for RORC

Z-value: 0.27

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Transcription factors associated with RORC

Gene Symbol Gene ID Gene Info
RORC
ENSG00000143365.19 RORC

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RORChg38_v1_chr1_-_151826085_151826108,
hg38_v1_chr1_-_151831768_151831833		0.222.5e-01Click!

Activity profile of RORC motif

Sorted Z-values of RORC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RORC

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_+_7060676 0.47 ENST00000617865.4
ENST00000402681.7
ENST00000360817.10
C1S
complement C1s
chr8_+_39913881 0.33 ENST00000518237.6
IDO1
indoleamine 2,3-dioxygenase 1
chr12_+_93570381 0.23 ENST00000549206.5
SOCS2
suppressor of cytokine signaling 2
chr12_+_93569814 0.23 ENST00000340600.6
SOCS2
suppressor of cytokine signaling 2
chr4_-_158173004 0.21 ENST00000585682.6
GASK1B
golgi associated kinase 1B
chr12_+_7061206 0.20 ENST00000423384.5
ENST00000413211.5
C1S
complement C1s
chr10_-_104085847 0.17 ENST00000648076.2
COL17A1
collagen type XVII alpha 1 chain
chr12_+_4562192 0.17 ENST00000543431.5
DYRK4
dual specificity tyrosine phosphorylation regulated kinase 4
chr9_-_107489754 0.16 ENST00000610832.1
ENST00000374672.5
KLF4
Kruppel like factor 4
chr3_-_50322759 0.15 ENST00000442581.1
ENST00000447092.5
HYAL2
hyaluronidase 2
chr3_-_50322733 0.15 ENST00000428028.1
ENST00000357750.9
HYAL2
hyaluronidase 2
chr16_-_1782526 0.14 ENST00000566339.6
SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr13_+_108596152 0.14 ENST00000356711.7
ENST00000251041.10
MYO16
myosin XVI
chr16_+_1782940 0.13 ENST00000262302.14
ENST00000563136.5
ENST00000565987.5
ENST00000568287.5
ENST00000565134.5
NUBP2
nucleotide binding protein 2
chr5_-_181238195 0.13 ENST00000509148.1
RACK1
receptor for activated C kinase 1
chr10_-_119536533 0.13 ENST00000392865.5
RGS10
regulator of G protein signaling 10
chr6_+_43770202 0.13 ENST00000372067.8
ENST00000672860.2
VEGFA
vascular endothelial growth factor A
chr11_-_64759967 0.12 ENST00000377432.7
ENST00000164139.4
PYGM
glycogen phosphorylase, muscle associated
chr1_-_149936816 0.12 ENST00000439741.4
MTMR11
myotubularin related protein 11
chr6_+_43770707 0.11 ENST00000324450.11
ENST00000417285.7
ENST00000413642.8
ENST00000372055.9
ENST00000482630.7
ENST00000425836.7
ENST00000372064.9
ENST00000372077.8
ENST00000519767.5
VEGFA
vascular endothelial growth factor A
chr4_-_119322128 0.11 ENST00000274024.4
FABP2
fatty acid binding protein 2
chr19_-_42423100 0.11 ENST00000597001.1
LIPE
lipase E, hormone sensitive type
chr12_-_81758665 0.10 ENST00000549325.5
ENST00000550584.6
PPFIA2
PTPRF interacting protein alpha 2
chr8_+_66043413 0.10 ENST00000522619.1
DNAJC5B
DnaJ heat shock protein family (Hsp40) member C5 beta
chr20_+_46894581 0.10 ENST00000357410.7
ENST00000611592.4
EYA2
EYA transcriptional coactivator and phosphatase 2
chr12_-_81758641 0.10 ENST00000552948.5
ENST00000548586.5
PPFIA2
PTPRF interacting protein alpha 2
chr12_-_68225806 0.08 ENST00000229134.5
IL26
interleukin 26
chr19_-_3546306 0.08 ENST00000398558.8
MFSD12
major facilitator superfamily domain containing 12
chr16_-_69351778 0.08 ENST00000288025.4
TMED6
transmembrane p24 trafficking protein 6
chr8_-_94436926 0.07 ENST00000481490.3
FSBP
fibrinogen silencer binding protein
chr7_+_112423137 0.07 ENST00000005558.8
ENST00000621379.4
IFRD1
interferon related developmental regulator 1
chr3_-_165196369 0.07 ENST00000475390.2
SLITRK3
SLIT and NTRK like family member 3
chr7_-_141841473 0.07 ENST00000350549.8
ENST00000438520.1
PRSS37
serine protease 37
chr3_-_165196689 0.07 ENST00000241274.3
SLITRK3
SLIT and NTRK like family member 3
chr16_+_16232516 0.06 ENST00000399336.9
ENST00000678538.1
ENST00000678192.1
ENST00000677777.1
ENST00000677260.1
ENST00000676550.1
ENST00000263012.10
NOMO3
NODAL modulator 3
chr16_+_14833713 0.06 ENST00000287667.12
ENST00000620755.4
ENST00000610363.4
NOMO1
NODAL modulator 1
chr3_+_185586270 0.06 ENST00000296257.10
SENP2
SUMO specific peptidase 2
chr20_+_38581186 0.06 ENST00000373348.4
ENST00000537425.2
ENST00000416116.2
ADIG
adipogenin
chr1_+_26543106 0.05 ENST00000530003.5
RPS6KA1
ribosomal protein S6 kinase A1
chr2_+_159733958 0.05 ENST00000409591.5
MARCHF7
membrane associated ring-CH-type finger 7
chr1_-_150234668 0.05 ENST00000616917.4
ANP32E
acidic nuclear phosphoprotein 32 family member E
chr7_-_712940 0.05 ENST00000544935.5
ENST00000430040.5
ENST00000456696.2
ENST00000406797.5
PRKAR1B
protein kinase cAMP-dependent type I regulatory subunit beta
chr12_+_56230043 0.05 ENST00000424625.5
ENST00000419753.5
ENST00000454355.7
ENST00000417965.5
ENST00000436633.5
SLC39A5
solute carrier family 39 member 5
chr17_-_50707855 0.05 ENST00000285243.7
ANKRD40
ankyrin repeat domain 40
chr20_-_23452857 0.04 ENST00000377007.3
ENST00000377009.8
CST11
cystatin 11
chr6_-_46954922 0.04 ENST00000265417.7
ADGRF5
adhesion G protein-coupled receptor F5
chr11_-_65662780 0.04 ENST00000534283.1
ENST00000527749.5
ENST00000533187.5
ENST00000525693.5
ENST00000534558.5
ENST00000532879.5
ENST00000406246.8
ENST00000532999.5
RELA
RELA proto-oncogene, NF-kB subunit
chr8_-_126557691 0.03 ENST00000652209.1
LRATD2
LRAT domain containing 2
chr1_+_67166448 0.03 ENST00000347310.10
IL23R
interleukin 23 receptor
chr2_+_148021083 0.03 ENST00000642680.2
MBD5
methyl-CpG binding domain protein 5
chr12_+_56230652 0.03 ENST00000266980.8
ENST00000437277.1
SLC39A5
solute carrier family 39 member 5
chr2_+_148021001 0.03 ENST00000407073.5
MBD5
methyl-CpG binding domain protein 5
chr20_+_58840692 0.02 ENST00000306090.12
GNAS
GNAS complex locus
chr2_+_118942188 0.02 ENST00000327097.5
MARCO
macrophage receptor with collagenous structure
chr10_-_101818405 0.02 ENST00000357797.9
ENST00000370094.7
OGA
O-GlcNAcase
chr17_-_39607876 0.02 ENST00000302584.5
NEUROD2
neuronal differentiation 2
chr16_+_28292485 0.02 ENST00000341901.5
SBK1
SH3 domain binding kinase 1
chr5_+_178130996 0.02 ENST00000515098.5
ENST00000502814.5
ENST00000313386.9
ENST00000507457.5
ENST00000508647.5
RMND5B
required for meiotic nuclear division 5 homolog B
chr19_-_8502621 0.02 ENST00000600262.1
ENST00000423345.5
PRAM1
PML-RARA regulated adaptor molecule 1
chr16_-_11915991 0.02 ENST00000420576.6
GSPT1
G1 to S phase transition 1
chr1_+_171841466 0.01 ENST00000367733.6
ENST00000627582.3
ENST00000355305.9
ENST00000367731.5
DNM3
dynamin 3
chr7_-_128775793 0.01 ENST00000249389.3
OPN1SW
opsin 1, short wave sensitive
chr1_-_153550083 0.01 ENST00000368714.1
S100A4
S100 calcium binding protein A4
chr6_-_111605859 0.01 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3IP2
TRAF3 interacting protein 2
chr3_-_184378136 0.01 ENST00000445696.6
THPO
thrombopoietin
chr12_+_51888217 0.01 ENST00000340970.8
ANKRD33
ankyrin repeat domain 33
chr2_+_161160420 0.01 ENST00000392749.7
ENST00000405852.5
TANK
TRAF family member associated NFKB activator
chr1_-_61725121 0.00 ENST00000371177.2
ENST00000606498.5
TM2D1
TM2 domain containing 1
chr2_+_161160299 0.00 ENST00000440506.5
ENST00000429217.5
ENST00000406287.5
ENST00000402568.5
TANK
TRAF family member associated NFKB activator

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0036269 swimming behavior(GO:0036269)
0.1 0.2 GO:1903572 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.1 0.3 GO:0070295 transformation of host cell by virus(GO:0019087) renal water absorption(GO:0070295)
0.1 0.2 GO:0014740 negative regulation of muscle hyperplasia(GO:0014740)
0.0 0.7 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:0007518 myoblast fate determination(GO:0007518)
0.0 0.5 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.0 0.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.1 GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051343)
0.0 0.0 GO:0006117 acetaldehyde metabolic process(GO:0006117)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.1 GO:1990630 IRE1-RACK1-PP2A complex(GO:1990630)
0.0 0.0 GO:0035525 NF-kappaB p50/p65 complex(GO:0035525)
0.0 0.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.1 0.3 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.1 0.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.2 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.2 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.1 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation