Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
Navigation
Downloads
Results for RUNX1_RUNX2
Z-value: 1.10
Motif logo
Transcription factors associated with RUNX1_RUNX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RUNX2 | hg38_v1_chr6_+_45328203_45328372 | -0.52 | 3.3e-03 | Click! |
| RUNX1 | hg38_v1_chr21_-_34889735_34889790 | -0.29 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RUNX1_RUNX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.9 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.2 | 5.6 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.3 | 4.1 | GO:0006824 | cobalt ion transport(GO:0006824) |
| 0.0 | 2.8 | GO:1902475 | L-alpha-amino acid transmembrane transport(GO:1902475) |
| 0.7 | 2.7 | GO:0018879 | biphenyl metabolic process(GO:0018879) |
| 0.1 | 2.7 | GO:0006768 | biotin metabolic process(GO:0006768) |
| 0.1 | 2.4 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.6 | 2.3 | GO:1900190 | biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229) |
| 0.0 | 2.2 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.7 | 2.1 | GO:0046271 | phenylpropanoid catabolic process(GO:0046271) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 3.6 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.2 | 3.5 | GO:0097433 | dense body(GO:0097433) |
| 0.1 | 3.4 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 2.9 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 2.8 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 2.7 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 2.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.6 | 2.4 | GO:0097196 | Shu complex(GO:0097196) |
| 0.1 | 2.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 4.0 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.2 | 3.8 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.2 | 3.5 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.1 | 3.2 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.6 | 2.5 | GO:0047708 | biotinidase activity(GO:0047708) |
| 0.1 | 2.5 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.0 | 2.4 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.5 | 2.3 | GO:0004803 | transposase activity(GO:0004803) |
| 0.1 | 2.2 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 2.1 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 2.2 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 2.2 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.8 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 1.8 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.0 | 1.8 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 1.6 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 1.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.5 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 1.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 4.0 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 3.3 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 3.2 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 2.8 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 2.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 2.6 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 2.5 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 2.2 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 1.7 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |