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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SIX5_SMARCC2_HCFC1
Z-value: 2.09
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Transcription factors associated with SIX5_SMARCC2_HCFC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMARCC2 | hg38_v1_chr12_-_56189548_56189609 | 0.41 | 2.4e-02 | Click! |
| HCFC1 | hg38_v1_chrX_-_153971169_153971233, hg38_v1_chrX_-_153971810_153971844 | 0.28 | 1.4e-01 | Click! |
| SIX5 | hg38_v1_chr19_-_45768843_45768869 | -0.25 | 1.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX5_SMARCC2_HCFC1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 10.7 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.5 | 10.1 | GO:0021670 | lateral ventricle development(GO:0021670) |
| 0.5 | 9.5 | GO:0042424 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 0.2 | 8.9 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 1.1 | 8.0 | GO:1903750 | regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751) |
| 0.5 | 7.2 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.1 | 7.0 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
| 0.1 | 6.8 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.1 | 6.8 | GO:0048678 | response to axon injury(GO:0048678) |
| 0.7 | 6.6 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 14.7 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.1 | 10.4 | GO:0031514 | motile cilium(GO:0031514) |
| 0.2 | 10.2 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.6 | 10.1 | GO:0032039 | integrator complex(GO:0032039) |
| 0.3 | 8.1 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.3 | 8.1 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.7 | 7.2 | GO:0005655 | nucleolar ribonuclease P complex(GO:0005655) |
| 1.3 | 6.6 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.1 | 6.0 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.6 | 4.7 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 67.5 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.2 | 12.9 | GO:0070888 | E-box binding(GO:0070888) |
| 3.5 | 10.4 | GO:0031862 | prostanoid receptor binding(GO:0031862) |
| 1.1 | 9.6 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.5 | 8.0 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.2 | 7.8 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.6 | 7.2 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 2.2 | 6.6 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 0.2 | 5.8 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.4 | 5.7 | GO:0031419 | cobalamin binding(GO:0031419) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.6 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 6.6 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 4.6 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 3.6 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 3.3 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 1.4 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.2 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.2 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 1.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 48.0 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 8.5 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.1 | 7.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 5.1 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.3 | 4.0 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.1 | 3.8 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 0.1 | 2.9 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 2.4 | REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 0.1 | 2.3 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.1 | 2.3 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |