Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
Navigation
Downloads
Results for SMAD1
Z-value: 2.04
Motif logo
Transcription factors associated with SMAD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD1 | hg38_v1_chr4_+_145482761_145482820 | -0.54 | 2.1e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_50968125 Show fit | 19.95 |
ENST00000594641.1
|
kallikrein related peptidase 6 |
|
| chr19_-_50968775 Show fit | 15.28 |
ENST00000391808.5
|
kallikrein related peptidase 6 |
|
| chr19_-_50953093 Show fit | 11.48 |
ENST00000593428.5
|
kallikrein related peptidase 5 |
|
| chr19_-_50952942 Show fit | 10.62 |
ENST00000594846.1
ENST00000336334.8 |
kallikrein related peptidase 5 |
|
| chr19_-_50953063 Show fit | 8.38 |
ENST00000391809.6
|
kallikrein related peptidase 5 |
|
| chr15_-_74212256 Show fit | 7.21 |
ENST00000416286.7
|
signaling receptor and transporter of retinol STRA6 |
|
| chr1_-_16978276 Show fit | 6.83 |
ENST00000375534.7
|
microfibril associated protein 2 |
|
| chr19_+_6531018 Show fit | 6.70 |
ENST00000245817.5
|
TNF superfamily member 9 |
|
| chr15_-_74212219 Show fit | 6.60 |
ENST00000449139.6
|
signaling receptor and transporter of retinol STRA6 |
|
| chrX_-_48470163 Show fit | 6.57 |
ENST00000595796.5
|
solute carrier family 38 member 5 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 45.0 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.3 | 45.0 | GO:0070268 | cornification(GO:0070268) |
| 5.1 | 30.5 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803) |
| 3.0 | 17.7 | GO:0061143 | alveolar primary septum development(GO:0061143) |
| 0.7 | 17.3 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.8 | 15.2 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.8 | 12.3 | GO:0015816 | glycine transport(GO:0015816) |
| 0.1 | 10.8 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 0.5 | 10.3 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 0.2 | 9.9 | GO:0035767 | endothelial cell chemotaxis(GO:0035767) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 92.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 51.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 4.8 | 33.5 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 32.6 | GO:0005576 | extracellular region(GO:0005576) |
| 0.4 | 23.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.6 | 13.8 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 13.3 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 11.9 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 10.8 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 10.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 128.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 25.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 16.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.8 | 15.2 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.1 | 14.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 12.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.3 | 12.1 | GO:0005504 | fatty acid binding(GO:0005504) |
| 1.0 | 11.6 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.3 | 11.4 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 0.7 | 11.1 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 55.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.7 | 46.1 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 38.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 17.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 12.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 12.1 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.1 | 12.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.2 | 11.5 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.2 | 10.9 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.4 | 10.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.4 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.2 | 14.3 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.4 | 14.2 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 14.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 12.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 11.2 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.4 | 10.6 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.6 | 10.3 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.2 | 9.5 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.2 | 9.5 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |