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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SMAD3

Z-value: 0.87

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Transcription factors associated with SMAD3

Gene Symbol Gene ID Gene Info
ENSG00000166949.17 SMAD3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD3hg38_v1_chr15_+_67125707_67125725,
hg38_v1_chr15_+_67166019_67166167
-0.461.1e-02Click!

Activity profile of SMAD3 motif

Sorted Z-values of SMAD3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD3

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr6_+_116616467 3.90 ENST00000229554.10
ENST00000368581.8
ENST00000368580.4
radial spoke head component 4A
chr15_+_82262781 3.25 ENST00000566205.1
ENST00000339465.5
ENST00000569120.1
ENST00000682753.1
ENST00000566861.5
ENST00000565432.1
stabilizer of axonemal microtubules 2
chr4_-_176195563 3.09 ENST00000280191.7
spermatogenesis associated 4
chr19_+_41088450 2.86 ENST00000330436.4
cytochrome P450 family 2 subfamily A member 13
chr4_+_54657918 2.74 ENST00000412167.6
ENST00000288135.6
KIT proto-oncogene, receptor tyrosine kinase
chr1_-_36440873 2.67 ENST00000433045.6
organic solute carrier partner 1
chr22_-_35617321 2.57 ENST00000397326.7
ENST00000442617.1
myoglobin
chr19_-_40850442 2.47 ENST00000301141.10
cytochrome P450 family 2 subfamily A member 6
chr6_+_52423680 2.36 ENST00000538167.2
EF-hand domain containing 1
chr2_-_219245389 2.05 ENST00000428427.1
ENST00000432839.1
ENST00000295759.12
ENST00000424620.1
galactosidase beta 1 like
chr2_-_219245465 2.01 ENST00000392089.6
galactosidase beta 1 like
chr1_-_60073733 2.00 ENST00000450089.6
chromosome 1 open reading frame 87
chr1_-_60073750 1.97 ENST00000371201.3
chromosome 1 open reading frame 87
chr18_+_46946821 1.95 ENST00000245121.9
ENST00000356157.12
katanin catalytic subunit A1 like 2
chr14_-_100159595 1.79 ENST00000553834.1
ENST00000305631.7
delta 4-desaturase, sphingolipid 2
chr19_-_55180242 1.64 ENST00000592470.1
ENST00000354308.8
synaptotagmin 5
chr16_+_649319 1.59 ENST00000549091.5
WD repeat domain 90
chr16_+_649351 1.59 ENST00000293879.9
WD repeat domain 90
chr14_-_106622837 1.59 ENST00000390628.3
immunoglobulin heavy variable 1-58
chr19_-_55180104 1.58 ENST00000537500.5
synaptotagmin 5
chr14_-_20802402 1.56 ENST00000412779.2
ribonuclease A family member 1, pancreatic
chr6_+_146598961 1.53 ENST00000522242.5
ENST00000397944.8
androglobin
chr16_-_30762052 1.52 ENST00000543610.6
ENST00000545825.1
ENST00000541260.5
coiled-coil domain containing 189
chr6_-_46954922 1.46 ENST00000265417.7
adhesion G protein-coupled receptor F5
chr1_-_225941383 1.41 ENST00000420304.6
left-right determination factor 2
chr6_-_27132750 1.29 ENST00000607124.1
ENST00000339812.3
H2B clustered histone 11
chr6_+_26216928 1.26 ENST00000303910.4
H2A clustered histone 8
chr3_-_112846856 1.21 ENST00000488794.5
CD200 receptor 1 like
chr7_-_120857124 1.18 ENST00000441017.5
ENST00000424710.5
ENST00000433758.5
tetraspanin 12
chr1_-_225941212 1.18 ENST00000366820.10
left-right determination factor 2
chr3_+_125969172 1.12 ENST00000514116.6
ENST00000513830.5
rhophilin associated tail protein 1B
chr3_-_52897541 1.12 ENST00000355083.11
ENST00000504329.1
STIM activating enhancer
STIMATE-MUSTN1 readthrough
chr3_+_125969152 1.04 ENST00000251776.8
ENST00000504401.1
rhophilin associated tail protein 1B
chr1_+_149832647 0.99 ENST00000578186.2
H4 clustered histone 14
chr1_-_9069797 0.97 ENST00000473209.1
solute carrier family 2 member 5
chr16_+_25216943 0.97 ENST00000219660.6
aquaporin 8
chr14_+_91114667 0.84 ENST00000523894.5
ENST00000522322.5
ENST00000523771.5
D-glutamate cyclase
chr6_+_27147094 0.81 ENST00000377459.3
H2A clustered histone 12
chr1_+_59297057 0.78 ENST00000303721.12
FGGY carbohydrate kinase domain containing
chr14_+_91114431 0.75 ENST00000428926.6
ENST00000517362.5
D-glutamate cyclase
chr14_+_91114364 0.74 ENST00000518868.5
D-glutamate cyclase
chr6_-_26216673 0.70 ENST00000541790.3
H2B clustered histone 8
chr17_-_35868885 0.67 ENST00000604834.6
HEAT repeat containing 9
chr1_+_59296971 0.64 ENST00000371218.8
FGGY carbohydrate kinase domain containing
chr17_-_35868858 0.64 ENST00000603870.5
ENST00000603218.1
HEAT repeat containing 9
chr9_+_97307645 0.64 ENST00000529487.3
coiled-coil domain containing 180
chr6_+_26240385 0.62 ENST00000244537.6
H4 clustered histone 6
chrX_+_9560465 0.59 ENST00000647060.1
transducin beta like 1 X-linked
chr18_+_13218195 0.58 ENST00000679167.1
low density lipoprotein receptor class A domain containing 4
chr3_+_125969214 0.56 ENST00000508088.1
rhophilin associated tail protein 1B
chr5_-_69332723 0.56 ENST00000511257.1
ENST00000396496.7
ENST00000383374.6
coiled-coil domain containing 125
chr6_+_27133032 0.55 ENST00000359193.3
H2A clustered histone 11
chr4_-_185775271 0.52 ENST00000430503.5
ENST00000319454.10
ENST00000450341.5
sorbin and SH3 domain containing 2
chr17_-_58544315 0.52 ENST00000671766.1
ENST00000672673.2
ENST00000321691.3
septin 4
chr4_+_40335324 0.52 ENST00000310169.3
cholinergic receptor nicotinic alpha 9 subunit
chr14_+_91114388 0.51 ENST00000519019.5
ENST00000523816.5
ENST00000517518.5
D-glutamate cyclase
chr3_-_123992046 0.51 ENST00000467907.5
ENST00000459660.5
ENST00000495093.1
ENST00000460743.5
ENST00000405845.7
ENST00000484329.1
ENST00000479867.1
ENST00000496145.5
rhophilin associated tail protein 1
chr17_+_50095331 0.50 ENST00000503176.6
pyruvate dehydrogenase kinase 2
chr3_-_120647018 0.47 ENST00000475447.2
homogentisate 1,2-dioxygenase
chr6_-_27893175 0.47 ENST00000359611.4
H2A clustered histone 17
chr15_+_51341648 0.45 ENST00000335449.11
ENST00000560215.5
gliomedin
chr11_-_34916310 0.43 ENST00000395787.4
APAF1 interacting protein
chr1_-_225923891 0.42 ENST00000472798.2
ENST00000489681.5
ENST00000612651.4
pyrroline-5-carboxylate reductase 2
chr11_+_66638661 0.40 ENST00000396053.9
ENST00000408993.6
RNA binding motif protein 4
chr19_+_51225059 0.39 ENST00000436584.6
ENST00000421133.6
ENST00000262262.5
ENST00000391796.7
CD33 molecule
chr8_-_100105619 0.39 ENST00000523287.5
ENST00000519092.5
regulator of G protein signaling 22
chr17_+_4710622 0.39 ENST00000574954.5
ENST00000269260.7
ENST00000346341.6
ENST00000572457.5
ENST00000381488.10
ENST00000412477.7
ENST00000571428.5
ENST00000575877.5
arrestin beta 2
chr6_-_27838362 0.39 ENST00000618958.2
H2A clustered histone 15
chr6_-_26027274 0.35 ENST00000377745.4
H4 clustered histone 2
chr14_-_105987068 0.35 ENST00000390594.3
immunoglobulin heavy variable 1-2
chr3_+_190388120 0.35 ENST00000456423.2
ENST00000264734.3
claudin 16
chr16_-_31065011 0.35 ENST00000539836.3
ENST00000535577.5
ENST00000442862.2
zinc finger protein 668
chr15_-_82647336 0.34 ENST00000617522.4
ENST00000684509.1
cytoplasmic polyadenylation element binding protein 1
chr6_-_27807916 0.33 ENST00000377401.3
H2B clustered histone 13
chr14_+_91114026 0.33 ENST00000521081.5
ENST00000520328.5
ENST00000524232.5
ENST00000522170.5
ENST00000256324.15
ENST00000519950.5
ENST00000523879.5
ENST00000521077.6
ENST00000518665.6
D-glutamate cyclase
chr6_-_41921105 0.33 ENST00000434077.1
ENST00000409312.5
ENST00000265350.9
mediator complex subunit 20
chr18_+_13611764 0.32 ENST00000585931.5
low density lipoprotein receptor class A domain containing 4
chr11_-_133532493 0.31 ENST00000524381.6
opioid binding protein/cell adhesion molecule like
chr21_+_31659666 0.30 ENST00000389995.4
ENST00000270142.11
superoxide dismutase 1
chr2_-_217944005 0.30 ENST00000611415.4
ENST00000615025.5
ENST00000449814.1
ENST00000171887.8
tensin 1
chr16_-_31064952 0.28 ENST00000426488.6
zinc finger protein 668
chr22_+_20080211 0.27 ENST00000383024.6
ENST00000351989.8
DGCR8 microprocessor complex subunit
chr6_+_30882914 0.27 ENST00000509639.5
ENST00000412274.6
ENST00000507901.5
ENST00000507046.5
ENST00000437124.6
ENST00000454612.6
ENST00000396342.6
discoidin domain receptor tyrosine kinase 1
chr14_-_24081986 0.26 ENST00000560550.1
neural retina leucine zipper
chr15_+_65530418 0.26 ENST00000562901.5
ENST00000261875.10
ENST00000442729.6
ENST00000565299.5
ENST00000568793.5
3-hydroxyacyl-CoA dehydratase 3
chr18_+_13612614 0.26 ENST00000586765.1
ENST00000677910.1
low density lipoprotein receptor class A domain containing 4
chr6_-_132798587 0.25 ENST00000275227.9
solute carrier family 18 member B1
chr12_+_67648737 0.25 ENST00000344096.4
ENST00000393555.3
dual specificity tyrosine phosphorylation regulated kinase 2
chr4_+_186069144 0.25 ENST00000513189.1
ENST00000296795.8
toll like receptor 3
chr5_+_141245384 0.24 ENST00000623671.1
ENST00000231173.6
protocadherin beta 15
chr20_-_64079479 0.23 ENST00000395042.2
regulator of G protein signaling 19
chr15_-_60397964 0.23 ENST00000558998.5
ENST00000560165.5
ENST00000557986.5
ENST00000559467.5
ENST00000677968.1
ENST00000678450.1
ENST00000332680.8
ENST00000396024.7
ENST00000557906.6
ENST00000558558.6
ENST00000559113.6
ENST00000559780.6
ENST00000559956.6
ENST00000560468.6
ENST00000678870.1
ENST00000678061.1
ENST00000451270.7
ENST00000421017.6
ENST00000560466.5
ENST00000558132.5
ENST00000559370.5
ENST00000559725.5
ENST00000558985.6
ENST00000679109.1
annexin A2
chr10_+_116591010 0.23 ENST00000530319.5
ENST00000527980.5
ENST00000471549.5
ENST00000534537.5
pancreatic lipase related protein 1
chr6_-_27831557 0.23 ENST00000611927.2
H4 clustered histone 12
chr19_-_36916021 0.23 ENST00000520965.5
zinc finger protein 829
chr14_-_24081928 0.22 ENST00000396995.1
neural retina leucine zipper
chr2_-_79086847 0.22 ENST00000454188.5
regenerating family member 1 beta
chr6_-_41921081 0.22 ENST00000409060.1
mediator complex subunit 20
chr2_-_24793382 0.22 ENST00000328379.6
peptidyl-tRNA hydrolase domain containing 1
chr10_+_116590956 0.21 ENST00000358834.9
ENST00000528052.5
pancreatic lipase related protein 1
chr11_+_124954108 0.21 ENST00000529051.5
coiled-coil domain containing 15
chr9_-_133131109 0.20 ENST00000372062.8
ral guanine nucleotide dissociation stimulator
chr6_-_53148822 0.20 ENST00000259803.8
glial cells missing transcription factor 1
chr2_+_96325294 0.20 ENST00000439118.3
ENST00000420176.5
ENST00000536814.1
ITPRIP like 1
chr15_-_43493105 0.19 ENST00000382039.7
ENST00000450115.6
ENST00000382044.9
tumor protein p53 binding protein 1
chr2_-_49154507 0.19 ENST00000406846.7
follicle stimulating hormone receptor
chr11_-_61333784 0.18 ENST00000680367.1
ENST00000681803.1
damage specific DNA binding protein 1
chr1_-_160862880 0.18 ENST00000368034.9
CD244 molecule
chr12_+_3491189 0.18 ENST00000382622.4
protein arginine methyltransferase 8
chr6_-_27814757 0.17 ENST00000333151.5
H2A clustered histone 14
chr6_+_26124161 0.17 ENST00000377791.4
ENST00000602637.1
H2A clustered histone 6
chr1_-_9069572 0.17 ENST00000377414.7
solute carrier family 2 member 5
chr11_+_66638678 0.17 ENST00000578778.5
ENST00000483858.5
ENST00000398692.8
ENST00000310092.12
ENST00000510173.6
ENST00000506523.6
ENST00000530235.1
ENST00000532968.1
RNA binding motif protein 4
chr2_-_49154433 0.16 ENST00000454032.5
ENST00000304421.8
follicle stimulating hormone receptor
chrX_-_49233309 0.16 ENST00000376251.5
ENST00000323022.10
ENST00000376265.2
calcium voltage-gated channel subunit alpha1 F
chrX_-_27463341 0.16 ENST00000412172.4
protein phosphatase 4 regulatory subunit 3C
chr8_-_118951876 0.16 ENST00000297350.9
TNF receptor superfamily member 11b
chr16_+_2471284 0.15 ENST00000293973.2
netrin 3
chr5_+_134874345 0.15 ENST00000358387.9
ENST00000506916.1
thioredoxin domain containing 15
chrX_-_111270474 0.14 ENST00000324068.2
calpain 6
chr1_-_88891496 0.14 ENST00000448623.5
ENST00000370500.10
ENST00000418217.1
general transcription factor IIB
chr12_+_49741802 0.13 ENST00000423828.5
ENST00000550445.5
transmembrane BAX inhibitor motif containing 6
chr11_-_5441514 0.13 ENST00000380211.1
olfactory receptor family 51 subfamily I member 1
chr11_+_113387773 0.13 ENST00000303941.4
ankyrin repeat and kinase domain containing 1
chr3_+_12796662 0.13 ENST00000456430.6
ENST00000626378.1
cullin associated and neddylation dissociated 2 (putative)
chr6_-_26123910 0.12 ENST00000314332.5
ENST00000396984.1
H2B clustered histone 4
chr2_-_135837170 0.12 ENST00000264162.7
lactase
chr6_+_26272923 0.12 ENST00000377733.4
H2B clustered histone 10
chr15_+_63597378 0.12 ENST00000638704.2
ENST00000534939.2
F-box and leucine rich repeat protein 22
chr9_-_14321948 0.12 ENST00000635877.1
ENST00000636432.1
ENST00000646622.1
nuclear factor I B
chr16_-_84186998 0.12 ENST00000567759.5
TATA-box binding protein associated factor, RNA polymerase I subunit C
chr12_+_14774362 0.12 ENST00000544848.2
H2A.J histone
chr19_-_37467185 0.11 ENST00000592490.5
ENST00000392149.6
zinc finger protein 569
chr6_-_11807045 0.11 ENST00000379415.6
androgen dependent TFPI regulating protein
chr16_-_84187026 0.11 ENST00000561955.1
ENST00000564454.1
ENST00000341690.10
ENST00000566732.6
ENST00000570117.5
ENST00000564345.5
ENST00000541676.5
TATA-box binding protein associated factor, RNA polymerase I subunit C
chr14_+_20190896 0.11 ENST00000641879.2
ENST00000641682.1
olfactory receptor family 11 subfamily G member 2
chr10_-_133358006 0.10 ENST00000278025.9
ENST00000368552.7
fucose mutarotase
chr15_+_63504583 0.10 ENST00000380324.8
ENST00000561442.5
ENST00000560070.5
ubiquitin specific peptidase 3
chr5_-_41870416 0.10 ENST00000196371.10
3-oxoacid CoA-transferase 1
chr9_+_5890872 0.09 ENST00000381477.8
ENST00000381476.5
ENST00000381471.1
melan-A
chr9_+_133534807 0.09 ENST00000393060.1
ADAMTS like 2
chr11_+_62771357 0.09 ENST00000526261.1
ENST00000294168.8
TATA-box binding protein associated factor 6 like
chr15_+_63504511 0.08 ENST00000540797.5
ubiquitin specific peptidase 3
chr1_-_8817633 0.08 ENST00000400908.7
arginine-glutamic acid dipeptide repeats
chr12_+_49741565 0.08 ENST00000549445.5
ENST00000550951.5
ENST00000549385.5
ENST00000548713.5
ENST00000548201.5
transmembrane BAX inhibitor motif containing 6
chr8_-_100105955 0.07 ENST00000523437.5
regulator of G protein signaling 22
chr11_-_65382632 0.07 ENST00000294187.10
ENST00000398802.6
ENST00000530936.1
solute carrier family 25 member 45
chr11_-_64744993 0.07 ENST00000377485.5
RAS guanyl releasing protein 2
chr3_+_51707059 0.07 ENST00000395052.8
glutamate metabotropic receptor 2
chr5_+_55851349 0.06 ENST00000652347.2
interleukin 31 receptor A
chr1_-_11858935 0.06 ENST00000376468.4
natriuretic peptide B
chr5_+_55851378 0.06 ENST00000396836.6
ENST00000359040.10
interleukin 31 receptor A
chr11_+_834466 0.05 ENST00000528011.2
CD151 molecule (Raph blood group)
chr19_+_42220283 0.05 ENST00000301215.8
ENST00000597945.1
zinc finger protein 526
chr9_+_133534697 0.05 ENST00000651351.2
ADAMTS like 2
chr12_+_49741544 0.05 ENST00000549966.5
ENST00000547832.5
ENST00000547187.5
ENST00000548894.5
ENST00000546914.5
ENST00000552699.5
ENST00000267115.10
transmembrane BAX inhibitor motif containing 6
chr1_-_110607307 0.05 ENST00000639048.2
ENST00000675391.1
ENST00000639233.2
potassium voltage-gated channel subfamily A member 2
chr16_+_30472700 0.05 ENST00000358164.9
integrin subunit alpha L
chr6_-_26033609 0.05 ENST00000615868.2
H2A clustered histone 4
chr5_-_133026533 0.05 ENST00000509437.6
ENST00000355372.6
ENST00000513541.5
ENST00000509008.1
ENST00000513848.5
ENST00000504170.2
ENST00000324170.7
zinc finger CCHC-type containing 10
chr16_+_30472733 0.04 ENST00000356798.11
ENST00000433423.2
integrin subunit alpha L
chr1_-_110607425 0.04 ENST00000633222.1
potassium voltage-gated channel subfamily A member 2
chr1_+_89821921 0.04 ENST00000394593.7
leucine rich repeat containing 8 VRAC subunit D
chr11_+_65027402 0.04 ENST00000377244.8
ENST00000534637.5
ENST00000524831.5
sorting nexin 15
chr6_+_27838600 0.03 ENST00000606613.1
H2B clustered histone 15
chr10_+_92691897 0.03 ENST00000492654.3
hematopoietically expressed homeobox
chr18_+_32018817 0.03 ENST00000217740.4
ENST00000583184.1
ring finger protein 125
novel transcript
chr18_+_46174014 0.02 ENST00000619301.4
ENST00000615052.5
chromosome 18 open reading frame 25
chr8_-_80029826 0.02 ENST00000519386.5
mitochondrial ribosomal protein S28
chr15_-_43493076 0.02 ENST00000413546.1
tumor protein p53 binding protein 1
chr7_+_120988683 0.02 ENST00000340646.9
ENST00000310396.10
cadherin like and PC-esterase domain containing 1
chr12_+_65169546 0.02 ENST00000308330.3
LEM domain containing 3
chr19_-_42220109 0.02 ENST00000595337.5
death effector domain containing 2
chr1_-_44017296 0.02 ENST00000357730.6
ENST00000360584.6
ENST00000528803.1
solute carrier family 6 member 9
chrX_-_49073989 0.01 ENST00000376386.3
ENST00000553851.3
PRA1 domain family member 2
chr5_-_180815528 0.01 ENST00000333055.8
alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
chr1_+_193121950 0.01 ENST00000367435.5
cell division cycle 73
chr10_+_92691813 0.00 ENST00000472590.6
hematopoietically expressed homeobox
chr6_-_52577012 0.00 ENST00000182527.4
translocation associated membrane protein 2
chr15_-_82709886 0.00 ENST00000666055.1
ENST00000261722.8
ENST00000535513.2
adaptor related protein complex 3 subunit beta 2
chr6_+_27808163 0.00 ENST00000358739.4
H2A clustered histone 13

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0070662 mast cell proliferation(GO:0070662)
0.8 2.5 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.6 1.8 GO:0006667 sphinganine metabolic process(GO:0006667)
0.6 2.9 GO:0009698 phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804)
0.3 2.6 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.2 0.9 GO:0098704 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.1 1.5 GO:0043129 surfactant homeostasis(GO:0043129) positive regulation of phospholipid biosynthetic process(GO:0071073)
0.1 0.4 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.1 1.4 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.1 2.7 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.1 0.4 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.1 0.5 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.1 0.6 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 0.4 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.1 1.1 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.2 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.1 0.4 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.1 3.9 GO:0035082 axoneme assembly(GO:0035082)
0.1 0.5 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 0.4 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.0 0.2 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 3.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.2 GO:0044111 development involved in symbiotic interaction(GO:0044111)
0.0 0.3 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.3 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.1 GO:1904798 regulation of core promoter binding(GO:1904796) positive regulation of core promoter binding(GO:1904798)
0.0 2.4 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 1.0 GO:0006833 water transport(GO:0006833)
0.0 1.2 GO:0010842 retina layer formation(GO:0010842)
0.0 0.5 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.5 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.4 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 2.4 GO:0021795 cerebral cortex cell migration(GO:0021795)
0.0 1.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.1 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 0.2 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 1.8 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 2.6 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.3 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 0.2 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.5 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0010265 SCF complex assembly(GO:0010265)
0.0 0.0 GO:0061011 hepatic duct development(GO:0061011)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.1 GO:0000066 mitochondrial ornithine transport(GO:0000066)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0001534 radial spoke(GO:0001534)
0.6 3.2 GO:1990769 proximal neuron projection(GO:1990769)
0.1 0.5 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 0.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 2.5 GO:0042629 mast cell granule(GO:0042629)
0.0 2.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.2 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 1.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 2.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.4 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 2.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)
0.0 2.4 GO:0031514 motile cilium(GO:0031514)
0.0 0.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.7 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.2 GO:0070938 contractile ring(GO:0070938)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.1 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.5 1.4 GO:0019150 D-ribulokinase activity(GO:0019150)
0.4 4.1 GO:0004565 beta-galactosidase activity(GO:0004565)
0.3 5.3 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.3 1.6 GO:0004522 ribonuclease A activity(GO:0004522)
0.2 1.9 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 2.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.2 0.9 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.1 2.6 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 0.4 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.1 0.4 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 0.5 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.4 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 1.0 GO:0015250 water channel activity(GO:0015250)
0.1 2.7 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.2 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.3 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.2 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 1.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 3.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 1.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.3 GO:0102344 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 0.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.3 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0050436 microfibril binding(GO:0050436)
0.0 0.1 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.0 1.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0008410 CoA-transferase activity(GO:0008410)
0.0 0.6 GO:0035198 miRNA binding(GO:0035198)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.1 GO:0042806 fucose binding(GO:0042806)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 1.1 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.5 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 2.7 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.1 1.0 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 2.2 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 1.8 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.9 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.5 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.4 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.4 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.5 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 3.0 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.0 0.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate