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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SMAD4
Z-value: 1.55
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Transcription factors associated with SMAD4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD4 | hg38_v1_chr18_+_51030100_51030270 | -0.75 | 1.7e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_50953093 Show fit | 4.44 |
ENST00000593428.5
|
kallikrein related peptidase 5 |
|
| chrX_-_48470243 Show fit | 3.97 |
ENST00000429543.2
ENST00000620913.5 |
solute carrier family 38 member 5 |
|
| chrX_-_48470163 Show fit | 3.90 |
ENST00000595796.5
|
solute carrier family 38 member 5 |
|
| chr19_-_18941117 Show fit | 3.63 |
ENST00000600077.5
|
homer scaffold protein 3 |
|
| chr22_+_31092447 Show fit | 3.38 |
ENST00000455608.5
|
smoothelin |
|
| chr19_-_50953063 Show fit | 3.09 |
ENST00000391809.6
|
kallikrein related peptidase 5 |
|
| chr9_+_128420812 Show fit | 3.09 |
ENST00000372838.9
|
cerebral endothelial cell adhesion molecule |
|
| chr10_+_86958557 Show fit | 2.85 |
ENST00000372017.4
ENST00000348795.8 |
synuclein gamma |
|
| chr19_-_50952942 Show fit | 2.71 |
ENST00000594846.1
ENST00000336334.8 |
kallikrein related peptidase 5 |
|
| chr5_+_149141483 Show fit | 2.64 |
ENST00000326685.11
ENST00000309868.12 |
actin binding LIM protein family member 3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 10.2 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.1 | 8.5 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.5 | 8.0 | GO:0015816 | glycine transport(GO:0015816) |
| 0.3 | 8.0 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.4 | 7.9 | GO:1901748 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.3 | 5.6 | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) |
| 0.0 | 5.1 | GO:0070268 | cornification(GO:0070268) |
| 0.5 | 4.0 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.2 | 3.7 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.1 | 3.5 | GO:0014059 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 10.7 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 10.3 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 9.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 8.9 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.0 | 6.4 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 6.1 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 5.7 | GO:0030424 | axon(GO:0030424) |
| 0.1 | 5.6 | GO:0045178 | basal part of cell(GO:0045178) |
| 0.0 | 5.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 4.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.7 | 8.0 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.4 | 7.9 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.4 | 7.5 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.1 | 6.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.3 | 4.9 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.0 | 4.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.9 | 4.3 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.9 | 3.8 | GO:0004992 | platelet activating factor receptor activity(GO:0004992) |
| 0.2 | 3.7 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 6.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 5.9 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 5.4 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 5.4 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 5.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 3.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 3.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 3.1 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 3.1 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.4 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 6.4 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.1 | 6.0 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 4.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 4.7 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 4.1 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 3.6 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 3.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 3.0 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |