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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SOX1

Z-value: 0.41

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Transcription factors associated with SOX1

Gene Symbol Gene ID Gene Info
SOX1
ENSG00000182968.5 SOX1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX1hg38_v1_chr13_+_112067143_1120671600.488.0e-03Click!

Activity profile of SOX1 motif

Sorted Z-values of SOX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_+_6863057 0.69 ENST00000641461.1
OR10A2
olfactory receptor family 10 subfamily A member 2
chr1_+_152985231 0.67 ENST00000368762.1
SPRR1A
small proline rich protein 1A
chr16_+_11965193 0.63 ENST00000053243.6
ENST00000396495.3
TNFRSF17
TNF receptor superfamily member 17
chr11_-_76670737 0.50 ENST00000260061.9
ENST00000404995.5
LRRC32
leucine rich repeat containing 32
chr7_+_142760398 0.47 ENST00000632998.1
PRSS2
serine protease 2
chr12_+_9827517 0.42 ENST00000537723.5
KLRF1
killer cell lectin like receptor F1
chr11_-_76669985 0.39 ENST00000407242.6
ENST00000421973.1
LRRC32
leucine rich repeat containing 32
chr3_-_58627596 0.38 ENST00000474531.5
ENST00000465970.1
FAM107A
family with sequence similarity 107 member A
chr7_+_142749465 0.37 ENST00000486171.5
ENST00000619214.4
ENST00000311737.12
PRSS1
serine protease 1
chr2_+_11724333 0.36 ENST00000425416.6
ENST00000396097.5
LPIN1
lipin 1
chr12_+_92702843 0.32 ENST00000397833.3
PLEKHG7
pleckstrin homology and RhoGEF domain containing G7
chr12_+_9827472 0.30 ENST00000617793.4
ENST00000617889.5
ENST00000354855.7
ENST00000279545.7
KLRF1
killer cell lectin like receptor F1
chr3_-_190122317 0.28 ENST00000427335.6
P3H2
prolyl 3-hydroxylase 2
chr13_+_108596152 0.26 ENST00000356711.7
ENST00000251041.10
MYO16
myosin XVI
chr4_+_155758990 0.26 ENST00000505154.5
ENST00000652626.1
ENST00000502959.5
ENST00000264424.13
ENST00000505764.5
ENST00000507146.5
ENST00000503520.5
GUCY1B1
guanylate cyclase 1 soluble subunit beta 1
chr20_-_50131125 0.25 ENST00000371656.3
PEDS1
plasmanylethanolamine desaturase 1
chr1_-_89175997 0.25 ENST00000294671.3
ENST00000650452.1
GBP7
guanylate binding protein 7
chr14_-_24609660 0.24 ENST00000557220.6
ENST00000216338.9
ENST00000382548.4
GZMH
granzyme H
chr2_+_101998955 0.23 ENST00000393414.6
IL1R2
interleukin 1 receptor type 2
chr9_-_120876356 0.21 ENST00000456291.1
PHF19
PHD finger protein 19
chr2_+_201116396 0.21 ENST00000395148.6
CFLAR
CASP8 and FADD like apoptosis regulator
chr19_-_43883964 0.20 ENST00000587539.2
ZNF404
zinc finger protein 404
chr1_+_184051678 0.20 ENST00000643231.1
TSEN15
tRNA splicing endonuclease subunit 15
chr3_+_136957948 0.19 ENST00000329582.9
IL20RB
interleukin 20 receptor subunit beta
chr1_+_184051696 0.19 ENST00000533373.6
ENST00000647437.1
ENST00000647465.1
ENST00000645668.2
ENST00000645963.2
TSEN15
tRNA splicing endonuclease subunit 15
chr4_-_141212877 0.19 ENST00000420921.6
RNF150
ring finger protein 150
chr1_+_70411241 0.17 ENST00000370938.8
ENST00000346806.2
CTH
cystathionine gamma-lyase
chr20_-_23605917 0.16 ENST00000376971.4
CST9
cystatin 9
chr1_-_52033772 0.16 ENST00000371614.2
KTI12
KTI12 chromatin associated homolog
chr4_-_170003738 0.16 ENST00000502832.1
ENST00000393704.3
MFAP3L
microfibril associated protein 3 like
chr17_-_81166160 0.16 ENST00000326724.9
AATK
apoptosis associated tyrosine kinase
chr8_-_98942557 0.16 ENST00000523601.5
STK3
serine/threonine kinase 3
chrX_-_63755032 0.16 ENST00000624538.2
ENST00000636276.1
ENST00000624843.3
ENST00000671907.1
ENST00000624210.3
ENST00000374870.8
ENST00000635967.1
ENST00000253401.10
ENST00000672194.1
ENST00000637723.2
ENST00000637417.1
ENST00000637520.1
ENST00000374872.4
ENST00000636926.1
ARHGEF9
Cdc42 guanine nucleotide exchange factor 9
chr1_+_184051643 0.15 ENST00000423085.7
ENST00000361641.6
TSEN15
tRNA splicing endonuclease subunit 15
chr15_-_45114149 0.15 ENST00000603300.1
ENST00000389039.11
DUOX2
dual oxidase 2
chr17_+_19282979 0.15 ENST00000395626.5
ENST00000571254.1
EPN2
epsin 2
chr6_+_130421086 0.14 ENST00000545622.5
TMEM200A
transmembrane protein 200A
chr20_-_45667177 0.14 ENST00000618797.4
WFDC11
WAP four-disulfide core domain 11
chr12_-_7695752 0.14 ENST00000329913.4
GDF3
growth differentiation factor 3
chr19_+_52397841 0.13 ENST00000360465.8
ENST00000391788.6
ENST00000436397.5
ENST00000391787.6
ENST00000494167.6
ENST00000493272.5
ZNF528
zinc finger protein 528
chr2_+_170178136 0.13 ENST00000409044.7
ENST00000408978.9
MYO3B
myosin IIIB
chr3_+_128051610 0.13 ENST00000464451.5
SEC61A1
SEC61 translocon subunit alpha 1
chr16_+_11965234 0.13 ENST00000562385.1
TNFRSF17
TNF receptor superfamily member 17
chr15_+_59611776 0.12 ENST00000396065.3
ENST00000560585.5
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr10_-_72217126 0.12 ENST00000317126.8
ASCC1
activating signal cointegrator 1 complex subunit 1
chr9_-_83267230 0.11 ENST00000328788.5
FRMD3
FERM domain containing 3
chr7_-_86965872 0.11 ENST00000398276.6
ENST00000416314.5
ENST00000425689.1
ELAPOR2
endosome-lysosome associated apoptosis and autophagy regulator family member 2
chr11_+_62242232 0.11 ENST00000244926.4
SCGB1D2
secretoglobin family 1D member 2
chr17_+_36064265 0.11 ENST00000616054.2
CCL18
C-C motif chemokine ligand 18
chr10_-_13972355 0.10 ENST00000264546.10
FRMD4A
FERM domain containing 4A
chr9_-_101487120 0.10 ENST00000374848.8
PGAP4
post-GPI attachment to proteins GalNAc transferase 4
chrX_+_49171889 0.10 ENST00000376327.6
PLP2
proteolipid protein 2
chr14_+_22040576 0.10 ENST00000390448.3
TRAV20
T cell receptor alpha variable 20
chrX_-_63755187 0.10 ENST00000635729.1
ENST00000623566.3
ARHGEF9
Cdc42 guanine nucleotide exchange factor 9
chr11_+_125626229 0.10 ENST00000532449.6
ENST00000534070.5
CHEK1
checkpoint kinase 1
chr19_-_10380454 0.09 ENST00000530829.1
ENST00000529370.5
TYK2
tyrosine kinase 2
chr7_-_93219545 0.09 ENST00000440868.5
HEPACAM2
HEPACAM family member 2
chrX_+_106920393 0.09 ENST00000336803.2
CLDN2
claudin 2
chr7_+_143954844 0.09 ENST00000641412.1
OR2F1
olfactory receptor family 2 subfamily F member 1
chr7_-_93219564 0.09 ENST00000341723.8
HEPACAM2
HEPACAM family member 2
chr12_-_9999176 0.08 ENST00000298527.10
ENST00000348658.4
CLEC1B
C-type lectin domain family 1 member B
chr3_+_158644510 0.08 ENST00000486715.6
ENST00000478576.5
ENST00000264263.9
ENST00000464732.1
GFM1
G elongation factor mitochondrial 1
chr2_-_208190001 0.08 ENST00000451346.5
ENST00000341287.9
C2orf80
chromosome 2 open reading frame 80
chr7_-_106285898 0.07 ENST00000424768.2
ENST00000681255.1
NAMPT
nicotinamide phosphoribosyltransferase
chr11_-_47378494 0.07 ENST00000533030.1
SPI1
Spi-1 proto-oncogene
chr20_-_50958520 0.07 ENST00000371588.10
ENST00000371584.9
ENST00000413082.1
ENST00000371582.8
DPM1
dolichyl-phosphate mannosyltransferase subunit 1, catalytic
chr3_-_44477639 0.07 ENST00000396077.8
ZNF445
zinc finger protein 445
chr1_+_65147657 0.07 ENST00000546702.5
AK4
adenylate kinase 4
chr18_-_54224578 0.07 ENST00000583046.1
ENST00000398398.6
ENST00000256429.8
MBD2
methyl-CpG binding domain protein 2
chrX_-_120878924 0.07 ENST00000613352.1
ENSG00000278646.1
novel protein similar to cancer/testis antigen family 47, member A12 (CT47A12)
chr19_+_54874218 0.07 ENST00000355524.8
ENST00000391726.7
FCAR
Fc fragment of IgA receptor
chr10_-_72216267 0.07 ENST00000342444.8
ENST00000533958.1
ENST00000672957.1
ENST00000527593.5
ENST00000672940.1
ENST00000530461.5
ENST00000317168.11
ENST00000524829.5
ASCC1
activating signal cointegrator 1 complex subunit 1
chrX_+_129906146 0.06 ENST00000394422.8
UTP14A
UTP14A small subunit processome component
chr13_-_60163764 0.06 ENST00000377908.6
ENST00000400319.5
ENST00000400320.5
ENST00000267215.8
DIAPH3
diaphanous related formin 3
chr9_-_127847117 0.06 ENST00000480266.5
ENG
endoglin
chr1_+_203795614 0.06 ENST00000367210.3
ENST00000432282.5
ENST00000453771.5
ENST00000367214.5
ENST00000639812.1
ENST00000367212.7
ENST00000332127.8
ENST00000550078.2
ZC3H11A
ZBED6
zinc finger CCCH-type containing 11A
zinc finger BED-type containing 6
chr4_+_68815991 0.06 ENST00000265403.12
ENST00000458688.2
UGT2B10
UDP glucuronosyltransferase family 2 member B10
chr1_-_111563934 0.05 ENST00000443498.5
TMIGD3
transmembrane and immunoglobulin domain containing 3
chr2_-_119366757 0.05 ENST00000414534.1
C2orf76
chromosome 2 open reading frame 76
chr13_+_32316063 0.05 ENST00000680887.1
BRCA2
BRCA2 DNA repair associated
chr12_-_10454485 0.05 ENST00000408006.7
ENST00000544822.2
ENST00000536188.5
KLRC1
killer cell lectin like receptor C1
chr17_-_17281232 0.05 ENST00000417352.5
ENST00000268717.10
COPS3
COP9 signalosome subunit 3
chr3_-_185938006 0.05 ENST00000342294.4
ENST00000453386.7
ENST00000382191.4
TRA2B
transformer 2 beta homolog
chr14_+_61697622 0.05 ENST00000539097.2
HIF1A
hypoxia inducible factor 1 subunit alpha
chr14_-_20333268 0.05 ENST00000358932.9
ENST00000557665.5
CCNB1IP1
cyclin B1 interacting protein 1
chr2_-_70995336 0.05 ENST00000606025.5
ENSG00000258881.6
novel protein
chrX_+_129906118 0.05 ENST00000425117.6
UTP14A
UTP14A small subunit processome component
chr11_-_133845495 0.05 ENST00000299140.8
ENST00000532889.1
SPATA19
spermatogenesis associated 19
chr13_-_21604145 0.05 ENST00000382374.9
ENST00000468222.2
MICU2
mitochondrial calcium uptake 2
chr14_-_20333306 0.05 ENST00000353689.8
ENST00000437553.6
CCNB1IP1
cyclin B1 interacting protein 1
chr3_-_16482850 0.05 ENST00000432519.5
RFTN1
raftlin, lipid raft linker 1
chr16_-_11782552 0.04 ENST00000396516.6
ZC3H7A
zinc finger CCCH-type containing 7A
chr11_-_124313949 0.04 ENST00000641015.1
OR8D1
olfactory receptor family 8 subfamily D member 1
chr15_-_73753308 0.04 ENST00000569673.3
INSYN1
inhibitory synaptic factor 1
chr3_+_98166696 0.04 ENST00000641450.1
OR5H15
olfactory receptor family 5 subfamily H member 15
chr2_+_209580024 0.04 ENST00000392194.5
MAP2
microtubule associated protein 2
chr6_+_28281555 0.04 ENST00000259883.3
ENST00000682144.1
PGBD1
piggyBac transposable element derived 1
chr11_-_26572102 0.03 ENST00000455601.6
MUC15
mucin 15, cell surface associated
chr2_-_162318613 0.03 ENST00000649979.2
ENST00000421365.2
IFIH1
interferon induced with helicase C domain 1
chr20_-_14337602 0.03 ENST00000378053.3
ENST00000341420.5
FLRT3
fibronectin leucine rich transmembrane protein 3
chr18_+_24139053 0.03 ENST00000463087.5
ENST00000585037.5
ENST00000399496.8
ENST00000486759.6
ENST00000577705.1
ENST00000415309.6
ENST00000621648.4
ENST00000581397.5
CABYR
calcium binding tyrosine phosphorylation regulated
chr7_-_43869491 0.03 ENST00000317534.6
ENST00000418740.5
MRPS24
mitochondrial ribosomal protein S24
chr3_-_33645433 0.03 ENST00000635664.1
ENST00000485378.6
ENST00000313350.10
ENST00000487200.5
CLASP2
cytoplasmic linker associated protein 2
chr3_+_138608700 0.02 ENST00000360570.7
FAIM
Fas apoptotic inhibitory molecule
chr3_+_138608575 0.02 ENST00000338446.8
FAIM
Fas apoptotic inhibitory molecule
chr1_-_43172504 0.02 ENST00000431635.6
EBNA1BP2
EBNA1 binding protein 2
chr11_-_26572130 0.02 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr1_+_65147514 0.02 ENST00000545314.5
AK4
adenylate kinase 4
chr7_-_105389365 0.02 ENST00000482897.5
SRPK2
SRSF protein kinase 2
chrX_-_72877864 0.01 ENST00000596389.5
DMRTC1
DMRT like family C1
chr14_-_73950393 0.01 ENST00000651776.1
FAM161B
FAM161 centrosomal protein B
chr10_+_76318330 0.01 ENST00000496424.2
LRMDA
leucine rich melanocyte differentiation associated
chr7_-_26200734 0.01 ENST00000354667.8
ENST00000618183.5
HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr17_+_76732978 0.01 ENST00000587459.1
ENSG00000267168.1
novel protein
chr3_+_138608851 0.01 ENST00000393035.6
FAIM
Fas apoptotic inhibitory molecule
chr15_+_75903893 0.01 ENST00000565036.5
ENST00000569054.5
FBXO22
F-box protein 22
chr12_-_120325936 0.01 ENST00000549767.1
PLA2G1B
phospholipase A2 group IB
chr6_-_70957029 0.00 ENST00000230053.11
B3GAT2
beta-1,3-glucuronyltransferase 2
chr19_+_35351552 0.00 ENST00000246553.3
FFAR1
free fatty acid receptor 1
chr14_-_60165363 0.00 ENST00000557185.6
DHRS7
dehydrogenase/reductase 7

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.1 0.2 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.1 0.9 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.1 0.4 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.2 GO:0048850 cuticle development(GO:0042335) hypophysis morphogenesis(GO:0048850)
0.0 0.2 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.0 0.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.1 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 0.5 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.1 GO:0048859 formation of anatomical boundary(GO:0048859)
0.0 0.1 GO:0039019 pronephric nephron development(GO:0039019)
0.0 0.2 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 0.1 GO:0001300 chronological cell aging(GO:0001300)
0.0 0.2 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.2 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.1 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.4 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.0 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0 0.3 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.1 GO:1990426 homologous recombination-dependent replication fork processing(GO:1990426)
0.0 0.7 GO:0018149 peptide cross-linking(GO:0018149)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.1 GO:0072563 endothelial microparticle(GO:0072563)
0.0 0.1 GO:0033593 BRCA2-MAGE-D1 complex(GO:0033593)
0.0 0.7 GO:0001533 cornified envelope(GO:0001533)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
0.1 0.5 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.6 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.7 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.2 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.1 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.2 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.1 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.1 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.0 0.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0047280 nicotinamide phosphoribosyltransferase activity(GO:0047280)
0.0 0.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.1 GO:0019862 IgA binding(GO:0019862)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.4 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE