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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SOX13_SOX12
Z-value: 1.09
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Transcription factors associated with SOX13_SOX12
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX12 | hg38_v1_chr20_+_325536_325565 | -0.24 | 2.1e-01 | Click! |
| SOX13 | hg38_v1_chr1_+_204073104_204073121 | -0.00 | 9.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX13_SOX12
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_91111460 Show fit | 7.16 |
ENST00000266718.5
|
lumican |
|
| chr10_+_116427839 Show fit | 5.67 |
ENST00000369230.4
|
pancreatic lipase related protein 3 |
|
| chr2_+_102311502 Show fit | 3.34 |
ENST00000404917.6
ENST00000410040.5 |
interleukin 1 receptor like 1 interleukin 18 receptor 1 |
|
| chr1_-_153460644 Show fit | 2.71 |
ENST00000368723.4
|
S100 calcium binding protein A7 |
|
| chr4_-_56681288 Show fit | 2.57 |
ENST00000556376.6
ENST00000420433.6 |
HOP homeobox |
|
| chr19_+_20923275 Show fit | 2.14 |
ENST00000300540.7
ENST00000595854.5 ENST00000601284.5 ENST00000599885.1 ENST00000596476.1 ENST00000345030.6 |
zinc finger protein 85 |
|
| chr4_-_68245683 Show fit | 2.09 |
ENST00000332644.6
|
transmembrane serine protease 11B |
|
| chr3_+_186640355 Show fit | 1.83 |
ENST00000382134.7
ENST00000265029.8 |
fetuin B |
|
| chr12_-_10130241 Show fit | 1.73 |
ENST00000353231.9
ENST00000525605.1 |
C-type lectin domain containing 7A |
|
| chr6_-_49744378 Show fit | 1.70 |
ENST00000371159.8
ENST00000263045.9 |
cysteine rich secretory protein 3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 7.5 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 0.1 | 5.2 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 4.1 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.5 | 3.2 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.6 | 3.0 | GO:0010751 | negative regulation of nitric oxide mediated signal transduction(GO:0010751) |
| 0.1 | 2.8 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) |
| 0.2 | 2.7 | GO:0010820 | positive regulation of T cell chemotaxis(GO:0010820) |
| 0.1 | 2.6 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.0 | 2.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 2.3 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 7.2 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 4.9 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 4.2 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 3.9 | GO:0005901 | caveola(GO:0005901) |
| 0.2 | 3.7 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 2.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 2.3 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 2.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 1.8 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 1.6 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.3 | 7.0 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.1 | 6.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 5.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.1 | 3.3 | GO:0042008 | interleukin-18 receptor activity(GO:0042008) |
| 0.1 | 3.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 2.7 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.0 | 2.5 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 2.0 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.1 | 1.9 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 3.8 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 3.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 3.2 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 2.4 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 2.2 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 1.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.7 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 1.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 1.2 | PID TNF PATHWAY | TNF receptor signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 7.1 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 3.8 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 2.2 | REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR | Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR) |
| 0.0 | 2.2 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 1.8 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 1.7 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 1.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 1.6 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 1.4 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 1.2 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |