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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SOX21

Z-value: 0.46

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Transcription factors associated with SOX21

Gene Symbol Gene ID Gene Info
SOX21
ENSG00000125285.6 SOX21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX21hg38_v1_chr13_-_94712505_94712553-0.067.5e-01Click!

Activity profile of SOX21 motif

Sorted Z-values of SOX21 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX21

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_+_152908538 1.57 ENST00000368764.4
IVL
involucrin
chr11_+_35180279 1.50 ENST00000531873.5
CD44
CD44 molecule (Indian blood group)
chr4_+_68447453 1.44 ENST00000305363.9
TMPRSS11E
transmembrane serine protease 11E
chr6_+_31403553 1.30 ENST00000449934.7
ENST00000421350.1
MICA
MHC class I polypeptide-related sequence A
chr15_-_79971164 1.11 ENST00000335661.6
ENST00000267953.4
ENST00000677151.1
BCL2A1
BCL2 related protein A1
chr12_-_89352395 1.01 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr19_+_16197848 0.99 ENST00000590263.5
ENST00000590756.5
AP1M1
adaptor related protein complex 1 subunit mu 1
chr19_+_16197900 0.97 ENST00000429941.6
ENST00000291439.8
ENST00000444449.6
ENST00000589822.5
AP1M1
adaptor related protein complex 1 subunit mu 1
chr11_+_35180342 0.95 ENST00000639002.1
CD44
CD44 molecule (Indian blood group)
chr12_-_89352487 0.93 ENST00000548755.1
ENST00000279488.8
DUSP6
dual specificity phosphatase 6
chr9_+_102995308 0.88 ENST00000612124.4
ENST00000374798.8
ENST00000487798.5
CYLC2
cylicin 2
chr4_-_39032922 0.87 ENST00000344606.6
TMEM156
transmembrane protein 156
chr7_-_73719629 0.67 ENST00000395155.3
ENST00000395154.7
ENST00000395156.7
ENST00000222812.8
STX1A
syntaxin 1A
chr19_-_7040179 0.65 ENST00000381394.9
MBD3L4
methyl-CpG binding domain protein 3 like 4
chr12_+_122527229 0.62 ENST00000450485.6
ENST00000333479.12
KNTC1
kinetochore associated 1
chrX_+_3066833 0.58 ENST00000359361.2
ARSF
arylsulfatase F
chr3_+_100635598 0.55 ENST00000475887.1
ADGRG7
adhesion G protein-coupled receptor G7
chr11_+_89924064 0.52 ENST00000623787.3
TRIM49D2
tripartite motif containing 49D2
chr19_-_2783241 0.49 ENST00000676943.1
ENST00000589251.5
ENST00000221566.7
ENST00000676984.1
SGTA
small glutamine rich tetratricopeptide repeat containing alpha
chr19_-_2783308 0.47 ENST00000677562.1
ENST00000677754.1
SGTA
small glutamine rich tetratricopeptide repeat containing alpha
chr8_-_86069662 0.44 ENST00000276616.3
PSKH2
protein serine kinase H2
chr11_+_5389377 0.43 ENST00000328611.5
OR51M1
olfactory receptor family 51 subfamily M member 1
chr3_+_58008350 0.43 ENST00000490882.5
ENST00000358537.7
ENST00000429972.6
ENST00000682871.1
ENST00000295956.9
FLNB
filamin B
chr12_-_949519 0.39 ENST00000397230.6
ENST00000542785.5
ENST00000544742.5
ENST00000536177.5
ENST00000541619.1
RAD52
RAD52 homolog, DNA repair protein
chr1_-_146344790 0.39 ENST00000584068.3
PPIAL4H
peptidylprolyl isomerase A like 4H
chr4_-_176269213 0.36 ENST00000296525.7
ASB5
ankyrin repeat and SOCS box containing 5
chr14_+_21941122 0.35 ENST00000390441.2
TRAV9-2
T cell receptor alpha variable 9-2
chr6_+_116399395 0.34 ENST00000644499.1
ENSG00000285446.1
novel protein
chr3_-_58577648 0.33 ENST00000394481.5
FAM107A
family with sequence similarity 107 member A
chr12_-_10172117 0.32 ENST00000545927.5
ENST00000309539.8
ENST00000432556.6
ENST00000544577.5
OLR1
oxidized low density lipoprotein receptor 1
chr1_+_67166448 0.32 ENST00000347310.10
IL23R
interleukin 23 receptor
chr20_+_44715360 0.31 ENST00000190983.5
CCN5
cellular communication network factor 5
chr8_-_142879820 0.31 ENST00000377675.3
ENST00000517471.5
ENST00000292427.10
CYP11B1
cytochrome P450 family 11 subfamily B member 1
chr18_+_32190033 0.29 ENST00000269202.11
MEP1B
meprin A subunit beta
chr9_+_96928310 0.29 ENST00000354649.7
NUTM2G
NUT family member 2G
chr18_+_32190015 0.29 ENST00000581447.1
MEP1B
meprin A subunit beta
chr16_-_18433412 0.29 ENST00000620440.4
NOMO2
NODAL modulator 2
chrX_-_132219439 0.28 ENST00000370874.2
RAP2C
RAP2C, member of RAS oncogene family
chr1_+_144592868 0.28 ENST00000581138.3
PPIAL4F
peptidylprolyl isomerase A like 4F
chr5_-_179618032 0.26 ENST00000519033.5
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
chrX_+_66164210 0.25 ENST00000343002.7
ENST00000336279.9
HEPH
hephaestin
chr1_-_26067622 0.25 ENST00000374272.4
TRIM63
tripartite motif containing 63
chr2_+_89851723 0.25 ENST00000429992.2
IGKV2D-40
immunoglobulin kappa variable 2D-40
chr8_+_127409026 0.21 ENST00000465342.4
POU5F1B
POU class 5 homeobox 1B
chr7_-_16421524 0.21 ENST00000407010.7
CRPPA
CDP-L-ribitol pyrophosphorylase A
chr6_-_112254647 0.20 ENST00000455073.1
ENST00000522006.5
ENST00000519932.5
LAMA4
laminin subunit alpha 4
chr1_+_149583865 0.19 ENST00000585245.2
PPIAL4C
peptidylprolyl isomerase A like 4C
chr3_+_141384790 0.18 ENST00000507722.5
ZBTB38
zinc finger and BTB domain containing 38
chr22_+_22720615 0.16 ENST00000390309.2
IGLV3-19
immunoglobulin lambda variable 3-19
chr9_-_101487120 0.16 ENST00000374848.8
PGAP4
post-GPI attachment to proteins GalNAc transferase 4
chr4_-_102825526 0.16 ENST00000504211.5
ENST00000508476.5
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr4_-_102825854 0.15 ENST00000350435.11
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr9_-_101487091 0.15 ENST00000374847.5
PGAP4
post-GPI attachment to proteins GalNAc transferase 4
chr7_+_2354810 0.15 ENST00000360876.9
ENST00000413917.5
ENST00000397011.2
EIF3B
eukaryotic translation initiation factor 3 subunit B
chr2_+_3658193 0.15 ENST00000252505.4
ALLC
allantoicase
chr19_+_18571730 0.15 ENST00000596304.5
ENST00000430157.6
ENST00000596273.5
ENST00000442744.7
ENST00000595683.5
ENST00000599256.5
ENST00000595158.5
ENST00000598780.5
UBA52
ubiquitin A-52 residue ribosomal protein fusion product 1
chr8_-_19602484 0.15 ENST00000454498.6
ENST00000520003.5
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr5_-_147906530 0.15 ENST00000318315.5
ENST00000515291.1
C5orf46
chromosome 5 open reading frame 46
chrX_-_101291325 0.14 ENST00000356784.2
TAF7L
TATA-box binding protein associated factor 7 like
chr15_+_58410543 0.13 ENST00000356113.10
ENST00000414170.7
LIPC
lipase C, hepatic type
chr1_-_13198130 0.13 ENST00000638454.1
PRAMEF13
PRAME family member 13
chr3_+_38496467 0.12 ENST00000453767.1
EXOG
exo/endonuclease G
chr4_-_102825767 0.11 ENST00000505207.5
ENST00000502404.5
ENST00000507845.5
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr12_-_10435940 0.11 ENST00000381901.5
ENST00000381902.7
ENST00000539033.1
KLRC2
ENSG00000255641.1
killer cell lectin like receptor C2
novel protein
chr11_+_118077067 0.10 ENST00000522307.5
ENST00000523251.5
ENST00000437212.8
ENST00000522824.5
ENST00000522151.5
TMPRSS4
transmembrane serine protease 4
chr10_-_13234329 0.10 ENST00000463405.2
UCMA
upper zone of growth plate and cartilage matrix associated
chr17_+_68259164 0.10 ENST00000448504.6
ARSG
arylsulfatase G
chr11_+_118077009 0.09 ENST00000616579.4
ENST00000534111.5
TMPRSS4
transmembrane serine protease 4
chr12_+_57591158 0.09 ENST00000422156.7
ENST00000354947.10
ENST00000540759.6
ENST00000551772.5
ENST00000550465.5
PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
chr12_-_10998304 0.09 ENST00000538986.2
TAS2R20
taste 2 receptor member 20
chr1_+_200027702 0.09 ENST00000367362.8
NR5A2
nuclear receptor subfamily 5 group A member 2
chr1_+_200027605 0.09 ENST00000236914.7
NR5A2
nuclear receptor subfamily 5 group A member 2
chr18_-_49492305 0.08 ENST00000615479.4
ENST00000583637.5
ENST00000618613.5
ENST00000615760.4
ENST00000578528.1
ENST00000578532.5
ENST00000580387.5
ENST00000579248.5
ENST00000580261.6
ENST00000581373.5
ENST00000618619.4
ENST00000617346.4
ENST00000583036.5
ENST00000332968.11
RPL17
RPL17-C18orf32
ribosomal protein L17
RPL17-C18orf32 readthrough
chr16_-_15888583 0.08 ENST00000575938.1
ENST00000573396.5
ENST00000573968.5
ENST00000255759.11
ENST00000575744.5
ENST00000573429.5
ENST00000575073.5
CEP20
centrosomal protein 20
chr17_+_68249200 0.08 ENST00000577985.5
AMZ2
archaelysin family metallopeptidase 2
chr10_-_13234368 0.08 ENST00000378681.8
UCMA
upper zone of growth plate and cartilage matrix associated
chr5_+_176448363 0.07 ENST00000261942.7
FAF2
Fas associated factor family member 2
chr1_+_158931539 0.07 ENST00000368140.6
ENST00000368138.7
ENST00000392254.6
ENST00000392252.7
ENST00000368135.4
PYHIN1
pyrin and HIN domain family member 1
chr11_-_8263858 0.07 ENST00000534484.1
ENST00000335790.8
LMO1
LIM domain only 1
chr22_-_40533808 0.06 ENST00000422851.1
ENST00000651694.1
ENST00000652095.2
MRTFA
myocardin related transcription factor A
chr12_-_949683 0.04 ENST00000358495.8
RAD52
RAD52 homolog, DNA repair protein
chr1_+_203795614 0.04 ENST00000367210.3
ENST00000432282.5
ENST00000453771.5
ENST00000367214.5
ENST00000639812.1
ENST00000367212.7
ENST00000332127.8
ENST00000550078.2
ZC3H11A
ZBED6
zinc finger CCCH-type containing 11A
zinc finger BED-type containing 6
chr4_-_103719980 0.04 ENST00000304883.3
TACR3
tachykinin receptor 3
chr19_+_41877267 0.04 ENST00000221972.8
ENST00000597454.1
ENST00000444740.2
CD79A
CD79a molecule
chr1_+_151198536 0.03 ENST00000349792.9
ENST00000409426.5
ENST00000368888.9
ENST00000441902.6
ENST00000368890.8
ENST00000424999.1
PIP5K1A
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
chr7_-_14903319 0.03 ENST00000403951.6
DGKB
diacylglycerol kinase beta
chr6_+_29396555 0.03 ENST00000623183.1
OR12D2
olfactory receptor family 12 subfamily D member 2
chr3_-_142028597 0.03 ENST00000467667.5
TFDP2
transcription factor Dp-2
chr3_-_71305986 0.03 ENST00000647614.1
FOXP1
forkhead box P1
chr6_+_42563981 0.03 ENST00000372899.6
ENST00000372901.2
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr17_-_44376169 0.03 ENST00000587295.5
ITGA2B
integrin subunit alpha 2b
chrX_+_51710512 0.02 ENST00000602548.2
CENPVL1
centromere protein V like 1
chr18_+_11857440 0.02 ENST00000602628.1
GNAL
G protein subunit alpha L
chr3_-_142028617 0.01 ENST00000477292.5
ENST00000478006.5
ENST00000495310.5
ENST00000486111.5
TFDP2
transcription factor Dp-2
chr10_-_69409275 0.00 ENST00000373307.5
TACR2
tachykinin receptor 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.4 1.9 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 1.0 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.2 2.5 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.7 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.1 1.3 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.1 2.0 GO:0035646 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.1 0.3 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.1 0.3 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.1 0.4 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.0 0.1 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.2 GO:0043605 cellular amide catabolic process(GO:0043605)
0.0 0.3 GO:0035865 cellular response to potassium ion(GO:0035865)
0.0 1.1 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.2 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.6 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334) cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.6 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.2 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.1 GO:0046013 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.3 GO:0032486 Rap protein signal transduction(GO:0032486)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0033150 cytoskeletal calyx(GO:0033150)
0.2 2.5 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2 0.7 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.2 0.6 GO:1990423 RZZ complex(GO:1990423)
0.1 0.3 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 2.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.6 GO:0001533 cornified envelope(GO:0001533)
0.0 0.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 1.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.3 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 0.3 GO:0047783 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
0.1 0.3 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.1 2.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.1 GO:0051400 BH domain binding(GO:0051400)
0.1 0.7 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.7 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0047238 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.8 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.0 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.0 0.3 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.1 GO:0035473 lipase binding(GO:0035473)
0.0 0.1 GO:0030169 low-density lipoprotein particle binding(GO:0030169)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.9 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.0 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.2 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.5 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.9 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.7 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.7 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.3 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.4 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha