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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SOX3_SOX2
Z-value: 1.68
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Transcription factors associated with SOX3_SOX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX2 | hg38_v1_chr3_+_181711915_181711934 | -0.42 | 2.2e-02 | Click! |
| SOX3 | hg38_v1_chrX_-_140505058_140505076 | 0.10 | 5.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX3_SOX2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_1744442 Show fit | 8.89 |
ENST00000433670.5
ENST00000425171.1 ENST00000252804.9 |
peroxidasin |
|
| chr1_-_205455954 Show fit | 6.27 |
ENST00000495594.2
ENST00000629624.2 |
LEM domain containing 1 bladder cancer associated transcript 1 |
|
| chr1_-_25906457 Show fit | 5.05 |
ENST00000426559.6
|
stathmin 1 |
|
| chr6_-_30687200 Show fit | 4.37 |
ENST00000399199.7
|
protein phosphatase 1 regulatory subunit 18 |
|
| chr1_-_153057504 Show fit | 4.36 |
ENST00000392653.3
|
small proline rich protein 2A |
|
| chr1_-_205449924 Show fit | 4.17 |
ENST00000367154.5
|
LEM domain containing 1 |
|
| chr19_-_49361475 Show fit | 3.90 |
ENST00000598810.5
|
TEA domain transcription factor 2 |
|
| chr6_+_113857333 Show fit | 3.80 |
ENST00000612661.2
|
myristoylated alanine rich protein kinase C substrate |
|
| chr8_+_85463997 Show fit | 3.55 |
ENST00000285379.10
|
carbonic anhydrase 2 |
|
| chr19_-_50969567 Show fit | 3.21 |
ENST00000310157.7
|
kallikrein related peptidase 6 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.3 | GO:1901998 | toxin transport(GO:1901998) |
| 0.2 | 8.9 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.3 | 8.8 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.7 | 8.4 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.3 | 6.9 | GO:0030903 | notochord development(GO:0030903) |
| 0.2 | 6.0 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.1 | 5.7 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
| 0.2 | 4.5 | GO:0010642 | negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642) |
| 0.1 | 4.0 | GO:1900739 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 1.3 | 3.9 | GO:0042938 | dipeptide transport(GO:0042938) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 11.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 11.0 | GO:0030055 | cell-substrate junction(GO:0030055) |
| 1.7 | 6.8 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 0.2 | 5.2 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 5.0 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.8 | 4.6 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 4.6 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 4.5 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 4.3 | GO:0005905 | clathrin-coated pit(GO:0005905) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 9.5 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.0 | 7.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 6.9 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.1 | 5.7 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.2 | 5.1 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.1 | 5.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 5.0 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 4.9 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.2 | 4.4 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.2 | 4.3 | GO:0019841 | retinol binding(GO:0019841) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 10.0 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.4 | 8.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 6.6 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 6.6 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.1 | 6.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 5.9 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 5.5 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 5.0 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 4.9 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.6 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 7.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 6.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 6.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 4.7 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.1 | 4.6 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.2 | 4.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 3.9 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.3 | 3.7 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 3.5 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |