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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SOX5
Z-value: 1.22
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Transcription factors associated with SOX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX5 | hg38_v1_chr12_-_23951020_23951037 | 0.12 | 5.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX5
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_55376818 Show fit | 6.29 |
ENST00000291934.4
|
transmembrane protein 190 |
|
| chr4_+_164754045 Show fit | 6.23 |
ENST00000515485.5
|
small integral membrane protein 31 |
|
| chr6_-_32589833 Show fit | 5.91 |
ENST00000360004.5
|
major histocompatibility complex, class II, DR beta 1 |
|
| chr7_-_16881967 Show fit | 5.69 |
ENST00000402239.7
ENST00000310398.7 ENST00000414935.1 |
anterior gradient 3, protein disulphide isomerase family member |
|
| chr4_+_164754116 Show fit | 5.42 |
ENST00000507311.1
|
small integral membrane protein 31 |
|
| chr15_+_70936487 Show fit | 4.98 |
ENST00000558456.5
ENST00000560158.6 ENST00000558808.5 ENST00000559806.5 ENST00000559069.1 |
leucine rich repeat containing 49 |
|
| chr3_-_19946970 Show fit | 4.68 |
ENST00000344838.8
|
EF-hand domain family member B |
|
| chr3_+_181711915 Show fit | 4.48 |
ENST00000325404.3
|
SRY-box transcription factor 2 |
|
| chr20_-_3781440 Show fit | 4.40 |
ENST00000379756.3
|
sperm flagellar 1 |
|
| chr7_-_131556602 Show fit | 4.35 |
ENST00000322985.9
ENST00000378555.8 |
podocalyxin like |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.8 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 0.5 | 6.0 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 1.5 | 5.9 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 0.7 | 5.3 | GO:0045631 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.0 | 5.1 | GO:0000910 | cytokinesis(GO:0000910) |
| 0.3 | 5.0 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.0 | 5.0 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 1.5 | 4.6 | GO:0021757 | caudate nucleus development(GO:0021757) putamen development(GO:0021758) |
| 0.1 | 4.6 | GO:1904886 | beta-catenin destruction complex disassembly(GO:1904886) |
| 0.3 | 4.5 | GO:0021781 | glial cell fate commitment(GO:0021781) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 6.3 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
| 0.0 | 6.2 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.7 | 6.0 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.3 | 5.9 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 5.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 5.1 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.2 | 5.0 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.1 | 4.9 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 4.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.3 | 4.4 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.1 | 6.3 | GO:0043621 | protein self-association(GO:0043621) |
| 0.2 | 5.9 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.2 | 5.7 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.1 | 5.2 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.2 | 4.8 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 4.5 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 4.2 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.1 | 4.0 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 3.8 | GO:0005178 | integrin binding(GO:0005178) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.9 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 6.8 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 6.6 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 6.5 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 4.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 4.6 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 4.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 3.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 2.3 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 2.2 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.0 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.3 | 5.9 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.0 | 5.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 4.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 4.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 2.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 2.7 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.2 | 2.4 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 2.2 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 2.0 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |