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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SOX7

Z-value: 0.34

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Transcription factors associated with SOX7

Gene Symbol Gene ID Gene Info
SOX7
ENSG00000171056.8 SOX7
PINX1
ENSG00000258724.1 PINX1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX7hg38_v1_chr8_-_10730498_107305250.135.0e-01Click!
PINX1hg38_v1_chr8_-_10839818_108398550.105.8e-01Click!

Activity profile of SOX7 motif

Sorted Z-values of SOX7 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX7

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr9_+_102995308 0.83 ENST00000612124.4
ENST00000374798.8
ENST00000487798.5
CYLC2
cylicin 2
chr4_+_68447453 0.50 ENST00000305363.9
TMPRSS11E
transmembrane serine protease 11E
chr3_-_71305986 0.49 ENST00000647614.1
FOXP1
forkhead box P1
chr12_-_56934403 0.38 ENST00000293502.2
SDR9C7
short chain dehydrogenase/reductase family 9C member 7
chr7_+_134565098 0.25 ENST00000652743.1
AKR1B15
aldo-keto reductase family 1 member B15
chr10_+_94683771 0.24 ENST00000339022.6
CYP2C18
cytochrome P450 family 2 subfamily C member 18
chr17_-_35880350 0.24 ENST00000605140.6
ENST00000651122.1
ENST00000603197.6
CCL5
C-C motif chemokine ligand 5
chr4_-_176269213 0.23 ENST00000296525.7
ASB5
ankyrin repeat and SOCS box containing 5
chr16_+_33009175 0.22 ENST00000565407.2
IGHV3OR16-8
immunoglobulin heavy variable 3/OR16-8 (non-functional)
chr16_-_20352707 0.22 ENST00000396134.6
ENST00000573567.5
ENST00000570757.5
ENST00000396138.9
ENST00000571174.5
ENST00000576688.2
UMOD
uromodulin
chr14_-_106117159 0.22 ENST00000390601.3
IGHV3-11
immunoglobulin heavy variable 3-11
chr16_-_33845229 0.21 ENST00000569103.2
IGHV3OR16-17
immunoglobulin heavy variable 3/OR16-17 (non-functional)
chr4_-_122456725 0.20 ENST00000226730.5
IL2
interleukin 2
chr2_+_86907953 0.19 ENST00000409776.6
RGPD1
RANBP2 like and GRIP domain containing 1
chrX_-_135781729 0.19 ENST00000617203.1
CT45A5
cancer/testis antigen family 45 member A5
chr10_+_4963406 0.18 ENST00000380872.9
ENST00000442997.5
AKR1C1
aldo-keto reductase family 1 member C1
chr4_-_47981535 0.16 ENST00000402813.9
CNGA1
cyclic nucleotide gated channel subunit alpha 1
chrX_+_51710512 0.16 ENST00000602548.2
CENPVL1
centromere protein V like 1
chr1_-_26067622 0.15 ENST00000374272.4
TRIM63
tripartite motif containing 63
chr19_-_38426162 0.13 ENST00000587738.2
ENST00000586305.5
RASGRP4
RAS guanyl releasing protein 4
chr2_-_89100352 0.12 ENST00000479981.1
IGKV1-16
immunoglobulin kappa variable 1-16
chr6_+_116399395 0.12 ENST00000644499.1
ENSG00000285446.1
novel protein
chr1_+_100133135 0.12 ENST00000370143.5
ENST00000370141.7
TRMT13
tRNA methyltransferase 13 homolog
chr1_+_222928415 0.11 ENST00000284476.7
DISP1
dispatched RND transporter family member 1
chr1_-_206003385 0.11 ENST00000617070.5
RAB7B
RAB7B, member RAS oncogene family
chr19_-_38426195 0.11 ENST00000615439.5
ENST00000614135.4
ENST00000622174.4
ENST00000587753.5
ENST00000454404.6
ENST00000617966.4
ENST00000618320.4
ENST00000293062.13
ENST00000433821.6
ENST00000426920.6
RASGRP4
RAS guanyl releasing protein 4
chr1_-_206003442 0.10 ENST00000623893.1
RAB7B
RAB7B, member RAS oncogene family
chr6_+_143843316 0.10 ENST00000367576.6
LTV1
LTV1 ribosome biogenesis factor
chr16_+_28292485 0.10 ENST00000341901.5
SBK1
SH3 domain binding kinase 1
chr6_+_150368892 0.09 ENST00000229447.9
ENST00000392256.6
IYD
iodotyrosine deiodinase
chr6_+_150368997 0.09 ENST00000392255.7
ENST00000500320.7
ENST00000344419.8
IYD
iodotyrosine deiodinase
chr19_-_5784599 0.09 ENST00000390672.2
ENST00000419421.3
PRR22
proline rich 22
chr8_-_19602484 0.08 ENST00000454498.6
ENST00000520003.5
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr12_-_10420550 0.08 ENST00000381903.2
ENST00000396439.7
KLRC3
killer cell lectin like receptor C3
chr3_-_71306012 0.08 ENST00000649431.1
ENST00000610810.5
FOXP1
forkhead box P1
chr4_+_74308463 0.07 ENST00000413830.6
EPGN
epithelial mitogen
chr5_+_162067764 0.06 ENST00000639213.2
ENST00000414552.6
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr2_-_89222461 0.06 ENST00000482769.1
IGKV2-28
immunoglobulin kappa variable 2-28
chr1_-_158426237 0.06 ENST00000641042.1
OR10K2
olfactory receptor family 10 subfamily K member 2
chr11_+_35186820 0.05 ENST00000531110.6
ENST00000525685.6
CD44
CD44 molecule (Indian blood group)
chr12_+_63779894 0.05 ENST00000261234.11
RXYLT1
ribitol xylosyltransferase 1
chr1_+_207325629 0.05 ENST00000618707.2
CD55
CD55 molecule (Cromer blood group)
chr5_+_162067458 0.05 ENST00000639975.1
ENST00000639111.2
ENST00000639683.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr10_+_24449426 0.04 ENST00000307544.10
KIAA1217
KIAA1217
chr5_+_162067858 0.04 ENST00000361925.9
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr15_+_75347030 0.04 ENST00000566313.5
ENST00000355059.9
ENST00000568059.1
ENST00000568881.1
NEIL1
nei like DNA glycosylase 1
chr6_-_111483700 0.03 ENST00000435970.5
ENST00000358835.7
REV3L
REV3 like, DNA directed polymerase zeta catalytic subunit
chr8_+_127409026 0.03 ENST00000465342.4
POU5F1B
POU class 5 homeobox 1B
chr8_-_86069662 0.03 ENST00000276616.3
PSKH2
protein serine kinase H2
chr1_+_86993009 0.03 ENST00000370548.3
ENSG00000267561.2
novel protein
chr6_+_42563981 0.02 ENST00000372899.6
ENST00000372901.2
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr8_+_12945667 0.02 ENST00000524591.7
TRMT9B
tRNA methyltransferase 9B (putative)
chrX_+_131083706 0.02 ENST00000370921.1
ARHGAP36
Rho GTPase activating protein 36
chr8_+_28338640 0.02 ENST00000522209.1
PNOC
prepronociceptin
chr1_+_158931539 0.02 ENST00000368140.6
ENST00000368138.7
ENST00000392254.6
ENST00000392252.7
ENST00000368135.4
PYHIN1
pyrin and HIN domain family member 1
chr11_+_56176618 0.02 ENST00000312298.1
OR5J2
olfactory receptor family 5 subfamily J member 2
chr10_+_94402486 0.01 ENST00000225235.5
TBC1D12
TBC1 domain family member 12
chr4_+_76074701 0.01 ENST00000355810.9
ENST00000349321.7
ART3
ADP-ribosyltransferase 3 (inactive)
chr6_-_85594063 0.01 ENST00000684150.1
SNX14
sorting nexin 14
chr6_-_85594101 0.01 ENST00000682171.1
ENST00000505648.5
SNX14
sorting nexin 14
chr11_+_7597182 0.01 ENST00000528883.5
PPFIBP2
PPFIA binding protein 2
chr5_+_162067500 0.01 ENST00000639384.1
ENST00000640985.1
ENST00000638772.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr1_+_200027702 0.00 ENST00000367362.8
NR5A2
nuclear receptor subfamily 5 group A member 2
chr19_-_2783241 0.00 ENST00000676943.1
ENST00000589251.5
ENST00000221566.7
ENST00000676984.1
SGTA
small glutamine rich tetratricopeptide repeat containing alpha

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.1 0.2 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 0.2 GO:0034164 negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.0 0.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.1 GO:0007225 patched ligand maturation(GO:0007225) signal maturation(GO:0035638)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.6 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.2 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.1 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.3 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.2 GO:0006570 tyrosine metabolic process(GO:0006570)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.1 GO:0034448 EGO complex(GO:0034448)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.0 0.2 GO:0031726 receptor signaling protein tyrosine kinase activator activity(GO:0030298) CCR1 chemokine receptor binding(GO:0031726)
0.0 0.2 GO:0004447 iodide peroxidase activity(GO:0004447)
0.0 0.2 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.3 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.4 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.1 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.2 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.2 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME XENOBIOTICS Genes involved in Xenobiotics