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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SOX8
Z-value: 1.04
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Transcription factors associated with SOX8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX8 | hg38_v1_chr16_+_981762_981782 | -0.06 | 7.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX8
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_16083695 Show fit | 6.43 |
ENST00000510224.5
|
prominin 1 |
|
| chr4_-_16083714 Show fit | 6.39 |
ENST00000508167.5
|
prominin 1 |
|
| chr4_-_16084002 Show fit | 5.90 |
ENST00000447510.7
|
prominin 1 |
|
| chr12_-_10130241 Show fit | 3.63 |
ENST00000353231.9
ENST00000525605.1 |
C-type lectin domain containing 7A |
|
| chr3_+_319683 Show fit | 3.39 |
ENST00000620033.4
|
cell adhesion molecule L1 like |
|
| chr5_-_160852200 Show fit | 3.36 |
ENST00000327245.10
|
ATPase phospholipid transporting 10B (putative) |
|
| chr6_+_32637419 Show fit | 3.31 |
ENST00000374949.2
|
major histocompatibility complex, class II, DQ alpha 1 |
|
| chr12_-_10130143 Show fit | 3.24 |
ENST00000298523.9
ENST00000396484.6 ENST00000310002.4 ENST00000304084.13 |
C-type lectin domain containing 7A |
|
| chr14_-_106622837 Show fit | 3.23 |
ENST00000390628.3
|
immunoglobulin heavy variable 1-58 |
|
| chr6_-_52803807 Show fit | 3.19 |
ENST00000334575.6
|
glutathione S-transferase alpha 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 18.7 | GO:2000768 | positive regulation of nephron tubule epithelial cell differentiation(GO:2000768) |
| 0.4 | 9.6 | GO:0009756 | carbohydrate mediated signaling(GO:0009756) |
| 2.0 | 8.1 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.1 | 6.2 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.3 | 4.6 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 0.0 | 4.2 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.1 | 3.4 | GO:0045332 | phospholipid translocation(GO:0045332) |
| 0.1 | 3.4 | GO:1901685 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
| 0.1 | 3.0 | GO:0060285 | cilium-dependent cell motility(GO:0060285) |
| 0.1 | 2.7 | GO:0035640 | exploration behavior(GO:0035640) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 16.9 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 5.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.3 | 5.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 2.8 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 1.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 1.8 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 1.5 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.4 | 1.1 | GO:0097232 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
| 0.1 | 1.1 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.1 | 1.1 | GO:0030008 | TRAPP complex(GO:0030008) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.6 | GO:0042805 | actinin binding(GO:0042805) |
| 0.3 | 10.0 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 2.0 | 8.1 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
| 0.1 | 5.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.4 | 5.0 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 3.7 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 3.5 | GO:0002020 | protease binding(GO:0002020) |
| 0.1 | 3.4 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 3.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 3.0 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.6 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.1 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.9 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.8 | ST ADRENERGIC | Adrenergic Pathway |
| 0.0 | 0.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.4 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 8.1 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 5.0 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 3.4 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 3.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 2.4 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 2.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.1 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 1.1 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 1.0 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.8 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |