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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SP1
Z-value: 1.43
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Transcription factors associated with SP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP1 | hg38_v1_chr12_+_53380141_53380210, hg38_v1_chr12_+_53380639_53380874 | 0.27 | 1.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_67431112 Show fit | 3.61 |
ENST00000326152.6
|
hydroxysteroid 11-beta dehydrogenase 2 |
|
| chr1_+_25616780 Show fit | 2.84 |
ENST00000374332.9
|
mannosidase alpha class 1C member 1 |
|
| chr19_-_51001138 Show fit | 2.74 |
ENST00000593490.1
|
kallikrein related peptidase 8 |
|
| chr16_-_52547113 Show fit | 2.26 |
ENST00000219746.14
|
TOX high mobility group box family member 3 |
|
| chr1_-_231040218 Show fit | 2.21 |
ENST00000366654.5
|
family with sequence similarity 89 member A |
|
| chr16_-_87869497 Show fit | 2.21 |
ENST00000261622.5
|
solute carrier family 7 member 5 |
|
| chr8_+_123416735 Show fit | 2.02 |
ENST00000524254.5
|
N-terminal glutamine amidase 1 |
|
| chr11_+_45922640 Show fit | 2.01 |
ENST00000401752.6
ENST00000325468.9 |
LARGE xylosyl- and glucuronyltransferase 2 |
|
| chr2_+_24049705 Show fit | 1.99 |
ENST00000380986.9
ENST00000452109.1 |
FKBP prolyl isomerase 1B |
|
| chr20_+_36461460 Show fit | 1.93 |
ENST00000482872.5
ENST00000495241.5 |
DLG associated protein 4 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 9.2 | GO:0030421 | defecation(GO:0030421) |
| 1.1 | 6.7 | GO:0006021 | inositol biosynthetic process(GO:0006021) |
| 0.0 | 6.2 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.4 | 5.3 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.3 | 4.9 | GO:0003084 | positive regulation of systemic arterial blood pressure(GO:0003084) |
| 0.5 | 4.6 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.1 | 4.6 | GO:0060612 | adipose tissue development(GO:0060612) |
| 0.1 | 4.3 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
| 0.1 | 4.2 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 0.1 | 4.1 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 48.7 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.1 | 35.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 31.7 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 12.0 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 10.9 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.1 | 10.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 9.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 7.7 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 7.6 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 7.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.7 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 12.4 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 10.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.8 | 6.3 | GO:0052832 | inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834) |
| 0.0 | 6.3 | GO:0002020 | protease binding(GO:0002020) |
| 0.1 | 6.1 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.1 | 5.3 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.3 | 5.1 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.2 | 5.0 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 5.0 | GO:0019003 | GDP binding(GO:0019003) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.1 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 11.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 8.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 7.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 7.4 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 6.1 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 6.1 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 5.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 5.5 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 5.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.3 | REACTOME TRIGLYCERIDE BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 0.2 | 10.0 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 8.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 8.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 7.1 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.2 | 6.5 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 6.0 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.2 | 5.5 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.2 | 4.9 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.2 | 4.9 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |