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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SP3
Z-value: 1.44
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Transcription factors associated with SP3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP3 | hg38_v1_chr2_-_173965356_173965380 | 0.12 | 5.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 26.8 | GO:0031055 | chromatin remodeling at centromere(GO:0031055) |
| 0.6 | 26.2 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 0.4 | 22.8 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.2 | 14.0 | GO:0006007 | glucose catabolic process(GO:0006007) |
| 0.2 | 13.9 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.7 | 13.8 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 3.1 | 12.5 | GO:0070982 | L-asparagine biosynthetic process(GO:0070981) L-asparagine metabolic process(GO:0070982) |
| 1.0 | 12.5 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.2 | 11.9 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 1.0 | 11.7 | GO:0085020 | protein K6-linked ubiquitination(GO:0085020) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 56.8 | GO:0005730 | nucleolus(GO:0005730) |
| 0.4 | 43.5 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.1 | 32.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.4 | 27.1 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.1 | 22.4 | GO:0005874 | microtubule(GO:0005874) |
| 0.2 | 22.3 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.1 | 21.4 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.4 | 14.3 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.1 | 13.9 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 1.7 | 13.8 | GO:0000796 | condensin complex(GO:0000796) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 32.9 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.1 | 26.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 14.2 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 13.4 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 13.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.5 | 12.7 | GO:0017166 | vinculin binding(GO:0017166) |
| 2.5 | 12.5 | GO:0004066 | asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066) |
| 0.2 | 12.5 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 12.4 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 12.1 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 46.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.6 | 36.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 21.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.3 | 17.9 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.3 | 15.3 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.2 | 14.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 13.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 13.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 12.9 | PID ATR PATHWAY | ATR signaling pathway |
| 0.9 | 12.5 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 45.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.9 | 35.8 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 1.1 | 33.8 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.6 | 27.5 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.9 | 24.9 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.3 | 21.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.8 | 17.9 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.5 | 17.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.3 | 17.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.6 | 16.8 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |