ISMARA results: SPI1

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SPI1

Z-value: 1.00

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Transcription factors associated with SPI1

Gene Symbol	Gene ID	Gene Info
SPI1 Ensembl NCBI GeneCards UniProt	ENSG00000066336.12	SPI1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SPI1	hg38_v1_chr11_-_47378391_47378410, hg38_v1_chr11_-_47378527_47378555	0.36	4.7e-02	Click!

Activity profile of SPI1 motif

Sorted Z-values of SPI1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SPI1

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Promoter	Score	Transcript	Gene	Gene Info
chr18_+_63702958 Show fit	3.70	ENST00000544088.6	SERPINB11 Ensembl NCBI GeneCards UniProt Show fit	serpin family B member 11
chr3_-_112975018 Show fit	2.70	ENST00000471858.5 ENST00000308611.8 ENST00000295863.4	CD200R1 Ensembl NCBI GeneCards UniProt Show fit	CD200 receptor 1
chr5_-_180591488 Show fit	2.53	ENST00000292641.4	SCGB3A1 Ensembl NCBI GeneCards UniProt Show fit	secretoglobin family 3A member 1
chr14_+_96482982 Show fit	2.34	ENST00000554706.1	AK7 Ensembl NCBI GeneCards UniProt Show fit	adenylate kinase 7
chr17_+_47831608 Show fit	2.28	ENST00000269025.9	LRRC46 Ensembl NCBI GeneCards UniProt Show fit	leucine rich repeat containing 46
chr3_-_112974912 Show fit	2.20	ENST00000440122.6 ENST00000490004.1	CD200R1 Ensembl NCBI GeneCards UniProt Show fit	CD200 receptor 1
chr1_-_150765735 Show fit	2.16	ENST00000679898.1 ENST00000448301.7 ENST00000680664.1 ENST00000679512.1 ENST00000368985.8 ENST00000679582.1	CTSS Ensembl NCBI GeneCards UniProt Show fit	cathepsin S
chr9_-_114387973 Show fit	1.91	ENST00000374088.8	AKNA Ensembl NCBI GeneCards UniProt Show fit	AT-hook transcription factor
chr1_-_150765785 Show fit	1.90	ENST00000680311.1 ENST00000681728.1 ENST00000680288.1	CTSS Ensembl NCBI GeneCards UniProt Show fit	cathepsin S
chr1_-_206921987 Show fit	1.77	ENST00000530505.1 ENST00000442471.4	FCMR Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgM receptor

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	4.1	GO:0034769	basement membrane disassembly(GO:0034769)
0.5	3.6	GO:0000821	regulation of arginine metabolic process(GO:0000821)
0.6	2.4	GO:0030037	actin filament reorganization involved in cell cycle(GO:0030037)
0.0	2.3	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.1	2.2	GO:0071800	podosome assembly(GO:0071800)
0.0	2.2	GO:0015949	nucleobase-containing small molecule interconversion(GO:0015949)
0.5	1.9	GO:0097089	methyl-branched fatty acid metabolic process(GO:0097089)
0.6	1.8	GO:0032707	negative regulation of interleukin-23 production(GO:0032707)
0.3	1.8	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	1.8	GO:1901741	positive regulation of myoblast fusion(GO:1901741)

Showing 1 to 10 of 253 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	4.1	GO:0036021	endolysosome lumen(GO:0036021)
0.0	2.4	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.3	2.3	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.2	2.2	GO:0032010	phagolysosome(GO:0032010)
0.1	2.1	GO:0031231	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0	1.9	GO:0036064	ciliary basal body(GO:0036064)
0.2	1.8	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	1.8	GO:0005871	kinesin complex(GO:0005871)
0.1	1.6	GO:0097539	ciliary transition fiber(GO:0097539)
0.0	1.6	GO:0005581	collagen trimer(GO:0005581)

Showing 1 to 10 of 102 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.2	GO:0001968	fibronectin binding(GO:0001968)
0.2	3.6	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	3.1	GO:0050681	androgen receptor binding(GO:0050681)
0.1	2.6	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.4	2.3	GO:0004127	cytidylate kinase activity(GO:0004127)
0.3	2.3	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.1	2.3	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	2.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	2.2	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1	2.1	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)

Showing 1 to 10 of 165 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	3.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	3.4	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	3.1	PID ALK1 PATHWAY	ALK1 signaling events
0.1	2.0	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	1.7	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	1.6	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	1.5	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.1	1.3	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.1	1.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Showing 1 to 10 of 35 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.4	4.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	2.9	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.2	2.5	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.1	2.5	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1	2.4	REACTOME KINESINS	Genes involved in Kinesins
0.1	2.0	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1	1.9	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	1.8	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.1	1.5	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling

Showing 1 to 10 of 52 entries

Results for SPI1

Z-value: 1.00

Motif logo

Transcription factors associated with SPI1

Activity-expression correlation:

Activity profile of SPI1 motif

Sorted Z-values of SPI1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SPI1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: