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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SPIC
Z-value: 1.54
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Transcription factors associated with SPIC
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPIC | hg38_v1_chr12_+_101475319_101475340 | 0.24 | 1.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPIC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 15.4 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803) |
| 2.5 | 10.0 | GO:0045658 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 0.8 | 9.1 | GO:0034626 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.4 | 8.3 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.0 | 7.9 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 0.3 | 7.3 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.6 | 6.7 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 0.1 | 6.5 | GO:1901998 | toxin transport(GO:1901998) |
| 2.0 | 6.0 | GO:0046136 | positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) |
| 1.4 | 5.7 | GO:0036058 | filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 15.4 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 12.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 12.0 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.3 | 9.2 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.3 | 7.8 | GO:0031011 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.0 | 6.1 | GO:0000922 | spindle pole(GO:0000922) |
| 0.3 | 5.6 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 5.5 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 5.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 5.1 | GO:0005796 | Golgi lumen(GO:0005796) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 10.5 | GO:0005525 | GTP binding(GO:0005525) |
| 1.7 | 10.0 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.8 | 9.1 | GO:0102336 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.3 | 6.8 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.2 | 6.6 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.3 | 6.0 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.2 | 5.9 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.4 | 5.6 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.3 | 5.5 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 15.4 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.3 | 15.0 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.2 | 12.6 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 8.5 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.2 | 8.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 7.5 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 5.9 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 5.0 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.3 | 4.6 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 4.5 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.0 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.3 | 9.1 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 6.2 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 6.1 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.3 | 5.6 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.2 | 5.1 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 4.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 4.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 4.3 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 4.2 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |