Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
Navigation
Downloads
Results for SREBF2
Z-value: 0.82
Motif logo
Transcription factors associated with SREBF2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SREBF2 | hg38_v1_chr22_+_41833079_41833142 | 0.67 | 5.5e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SREBF2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_151239951 Show fit | 4.50 |
ENST00000402676.7
|
A-kinase anchoring protein 12 |
|
| chr4_+_74365136 Show fit | 3.47 |
ENST00000244869.3
|
epiregulin |
|
| chr1_+_55039511 Show fit | 3.34 |
ENST00000302118.5
|
proprotein convertase subtilisin/kexin type 9 |
|
| chr8_+_26577843 Show fit | 3.01 |
ENST00000311151.9
|
dihydropyrimidinase like 2 |
|
| chr19_+_11089446 Show fit | 2.47 |
ENST00000557933.5
ENST00000455727.6 ENST00000535915.5 ENST00000545707.5 ENST00000558518.6 ENST00000558013.5 |
low density lipoprotein receptor |
|
| chr20_+_34876603 Show fit | 1.99 |
ENST00000360596.7
ENST00000253382.5 |
acyl-CoA synthetase short chain family member 2 |
|
| chr2_-_25982471 Show fit | 1.88 |
ENST00000264712.8
|
kinesin family member 3C |
|
| chr6_-_53348902 Show fit | 1.85 |
ENST00000370913.5
ENST00000304434.11 |
ELOVL fatty acid elongase 5 |
|
| chr18_-_23586422 Show fit | 1.82 |
ENST00000269228.10
|
NPC intracellular cholesterol transporter 1 |
|
| chr17_-_82098187 Show fit | 1.79 |
ENST00000634990.1
|
fatty acid synthase |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 4.5 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.5 | 3.5 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.0 | 3.5 | GO:0030183 | B cell differentiation(GO:0030183) |
| 1.1 | 3.3 | GO:2000646 | positive regulation of receptor catabolic process(GO:2000646) |
| 0.0 | 3.0 | GO:0030516 | regulation of axon extension(GO:0030516) |
| 0.2 | 2.9 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.2 | 2.8 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.1 | 2.7 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
| 0.6 | 2.5 | GO:1905167 | positive regulation of lysosomal protein catabolic process(GO:1905167) |
| 0.4 | 2.4 | GO:0006696 | ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 5.8 | GO:1990666 | PCSK9-LDLR complex(GO:1990666) |
| 0.0 | 5.5 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 3.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.9 | 2.8 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 0.0 | 2.4 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 2.2 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.2 | 1.8 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.1 | 1.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 1.2 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 1.0 | GO:0000796 | condensin complex(GO:0000796) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.5 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.8 | 3.3 | GO:0034189 | very-low-density lipoprotein particle binding(GO:0034189) |
| 1.0 | 3.0 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 1.0 | 2.9 | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity(GO:0004421) |
| 0.5 | 2.8 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) |
| 0.5 | 2.7 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.0 | 2.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.5 | 2.5 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 0.4 | 2.4 | GO:0004310 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
| 0.5 | 2.0 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 2.1 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 2.0 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.9 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 1.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 1.4 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 1.4 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 1.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.7 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.1 | 5.3 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 3.0 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 2.7 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.1 | 2.5 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 2.1 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.2 | 2.0 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 1.9 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 1.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 1.9 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |